R J Gilbert

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Imaging of three-dimensional epithelial architecture and function in cultured CaCo2a monolayers with two-photon excitation microscopy
    R J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
    Microsc Res Tech 51:204-10. 2000
  2. doi request reprint Resolving the three-dimensional myoarchitecture of bovine esophageal wall with diffusion spectrum imaging and tractography
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell Tissue Res 332:461-8. 2008
  3. ncbi request reprint Three-dimensional myoarchitecture of the bovine tongue demonstrated by diffusion spectrum magnetic resonance imaging with tractography
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:1173-82. 2006
  4. pmc Mapping complex myoarchitecture in the bovine tongue with diffusion-spectrum magnetic resonance imaging
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biophys J 91:1014-22. 2006
  5. ncbi request reprint Anatomical basis of lingual hydrostatic deformation
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology and the Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Cambridge, MA 02139, USA
    J Exp Biol 210:4069-82. 2007
  6. pmc Quantitative analysis of three-dimensional-resolved fiber architecture in heterogeneous skeletal muscle tissue using nmr and optical imaging methods
    V J Napadow
    Department of Mechanical Engineering and Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biophys J 80:2968-75. 2001
  7. ncbi request reprint Three dimensional myoarchitecture of the human tongue determined in vivo by diffusion tensor imaging with tractography
    Terry A Gaige
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Magn Reson Imaging 26:654-61. 2007
  8. ncbi request reprint Determination of regional pulmonary parenchymal strain during normal respiration using spin inversion tagged magnetization MRI
    V J Napadow
    Department of of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02138, USA
    J Magn Reson Imaging 13:467-74. 2001
  9. ncbi request reprint A biomechanical model of sagittal tongue bending
    Vitaly J Napadow
    Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Biomech Eng 124:547-56. 2002
  10. doi request reprint Associating the mesoscale fiber organization of the tongue with local strain rate during swallowing
    Samuel M Felton
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Biomech 41:1782-9. 2008

