Robert E Gerszten

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint The search for new cardiovascular biomarkers
    Robert E Gerszten
    Massachusetts General Hospital, Cardiology Division, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 451:949-52. 2008
  2. doi request reprint Two roads diverge: weight loss interventions and circulating amino acids
    Robert E Gerszten
    Cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Sci Transl Med 3:80ps15. 2011
  3. doi request reprint Integration of proteomic-based tools for improved biomarkers of myocardial injury
    Robert E Gerszten
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Clin Chem 56:194-201. 2010
  4. pmc A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients
    Sahir Kalim
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA
    J Am Heart Assoc 2:e000542. 2013
  5. pmc Metabolite profiling identifies pathways associated with metabolic risk in humans
    Susan Cheng
    Cardiology Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 125:2222-31. 2012
  6. pmc Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 121:1402-11. 2011
  7. pmc β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors
    Lee D Roberts
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Metab 19:96-108. 2014
  8. pmc A genome-wide association study of the human metabolome in a community-based cohort
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 18:130-43. 2013
  9. pmc A combined epidemiologic and metabolomic approach improves CKD prediction
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Soc Nephrol 24:1330-8. 2013
  10. pmc Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics
    Robert E Gerszten
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, 02114, USA
    Circ Res 109:463-74. 2011

Research Grants

  1. CHEMOKINE SIGNAL IN MONOCYTE RECRUITMENT
    Robert Gerszten; Fiscal Year: 2001
  2. Role of ILK in Leukocyte Recruitment
    Robert Gerszten; Fiscal Year: 2009
  3. Metabolomic predictors of insulin resistance and diabetes
    Robert Gerszten; Fiscal Year: 2009
  4. Discovery & Application of Proteomics-Based Biomarkers of Early Myocardial Injury
    Robert Gerszten; Fiscal Year: 2009
  5. Metabolomic Biomarkers of Early Myocardial Injury
    Marc S Sabatine; Fiscal Year: 2010
  6. Metabolomic predictors of insulin resistance and diabetes
    Thomas J Wang; Fiscal Year: 2010
  7. Role of ILK in Leukocyte Recruitment
    Robert Gerszten; Fiscal Year: 2007
  8. Novel Markers: Pathways, Prognosis, & Pharmacoproteomics
    Robert Gerszten; Fiscal Year: 2007
  9. Chemokine Signaling in Monocyte Recruitment In Vivo
    Robert Gerszten; Fiscal Year: 2002
  10. CHEMOKINE SIGNAL IN MONOCYTE RECRUITMENT
    Robert Gerszten; Fiscal Year: 2002

Detail Information

Publications50

  1. doi request reprint The search for new cardiovascular biomarkers
    Robert E Gerszten
    Massachusetts General Hospital, Cardiology Division, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 451:949-52. 2008
    ..Thus, new biomarkers are needed to augment the information obtained from traditional indicators and to illuminate disease mechanisms...
  2. doi request reprint Two roads diverge: weight loss interventions and circulating amino acids
    Robert E Gerszten
    Cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Sci Transl Med 3:80ps15. 2011
    ..These observations raise the possibility that changes in circulating amino acids play a role in the correction of glycemic control observed shortly after GBP...
  3. doi request reprint Integration of proteomic-based tools for improved biomarkers of myocardial injury
    Robert E Gerszten
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Clin Chem 56:194-201. 2010
    ....
  4. pmc A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients
    Sahir Kalim
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA
    J Am Heart Assoc 2:e000542. 2013
    ..The marked excess in cardiovascular mortality that results from uremia remains poorly understood...
  5. pmc Metabolite profiling identifies pathways associated with metabolic risk in humans
    Susan Cheng
    Cardiology Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 125:2222-31. 2012
    ..Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood...
  6. pmc Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 121:1402-11. 2011
    ..These studies identify a relationship between lipid acyl chain content and diabetes risk and demonstrate how lipid profiling could aid in clinical risk assessment...
  7. pmc β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors
    Lee D Roberts
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Metab 19:96-108. 2014
    ..In humans, plasma BAIBA concentrations are increased with exercise and inversely associated with metabolic risk factors. BAIBA may thus contribute to exercise-induced protection from metabolic diseases...
