Peter Gerner

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor
    Patrick L Sheets
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Neurophysiol 96:1848-59. 2006
  2. ncbi request reprint Tricyclic antidepressants and their local anesthetic properties: from bench to bedside and back again
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Reg Anesth Pain Med 29:286-9. 2004
  3. pmc Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 107:82-90. 2007
  4. pmc Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve
    Peter Gerner
    Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesthesiology 109:872-8. 2008
  5. ncbi request reprint Doxepin by topical application and intrathecal route in rats
    Peter Gerner
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 102:283-7. 2006
  6. ncbi request reprint Differential block of N-propyl derivatives of amitriptyline and doxepin for sciatic nerve block in rats
    Peter Gerner
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Reg Anesth Pain Med 30:344-50. 2005
  7. ncbi request reprint Assessment of differential blockade by amitriptyline and its N-methyl derivative in different species by different routes
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 98:1484-90. 2003
  8. pmc Postthoracotomy pain management problems
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesthesiol Clin 26:355-67, vii. 2008
  9. ncbi request reprint Topical amitriptyline in healthy volunteers
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Reg Anesth Pain Med 28:289-93. 2003
  10. pmc Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1397-405. 2008

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor
    Patrick L Sheets
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Neurophysiol 96:1848-59. 2006
    ..7 channels with nanomolar concentrations of TFP raises the possibility that TFP, or TFP analogues, might be useful for regional anesthesia and pain management and could be more potent than traditional local anesthetics...
  2. ncbi request reprint Tricyclic antidepressants and their local anesthetic properties: from bench to bedside and back again
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Reg Anesth Pain Med 29:286-9. 2004
  3. pmc Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 107:82-90. 2007
    ..Bulleyaconitine A (BLA) is an active ingredient of Aconitum bulleyanum plants. BLA has been approved for the treatment of chronic pain and rheumatoid arthritis in China, but its underlying mechanism remains unclear...
  4. pmc Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve
    Peter Gerner
    Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesthesiology 109:872-8. 2008
    ..05% capsaicin, in a rat sciatic nerve block model...
  5. ncbi request reprint Doxepin by topical application and intrathecal route in rats
    Peter Gerner
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 102:283-7. 2006
    ..Intrathecally, 20 mM of doxepin was not significantly different for motor and proprioceptive function from 23 mM (0.75%) bupivacaine; however, neurotoxicity (defined as persistent neurological deficit) commenced at 50 mM...
  6. ncbi request reprint Differential block of N-propyl derivatives of amitriptyline and doxepin for sciatic nerve block in rats
    Peter Gerner
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Reg Anesth Pain Med 30:344-50. 2005
    ..In addition, tetrodotoxin (TTX), a naturally occuring Na + channel blocker, was coinjected to investigate whether it increased block duration...
  7. ncbi request reprint Assessment of differential blockade by amitriptyline and its N-methyl derivative in different species by different routes
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 98:1484-90. 2003
    ..Most drugs show a different profile depending on the model or species studied. This study was designed to investigate the differential nerve-blocking properties of amitriptyline and its quaternary ammonium derivative in rats and sheep...
  8. pmc Postthoracotomy pain management problems
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesthesiol Clin 26:355-67, vii. 2008
    ..Nevertheless, severe ipsilateral shoulder pain and the prevention of the postthoracotomy pain syndrome remain the most important challenges for management of postthoracotomy pain...
  9. ncbi request reprint Topical amitriptyline in healthy volunteers
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Reg Anesth Pain Med 28:289-93. 2003
    ..In a randomized, double-blinded, and placebo-controlled trial, we investigated whether amitriptyline also is capable of providing cutaneous analgesia when applied topically in 14 healthy volunteers...
  10. pmc Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1397-405. 2008
    ..BLA has several potential targets, including voltage-gated Na+ channels. We tested whether BLA elicited long-lasting cutaneous analgesia, when co-injected with lidocaine and epinephrine, as a model for prolonged infiltration anesthesia...
  11. doi request reprint The relationship between functional sciatic nerve block duration and the rate of release of lidocaine from a controlled-release matrix
    Peter Gerner
    Brigham and Women s Hospital, MRB 611, 75 Francis St, Boston, MA 02115 6110, USA
    Anesth Analg 111:221-9. 2010
    ..The relationship between the duration of such blocks and the rate at which a local anesthetic is released is important to know for developing a localized drug delivery system that will optimize block duration...