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Imaging of three-dimensional epithelial architecture and function in cultured CaCo2a monolayers with two-photon excitation microscopy
    R J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
    Microsc Res Tech 51:204-10. 2000
    ....
  2. doi request reprint Resolving the three-dimensional myoarchitecture of bovine esophageal wall with diffusion spectrum imaging and tractography
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell Tissue Res 332:461-8. 2008
    ....
  3. ncbi request reprint Three-dimensional myoarchitecture of the bovine tongue demonstrated by diffusion spectrum magnetic resonance imaging with tractography
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:1173-82. 2006
    ..We postulate that the properties associated with these myofiber tracts predict the mechanical behavior of the tissue and thus constitute a method to relate structure and function for anatomically complex muscular tissues...
  4. pmc Mapping complex myoarchitecture in the bovine tongue with diffusion-spectrum magnetic resonance imaging
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biophys J 91:1014-22. 2006
    ..We conclude that DSI has the capacity to determine three-dimensional fiber orientation in structurally complex muscular tissues...
  5. ncbi request reprint Anatomical basis of lingual hydrostatic deformation
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology and the Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Cambridge, MA 02139, USA
    J Exp Biol 210:4069-82. 2007
    ..Evidence is provided in support of the supposition that hydrostatic deformation is based on the contraction of orthogonally aligned intramural fibers functioning as a mechanical continuum...
  6. pmc Quantitative analysis of three-dimensional-resolved fiber architecture in heterogeneous skeletal muscle tissue using nmr and optical imaging methods
    V J Napadow
    Department of Mechanical Engineering and Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biophys J 80:2968-75. 2001
    ....
  7. ncbi request reprint Three dimensional myoarchitecture of the human tongue determined in vivo by diffusion tensor imaging with tractography
    Terry A Gaige
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Magn Reson Imaging 26:654-61. 2007
    ..To study the anatomical relationships involving the intrinsic and extrinsic myofiber populations of the human tongue employing diffusion tensor imaging (DTI) with tractography...
  8. ncbi request reprint Determination of regional pulmonary parenchymal strain during normal respiration using spin inversion tagged magnetization MRI
    V J Napadow
    Department of of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02138, USA
    J Magn Reson Imaging 13:467-74. 2001
    ..This study demonstrates that localized pulmonary deformation can be measured in vivo with tagging MRI, and quantified by applying finite strain definitions from continuum mechanics...
  9. ncbi request reprint A biomechanical model of sagittal tongue bending
    Vitaly J Napadow
    Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Biomech Eng 124:547-56. 2002
    ..This fundamental reliance of tongue bending on the synergistic contraction of its intrinsic fibers supports the muscular hydrostat theory of tongue function...
  10. doi request reprint Associating the mesoscale fiber organization of the tongue with local strain rate during swallowing
    Samuel M Felton
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Biomech 41:1782-9. 2008
    ..These data demonstrate that lingual deformation during swallowing involves complex interactions involving intrinsic and extrinsic muscles, whose contractility is directed by the alignment of mesoscale fiber tracts...
  11. ncbi request reprint Three-dimensional muscular architecture of the human tongue determined in vivo with diffusion tensor magnetic resonance imaging
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Dysphagia 20:1-7. 2005
    ..These findings demonstrate that the muscular anatomy of the tongue can be displayed as a continuous array of structural units, or tensors, representing fibers of varying orientations throughout the tissue...
  12. pmc Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Cardiovasc Imaging 2:206-12. 2009
    ..Unlike diffusion tensor imaging, DSI tractography resolves multiple myofiber populations per voxel, thus generating accurate 3D tractograms, which we present in the myocardium for the first time...
  13. doi request reprint Multiscale structural analysis of mouse lingual myoarchitecture employing diffusion spectrum magnetic resonance imaging and multiphoton microscopy
    Terry A Gaige
    Massachusetts Institute of Technology, Department of Mechanical and Biological Engineering, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 13:064005. 2008
    ....
  14. ncbi request reprint Mechanical basis for lingual deformation during the propulsive phase of swallowing as determined by phase-contrast magnetic resonance imaging
    Samuel M Felton
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Appl Physiol 103:255-65. 2007
    ..These data support the concept that propulsive lingual deformation is due to complex muscular interactions involving both extrinsic and intrinsic muscles...
  15. ncbi request reprint Computational and functional evaluation of a microfluidic blood flow device
    Richard J Gilbert
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02135, USA
    ASAIO J 53:447-55. 2007
    ..Such technology should foster the development of miniature oxygenators and similar biomedical devices requiring both a microscale reaction volume and physiological blood flow...
  16. doi request reprint Resolving myoarchitectural disarray in the mouse ventricular wall with diffusion spectrum magnetic resonance imaging
    Teresa T Wang
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA
    Ann Biomed Eng 38:2841-50. 2010
    ....
  17. ncbi request reprint Photolytically driven generation of dissolved oxygen and increased oxyhemoglobin in whole blood
    Bruce F Monzyk
    Battelle Memorial Institute, Columbus, Ohio, USA
    ASAIO J 52:456-66. 2006
    ..We conclude that it is feasible to photolytically oxygenate the hemoglobin contained in whole blood with oxygen derived from the blood's own water content without involving a gaseous phase...
  18. ncbi request reprint Computational and experimental evaluation of the fluid dynamics and hemocompatibility of the CentriMag blood pump
    Juntao Zhang
    Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA
    Artif Organs 30:168-77. 2006
    ..0029 +/- 0.006) without a decrease of the pump's hydrodynamic performance (pressure head: 352 mm Hg at a flow rate of 5.0 L/min and a rotational speed of 4,000 rpm)...

Research Grants6

  1. Lingual Mechanical Function During Swallowing
    Richard Gilbert; Fiscal Year: 2005
    ..It is anticipated that this understanding will result in novel hypotheses of pathological lingual function for patients with oropharyngeal dysphagia. ..
  2. Development of a Photoactivated Respiratory Support Device
    Richard Gilbert; Fiscal Year: 2007
    ....
  3. Development of a Photoactivated Respiratory Support Device
    Richard Gilbert; Fiscal Year: 2009
    ....