Frank Gertler

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Ena/VASP is required for endothelial barrier function in vivo
    Craig Furman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 179:761-75. 2007
  2. pmc An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype
    Irina M Shapiro
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Genet 7:e1002218. 2011
  3. pmc Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Breast Cancer Res 12:R101. 2010
  4. pmc Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy
    Erik Sahai
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    BMC Biotechnol 5:14. 2005
  5. pmc Metastasis: tumor cells becoming MENAcing
    Frank Gertler
    Department of Biology and Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology MIT, 77 Massachusetts Ave, Cambridge, MA 02138, USA
    Trends Cell Biol 21:81-90. 2011
  6. ncbi request reprint Arp2/3 is a negative regulator of growth cone translocation
    Geraldine A Strasser
    Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 43:81-94. 2004
  7. ncbi request reprint Cytoskeletal dynamics and transport in growth cone motility and axon guidance
    Erik W Dent
    Biology Department, 68 270, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 40:209-27. 2003
  8. ncbi request reprint Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system
    A Sheila Menzies
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    J Neurosci 24:8029-38. 2004
  9. ncbi request reprint Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1
    Cecile Lebrand
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 42:37-49. 2004
  10. ncbi request reprint Ena/VASP Is Required for neuritogenesis in the developing cortex
    Adam V Kwiatkowski
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 56:441-55. 2007

Research Grants

  1. CELLULAR AND DEVELOPMENTAL FUNCTIONS IN MENA
    Frank Gertler; Fiscal Year: 2006
  2. CELLULAR AND DEVELOPMENTAL FUNCTIONS OF MENA
    Frank Gertler; Fiscal Year: 2001
  3. CELLULAR AND DEVELOPMENTAL FUNCTIONS OF MENA
    Frank Gertler; Fiscal Year: 2002
  4. CELLULAR AND DEVELOPMENTAL FUNCTIONS OF MENA
    Frank Gertler; Fiscal Year: 2003
  5. Cellular and Developmental Function of Mena
    Frank Gertler; Fiscal Year: 2009
  6. CELLULAR AND DEVELOPMENTAL FUNCTIONS IN MENA
    Frank Gertler; Fiscal Year: 2004
  7. CELLULAR AND DEVELOPMENTAL FUNCTIONS IN MENA
    Frank Gertler; Fiscal Year: 2005
  8. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2010
  9. Cellular and Developmental Function of Mena
    Frank B Gertler; Fiscal Year: 2010
  10. Cellular and Developmental Function of Mena
    Frank B Gertler; Fiscal Year: 2011

