J Gaziano

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 308:1871-80. 2012
  2. pmc Nut consumption and risk of atrial fibrillation in the Physicians' Health Study
    O Khawaja
    Harvard Medical School, Boston, MA, USA
    Nutr J 11:17. 2012
  3. pmc Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
    Susan M Wernimont
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    BMC Med Genet 12:150. 2011
  4. pmc Apolipoprotein ε4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study
    Catherine R Rahilly-Tierney
    Massachusetts Veterans Epidemiology and Information Research Center MAVERIC, Boston VA Healthcare, Boston, Massachusetts, USA
    Lipids Health Dis 10:167. 2011
  5. pmc Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 301:52-62. 2009
  6. ncbi request reprint Vitamin E and cardiovascular disease: observational studies
    J Michael Gaziano
    Brigham and Women s Hospital, Division of Aging, 1620 Tremont Street, Boston MA 02120, USA
    Ann N Y Acad Sci 1031:280-91. 2004
  7. pmc Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes
    J Michael Gaziano
    Massachusetts Veterans Epidemiology Research and Information Center VA Cooperative Studies Programs, VA Boston Healthcare System, Boston, Massachusetts, USA
    Diabetes Care 33:1503-8. 2010
  8. ncbi request reprint Potential for drug-drug interactions in patients taking analgesics for mild-to-moderate pain and low-dose aspirin for cardioprotection
    J Michael Gaziano
    Divisions of Aging, Preventive Medicine and Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 97:23-9. 2006
  9. ncbi request reprint Smoking and the risk of hemorrhagic stroke in men
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Stroke 34:1151-5. 2003
  10. ncbi request reprint Association between body mass index and CKD in apparently healthy men
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Kidney Dis 46:871-80. 2005

Detail Information

Publications91

  1. pmc Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 308:1871-80. 2012
    ..Observational studies have not provided evidence regarding associations of multivitamin use with total and site-specific cancer incidence or mortality...
  2. pmc Nut consumption and risk of atrial fibrillation in the Physicians' Health Study
    O Khawaja
    Harvard Medical School, Boston, MA, USA
    Nutr J 11:17. 2012
    ..3 million people in USA and 4.5 million people in European Union. The aim of the study was to examine the association between nut consumption and incident atrial fibrillation...
  3. pmc Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
    Susan M Wernimont
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    BMC Med Genet 12:150. 2011
    ..Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease...
  4. pmc Apolipoprotein ε4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study
    Catherine R Rahilly-Tierney
    Massachusetts Veterans Epidemiology and Information Research Center MAVERIC, Boston VA Healthcare, Boston, Massachusetts, USA
    Lipids Health Dis 10:167. 2011
    ....
  5. pmc Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 301:52-62. 2009
    ..No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer...
  6. ncbi request reprint Vitamin E and cardiovascular disease: observational studies
    J Michael Gaziano
    Brigham and Women s Hospital, Division of Aging, 1620 Tremont Street, Boston MA 02120, USA
    Ann N Y Acad Sci 1031:280-91. 2004
    ..Currently, the American Heart Association maintains that there are insufficient efficacy data from completed randomized trials to justify population-wide recommendations for use of vitamin E supplements in disease prevention...
  7. pmc Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes
    J Michael Gaziano
    Massachusetts Veterans Epidemiology Research and Information Center VA Cooperative Studies Programs, VA Boston Healthcare System, Boston, Massachusetts, USA
    Diabetes Care 33:1503-8. 2010
    ..The Cycloset Safety Trial, a 52-week, randomized, double-blind, multicenter trial, evaluated the overall safety and cardiovascular safety of this novel therapy for type 2 diabetes...
  8. ncbi request reprint Potential for drug-drug interactions in patients taking analgesics for mild-to-moderate pain and low-dose aspirin for cardioprotection
    J Michael Gaziano
    Divisions of Aging, Preventive Medicine and Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 97:23-9. 2006
    ..Acetaminophen is considered a first-line therapy for patients with mild-to-moderate joint pain...