  8. pmc A genome-wide association study of the human metabolome in a community-based cohort
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 18:130-43. 2013
    ..Thus, our study outlines the relative contributions of inherited and clinical factors on the plasma metabolome and provides a resource for metabolism research. ..
  9. pmc A combined epidemiologic and metabolomic approach improves CKD prediction
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Soc Nephrol 24:1330-8. 2013
    ..0001). Thus, the addition of metabolite profiling to clinical data may significantly improve the ability to predict whether an individual will develop CKD by identifying predictors of renal risk that are independent of estimated GFR. ..
  10. pmc Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics
    Robert E Gerszten
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, 02114, USA
    Circ Res 109:463-74. 2011
    ..In this review, we focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes...
  11. pmc Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure
    Anjali K Nath
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FASEB J 27:1928-38. 2013
    ....
  12. pmc Early dynamic risk stratification with baseline troponin levels and 90-minute ST-segment resolution to predict 30-day cardiovascular mortality in ST-segment elevation myocardial infarction: analysis from CLopidogrel as Adjunctive ReperfusIon TherapY (CLAR
    Matthew W Sherwood
    TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am Heart J 159:964-971.e1. 2010
    ..The incremental prognostic use of the initial magnitude of troponin elevation and its value in conjunction with ST-segment resolution (STRes) in ST elevation myocardial infarction (STEMI) is less well defined...
  13. pmc Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells
    Dongxiao Shen
    Cardiovascular Research Center, Massachusetts General Hospital East 8307, Charlestown, MA 02129, USA
    Circ Res 109:616-28. 2011
    ..ILK plays a role in the activation of kinases including protein kinase B/Akt and glycogen synthase kinase 3β and regulates cell proliferation, motility, and survival...
  14. pmc Toward new biomarkers of cardiometabolic diseases
    Lee D Roberts
    Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 18:43-50. 2013
    ..Furthermore, experimental work in model systems and integration with other functional genomic approaches will facilitate the discovery of causal links between select biomarkers and disease pathogenesis. ..
  15. pmc Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab
    Heloisa Sawaya
    Cardiac Ultrasound Laboratory and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circ Cardiovasc Imaging 5:596-603. 2012
    ..The present study investigates whether early alterations of myocardial strain and blood biomarkers predict incident cardiotoxicity in patients with breast cancer during treatment with anthracyclines, taxanes, and trastuzumab...
  16. pmc Metabolite profiles and the risk of developing diabetes
    Thomas J Wang
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:448-53. 2011
    ..These findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment...
  17. pmc Metabolite profiling identifies markers of uremia
    Eugene P Rhee
    Massachusetts General Hospital, 149 13th Street, 8th Floor, Boston, MA, USA
    J Am Soc Nephrol 21:1041-1051. 2010
    ..In summary, this study demonstrates the application of metabolite profiling to identify markers of ESRD, provide perspective on uremic dyslipidemia, and broaden our understanding of the biochemical effects of hemodialysis...
  18. pmc Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury
    Gregory D Lewis
    Cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Clin Invest 118:3503-12. 2008
    ..Our results identify a role for metabolic profiling in the early detection of myocardial injury and suggest that similar approaches may be used for detection or prediction of other disease states...
  19. ncbi request reprint SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration
    Kimberly A Kelly
    Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Leukoc Biol 81:748-56. 2007
    ..These findings provide new insight into the mechanisms of transendothelial leukocyte migration and suggest a potential, targetable interaction for therapeutic intervention...
  20. ncbi request reprint In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Arterioscler Thromb Vasc Biol 22:1929-35. 2002
    ..In this study, we investigated the ability of a novel thrombin-activatable molecular probe to provide in vivo images of thrombin activity in experimental thrombi...
  21. pmc Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus
    Geoffrey A Walford
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114 Department of Medicine, Massachusetts General Hospital, Boston, MA 02114 Harvard Medical School, Boston, MA, 02115
    Metabolism 62:1772-8. 2013
    ..BCAA/AAAs decrease acutely during an oral glucose tolerance test (OGTT), a diagnostic test for T2D. It is unknown whether changes in BCAA/AAAs also signal an early response to commonly used medical therapies for T2D...