  12. ncbi request reprint Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline
    Yukari Sudoh
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Reg Anesth Pain Med 29:434-40. 2004
    ..We evaluated spinal block after various concentrations of amitriptyline administered intrathecally in a fixed high volume...
  13. ncbi request reprint N-phenylethyl amitriptyline in rat sciatic nerve blockade
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 96:1435-42. 2002
    ..As with other drug modifications, adding a phenylethyl group to obtain a permanently charged quaternary ammonium derivative may improve these advantageous properties...
  14. doi request reprint An absorbable local anesthetic matrix provides several days of functional sciatic nerve blockade
    Chi Fei Wang
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesth Analg 108:1027-33. 2009
    ..We report on an implantable, controlled-release drug delivery system intended for use in bone and consisting of a Food and Drug Administration-approved matrix containing lidocaine that is capable of local delivery for several days...
  15. ncbi request reprint The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats
    Venkatesh Srinivasa
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 97:91-5, table of contents. 2003
    ..5 +/- 7 mg/kg and 22.7 +/- 7 mg/kg, respectively) (P < 0.05). A significantly larger dose of amitriptyline, given by rapid infusion, is required to cause CV and CNS toxicity in rats, when compared with bupivacaine and levobupivacaine...
  16. ncbi request reprint Safety evaluation of topically applied amitriptyline in porcine full-thickness wounds
    Bohdan Pomahac
    Division of Plastic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Reg Anesth Pain Med 32:377-81. 2007
    ..We assessed if daily topical application of amitriptyline into the wound chambers for 10 days impedes wound healing as measured by (1) wound contraction and (2) histopathological findings...
  17. doi request reprint Prolonged suppression of postincisional pain by a slow-release formulation of lidocaine
    Chi Fei Wang
    Tufts School of Medicine, Boston, Massachusetts, USA
    Anesthesiology 114:135-49. 2011
    ..Here we tested Xybrex (Orthocon, Inc., Irvington, NY), a slow-release formulation of lidocaine that blocks rat sciatic nerve for 1-2 days, for its ability to suppress postincisional pain...
  18. doi request reprint Prolonged cutaneous analgesia with transdermal application of amitriptyline and capsaicin
    Anna Christin Colvin
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Reg Anesth Pain Med 36:236-40. 2011
    ..Here we examine whether the combined application of amitriptyline and capsaicin as a transdermal patch will produce prolonged cutaneous analgesia compared with amitriptyline alone...
  19. ncbi request reprint Use of a charged lidocaine derivative, tonicaine, for prolonged infiltration anesthesia
    Mohammed A Khan
    Department of Anesthesiology, Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts
    Reg Anesth Pain Med 27:173-9. 2002
    ....
  20. doi request reprint Low-dose systemic bupivacaine prevents the development of allodynia after thoracotomy in rats
    Jin Woo Shin
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1587-91. 2008
    ..Our purpose was to test whether intercostal and systemic injection of bupivacaine prevented the development of allodynia in an animal model of chronic intercostal neuropathic pain...
  21. ncbi request reprint ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 114:149-59. 2005
    ..The sequential activation of ERK in dorsal horn microglia and then in astrocytes might reflect distinct roles for these two subtypes of glia in the temporal evolution of neuropathic pain...
  22. doi request reprint Demographics and perioperative outcome in patients with depression and anxiety undergoing total joint arthroplasty: a population-based study
    Ottokar Stundner
    Department of Anesthesiology, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Psychosomatics 54:149-57. 2013
    ..This study is intended to gain insight into epidemiology and effects on perioperative morbidity, mortality, length of hospital stay, discharge and cost...
  23. doi request reprint Perioperative management of partial face transplantation involving a heparin antibody-positive donor
    Thomas Edrich
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Anesth 23:318-21. 2011
    ..The anesthesia team was involved in the early planning phase and had detailed access to the donor's medical history; alternative anticoagulation for the donor and recipient was suggested so as to avoid a possible complication...
  24. ncbi request reprint Amitriptyline for prolonged cutaneous analgesia in the rat
    Mohammed A Khan
    Department of Anesthesiology, Perioperative and Pain Medicne, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 96:109-16. 2002
    ..In keeping with the objective of identifying drugs for prolonged cutaneous analgesia, the authors compared the cutaneous analgesic effectiveness of amitriptyline and bupivacaine in rats...
