Rajesh Garg

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Provider response to insulin-induced hypoglycemia in hospitalized patients
    Rajesh Garg
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Hosp Med 2:258-60. 2007
  2. doi request reprint Preoperative A1C and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures
    Patricia Underwood
    Corresponding author Rajesh Garg
    Diabetes Care 37:611-6. 2014
  3. pmc Hypoglycemia, with or without insulin therapy, is associated with increased mortality among hospitalized patients
    Rajesh Garg
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Diabetes Care 36:1107-10. 2013
  4. doi request reprint Predictors of hyperglycemia after cardiac surgery in nondiabetic patients
    Rajesh Garg
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 145:1083-7. 2013
  5. pmc Aldosterone production and insulin resistance in healthy adults
    Rajesh Garg
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 95:1986-90. 2010
  6. ncbi request reprint Hyperglycemia and length of stay in patients hospitalized for bone marrow transplantation
    Rajesh Garg
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Diabetes Care 30:993-4. 2007
  7. pmc Low-salt diet increases insulin resistance in healthy subjects
    Rajesh Garg
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 60:965-8. 2011
  8. doi request reprint Delay in blood glucose monitoring during an insulin infusion protocol is associated with increased risk of hypoglycemia in intensive care units
    Rajesh Garg
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Hosp Med 4:E5-7. 2009
  9. ncbi request reprint Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, Diabetes Endocrinology Center of Western New York, State University of New York at Buffalo, and Kaleida Health, Buffalo, NY 14209, USA
    Circulation 111:1448-54. 2005
  10. pmc Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone
    Jenifer M Brown
    Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, RFB, Boston, MA 02115
    Hypertension 63:273-80. 2014

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Provider response to insulin-induced hypoglycemia in hospitalized patients
    Rajesh Garg
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Hosp Med 2:258-60. 2007
    ..Risk of hypoglycemia is a major barrier to the implementation of tight blood glucose (BG) control in hospitalized patients. The objective of this study was to evaluate the changes in diabetes treatment after an episode of hypoglycemia...
  2. doi request reprint Preoperative A1C and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures
    Patricia Underwood
    Corresponding author Rajesh Garg
    Diabetes Care 37:611-6. 2014
    ..To evaluate the relationship between preoperative A1C and clinical outcomes in individuals with diabetes mellitus undergoing noncardiac surgery...
  3. pmc Hypoglycemia, with or without insulin therapy, is associated with increased mortality among hospitalized patients
    Rajesh Garg
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Diabetes Care 36:1107-10. 2013
    ..Hypoglycemia is associated with increased mortality in hospitalized patients. We investigated the relationship between spontaneous hypoglycemia versus insulin-associated hypoglycemia and mortality in hospitalized patients...
  4. doi request reprint Predictors of hyperglycemia after cardiac surgery in nondiabetic patients
    Rajesh Garg
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 145:1083-7. 2013
    ..However, some experts consider hyperglycemia to be an epiphenomenon related to acute stress. We investigated whether preoperative patient characteristics can predict hyperglycemia after cardiac surgery in nondiabetic patients...
  5. pmc Aldosterone production and insulin resistance in healthy adults
    Rajesh Garg
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 95:1986-90. 2010
    ..Aldosterone production is associated with insulin resistance in obese and hypertensive subjects. However, its effect on insulin sensitivity in healthy subjects is not clear...
  6. ncbi request reprint Hyperglycemia and length of stay in patients hospitalized for bone marrow transplantation
    Rajesh Garg
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Diabetes Care 30:993-4. 2007
  7. pmc Low-salt diet increases insulin resistance in healthy subjects
    Rajesh Garg
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 60:965-8. 2011
    ..Low-salt diet is associated with an increase in IR. The impact of our findings on the pathogenesis of diabetes and cardiovascular disease needs further investigation...
