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Genomes and Genes | Z GeSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Publications
Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in miceVarada P Rao
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cancer Res 66:7395-400. 2006..The possibility that dysregulated gut microbial infections in humans may lead to cancer in anatomically distant organs, such as breast, highlights the need for novel immune-based strategies in cancer prevention and treatment...- The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticusSebastian Suerbaum
Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
Proc Natl Acad Sci U S A 100:7901-6. 2003.... - CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in miceSusan E Erdman
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Cancer Res 63:6042-50. 2003..Regulatory lymphocytes and cytokines may have implications for novel therapies for colon cancer in humans... - Cytolethal distending toxin: a potential virulence factor for Helicobacter cinaediNancy S Taylor
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Infect Dis 188:1892-7. 2003..cinaedi isolates. H. cinaedi shares the production of Cdt with other enteric pathogens, including enterohepatic Helicobacter species. This is the first report of a putative virulence factor in H. cinaedi... - Genomic characterization of Helicobacter hepaticus: ordered cosmid library and comparative sequence analysisZ Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
FEMS Microbiol Lett 204:147-53. 2001..jejuni; (2) significant genomic alterations exist between H. hepaticus and H. pylori, including gene organization, protein sequences and GC content, probably in part due to specific adaptation to distinct ecological niches... - Colonization dynamics of altered Schaedler flora is influenced by gender, aging, and Helicobacter hepaticus infection in the intestines of Swiss Webster miceZhongming Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Appl Environ Microbiol 72:5100-3. 2006..All ASF strains were detected in the cecum and colon, but some strains displayed significant variation in colonization levels with host age, gender, and H. hepaticus infection status... - Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesisZhongming Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Cell Microbiol 9:2070-80. 2007.... - Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr miceZhongming Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Microb Pathog 45:18-24. 2008..These results indicate that H. hepaticus urease activity plays a crucial role in hepatic disease but is not required for cecal colonization by H. hepaticus... - Potential of fumarate reductase as a novel therapeutic target in Helicobacter pylori infectionZhongming Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Expert Opin Ther Targets 6:135-46. 2002..Given that FrdA is strongly immunogenic in the sera from H. pylori-positive patients, this protein may also be used as a candidate for the development of an anti-H. pylori vaccine... - In vivo virulence properties of bacterial cytolethal-distending toxinZhongming Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell Microbiol 10:1599-607. 2008..Thus, both in vitro and in vivo data indicate that CDT is a bacterial virulence factor... - Coinfection with Enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori-induced gastric pathology in C57BL/6 miceZhongming Ge
Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Infect Immun 79:3861-71. 2011..pylori-induced gastric pathology in C57BL/6 mice. This modulation was related to the variable effects of EHS on gastric interleukin 17 (IL-17) responses to H. pylori infection... - Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster miceZhongming Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02131, USA
Infect Immun 73:3559-67. 2005..hepaticus in cecum, colon, and jejunum but only transient colonization of H. hepaticus in the ileum of female mice; (iv) H. hepaticus colonization was associated with down-regulation of colonic IL-10 production... - Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomachZ Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Microb Pathog 29:279-87. 2000..pylori prevention and eradication... - Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticusZ Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Clin Microbiol 39:2598-602. 2001..hepaticus DNA. Therefore, this assay can be used with high sensitivity and specificity to quantify H. hepaticus in experimentally infected mouse models as well as in naturally infected mice... - CD4+ lymphocytes modulate prostate cancer progression in miceTheofilos Poutahidis
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
Int J Cancer 125:868-78. 2009..Taken together, chronically elevated proinflammatory cytokines promoted carcinoma in Apc(Min/+) mice. T(REG) lymphocytes downregulated inflammation-associated carcinogenic processes and contributed to immune and epithelial homeostasis... - Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's floraM T Whary