  25. pmc Phase 1A safety assessment of intravenous amitriptyline
    Peter Fridrich
    Trauma Hospital, Lorenz Boehler, Vienna, and Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Austria
    J Pain 8:549-55. 2007
    ..As this occurs at very low plasma concentrations, a single preoperative intravenous infusion of amitriptyline could provide long-lasting pain relief and decrease the incidence of chronic pain...
  26. ncbi request reprint Tricyclic antidepressants as long-acting local anesthetics
    Yukari Sudoh
    Department of Anesthesia, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115 USA
    Pain 103:49-55. 2003
    ..TCAs with a tertiary amine appear more effective in penetrating these membrane barriers than TCAs with a secondary amine...
  27. ncbi request reprint Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats
    Anna Haderer
    Department of Anesthesiology, Ried General Hospital, Ried, Austria
    Anesth Analg 96:1707-10, table of contents. 2003
    ..The development of amitriptyline as a longer-lasting topical analgesic may improve our ability to treat chronic pain, such as neuropathic pain and neuralgia, and to prevent pain in procedures such as venipuncture...
  28. ncbi request reprint Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy
    Peter Fridrich
    Trauma Hospital Lorenz Boehler, Vienna, Austria
    Anesthesiology 100:1511-8. 2004
    ..Therefore, the authors investigated the adverse effects and effectiveness of this drug when given for ulnar nerve blockade in human volunteers...
  29. ncbi request reprint Ephedrine blocks rat sciatic nerve in vivo and sodium channels in vitro
    Yu Chun Hung
    Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    Anesthesiology 103:1246-52. 2005
    ....
  30. ncbi request reprint Efficacy of lidocaine or bupivacaine combined with ephedrine in rat sciatic nerve block
    Yi Chuan Kau
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Reg Anesth Pain Med 31:14-8. 2006
    ..We therefore hypothesized that either lidocaine or bupivacaine would show synergy with ephedrine in a rat sciatic nerve block model, allowing a dose reduction and limiting side effects while improving efficacy...
  31. ncbi request reprint The role of sodium channels in chronic inflammatory and neuropathic pain
    Ron Amir
    Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    J Pain 7:S1-29. 2006
    ..This restricted expression raises the possibility that isoform-specific drugs might be analgesic and lacking the cardiotoxicity and neurotoxicity that limit the use of current sodium-channel blockers...
  32. ncbi request reprint The neurotoxic effects of amitriptyline are mediated by apoptosis and are effectively blocked by inhibition of caspase activity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Austria
    Anesth Analg 102:1728-33. 2006
    ..In vivo studies will have to corroborate whether the co-injection of anti-apoptotic drugs with local anesthetics decreases neurotoxic side effects...
  33. ncbi request reprint Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 mitogen-activated protein kinase in vitro and in vivo
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Austria
    Anesthesiology 104:1266-73. 2006
    ....
  34. doi request reprint In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Anesth Analg 106:1456-64, table of contents. 2008
    ....
  35. pmc Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic-nerve block
    Yu Chun Hung
    Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    Reg Anesth Pain Med 32:288-95. 2007
    ..Further, the mechanism of possible synergy between LAs and MgSO(4) was investigated in whole-cell mode patch-clamp experiments...
  36. doi request reprint Impact of analgesia on bone fracture healing
    Peter Gerner
    Anesthesiology 108:349-50. 2008
  37. doi request reprint Sensory and motor complications of local anesthetics
    Peter Gerner
    Muscle Nerve 37:421-5. 2008
  38. ncbi request reprint In vitro, lidocaine-induced axonal injury is prevented by peripheral inhibition of the p38 mitogen-activated protein kinase, but not by inhibiting caspase activity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Anesth Analg 105:1657-64, table of contents. 2007
    ..This approach, however, does not accurately reflect the in vivo situation for peripheral nerve blockade, where LA is applied to the axon alone...
  39. ncbi request reprint Neurotoxicity of lidocaine involves specific activation of the p38 mitogen-activated protein kinase, but not extracellular signal-regulated or c-jun N-terminal kinases, and is mediated by arachidonic acid metabolites
    Ingrid Haller
    Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria
    Anesthesiology 105:1024-33. 2006
    ....

Research Grants1

  1. Development of Sensory/Pain-Selective Local Anesthetics
    Peter Gerner; Fiscal Year: 2006
    ..abstract_text> ..