  9. ncbi request reprint Smoking and the risk of hemorrhagic stroke in men
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Stroke 34:1151-5. 2003
    ..Smoking is an established risk factor for ischemic stroke and subarachnoid hemorrhage (SAH), but the impact of smoking on intracerebral hemorrhage (ICH) is less clear...
  10. ncbi request reprint Association between body mass index and CKD in apparently healthy men
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Kidney Dis 46:871-80. 2005
    ..Conversely, their association with the development of CKD is less clear...
  11. pmc Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial
    Jennifer Lin
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    J Natl Cancer Inst 101:14-23. 2009
    ..However, findings from randomized trials of the association between antioxidant use and cancer risk have been mostly negative...
  12. pmc Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease
    Jane A Driver
    Department of Medicine, Division of Aging, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:2003-5. 2008
    ..To evaluate the association between type 2 diabetes and newly reported Parkinson's disease...
  13. pmc Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial
    Shumin M Zhang
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    JAMA 300:2012-21. 2008
    ..Folate, vitamin B(6), and vitamin B(12) are thought to play an important role in cancer prevention...
  14. pmc Cystatin C and risk of heart failure in the Physicians' Health Study (PHS)
    Luc Djousse
    Department of Medicine, Division of Aging, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am Heart J 155:82-6. 2008
    ..Chronic kidney disease is a risk factor for heart failure (HF). Although cystatin C can detect early kidney dysfunction, limited data are available on the association between cystatin C and HF...
  15. ncbi request reprint A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ..Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women...
  16. ncbi request reprint A prospective study of plasma C-peptide and colorectal cancer risk in men
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:546-53. 2004
    ..We used the concentration of plasma C-peptide (an indicator of insulin production) to determine whether insulin and insulin resistance are associated with the risk of developing colorectal cancer...
  17. ncbi request reprint Predictors of 14-year changes in the total cholesterol to high-density lipoprotein cholesterol ratio in men
    Richard Scranton
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Am Heart J 147:1033-8. 2004
    ..We examined predictors of a change in TC/HDL ratio over a period of 14 years among 4451 men free of CVD from the Physicians' Health Study...
  18. ncbi request reprint Body mass index and the risk of stroke in men
    Tobias Kurth
    Brigham and Women s Hospital, Division of Preventive Medicine, 900 Commonwealth Ave East, Boston, MA 02215 1204, USA
    Arch Intern Med 162:2557-62. 2002
    ..Although obesity is an established risk factor for coronary heart disease, its role as a risk factor for stroke remains controversial...
  19. ncbi request reprint A randomized trial of beta carotene and age-related cataract in US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Third Floor, Boston, MA 02215 1204, USA
    Arch Ophthalmol 121:372-8. 2003
    ..To examine the development of age-related cataract in a trial of beta carotene supplementation in men...
  20. pmc Egg consumption and risk of type 2 diabetes in men and women
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 32:295-300. 2009
    ..This project sought to examine the relation between egg intake and the risk of type 2 diabetes in two large prospective cohorts...
  21. ncbi request reprint Healthy lifestyle and the risk of stroke in women
    Tobias Kurth
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 166:1403-9. 2006
    ..Healthy lifestyle has been associated with decreased risk of coronary heart disease. In contrast, little is known about its association with stroke risk...
  22. ncbi request reprint Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: the Physicians' Health Study
    Howard D Sesso
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Control Clin Trials 23:686-702. 2002
    ..In contrast, diseases and risk factors explain some, but not all, of the lower mortality rates of physicians based on eligibility status and their ability to complete a run-in phase...
  23. pmc Nut consumption and risk of hypertension in US male physicians
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Clin Nutr 28:10-4. 2009
    ..Hypertension is a risk factor for cardiovascular disease and dietary factors may play an important role in its prevention. We sought to examine the association between nut consumption and incident hypertension...