Collaborators

Detail Information

Publications45

  1. pmc Ena/VASP is required for endothelial barrier function in vivo
    Craig Furman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 179:761-75. 2007
    ..These findings demonstrate that Ena/VASP is critical for actin cytoskeleton remodeling events involved in the maintenance of functional endothelia...
  2. pmc An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype
    Irina M Shapiro
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Genet 7:e1002218. 2011
    ..The molecular description obtained here may aid in the development of new diagnostic and prognostic markers for analysis of breast cancer progression...
  3. pmc Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Breast Cancer Res 12:R101. 2010
    ..Whether Mena is required for tumor progression is still unknown. Here we report the effects of Mena deficiency on tumor progression, metastasis and on normal mammary gland development...
  4. pmc Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy
    Erik Sahai
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    BMC Biotechnol 5:14. 2005
    ..However, the use of genetically encoded fluorescent proteins to distinguish different cell types in living animals has not been described at single cell resolution using multiphoton microscopy...
  5. pmc Metastasis: tumor cells becoming MENAcing
    Frank Gertler
    Department of Biology and Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology MIT, 77 Massachusetts Ave, Cambridge, MA 02138, USA
    Trends Cell Biol 21:81-90. 2011
    ..This change in Mena isoform expression enables tumor cells to invade in response to otherwise benign EGF stimulus levels and could offer an opportunity to identify metastatic risk in patients...
  6. ncbi request reprint Arp2/3 is a negative regulator of growth cone translocation
    Geraldine A Strasser
    Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 43:81-94. 2004
    ..Surprisingly, Arp2/3 inhibition significantly enhances axon elongation and causes defects in growth cone guidance. These results indicate that Arp2/3 is a negative regulator of growth cone translocation...
  7. ncbi request reprint Cytoskeletal dynamics and transport in growth cone motility and axon guidance
    Erik W Dent
    Biology Department, 68 270, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 40:209-27. 2003
    ..An important goal for the future will be to understand the coordinated response of the cytoskeleton to signaling cascades induced by guidance receptor activation...
  8. ncbi request reprint Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system
    A Sheila Menzies
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    J Neurosci 24:8029-38. 2004
    ..Mena-/-VASP-/- double mutants die perinatally and display defects in neurulation, craniofacial structures, and the formation of several fiber tracts in the CNS and peripheral nervous system...
  9. ncbi request reprint Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1
    Cecile Lebrand
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 42:37-49. 2004
    ..We propose that Ena/VASP proteins control filopodial dynamics in neurons by remodeling the actin network in response to guidance cues...
  10. ncbi request reprint Ena/VASP Is Required for neuritogenesis in the developing cortex
    Adam V Kwiatkowski
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 56:441-55. 2007
    ..These findings provide insight into the regulation of neurite formation and the role of the actin cytoskeleton during cortical development...
  11. ncbi request reprint Filopodia: the fingers that do the walking
    Stephanie L Gupton
    Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci STKE 2007:re5. 2007
    ..We discuss established and novel proteins that mediate the formation and dynamics of filopodia, different mechanisms of filopodium formation, and the various functions that distinct filopodia perform...
  12. ncbi request reprint Function and regulation of Ena/VASP proteins
    Adam V Kwiatkowski
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Trends Cell Biol 13:386-92. 2003
    ..This review will examine the mechanisms by which Ena/VASP function might control actin dynamics and how these proteins are linked to various signaling pathways...
  13. ncbi request reprint The Ena/VASP enigma
    Matthias Krause
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    J Cell Sci 115:4721-6. 2002
    ..Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as 'anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments...
  14. pmc Ena/VASP: proteins at the tip of the nervous system
    Frauke Drees
    David H Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Curr Opin Neurobiol 18:53-9. 2008
    ..Here we review recent findings into Ena/VASP function in neurite initiation, axon outgrowth and guidance...
  15. ncbi request reprint Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration
    Matthias Krause
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Cell Dev Biol 19:541-64. 2003
    ..Phosphorylation by these kinases appears to modulate Ena/VASP function within cells, although the mechanism underlying this regulation remains to be determined...
  16. pmc Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration
    Joseph J Loureiro
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Mol Biol Cell 13:2533-46. 2002
    ..Interestingly, expression of the C-terminal EVH2 domain alone is sufficient to complement loss of Ena/VASP function in random cell motility...
  17. ncbi request reprint Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins
    Shabeen Ally
    Infectious Disease Division, Massachusetts General Hospital, Cambridge, MA 02139, USA
    Cell Microbiol 6:355-66. 2004
    ..Thus, although VASP is recruited to the surface of intracellular Shigella, it is not essential for Shigella actin-based motility...
  18. ncbi request reprint Ena/VASP proteins regulate cortical neuronal positioning
    Keow Lin Goh
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Biol 12:565-9. 2002
    ..The abnormally placed pyramidal neurons exhibited grossly normal morphology and polarity. Our results are consistent with a model in which Ena/VASP proteins function in vivo to control the position of neurons in the mouse neocortex...
  19. pmc A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis
    Ulrike Philippar
    Massachusetts Institute of Technology, Koch Institute, Cambridge, MA 02139, USA
    Dev Cell 15:813-28. 2008
    ..Upregulation of Mena(INV) could therefore enable tumor cells to invade in response to otherwise benign EGF stimulus levels...
  20. ncbi request reprint Filopodia are required for cortical neurite initiation
    Erik W Dent
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Nat Cell Biol 9:1347-59. 2007
    ..Neurite initiation also requires microtubule extension into filopodia, suggesting that interactions between actin-filament bundles and dynamic microtubules within filopodia are crucial for neuritogenesis...
  21. ncbi request reprint Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
    Matthias Krause
    Department of Biology and Center for Cancer Research, MIT, Cambridge, MA 02139, USA
    Dev Cell 7:571-83. 2004
    ..These phenotypes are more severe than loss of Ena/VASP, suggesting that Lpd regulates other effectors of the actin cytoskeleton in addition to Ena/VASP...
  22. pmc Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis
    Stephanie L Gupton