  22. doi request reprint Metabolomics and cardiovascular biomarker discovery
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, MA, USA
    Clin Chem 58:139-47. 2012
    ..Metabolomics, the systematic analysis of low molecular weight biochemical compounds in a biological specimen, has been increasingly applied to biomarker discovery...
  23. pmc Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs
    Robert E Gerszten
    Cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Physiol Lung Cell Mol Physiol 295:L16-22. 2008
    ..Strategies to overcome these challenges are discussed...
  24. pmc Metabolic signatures of exercise in human plasma
    Gregory D Lewis
    Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 2:33ra37. 2010
    ..Plasma metabolic profiles obtained during exercise provide signatures of exercise performance and cardiovascular disease susceptibility, in addition to highlighting molecular pathways that may modulate the salutary effects of exercise...
  25. pmc Targeted metabolomics
    Lee D Roberts
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2012
    ..Specifically, protocols are described for analyzing these metabolites using targeted metabolomics experiments based on liquid chromatography-mass spectrometry...
  26. pmc Application of metabolomics to cardiovascular biomarker and pathway discovery
    Gregory D Lewis
    Center for Immunology and Inflammatory Diseases and Cardiology Division, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Am Coll Cardiol 52:117-23. 2008
    ....
  27. pmc Novel antibody markers of unstable atherosclerotic lesions
    Donald B Bloch
    Center for Immunology and Inflammatory Diseases and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 118:2675-7. 2008
    ..Further studies that include an adequate number of patients presenting very early after the onset of symptoms and additional control patient populations are warranted to compare the utility of these biomarkers to those in clinical use...
  28. ncbi request reprint A novel near-infrared fluorescence sensor for detection of thrombin activation in blood
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, MA 02129, USA
    Chembiochem 3:207-11. 2002
    ..In addition to potentially furthering our understanding of thrombin regulation in vivo, the thrombin-activated near-infrared probe may have broad clinical application to the diagnosis of arterial and venous thrombosis...
  29. ncbi request reprint Inhibited aortic aneurysm formation in BLT1-deficient mice
    Neil Ahluwalia
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 179:691-7. 2007
    ..These findings extend the role of BLT1 to a critical complication of vascular disease and underscore its potential as a target for intervention in modulating multiple pathologies related to atherosclerosis...
  30. ncbi request reprint Role of integrin-linked kinase in leukocyte recruitment
    Erik B Friedrich
    Center for Immunology and Inflammatory Diseases, Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:16371-5. 2002
    ..These data implicate ILK in the dynamic signaling events involved in the regulation of leukocyte integrin avidity for endothelial substrates...
  31. ncbi request reprint Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 4:982-90. 2003
    ..Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment...
  32. pmc Metabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke
    W Taylor Kimberly
    Center for Human Genetic Research and Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Stroke 44:1389-95. 2013
    ..The identification of changes in circulating plasma metabolites during cerebral infarction may provide insight into disease pathogenesis and identify novel biomarkers...
  33. pmc An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action
    Shan Jin
    Massachusetts General Hospital, Harvard Medical School, Department of Medicine, Charlestown, MA, USA
    J Biomol Screen 18:108-15. 2013
    ..These findings suggest that zebrafish screens might be a broadly applicable approach for discovering compounds that counteract the toxic effects of accidental or malicious poisonous exposures...
  34. doi request reprint Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 117:1936-44. 2008
    ....
  35. pmc Mice deficient in alpha-actinin-4 have severe glomerular disease
    Claudine H Kos
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 111:1683-90. 2003
    ..In addition, these genetic studies demonstrate that the nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement...
  36. pmc Bone marrow-derived lin(-)c-kit(+)Sca-1+ stem cells do not contribute to vasculogenesis in Lewis lung carcinoma
    Vivek R Shinde Patil
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neoplasia 7:234-40. 2005
    ..Furthermore, our results support the hypothesis that new vessel formation in carcinomas occurs primarily through endothelialization from adjacent and preexisting vasculature...