Division of Comparative Medicine, Massachusette Institute of Technology, 77 Massachusetts Avenue, Bldg 16 825A, Cambridge, MA 02139, USA
Infect Immun 74:6615-23. 2006..trogontum (with or without H. rodentium) induces a rapid-onset, erosive to ulcerative typhlocolitis which impacts the normal anaerobic flora of the colon and increases the risk of sepsis... - Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn miceZhongming Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Microbes Infect 10:726-33. 2008..05) at 13 WPI. These results demonstrate that genes in the HHGI1 contribute to the pathogenicity of H. hepaticus, at least in part via up-regulation of proinflammatory mediators IFN-gamma, TNF-alpha and IL-17a... - Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) miceVarada P Rao
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Cancer Res 66:57-61. 2006..These findings define a novel mouse model of inflammation-driven mammary carcinoma and suggest that epithelial carcinogenesis can be mitigated by anti-inflammatory cells and cytokines known to regulate IBD in humans and mice... - A novel urease-negative Helicobacter species associated with colitis and typhlitis in IL-10-deficient miceJ G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Infect Immun 67:1757-62. 1999..The mouse model of helicobacter-associated intestinal inflammation should prove valuable in understanding how specific microbial antigens influence a complex disease process... - Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritisChung Wei Lee
Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Infect Immun 75:2699-707. 2007..pylori-mediated inflammation and in regulatory effects between wt T(R) and IL-10(-/-) T(R) cells suggest that IL-10 expression by wt T(R) cells is important to regulatory suppression of gastric inflammation... - Long-term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 miceM T Whary
Massachusetts Institute of Technology, Cambridge 02139, USA
Comp Med 51:413-7. 2001..hepaticus in the cecum, compared with those of hepatitis-resistant C57BL/6 mice. Host responses of A/JCr mice that limit cecal colonization with H. hepaticus may have important roles in the pathogenesis of hepatic lesions... - Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancyChung Wei Lee
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Int J Cancer 122:1068-76. 2008..pylori-induced premalignant gastric lesions. In addition, less severe gastric lesions in H.pylori infected gulo(-/-) mice supplemented with low vitamin C correlated with an attenuated Th1 inflammatory response... - Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemiaJames G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
Gastroenterology 124:1879-90. 2003..The INS-GAS model is effective for investigating discrete host-microbial interactions that culminate in gastric cancer within the context of biologic conditions induced by H. pylori... - Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancerJ G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Mucosal Immunol 4:22-30. 2011..hepaticus pathogenesis. Delineating targets of H. hepaticus virulence factors could facilitate novel approaches to treating microbially induced lower bowel inflammatory diseases... - Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter sppC C Chien
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
J Med Microbiol 49:525-34. 2000..Cdt caused cell cycle arrest at G2/M phase as measured by flow cytometry. The results demonstrated the presence of a toxin in these Helicobacter spp. belonging to the family of Cdt... - Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient miceS E Erdman
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 106:1027-32. 2009..Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis... - Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS miceChung Wei Lee
Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cancer Res 68:3540-8. 2008..pylori eradication prevented gastric cancer to the greatest extent when antibiotics are given at an early point of infection, but that eradication therapy given at a later time point delayed the development of severe dysplastic lesions... - Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathologyLaura B Lemke
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 825, Cambridge, MA 02139, USA
Infect Immun 77:2147-58. 2009..pylori infection, particularly in developing countries, may occur where coinfection with lower bowel helicobacters and H. pylori may be common... - Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS miceMasahiro Ohtani
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825C, Cambridge, MA 02139, USA
Carcinogenesis 28:2597-604. 2007..These results demonstrate a protective effect of E2 in H.pylori-induced gastric cancer in a mouse model... - Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr miceArlin B Rogers