    The Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 18:725-36. 2010
    ..These regulated changes and coordination of cytoskeletal and exocytic machinery may be used in other physiological contexts involving cell motility and morphogenesis...
  23. pmc In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression
    Corbin E Meacham
    The Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 41:1133-7. 2009
    ....
  24. pmc Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence
    Hyung Do Kim
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Biol Cell 19:4249-59. 2008
    ..Thus, the EGF-enhanced 3D tumor cell migration results only partially from cell-intrinsic effects, with override of cell-intrinsic persistence decrease by protease-mediated cell-extrinsic reduction of matrix steric hindrance...
  25. ncbi request reprint Nervous Rac: DOCK7 regulation of axon formation
    Elaine Maria Pinheiro
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Neuron 51:674-6. 2006
    ..Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation...
  26. ncbi request reprint Tuba stimulates intracellular N-WASP-dependent actin assembly
    Eva M Kovacs
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Sci 119:2715-26. 2006
    ..These results suggest first that Tuba-stimulated dorsal ruffling might represent a novel mechanism for the coordination of N-WASP-dependent cytoskeletal rearrangements and second that Tuba function is implicated in motility processes...
  27. ncbi request reprint A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila
    Aleksey Kazantsev
    Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Genet 30:367-76. 2002
    ..These results suggest that targeting the protein interactions leading to aggregate formation may be beneficial for the design and development of therapeutic agents for Huntington disease...
  28. ncbi request reprint Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility
    James E Bear
    Massachusetts Institute of Technology, Department of Biology, Cambridge 02139, USA
    Cell 109:509-21. 2002
    ..We conclude that Ena/VASP regulates cell motility by controlling the geometry of actin filament networks within lamellipodia...
  29. ncbi request reprint Palladin is a novel binding partner for Ena/VASP family members
    Malika Boukhelifa
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
    Cell Motil Cytoskeleton 58:17-29. 2004
    ..These results suggest that the recently described actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking...
  30. ncbi request reprint Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end
    Marisan R Mejillano
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Cell 118:363-73. 2004
    ....
  31. ncbi request reprint Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility
    Victoria Auerbuch
    Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
    Mol Microbiol 49:1361-75. 2003
    ..Lastly, we showed the pathogenic relevance of these findings by the observation that L. monocytogenes lacking ActA Ena/VASP-binding sites were up to 400-fold less virulent during an adaptive immune response...
  32. pmc Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
    Catherine I Lacayo
    Department of Biochemistry, Stanford University, Stanford, California, United States of America
    PLoS Biol 5:e233. 2007
    ....
  33. pmc Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation
    Asha Dwivedy
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Development 134:2137-46. 2007
    ....
  34. pmc Ena/VASP proteins have an anti-capping independent function in filopodia formation
    Derek A Applewhite
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mol Biol Cell 18:2579-91. 2007
    ..Furthermore, the EVH1 domain, together with the GAB motif in the EVH2 domain, helps to maintain Ena/VASP at the growing barbed ends...
  35. pmc Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization
    Marcus Geese
    Department of Cell Biology, Gesellschaft fur Biotechnologische Forschung, D 38124 Braunschweig, Germany
    Mol Biol Cell 13:2383-96. 2002
    ..Our data suggest that Ena/VASP proteins contribute to Listeria motility by regulating both the nucleation and elongation of actin filaments at the bacterial surface...
  36. pmc The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network
    Friedhelm Bladt
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Mol Cell Biol 23:4586-97. 2003
    ..These data suggest that the Nck SH2/SH3 adaptors have important functions in the development of mesodermal structures during embryogenesis, potentially linked to a role in cell movement and cytoskeletal organization...
  37. pmc Targeted disruption of the murine zyxin gene
    Laura M Hoffman
    Huntsman Cancer Institute and Department of Biology, University of Utah, Salt Lake City 84112, USA
    Mol Cell Biol 23:70-9. 2003
    ....
  38. pmc Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines
    Maria S Pino
    Division of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy
    Clin Cancer Res 14:4943-50. 2008
    ..The aim of this study was to determine whether or not the expression of hMena isoforms correlated with sensitivity to EGFR tyrosine kinase inhibitors and could serve as markers with potential clinical use...
  39. ncbi request reprint Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton
    Marco A Salazar
    Department of Cell Biology and the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Biol Chem 278:49031-43. 2003
    ..The properties of Tuba provide new evidence for a close functional link between dynamin, Rho GTPase signaling, and the actin cytoskeleton...
  40. ncbi request reprint RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
    Esther M Lafuente
    Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 7:585-95. 2004
    ..RIAM knockdown displaced Rap1-GTP from the plasma membrane and abrogated Rap1-induced adhesion. Thus, RIAM links Rap1 to integrin activation and plays a role in regulating actin dynamics...
  41. ncbi request reprint WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Cell Sci 118:1537-47. 2005
    ....
  42. pmc Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts
    Jeanie A Scott
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
    Mol Biol Cell 17:1085-95. 2006
    ..We propose that Ena/VASP proteins may serve as higher order regulators of the cytoskeleton at cadherin contacts through their ability to modulate distinct modes of actin organization at those contacts...
  43. ncbi request reprint Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila
    Julie Gates
    Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Development 134:2027-39. 2007
    ..We also explored filopodial regulation in cultured Drosophila cells and embryos. These data provide new insights into developmental and mechanistic roles of this important actin regulator...
  44. ncbi request reprint Ena/VASP proteins mediate repulsion from ephrin ligands
    Iwan R Evans
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Cell Sci 120:289-98. 2007
    ..Our results suggest that Ena/VASP proteins regulate ephrin-induced Eph receptor signalling events, possibly by destabilising lamellipodial protrusions...
  45. ncbi request reprint MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin
    Chieh Chang
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Curr Biol 16:854-62. 2006
    ..In cultured cells, mammalian MIG-10 promotes lamellipodial growth and Ena/VASP proteins induce filopodia...