  37. ncbi request reprint Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment
    Eric A Heller
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, East 8307, 149 13th St, Charlestown, MA 02129, USA
    Circulation 112:578-86. 2005
    ..LTB(4) signals primarily through its high-affinity G protein-coupled receptor BLT1, which is expressed on specific leukocyte subsets. BLT1 receptor expression and function on other atheroma-associated cell types is unknown...
  38. ncbi request reprint Metabolomic identification of novel biomarkers of myocardial ischemia
    Marc S Sabatine
    Cardiovascular Division, Brigham and Women s Hospital, Donald W Reynolds Cardiovascular Clinical Research Center on Atherosclerosis, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 112:3868-75. 2005
    ..Recent advances in proteomic and metabolic profiling technologies may offer the possibility of identifying novel biomarkers and pathways activated in myocardial ischemia...
  39. pmc Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture
    Victoria L King
    Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA
    Circulation 119:426-35. 2009
    ..T-helper type 1 cytokines, including interferon-gamma and CXCL10, have been strongly implicated in atherosclerotic plaque development...
  40. pmc Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival
    Emerson Liu
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, 02129, USA
    Mol Cell Biol 25:11145-55. 2005
    ..These data extend the role of ILK to immune-cell trafficking and survival via modulation of Akt- and Rac-dependent substrates, and have implications for cell recruitment in both homeostatic and pathological processes...
  41. ncbi request reprint Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells
    Peter J Kuhlencordt
    Cardiovascular Research Center, Massachusetts General Hospital East, 149 East 13th St, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 286:C1195-202. 2004
    ..We propose that eNOS derived NO does not chronically suppress endothelial cell activation in an autocrine fashion but serves to counterbalance signals that mediate activation...
  42. ncbi request reprint Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 116:1555-62. 2007
    ..We tested the hypothesis that sildenafil, an effective therapy for pulmonary arterial hypertension, would lower pulmonary vascular resistance and improve exercise capacity in patients with HF complicated by PH...
  43. pmc Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions
    Moritz F Kircher
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass, USA
    Circulation 117:388-95. 2008
    ..We sought to establish a noninvasive technique to determine monocyte trafficking to atherosclerotic lesions in live animals...
  44. pmc Vascular effects of a low-carbohydrate high-protein diet
    Shi Yin Foo
    Cardiovascular Division of the Beth Israel Deaconess Medical Center, Cardiovascular Institute, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 106:15418-23. 2009
    ..Taken together, these data demonstrate that in animal models LCHP diets have adverse vascular effects not reflected in serum markers and that nonlipid macronutrients can modulate vascular progenitor cells and pathophysiology...
  45. pmc MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    S Hani Najafi-Shoushtari
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Science 328:1566-9. 2010
    ..Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases...
  46. ncbi request reprint Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions
    Steffen E Meiler
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Charlestown, MA, MA 02114, USA
    J Mol Cell Cardiol 34:349-59. 2002
    ..We conclude that IKK beta is necessary for the cytokine-induced inflammatory phenotype of human endothelium and endothelial recruitment of human monocytes under flow...
  47. ncbi request reprint Biomarker discovery and validation
    Nader Rifai
    Clin Chem 52:1635-7. 2006
  48. ncbi request reprint A functional annotation of subproteomes in human plasma
    Peipei Ping
    Department of Physiology and Medicine, Division of Cardiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA
    Proteomics 5:3506-19. 2005
    ..The HPPP-organized, multi-laboratory effort, as described herein, resulted in much synergy and was essential to the success of this project...
  49. pmc Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
    Oded Shaham
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Syst Biol 4:214. 2008
    ..Our findings lay the groundwork for using metabolic profiling to define an individual's 'insulin response profile', which could have value in predicting diabetes, its complications, and in guiding therapy...
  50. ncbi request reprint On the interpretation of genetic association studies
    Sekar Kathiresan
    Eur Heart J 25:1378-81. 2004

Research Grants22

  1. CHEMOKINE SIGNAL IN MONOCYTE RECRUITMENT
    Robert Gerszten; Fiscal Year: 2001
    ....