  24. pmc Age-related cataract in a randomized trial of vitamins E and C in men
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 128:1397-405. 2010
    ..To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of age-related cataract in a large cohort of men...
  25. pmc Nut consumption and risk of heart failure in the Physicians' Health Study I
    Luc Djousse
    Division of Aging and Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am J Clin Nutr 88:930-3. 2008
    ....
  26. ncbi request reprint Body mass index and mortality among US male physicians
    Umed A Ajani
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Ann Epidemiol 14:731-9. 2004
    ..To assess the relationship between body mass index and mortality in a population homogeneous in educational attainment and socioeconomic status...
  27. pmc Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Lancet Oncol 9:1039-47. 2008
    ..We assessed the effect of prediagnostic BMI and plasma C-peptide concentration (reflecting insulin secretion) on prostate cancer-specific mortality after diagnosis...
  28. pmc Beta carotene supplementation and age-related maculopathy in a randomized trial of US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Arch Ophthalmol 125:333-9. 2007
    ..To test whether beta carotene supplementation affects the incidence of age-related maculopathy (ARM) in a large-scale randomized trial...
  29. ncbi request reprint Aspirin, NSAIDs, and COX-2 inhibitors in cardiovascular disease: possible interactions and implications for treatment of rheumatoid arthritis
    Tobias Kurth
    Brigham and Women s Hospital, Division of Aging, 1620 Tremont Street, Boston, MA 02120, USA
    Curr Rheumatol Rep 6:351-6. 2004
    ..The more widespread and appropriate use of aspirin in patients with rheumatoid arthritis will avoid many premature deaths in secondary prevention for CVD and first myocardial infarctions in primary prevention...
  30. ncbi request reprint Inhibition of clinical benefits of aspirin on first myocardial infarction by nonsteroidal antiinflammatory drugs
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, Mass 02215 1204, USA
    Circulation 108:1191-5. 2003
    ..Recent data also suggest that other nonsteroidal anti-inflammatory drugs (NSAIDs) may interfere with this benefit of aspirin...
  31. ncbi request reprint Analgesic use and risk of subsequent hypertension in apparently healthy men
    Tobias Kurth
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 165:1903-9. 2005
    ..We tested whether apparently healthy male physicians who reported analgesic use had an increased risk of subsequent hypertension...
  32. ncbi request reprint Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
    I Min Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:56-65. 2005
    ..Randomized trials do not generally support benefits of vitamin E, but there are few trials of long duration among initially healthy persons...
  33. ncbi request reprint Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians
    A Elisabeth Hak
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Ave, Boston, Mass 02115 5804, USA
    Circulation 108:802-7. 2003
    ..Increased intake of carotenoids and vitamin E may protect against myocardial infarction (MI). However, prospective data on blood levels of carotenoids other than beta-carotene and vitamin E (tocopherol) and risk of MI are sparse...
  34. pmc A prospective study of body mass index and the risk of developing hypertension in men
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 20:370-7. 2007
    ..Although obesity is known to increase the risk of hypertension, few studies have prospectively evaluated body mass index (BMI) across the range of normal weight and overweight as a primary risk factor...
  35. ncbi request reprint A prospective cohort study of cancer incidence following the diagnosis of Parkinson's disease
    Jane A Driver
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120 1613, USA
    Cancer Epidemiol Biomarkers Prev 16:1260-5. 2007
    ..Prior studies suggest a decreased risk of cancer among patients with Parkinson's disease (PD)...
  36. pmc Body mass index and vigorous physical activity and the risk of heart failure among men
    Satish Kenchaiah
    Physicians Health Study, Brigham and Women s Hospital, Boston, MA 02215, USA
    Circulation 119:44-52. 2009
    ..However, the impact of overweight or preobese (BMI, 25 to 29.9 kg/m(2)) status and physical activity on HF risk is unclear...