Research Grants19

  1. CELLULAR AND DEVELOPMENTAL FUNCTIONS IN MENA
    Frank Gertler; Fiscal Year: 2006
    ..Interestingly, Abi proteins are present in complexes that regulate the SCAR/WAVE family of Arp2/3 activating proteins, suggesting that NESH could serve as a link between Ena/VASP and SCAR/WAVE function. ..
  2. CELLULAR AND DEVELOPMENTAL FUNCTIONS OF MENA
    Frank Gertler; Fiscal Year: 2001
    ..These Mena-deficient cells will also serve as an experimental system in which to conduct a structure-function analysis of the Mena protein. ..
  3. CELLULAR AND DEVELOPMENTAL FUNCTIONS OF MENA
    Frank Gertler; Fiscal Year: 2002
    ..These Mena-deficient cells will also serve as an experimental system in which to conduct a structure-function analysis of the Mena protein. ..
  4. CELLULAR AND DEVELOPMENTAL FUNCTIONS OF MENA
    Frank Gertler; Fiscal Year: 2003
    ..These Mena-deficient cells will also serve as an experimental system in which to conduct a structure-function analysis of the Mena protein. ..
  5. Cellular and Developmental Function of Mena
    Frank Gertler; Fiscal Year: 2009
    ....
  6. CELLULAR AND DEVELOPMENTAL FUNCTIONS IN MENA
    Frank Gertler; Fiscal Year: 2004
    ..Interestingly, Abi proteins are present in complexes that regulate the SCAR/WAVE family of Arp2/3 activating proteins, suggesting that NESH could serve as a link between Ena/VASP and SCAR/WAVE function. ..
  7. CELLULAR AND DEVELOPMENTAL FUNCTIONS IN MENA
    Frank Gertler; Fiscal Year: 2005
    ..Interestingly, Abi proteins are present in complexes that regulate the SCAR/WAVE family of Arp2/3 activating proteins, suggesting that NESH could serve as a link between Ena/VASP and SCAR/WAVE function. ..
  8. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2010
    ..We seek a comprehensive understanding of how nerve fibers form and are guided to their targets initially during fetal development expecting that this will help us learn to repair damage to the brain. ..
  9. Cellular and Developmental Function of Mena
    Frank B Gertler; Fiscal Year: 2010
    ....
  10. Cellular and Developmental Function of Mena
    Frank B Gertler; Fiscal Year: 2011
    ....
  11. CYTOSKELETAL REGULATION DURING GROWTH CONE GUIDANCE
    Frank Gertler; Fiscal Year: 2007
    ..This work should yield valuable insight into how the nervous system develops and how to design methods to repair it after injury. ..
  12. CELLULAR AND DEVELOPMENTAL FUNCTIONS IN MENA
    Frank Gertler; Fiscal Year: 2007
    ..Interestingly, Abi proteins are present in complexes that regulate the SCAR/WAVE family of Arp2/3 activating proteins, suggesting that NESH could serve as a link between Ena/VASP and SCAR/WAVE function. ..
  13. CYTOSKELETAL REGULATION DURING GROWTH CONE GUIDANCE
    Frank Gertler; Fiscal Year: 2006
    ..This work should yield valuable insight into how the nervous system develops and how to design methods to repair it after injury. ..
  14. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2011
    ..We seek a comprehensive understanding of how nerve fibers form and are guided to their targets initially during fetal development expecting that this will help us learn to repair damage to the brain. ..
  15. CYTOSKELETAL REGULATION DURING GROWTH CONE GUIDANCE
    Frank Gertler; Fiscal Year: 2004
    ..This work should yield valuable insight into how the nervous system develops and how to design methods to repair it after injury. ..
  16. CYTOSKELETAL REGULATION DURING GROWTH CONE GUIDANCE
    Frank Gertler; Fiscal Year: 2003
    ..This work should yield valuable insight into how the nervous system develops and how to design methods to repair it after injury. ..
  17. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank Gertler; Fiscal Year: 2009
    ..We seek a comprehensive understanding of how nerve fibers form and are guided to their targets initially during fetal development expecting that this will help us learn to repair damage to the brain. ..
  18. CYTOSKELETAL REGULATION DURING GROWTH CONE GUIDANCE
    Frank Gertler; Fiscal Year: 2005
    ..This work should yield valuable insight into how the nervous system develops and how to design methods to repair it after injury. ..
  19. CELLULAR AND DEVELOPMENTAL FUNCTIONS OF MENA
    Frank Gertler; Fiscal Year: 2000
    ..These Mena-deficient cells will also serve as an experimental system in which to conduct a structure-function analysis of the Mena protein. ..