Z Ge

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:7901-6. 2003
  2. ncbi request reprint CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 63:6042-50. 2003
  3. ncbi request reprint Cytolethal distending toxin: a potential virulence factor for Helicobacter cinaedi
    Nancy S Taylor
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Infect Dis 188:1892-7. 2003
  4. ncbi request reprint Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 66:7395-400. 2006
  5. pmc Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization
    Kvin Lertpiriyapong
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e42842. 2012
  6. pmc Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02131, USA
    Infect Immun 73:3559-67. 2005
  7. ncbi request reprint Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cell Microbiol 9:2070-80. 2007
  8. ncbi request reprint Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 45:18-24. 2008
  9. doi request reprint In vivo virulence properties of bacterial cytolethal-distending toxin
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell Microbiol 10:1599-607. 2008
  10. ncbi request reprint Potential of fumarate reductase as a novel therapeutic target in Helicobacter pylori infection
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Expert Opin Ther Targets 6:135-46. 2002

Collaborators

Detail Information

Publications48

  1. pmc The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:7901-6. 2003
    ....
  2. ncbi request reprint CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 63:6042-50. 2003
    ..Regulatory lymphocytes and cytokines may have implications for novel therapies for colon cancer in humans...
  3. ncbi request reprint Cytolethal distending toxin: a potential virulence factor for Helicobacter cinaedi
    Nancy S Taylor
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Infect Dis 188:1892-7. 2003
    ..cinaedi isolates. H. cinaedi shares the production of Cdt with other enteric pathogens, including enterohepatic Helicobacter species. This is the first report of a putative virulence factor in H. cinaedi...
  4. ncbi request reprint Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 66:7395-400. 2006
    ..The possibility that dysregulated gut microbial infections in humans may lead to cancer in anatomically distant organs, such as breast, highlights the need for novel immune-based strategies in cancer prevention and treatment...
  5. pmc Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization
    Kvin Lertpiriyapong
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e42842. 2012
    ..jejuni pathogenesis...
  6. pmc Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02131, USA
    Infect Immun 73:3559-67. 2005
    ..hepaticus in cecum, colon, and jejunum but only transient colonization of H. hepaticus in the ileum of female mice; (iv) H. hepaticus colonization was associated with down-regulation of colonic IL-10 production...
  7. ncbi request reprint Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cell Microbiol 9:2070-80. 2007
    ....
  8. ncbi request reprint Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 45:18-24. 2008
    ..These results indicate that H. hepaticus urease activity plays a crucial role in hepatic disease but is not required for cecal colonization by H. hepaticus...
  9. doi request reprint In vivo virulence properties of bacterial cytolethal-distending toxin
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell Microbiol 10:1599-607. 2008
    ..Thus, both in vitro and in vivo data indicate that CDT is a bacterial virulence factor...
  10. ncbi request reprint Potential of fumarate reductase as a novel therapeutic target in Helicobacter pylori infection
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Expert Opin Ther Targets 6:135-46. 2002
    ..Given that FrdA is strongly immunogenic in the sera from H. pylori-positive patients, this protein may also be used as a candidate for the development of an anti-H. pylori vaccine...
  11. pmc Colonization dynamics of altered Schaedler flora is influenced by gender, aging, and Helicobacter hepaticus infection in the intestines of Swiss Webster mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Appl Environ Microbiol 72:5100-3. 2006
    ..All ASF strains were detected in the cecum and colon, but some strains displayed significant variation in colonization levels with host age, gender, and H. hepaticus infection status...
  12. ncbi request reprint Genomic characterization of Helicobacter hepaticus: ordered cosmid library and comparative sequence analysis
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    FEMS Microbiol Lett 204:147-53. 2001
    ..jejuni; (2) significant genomic alterations exist between H. hepaticus and H. pylori, including gene organization, protein sequences and GC content, probably in part due to specific adaptation to distinct ecological niches...
  13. pmc Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 39:2598-602. 2001
    ..hepaticus DNA. Therefore, this assay can be used with high sensitivity and specificity to quantify H. hepaticus in experimentally infected mouse models as well as in naturally infected mice...
  14. ncbi request reprint Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 29:279-87. 2000
    ..pylori prevention and eradication...
  15. pmc Coinfection with Enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori-induced gastric pathology in C57BL/6 mice
    Zhongming Ge
    Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Infect Immun 79:3861-71. 2011
    ..pylori-induced gastric pathology in C57BL/6 mice. This modulation was related to the variable effects of EHS on gastric interleukin 17 (IL-17) responses to H. pylori infection...