  37. ncbi request reprint Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial
    Rex L Jamison
    Veterans Affairs Palo Alto Health Care Systems and Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94304, USA
    JAMA 298:1163-70. 2007
    ..Folic acid and B vitamins decrease homocysteine levels in this population but whether they lower mortality is unknown...
  38. ncbi request reprint Strawberry intake, lipids, C-reactive protein, and the risk of cardiovascular disease in women
    Howard D Sesso
    Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston MA 02215 1204, USA
    J Am Coll Nutr 26:303-10. 2007
    ..In the Women's Health Study, we examined strawberry intake for both its prospective association with CVD risk in 38,176 women and its cross-sectional association with lipids and C-reactive protein (CRP) in a subset of 26,966 women...
  39. pmc Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 88:747-54. 2008
    ..Cardiovascular disease (CVD) risk factors may potentially influence plasma concentrations of carotenoids. However, data on the association of plasma carotenoids with CVD related biomarkers are only limited...
  40. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    ..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
  41. ncbi request reprint Development of a risk score for colorectal cancer in men
    Jane A Driver
    The Brigham and Women s Hospital Divisions of Aging, Boston, Mass 02120, USA
    Am J Med 120:257-63. 2007
    ..Colorectal cancer is a common and preventable disease for which screening rates remain unacceptably low...
  42. ncbi request reprint Smoking and risk of hemorrhagic stroke in women
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Stroke 34:2792-5. 2003
    ..A recent study added smoking as a risk factor for intracerebral hemorrhage (ICH) in men. In contrast, the impact of smoking on ICH in women is less clear...
  43. ncbi request reprint Reducing the global burden of cardiovascular disease: the role of risk factors
    James W Levenson
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    Prev Cardiol 5:188-99. 2002
    ..The authors outline the major challenges facing countries in different economic sectors, and discuss ways to address these challenges with the goal of reducing the global burden of CVD...
  44. ncbi request reprint Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 79:47-53. 2004
    ..Growing evidence suggests that lycopene has significant in vitro antioxidant potential. Lycopene has rarely been tested in prospective studies for its role in cardiovascular disease (CVD) prevention...
  45. ncbi request reprint Nonnarcotic analgesics and hypertension
    J Michael Gaziano
    Divisions of Aging, Preventive Medicine and Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 97:10-6. 2006
    ..This is followed by a summary of data on the relation between analgesics and blood pressure from both observational and randomized trials...
  46. pmc Colorectal cancer after start of nonsteroidal anti-inflammatory drug use
    TIL STURMER
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Am J Med 119:494-502. 2006
    ....
  47. ncbi request reprint Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Epidemiol 164:576-85. 2006
    ..91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women...
  48. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  49. doi request reprint Alcohol consumption and the risk of hypertension in women and men
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston MA 02215 1204, USA
    Hypertension 51:1080-7. 2008
    ..The threshold above which alcohol became deleterious for hypertension risk emerged at >or=4 drinks per day in women versus a moderate level of >or=1 drink per day in men...
  50. pmc Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study
    William G Christen
    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 126:102-9. 2008
    ..To examine in prospective data the relation between dietary intake of carotenoids and vitamins C and E and the risk of cataract in women...
  51. ncbi request reprint A prospective study of plasma lipid levels and hypertension in women
    Howard D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Arch Intern Med 165:2420-7. 2005
    ..Although dyslipidemia and hypertension occur together more often than can be explained by chance, few studies have carefully explored the nature of the relationship between plasma lipid levels and the risk of developing hypertension...
  52. ncbi request reprint Dyslipidemia and the risk of incident hypertension in men
    Ruben O Halperin
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 47:45-50. 2006
    ..These prospective cohort data suggest that dyslipidemias may lead to the subsequent development of hypertension. Thus, plasma lipids may be useful in the identification of men at risk for hypertension...
  53. pmc Measures of obesity and cardiovascular risk among men and women
    Rebecca P Gelber
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 52:605-15. 2008
    ....