  2. Role of ILK in Leukocyte Recruitment
    Robert Gerszten; Fiscal Year: 2009
    ..Understanding the role of specific signaling pathways in leukocyte recruitment may provide new targets for the management of many inflammatory disorders. ..
  3. Metabolomic predictors of insulin resistance and diabetes
    Robert Gerszten; Fiscal Year: 2009
    ..Our goal is to use genetics and other systematic approaches to develop novel markers of preclinical disease and illuminate our understanding of the underlying disease mechanisms in DM. ..
  4. Discovery & Application of Proteomics-Based Biomarkers of Early Myocardial Injury
    Robert Gerszten; Fiscal Year: 2009
    ..This project describes the application of new proteomics technology for biomarker discovery and validation of early markers of myocardial injury. ..
  5. Metabolomic Biomarkers of Early Myocardial Injury
    Marc S Sabatine; Fiscal Year: 2010
    ..This project describes the application of a new metabolomics technology for biomarker discovery to address this clinical need. ..
  6. Metabolomic predictors of insulin resistance and diabetes
    Thomas J Wang; Fiscal Year: 2010
    ..Our goal is to use genetics and other systematic approaches to develop novel markers of preclinical disease and illuminate our understanding of the underlying disease mechanisms in DM. ..
  7. Role of ILK in Leukocyte Recruitment
    Robert Gerszten; Fiscal Year: 2007
    ..Understanding the role of specific signaling pathways in leukocyte recruitment may provide new targets for the management of many inflammatory disorders. ..
  8. Novel Markers: Pathways, Prognosis, & Pharmacoproteomics
    Robert Gerszten; Fiscal Year: 2007
    ..abstract_text> ..
  9. Chemokine Signaling in Monocyte Recruitment In Vivo
    Robert Gerszten; Fiscal Year: 2002
    ..As evidenced by seven years of vascular biology research, the applicant remains firmly committed to a long-term career in basic science investigation. (End of Abstract) ..
  10. CHEMOKINE SIGNAL IN MONOCYTE RECRUITMENT
    Robert Gerszten; Fiscal Year: 2002
    ....
  11. Clinical Evaluation of Novel Markers of MI
    Robert Gerszten; Fiscal Year: 2002
    ..In Specific Aim 3, we will correlate elevations in novel protein markers and response proteins with outcomes in patients with acute MI in the TIMI trial. ..
  12. CHEMOKINE SIGNAL IN MONOCYTE RECRUITMENT
    Robert Gerszten; Fiscal Year: 2003
    ....
  13. Clinical Evaluation of Novel Markers of MI
    Robert Gerszten; Fiscal Year: 2003
    ..In Specific Aim 3, we will correlate elevations in novel protein markers and response proteins with outcomes in patients with acute MI in the TIMI trial. ..
  14. Clinical Evaluation of Novel Markers of MI
    Robert Gerszten; Fiscal Year: 2004
    ..In Specific Aim 3, we will correlate elevations in novel protein markers and response proteins with outcomes in patients with acute MI in the TIMI trial. ..
  15. Clinical Evaluation of Novel Markers of MI
    Robert Gerszten; Fiscal Year: 2005
    ..In Specific Aim 3, we will correlate elevations in novel protein markers and response proteins with outcomes in patients with acute MI in the TIMI trial. ..
  16. Role of ILK in Leukocyte Recruitment
    Robert Gerszten; Fiscal Year: 2005
    ..Understanding the role of specific signaling pathways in leukocyte recruitment may provide new targets for the management of many inflammatory disorders. ..
  17. Role of ILK in Leukocyte Recruitment
    Robert Gerszten; Fiscal Year: 2006
    ..Understanding the role of specific signaling pathways in leukocyte recruitment may provide new targets for the management of many inflammatory disorders. ..
  18. Discovery & Application of Proteomics-Based Biomarkers of Early Myocardial Injury
    Marc S Sabatine; Fiscal Year: 2010
    ..This project describes the application of new proteomics technology for biomarker discovery and validation of early markers of myocardial injury. ..