  16. doi request reprint CD4+ lymphocytes modulate prostate cancer progression in mice
    Theofilos Poutahidis
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Int J Cancer 125:868-78. 2009
    ..Taken together, chronically elevated proinflammatory cytokines promoted carcinoma in Apc(Min/+) mice. T(REG) lymphocytes downregulated inflammation-associated carcinogenic processes and contributed to immune and epithelial homeostasis...
  17. pmc Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora
    M T Whary
    Division of Comparative Medicine, Massachusette Institute of Technology, 77 Massachusetts Avenue, Bldg 16 825A, Cambridge, MA 02139, USA
    Infect Immun 74:6615-23. 2006
    ..trogontum (with or without H. rodentium) induces a rapid-onset, erosive to ulcerative typhlocolitis which impacts the normal anaerobic flora of the colon and increases the risk of sepsis...
  18. pmc Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Microbes Infect 10:726-33. 2008
    ..05) at 13 WPI. These results demonstrate that genes in the HHGI1 contribute to the pathogenicity of H. hepaticus, at least in part via up-regulation of proinflammatory mediators IFN-gamma, TNF-alpha and IL-17a...
  19. ncbi request reprint Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 66:57-61. 2006
    ..These findings define a novel mouse model of inflammation-driven mammary carcinoma and suggest that epithelial carcinogenesis can be mitigated by anti-inflammatory cells and cytokines known to regulate IBD in humans and mice...
  20. pmc A novel urease-negative Helicobacter species associated with colitis and typhlitis in IL-10-deficient mice
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 67:1757-62. 1999
    ..The mouse model of helicobacter-associated intestinal inflammation should prove valuable in understanding how specific microbial antigens influence a complex disease process...
  21. pmc Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis
    Chung Wei Lee
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Infect Immun 75:2699-707. 2007
    ..pylori-mediated inflammation and in regulatory effects between wt T(R) and IL-10(-/-) T(R) cells suggest that IL-10 expression by wt T(R) cells is important to regulatory suppression of gastric inflammation...
  22. ncbi request reprint Long-term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 mice
    M T Whary
    Massachusetts Institute of Technology, Cambridge 02139, USA
    Comp Med 51:413-7. 2001
    ..hepaticus in the cecum, compared with those of hepatitis-resistant C57BL/6 mice. Host responses of A/JCr mice that limit cecal colonization with H. hepaticus may have important roles in the pathogenesis of hepatic lesions...
  23. pmc Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy
    Chung Wei Lee
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 122:1068-76. 2008
    ..pylori-induced premalignant gastric lesions. In addition, less severe gastric lesions in H.pylori infected gulo(-/-) mice supplemented with low vitamin C correlated with an attenuated Th1 inflammatory response...
  24. ncbi request reprint Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Gastroenterology 124:1879-90. 2003
    ..We examined the effects of an H. pylori cancer-associated determinant (cagE), IL-1beta, and host gender in a transgenic hypergastrinemic (INS-GAS) murine model of gastric carcinogenesis...
  25. ncbi request reprint Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp
    C C Chien
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Med Microbiol 49:525-34. 2000
    ..Cdt caused cell cycle arrest at G2/M phase as measured by flow cytometry. The results demonstrated the presence of a toxin in these Helicobacter spp. belonging to the family of Cdt...
  26. doi request reprint Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mucosal Immunol 4:22-30. 2011
    ..hepaticus pathogenesis. Delineating targets of H. hepaticus virulence factors could facilitate novel approaches to treating microbially induced lower bowel inflammatory diseases...
  27. pmc Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice
    S E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1027-32. 2009
    ..Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis...
  28. pmc Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice
    Chung Wei Lee
    Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 68:3540-8. 2008
    ..pylori eradication prevented gastric cancer to the greatest extent when antibiotics are given at an early point of infection, but that eradication therapy given at a later time point delayed the development of severe dysplastic lesions...
  29. pmc Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology
    Laura B Lemke
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 825, Cambridge, MA 02139, USA
    Infect Immun 77:2147-58. 2009
    ..pylori infection, particularly in developing countries, may occur where coinfection with lower bowel helicobacters and H. pylori may be common...
  30. ncbi request reprint Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice
    Masahiro Ohtani
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825C, Cambridge, MA 02139, USA
    Carcinogenesis 28:2597-604. 2007
    ..These results demonstrate a protective effect of E2 in H.pylori-induced gastric cancer in a mouse model...
  31. doi request reprint Unifying roles for regulatory T cells and inflammation in cancer
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 126:1651-65. 2010
    ..Enhancing protective T(REG) functions may promote healthful longevity and significantly reduce risk of cancer...