  54. ncbi request reprint Analgesic use and change in kidney function in apparently healthy men
    Tobias Kurth
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Am J Kidney Dis 42:234-44. 2003
    ..Studies using a single creatinine measurement have yielded inconsistent results regarding analgesic use and kidney function...
  55. ncbi request reprint Effects of age and hypertension status on cognition: the Veterans Affairs Normative Aging Study
    Christopher B Brady
    Veterans Affairs Boston Healthcare System and Harvard Medical School, Boston, MA 02130, USA
    Neuropsychology 19:770-7. 2005
    ..These and previous findings illustrate that health conditions such as hypertension should be regularly considered in studies of "normal" cognitive aging...
  56. pmc Homocysteine lowering and cognition in CKD: the Veterans Affairs homocysteine study
    Christopher B Brady
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
    Am J Kidney Dis 54:440-9. 2009
    ..Whether treatment with high-dose B vitamins to decrease high tHcy levels improves cognition in persons with kidney disease is unknown...
  57. pmc A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Intern Med 167:1610-8. 2007
    ..Few trials have examined interactions among antioxidants, and, to our knowledge, no previous trial has examined the individual effect of ascorbic acid (vitamin C) on CVD...
  58. ncbi request reprint Whole- and refined-grain intakes and the risk of hypertension in women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 86:472-9. 2007
    ..Prospective studies linking whole- and refined-grain intakes with the risk of hypertension, a major cardiovascular disease risk factor, remain limited...
  59. ncbi request reprint Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer
    Haojie Li
    Channing Laboratory, Department of Medicine Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 65:2498-504. 2005
    ..Both endogenous and exogenous antioxidants play an important and interdependent role in preventing clinically significant prostate cancer...
  60. ncbi request reprint Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:47-55. 2005
    ..Basic research and observational evidence as well as results from trials of colon polyp recurrence suggest a role for aspirin in the chemoprevention of cancer...
  61. pmc Alcohol consumption and heart failure in hypertensive US male physicians
    Luc Djousse
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 102:593-7. 2008
    ..In conclusion, our data suggested that light to moderate alcohol consumption was associated with a lower risk of HF in hypertensive male physicians...
  62. ncbi request reprint Plasma C-peptide and cognitive performance in older men without diabetes
    Olivia Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Geriatr Psychiatry 14:1041-50. 2006
    ..Emerging evidence suggests that type 2 diabetes may be related to diminished cognition, but little data are available directly regarding the role of insulin levels...
  63. ncbi request reprint Nut consumption and decreased risk of sudden cardiac death in the Physicians' Health Study
    Christine M Albert
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Arch Intern Med 162:1382-7. 2002
    ..Since components of nuts may have antiarrhythmic properties, part of the benefit may be due to a reduction in sudden cardiac death...
  64. pmc C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 118:2243-51, 4p following 2251. 2008
    ....
  65. pmc Chronic disease in men with newly diagnosed cancer: a nested case-control study
    Jane A Driver
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 172:299-308. 2010
    ..72, 95% CI: 0.62, 0.84) and diabetes (OR = 0.72, 95% CI: 0.58, 0.89). Overall, men who developed cancer had no more comorbidity or frequent history of chronic disease than their age-matched controls...
  66. pmc Incidence and remaining lifetime risk of Parkinson disease in advanced age
    Jane A Driver
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Neurology 72:432-8. 2009
    ..To estimate the incidence and lifetime risk (LTR) of Parkinson disease (PD) in a large cohort of men...
  67. pmc Fasting plasma insulin, C-peptide and cognitive change in older men without diabetes: results from the Physicians' Health Study II
    Olivia I Okereke
    Divisions of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neuroepidemiology 34:200-7. 2010
    ..We examined prospectively relations of fasting insulin levels and insulin secretion to cognitive decline among healthy, community-dwelling older men without diabetes...