Comparative Pathology Laboratory 16 849, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Toxicol Pathol 32:668-77. 2004..Continued study of chronic hepatitis progression may reveal therapeutic targets to reduce the risk of hepatocellular carcinoma... - Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strainsJames G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Infect Immun 72:1116-25. 2004..jejuni to escape immune surveillance. NF-kappaB-deficient mice should be a useful model to further study the role of CDT and other aspects of C. jejuni pathogenesis... - Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected miceJames G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Am J Pathol 171:1520-8. 2007..pylori-infected mice at 19 months pi. These data support a protective role for TFF2 in part by modulating levels of gastric interferon-gamma in the development of H. pylori-associated premalignancy of the distal stomach... - T-cell function is critical for murine cholesterol gallstone formationKirk J Maurer
Department of Biological Engineering, Massachusetts Institute of Technology, Boston, Massachusetts, USA
Gastroenterology 133:1304-15. 2007..Although gallbladder inflammation is believed to be common during cholelithogenesis, the role of immunologic factors is unknown... - Unifying roles for regulatory T cells and inflammation in cancerSusan E Erdman
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Int J Cancer 126:1651-65. 2010..Enhancing protective T(REG) functions may promote healthful longevity and significantly reduce risk of cancer... - Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil modelHeather R Martin
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Microbes Infect 12:748-58. 2010..Initial systemic responses to B. pahangi resulted in attenuated gastritis in coinfected gerbils, but subsequent filarid-associated hyporesponsiveness appears to have promoted H. pylori gastritis... - CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ miceSusan E Erdman
Division of Comparative Medicine and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Cancer Res 65:3998-4004. 2005..Similarities with cancer of the breast, prostate, lung, and other sites raise the possibility of broader roles for regulatory lymphocytes in prevention and treatment of epithelial cancers in humans... - Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuniMing L Chen
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 56 787, Cambridge, MA 02139, USA
Infect Immun 74:6581-9. 2006..These results suggest that compromised barrier function and increased chemokine expression contribute to the pathogenesis of C. jejuni-induced enterocolitis... - Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective studyKirk J Maurer
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
Am J Physiol Gastrointest Liver Physiol 290:G175-82. 2006..Nonetheless, the C57L mouse develops severe lesions of both the glandular and nonglandular stomach in response to H. pylori infection and the lithogenic diet, respectively... - Characterization of proteins in the outer membrane preparation of a murine pathogen, Helicobacter bilisZ Ge
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Infect Immun 69:3502-6. 2001..These results indicate that H. bilis has a conserved, unique OMP protein profile that is distinct from those of H. pylori... - Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitisSamuel R Boutin
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-825C, Cambridge, MA 02139, USA
Infect Immun 73:8449-52. 2005..Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1... - Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitisKoichiro Watanabe
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
Infect Immun 76:5834-42. 2008.... - Spatial distribution and stability of the eight microbial species of the altered schaedler flora in the mouse gastrointestinal tractRamahi B Sarma-Rupavtarm
Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Appl Environ Microbiol 70:2791-800. 2004.... - Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infectionsCalin Stoicov
Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 173:3329-36. 2004..These data demonstrate the profound interactions between the immune response to unrelated organisms, and suggest these types of interactions my impact clinical disease... - Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinomaTheofilos Poutahidis
Division of Comparative Medicine
Carcinogenesis 28:2614-23. 2007..These data provide insights into etiopathogenesis of inflammation-associated epithelial invasion and maintenance of epithelial homeostasis... - Evaluation of Helicobacter hepaticus bacterial shedding in fostered and sex-segregated C57BL/6 miceRobin Crisler-Roberts
Division of Laboratory Animal Medicine, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, Louisiana, USA
Comp Med 55:515-22. 2005..Our findings likely will prove useful in Helicobacter eradication efforts and in studies designed to further elucidate the role of H. hepaticus in disease... - Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancerShigeo Takaishi
Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Gastroenterology 128:1965-83. 2005..felis/INS-GAS mice, while the proton pump inhibitor showed no such effects. These results support an important role for the gastrin-histamine axis in Helicobacter-induced gastric carcinogenesis...