  32. pmc Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil model
    Heather R Martin
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Microbes Infect 12:748-58. 2010
    ..Initial systemic responses to B. pahangi resulted in attenuated gastritis in coinfected gerbils, but subsequent filarid-associated hyporesponsiveness appears to have promoted H. pylori gastritis...
  33. pmc Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Am J Pathol 171:1520-8. 2007
    ..pylori-infected mice at 19 months pi. These data support a protective role for TFF2 in part by modulating levels of gastric interferon-gamma in the development of H. pylori-associated premalignancy of the distal stomach...
  34. pmc T-cell function is critical for murine cholesterol gallstone formation
    Kirk J Maurer
    Department of Biological Engineering, Massachusetts Institute of Technology, Boston, Massachusetts, USA
    Gastroenterology 133:1304-15. 2007
    ..Although gallbladder inflammation is believed to be common during cholelithogenesis, the role of immunologic factors is unknown...
  35. ncbi request reprint Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice
    Arlin B Rogers
    Comparative Pathology Laboratory 16 849, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:668-77. 2004
    ..Continued study of chronic hepatitis progression may reveal therapeutic targets to reduce the risk of hepatocellular carcinoma...
  36. pmc Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 72:1116-25. 2004
    ..jejuni to escape immune surveillance. NF-kappaB-deficient mice should be a useful model to further study the role of CDT and other aspects of C. jejuni pathogenesis...
  37. ncbi request reprint CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
    Susan E Erdman
    Division of Comparative Medicine and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:3998-4004. 2005
    ..Similarities with cancer of the breast, prostate, lung, and other sites raise the possibility of broader roles for regulatory lymphocytes in prevention and treatment of epithelial cancers in humans...
  38. pmc Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuni
    Ming L Chen
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 56 787, Cambridge, MA 02139, USA
    Infect Immun 74:6581-9. 2006
    ..These results suggest that compromised barrier function and increased chemokine expression contribute to the pathogenesis of C. jejuni-induced enterocolitis...
  39. ncbi request reprint Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Am J Physiol Gastrointest Liver Physiol 290:G175-82. 2006
    ..Nonetheless, the C57L mouse develops severe lesions of both the glandular and nonglandular stomach in response to H. pylori infection and the lithogenic diet, respectively...
  40. pmc Characterization of proteins in the outer membrane preparation of a murine pathogen, Helicobacter bilis
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 69:3502-6. 2001
    ..These results indicate that H. bilis has a conserved, unique OMP protein profile that is distinct from those of H. pylori...
  41. pmc Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis
    Samuel R Boutin
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16 825C, Cambridge, MA 02139, USA
    Infect Immun 73:8449-52. 2005
    ..Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1...
  42. pmc Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis
    Koichiro Watanabe
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Infect Immun 76:5834-42. 2008
    ....
  43. pmc Spatial distribution and stability of the eight microbial species of the altered schaedler flora in the mouse gastrointestinal tract
    Ramahi B Sarma-Rupavtarm
    Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Appl Environ Microbiol 70:2791-800. 2004
    ....
  44. ncbi request reprint Evaluation of Helicobacter hepaticus bacterial shedding in fostered and sex-segregated C57BL/6 mice
    Robin Crisler-Roberts
    Division of Laboratory Animal Medicine, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, Louisiana, USA
    Comp Med 55:515-22. 2005
    ..Our findings likely will prove useful in Helicobacter eradication efforts and in studies designed to further elucidate the role of H. hepaticus in disease...
  45. pmc Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice
    Jeremy A Pena
    Department of Molecular Virology and Pathology, Baylor College of Medicine, 6621 Fannin St, Houston, TX 77030, USA
    Infect Immun 73:912-20. 2005
    ..In this H. hepaticus-challenged IL-10-deficient murine colitis model, lactobacilli demonstrated probiotic effects by direct modulation of mucosal inflammatory responses...
  46. ncbi request reprint Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma
    Theofilos Poutahidis
    Division of Comparative Medicine
    Carcinogenesis 28:2614-23. 2007
    ..These data provide insights into etiopathogenesis of inflammation-associated epithelial invasion and maintenance of epithelial homeostasis...
  47. ncbi request reprint Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections
    Calin Stoicov
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 173:3329-36. 2004
    ..These data demonstrate the profound interactions between the immune response to unrelated organisms, and suggest these types of interactions my impact clinical disease...
  48. ncbi request reprint Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Gastroenterology 128:1965-83. 2005
    ..We used this model to examine the role of cholecystokinin 2 (CCK2)/gastrin receptor and histamine H2-receptor signaling in the development of gastric atrophy and cancer...