  68. pmc Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:3140-9. 2010
    ..We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk...
  69. ncbi request reprint Alcohol consumption and mortality in men with preexisting cerebrovascular disease
    Vicki A Jackson
    Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA
    Arch Intern Med 163:1189-93. 2003
    ..In counseling patients with a history of stroke, clinicians have limited information regarding the risks and benefits of alcohol consumption...
  70. pmc Incidence of cardiovascular disease and cancer in advanced age: prospective cohort study
    Jane A Driver
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    BMJ 337:a2467. 2008
    ..To investigate the influence of increasing age on the incidence and remaining lifetime risk of cardiovascular disease and cancer in a cohort of older men...
  71. pmc Physical activity, body mass index, and diabetes risk in men: a prospective study
    Lydia C Siegel
    Massachusetts Veterans Epidemiology Research and Information Center at the VA Boston Healthcare System, Boston, Mass, USA
    Am J Med 122:1115-21. 2009
    ..We investigated the independent and joint associations between vigorous activity and BMI on diabetes risk in men...
  72. ncbi request reprint Midlife plasma insulin-like growth factor I and cognitive function in older men
    Olivia I Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 91:4306-12. 2006
    ..Emerging biological and epidemiological evidence suggests possible benefits of higher IGF-I levels in cognitive aging...
  73. ncbi request reprint A prospective study of cigarette smoking and risk of incident hypertension in women
    Thomas S Bowman
    Veterans Affairs Boston Healthcare System, Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, Massachusetts, USA
    J Am Coll Cardiol 50:2085-92. 2007
    ..We undertook this study to prospectively evaluate whether cigarette smoking was associated with an increased risk of developing hypertension...
  74. doi request reprint Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years
    Laurel B Yates
    Division of Aging, Brigham and Women s Hospital, 1620 Tremont St, Boston, MA 02120, USA
    Arch Intern Med 168:284-90. 2008
    ..We examined modifiable factors associated with a life span of 90 or more years and late-life function in men...
  75. doi request reprint Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults
    Olivia I Okereke
    Division of Aging and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 56:1028-36. 2008
    ..To relate diabetes mellitus (DM) status and duration to late-life cognitive impairment and decline in men and women...
  76. pmc Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
    ..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
  77. pmc Laboratory-based versus non-laboratory-based method for assessment of cardiovascular disease risk: the NHANES I Follow-up Study cohort
    Thomas A Gaziano
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 371:923-31. 2008
    ....
  78. ncbi request reprint Effect of age on blood pressure parameters and risk of cardiovascular death in men
    Thomas S Bowman
    Veterans Affairs Boston Healthcare System, Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA, USA
    Am J Hypertens 19:47-52. 2006
    ..We sought to determine which BP parameters are important predictors of CVD death across a wide age range...
  79. pmc Eight-year change in body mass index and subsequent risk of cardiovascular disease among healthy non-smoking men
    Thomas S Bowman
    VA Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center MAVERIC, Boston, MA, USA
    Prev Med 45:436-41. 2007
    ..To determine how change in BMI over 8 years is associated with risk of subsequent cardiovascular disease (CVD) among middle aged men...
  80. ncbi request reprint JNC 7 category and risk of cardiovascular death in men: are there differences by age?
    Thomas S Bowman
    Harvard University General Internal Medicine Fellowship Program, Veterans Affairs Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA 02120, USA
    Am J Geriatr Cardiol 14:126-31; quiz 132-3. 2005
    ..22). In this large cohort, the JNC 7 categorization of prehypertension was not associated with a significantly increased risk of cardiovascular disease death, and there was no significant effect modification by age...
  81. ncbi request reprint Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality
    Jorg Muntwyler
    Department of Internal Medicine, University Hospital of Zurich, Switzerland
    Arch Intern Med 162:1472-6. 2002
    ..Although basic research suggests that vitamins may have an important role in the prevention of cardiovascular diseases (CVD), the data from cohort studies and clinical trials are inconclusive...
