Research Topics
| R J GilbertSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
Research Grants
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Detail Information
Publications
Imaging of three-dimensional epithelial architecture and function in cultured CaCo2a monolayers with two-photon excitation microscopyR J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
Microsc Res Tech 51:204-10. 2000....
Resolving the three-dimensional myoarchitecture of bovine esophageal wall with diffusion spectrum imaging and tractographyRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell Tissue Res 332:461-8. 2008....- Three-dimensional myoarchitecture of the bovine tongue demonstrated by diffusion spectrum magnetic resonance imaging with tractographyRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
Anat Rec A Discov Mol Cell Evol Biol 288:1173-82. 2006..We postulate that the properties associated with these myofiber tracts predict the mechanical behavior of the tissue and thus constitute a method to relate structure and function for anatomically complex muscular tissues... 
Mapping complex myoarchitecture in the bovine tongue with diffusion-spectrum magnetic resonance imagingRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
Biophys J 91:1014-22. 2006..We conclude that DSI has the capacity to determine three-dimensional fiber orientation in structurally complex muscular tissues...- Anatomical basis of lingual hydrostatic deformationRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology and the Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Cambridge, MA 02139, USA
J Exp Biol 210:4069-82. 2007..Evidence is provided in support of the supposition that hydrostatic deformation is based on the contraction of orthogonally aligned intramural fibers functioning as a mechanical continuum... - Quantitative analysis of three-dimensional-resolved fiber architecture in heterogeneous skeletal muscle tissue using nmr and optical imaging methodsV J Napadow
Department of Mechanical Engineering and Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Biophys J 80:2968-75. 2001.... - Three dimensional myoarchitecture of the human tongue determined in vivo by diffusion tensor imaging with tractographyTerry A Gaige
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Magn Reson Imaging 26:654-61. 2007..To study the anatomical relationships involving the intrinsic and extrinsic myofiber populations of the human tongue employing diffusion tensor imaging (DTI) with tractography... - Determination of regional pulmonary parenchymal strain during normal respiration using spin inversion tagged magnetization MRIV J Napadow
Department of of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02138, USA
J Magn Reson Imaging 13:467-74. 2001..This study demonstrates that localized pulmonary deformation can be measured in vivo with tagging MRI, and quantified by applying finite strain definitions from continuum mechanics... - A biomechanical model of sagittal tongue bendingVitaly J Napadow
Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
J Biomech Eng 124:547-56. 2002..This fundamental reliance of tongue bending on the synergistic contraction of its intrinsic fibers supports the muscular hydrostat theory of tongue function... - Associating the mesoscale fiber organization of the tongue with local strain rate during swallowingSamuel M Felton
Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
J Biomech 41:1782-9. 2008..These data demonstrate that lingual deformation during swallowing involves complex interactions involving intrinsic and extrinsic muscles, whose contractility is directed by the alignment of mesoscale fiber tracts... - Three-dimensional muscular architecture of the human tongue determined in vivo with diffusion tensor magnetic resonance imagingRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Dysphagia 20:1-7. 2005..These findings demonstrate that the muscular anatomy of the tongue can be displayed as a continuous array of structural units, or tensors, representing fibers of varying orientations throughout the tissue... - Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardiumDavid E Sosnovik
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Circ Cardiovasc Imaging 2:206-12. 2009..Unlike diffusion tensor imaging, DSI tractography resolves multiple myofiber populations per voxel, thus generating accurate 3D tractograms, which we present in the myocardium for the first time... - Multiscale structural analysis of mouse lingual myoarchitecture employing diffusion spectrum magnetic resonance imaging and multiphoton microscopyTerry A Gaige
Massachusetts Institute of Technology, Department of Mechanical and Biological Engineering, Cambridge, Massachusetts 02139, USA
J Biomed Opt 13:064005. 2008.... - Mechanical basis for lingual deformation during the propulsive phase of swallowing as determined by phase-contrast magnetic resonance imagingSamuel M Felton
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Appl Physiol 103:255-65. 2007..These data support the concept that propulsive lingual deformation is due to complex muscular interactions involving both extrinsic and intrinsic muscles... - Computational and functional evaluation of a microfluidic blood flow deviceRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02135, USA
ASAIO J 53:447-55. 2007..Such technology should foster the development of miniature oxygenators and similar biomedical devices requiring both a microscale reaction volume and physiological blood flow... - Resolving myoarchitectural disarray in the mouse ventricular wall with diffusion spectrum magnetic resonance imagingTeresa T Wang
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA
Ann Biomed Eng 38:2841-50. 2010.... - Photolytically driven generation of dissolved oxygen and increased oxyhemoglobin in whole bloodBruce F Monzyk
Battelle Memorial Institute, Columbus, Ohio, USA
ASAIO J 52:456-66. 2006..We conclude that it is feasible to photolytically oxygenate the hemoglobin contained in whole blood with oxygen derived from the blood's own water content without involving a gaseous phase... - Computational and experimental evaluation of the fluid dynamics and hemocompatibility of the CentriMag blood pumpJuntao Zhang
Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA
Artif Organs 30:168-77. 2006..0029 +/- 0.006) without a decrease of the pump's hydrodynamic performance (pressure head: 352 mm Hg at a flow rate of 5.0 L/min and a rotational speed of 4,000 rpm)...
Research Grants
- Lingual Mechanical Function During SwallowingRichard Gilbert; Fiscal Year: 2005..It is anticipated that this understanding will result in novel hypotheses of pathological lingual function for patients with oropharyngeal dysphagia. ..
- Development of a Photoactivated Respiratory Support DeviceRichard Gilbert; Fiscal Year: 2007....
- Development of a Photoactivated Respiratory Support DeviceRichard Gilbert; Fiscal Year: 2009....