  8. doi request reprint Delay in blood glucose monitoring during an insulin infusion protocol is associated with increased risk of hypoglycemia in intensive care units
    Rajesh Garg
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Hosp Med 4:E5-7. 2009
    ..Hypoglycemia during insulin infusion therapy is a major problem. We investigated whether a delay in blood glucose (BG) monitoring during an insulin infusion protocol (IIP) in the intensive care unit (ICU) is associated with hypoglycemia...
  9. ncbi request reprint Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, Diabetes Endocrinology Center of Western New York, State University of New York at Buffalo, and Kaleida Health, Buffalo, NY 14209, USA
    Circulation 111:1448-54. 2005
  10. pmc Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone
    Jenifer M Brown
    Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, RFB, Boston, MA 02115
    Hypertension 63:273-80. 2014
    ..Future studies to evaluate the impact of RAAS inhibitors in treating PTH-mediated disorders are warranted. ..
  11. ncbi request reprint Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction
    Ajay Chaudhuri
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, NY 14209, USA
    Circulation 109:849-54. 2004
    ..We assessed this potential effect of insulin in STEMI patients treated with fibrinolytics...
  12. ncbi request reprint Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 88:4496-501. 2003
    ..In contrast, quinapril and simvastatin produced no similar effect over the period of 1 wk. Our observations may also have implications to clinical situations in which a rapid antiinflammatory effect is required...
  13. pmc Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, RFB 386, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 97:3775-82. 2012
    ..However, studies supporting these assumptions may have been confounded by participant inclusion criteria, and study results may reflect target organ damage...
  14. doi request reprint Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis
    Daniel H Solomon
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    JAMA 305:2525-31. 2011
    ..Rheumatoid arthritis (RA) and psoriasis have been linked with insulin resistance and diabetes mellitus (DM). Prior investigations suggest that systemic immunosuppressive drugs may improve insulin resistance and reduce the risk of DM...
  15. pmc Mineralocorticoid receptor antagonists and the metabolic syndrome
    Amir Tirosh
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Curr Hypertens Rep 12:252-7. 2010
    ..Clinical trials have demonstrated benefits of MR antagonists in heart failure, hypertension, and diabetic nephropathy, but additional trials are needed to demonstrate the clinical significance of MR blockade in MetS...
  16. ncbi request reprint Body mass index predicts aldosterone production in normotensive adults on a high-salt diet
    Rhonda Bentley-Lewis
    Division of Endocrinology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:4472-5. 2007
    ..The mechanisms underlying obesity-mediated cardiovascular disease are not fully understood. Aldosterone and insulin resistance both are associated with obesity and cardiovascular disease...
  17. pmc Insulin infusion in acute illness
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, and Kaleida Health, Buffalo, New York, New York, USA
    J Clin Invest 115:2069-72. 2005
    ....
  18. pmc Hydroxychloroquine improves insulin sensitivity in obese non-diabetic individuals
    Emileigh Mercer
    Division of Rheumatology, Brigham and Women s Hospital Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 14:R135. 2012
    ..To investigate the mechanism of this effect, we examined the effect of HCQ on insulin resistance, insulin sensitivity, and pancreatic β-cell secretion of insulin in non-diabetic, obese subjects...
  19. doi request reprint Role of mineralocorticoid receptor in insulin resistance
    Rajesh Garg
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Endocrinol Diabetes Obes 19:168-75. 2012
    ..This review discusses new evidence linking mineralocorticoid receptor to insulin resistance and the underlying mechanisms of these effects...
  20. ncbi request reprint Insulin as an anti-inflammatory and antiatherosclerotic hormone
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York, Kaleida Health Buffalo, New York, USA
    Clin Cornerstone . 2003
    ..The authors conclude that insulin is both anti-inflammatory and antiatherogenic and may be of use in the treatment of cardiovascular inflammatory conditions, including AMI...
  21. ncbi request reprint Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy
    Rajesh Garg
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, New York 14209, USA
    Stroke 37:267-73. 2006
    ..Hyperglycemia is associated with increased mortality and morbidity in acute ischemic stroke...