  82. ncbi request reprint Blood pressure measures and risk of chronic kidney disease in men
    Elke S Schaeffner
    Department of Medicine, Charite Campus Virchow, Berlin, Germany
    Nephrol Dial Transplant 23:1246-51. 2008
    ..High blood pressure (BP) has been associated with a decrease in kidney function. However, it remains unclear which BP measure best predicts impaired kidney function...
  83. ncbi request reprint Geographic patterns in overall and specific cardiovascular disease incidence in apparently healthy men in the United States
    David Q Rich
    Department of Epidemiology, University of Medicine and Dentistry of New Jersey School of Public Health, Piscataway, NJ, USA
    Stroke 38:2221-7. 2007
    ..However, data on regional variability in overall cardiovascular disease (CVD) and specific coronary heart disease incidence are sparse...
  84. ncbi request reprint Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community
    Ravi Dhingra
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803, USA
    Circulation 116:480-8. 2007
    ..Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals...
  85. ncbi request reprint A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II
    Francine Grodstein
    Channing Laboratory, School of Public Health, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Arch Intern Med 167:2184-90. 2007
    ..Oxidative stress contributes to brain aging. Antioxidant treatment, especially over the long term, might confer cognitive benefits...
  86. ncbi request reprint Vitamin E in the prevention of prostate cancer: where are we today?
    I Min Lee
    J Natl Cancer Inst 98:225-7. 2006
  87. ncbi request reprint Design and statistical issues in the homocysteinemia in kidney and end stage renal disease (HOST) study
    Rex L Jamison
    Division of Nephrology, Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Clin Trials 1:451-60. 2004
    ..Data will be stored and analyzed at a coordinating center. The study design has the power to detect a reduction in all cause mortality rate of 17%. Issues related to the unique features of the design of this study are discussed...
  88. ncbi request reprint Alcohol consumption and cardiovascular disease mortality in hypertensive men
    Maciej K Malinski
    St Vincent Hospital, Worcester Medical Center, University of Massachusetts Medical School, Worcester, USA
    Arch Intern Med 164:623-8. 2004
    ..Heavy alcohol drinking is associated with a dose-dependent increase in blood pressure, but data on the relation between alcohol consumption and mortality in hypertensive patients are sparse...
  89. ncbi request reprint Impact of obesity on the risk of heart failure and survival after the onset of heart failure
    Satish Kenchaiah
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Med Clin North Am 88:1273-94. 2004
    ....
  90. ncbi request reprint Cholesterol and the risk of ischemic stroke
    Thomas S Bowman
    Harvard University General Internal Medicine Fellowship Program, Veterans Affairs Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA 02130, USA
    Stroke 34:2930-4. 2003
    ....
  91. ncbi request reprint Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Am J Clin Nutr 81:990-7. 2005
    ..Emerging evidence suggests a possible role of lycopene in the primary prevention of cardiovascular disease (CVD)...

Research Grants11

  1. Physicians' Health Study II: Prevention Trial of Vitamins
    J Gaziano; Fiscal Year: 2007
    ..S. physicians. The results of this trial of a typical multivitamin will have important ramifications for public health, as multivitamins have become increasingly popular. ..
  2. Boston Geriatric Research Scholars Program
    J Gaziano; Fiscal Year: 2007
    ..By developing a strong relationship with the students during the program, the Scholar tracking will be a continuation of the mentoring experience and a forum to increase Scholar interest in aging research. ..
  3. Physicians Health Study II: Prevention Trial of Vitamins
    J Gaziano; Fiscal Year: 2006
    ..abstract_text> ..
  4. Physicians' Health Study II: Prevention Trial of Vitamins
    J Michael Gaziano; Fiscal Year: 2010
    ..S. physicians. The results of this trial of a typical multivitamin will have important ramifications for public health, as multivitamins have become increasingly popular. ..