  22. ncbi request reprint Contrasting testosterone concentrations in type 1 and type 2 diabetes
    Rashmi Tomar
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York, USA
    Diabetes Care 29:1120-2. 2006
  23. doi request reprint Diabetes management in the kidney patient
    Rajesh Garg
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Med Clin North Am 97:135-56. 2013
    ..This article reviews metabolic changes present in kidney impairment/failure, current views about glycemic goals, and treatment options for the diabetic patient with CKD...
  24. pmc Aldosterone and myocardial extracellular matrix expansion in type 2 diabetes mellitus
    Ajay D Rao
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Cardiol 112:73-8. 2013
    ..These results implicate aldosterone in early myocardial remodeling in type 2 diabetes mellitus...
  25. pmc Changes in glycosylated hemoglobin after initiation of hydroxychloroquine or methotrexate treatment in diabetes patients with rheumatic diseases
    Laura R Rekedal
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Rheum 62:3569-73. 2010
    ..We examined medical records of patients with diabetes mellitus (DM) and concomitant rheumatic illness to measure changes in HbA(1c) after starting HCQ or methotrexate (MTX)...
  26. ncbi request reprint Insulin resistance as a proinflammatory state: mechanisms, mediators, and therapeutic interventions
    Rajesh Garg
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Curr Drug Targets 4:487-92. 2003
    ..These effects may be of considerable clinical significance if sustained during long-term therapy, given the morbidity and mortality associated with atherosclerosis, the major complication of insulin resistance...
  27. pmc Improving the management of diabetes in hospitalized patients: the results of a computer-based house staff training program
    Anand Vaidya
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Technol Ther 14:610-8. 2012
    ..We hypothesized that computer-based diabetes training could improve house staff knowledge and comfort for the management of diabetes in a large tertiary-care hospital...
  28. pmc Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis
    Rajesh Garg
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 33:2349-54. 2010
    ..Cases of acute pancreatitis have been reported in association with exenatide, sitagliptin, and type 2 diabetes without use of these medications. It remains unknown whether exenatide or sitagliptin increase the risk of acute pancreatitis...
  29. ncbi request reprint High Hemoglobin A1c levels and glycemic variability increase risk of severe hypoglycemia in diabetic hemodialysis patients
    Mark E Williams
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Hemodial Int 18:423-32. 2014
    ..High HgbA1c and glycemic variability are associated with increased risk of hypoglycemia in individuals with diabetes and ESRD. ..
  30. pmc Hip geometry in diabetic women: implications for fracture risk
    Rajesh Garg
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Metabolism 61:1756-62. 2012
    ..We hypothesized that bone strength is diminished in women with T2DM after accounting for lean body mass, which may contribute to their increased fracture risk...
  31. ncbi request reprint Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells
    Priya Mohanty
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, USA
    Am J Clin Nutr 75:767-72. 2002
    ..It was recently shown that glucose challenge leads to increased generation of reactive oxygen species (ROS) by polymorphonuclear leukocytes (PMNs) and mononuclear cells (MNCs)...
  32. ncbi request reprint Exogenous insulin and hypoglycemia as prognostic factors in critically ill patients
    Rajesh Garg
    JAMA 291:559; author reply 559-60. 2004
  33. ncbi request reprint Use of continuous subcutaneous insulin infusion pump in patients with type 2 diabetes mellitus
    Susan Nielsen
    Millard Fillmore Hospital, 3 Gates Circle, Buffalo, NY 14209, USA
    Diabetes Educ 31:843-8. 2005
    ..These patients pose a major management problem. The authors therefore investigated whether insulin given as a subcutaneous continuous infusion of insulin (CSII) would result in an improvement in glucose homeostasis...
  34. ncbi request reprint Glycemic durability of monotherapy for diabetes
    Rajesh Garg
    N Engl J Med 356:1379; author reply 1380. 2007