Rajesh T Gandhi

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Update on human immunodeficiency virus (HIV)-2 infection
    Omobolaji T Campbell-Yesufu
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Infect Dis 52:780-7. 2011
  2. pmc Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection
    Marylyn M Addo
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America
    PLoS ONE 2:e321. 2007
  3. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
  4. ncbi Immunologic control of HIV-1
    Rajesh T Gandhi
    Partners AIDS Research Center and Infectious Diseases Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Med 53:149-72. 2002
  5. ncbi Hepatitis C in schizophrenia: screening experience in a community-dwelling clozapine cohort
    Oliver Freudenreich
    Massachusetts General Hospital Schizophrenia Program, Freedom Trail Clinic, the Division of Infectious Diseases and Partners AIDS Research Center, and Harvard Medical School, Boston, MA 02114, USA
    Psychosomatics 48:405-11. 2007
  6. doi Antiretroviral therapy-associated toxicities in the resource-poor world: the challenge of a limited formulary
    Richard A Murphy
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 196:S449-56. 2007
  7. pmc Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384
    Gregory K Robbins
    Infectious Diseases Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Infect Dis 48:350-61. 2009
  8. pmc A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy
    Rajesh T Gandhi
    Massachusetts General Hospital, 55 Fruit St, GRJ 504, Boston, MA 02114, United States
    Vaccine 27:6088-94. 2009
  9. doi Clozapine use in HIV-infected schizophrenia patients: a case-based discussion and review
    Shamim Hashemi Nejad
    Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychosomatics 50:626-32. 2009
  10. pmc No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 201:293-6. 2010

Detail Information

Publications24

  1. pmc Update on human immunodeficiency virus (HIV)-2 infection
    Omobolaji T Campbell-Yesufu
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Infect Dis 52:780-7. 2011
    ..In this review, we present information on recent clinical advances in our understanding of HIV-2 infection and highlight remaining diagnostic and therapeutic challenges...
  2. pmc Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection
    Marylyn M Addo
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America
    PLoS ONE 2:e321. 2007
    ..Recent data suggest that impaired maturation, as defined by the lineage markers CD45RA and CCR7, may contribute to a lack of immune control by these responses...
  3. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
    ..Together, these data indicate that viral escape from CD8+ T cell responses occurs during human HCV infection and that acute immune selection pressure is of sufficient magnitude to influence HCV evolution...
  4. ncbi Immunologic control of HIV-1
    Rajesh T Gandhi
    Partners AIDS Research Center and Infectious Diseases Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Med 53:149-72. 2002
    ..Based on this understanding of the immunologic correlates of control of HIV-1, exciting new immunotherapeutic strategies for HIV-1 infection are being designed and tested...
  5. ncbi Hepatitis C in schizophrenia: screening experience in a community-dwelling clozapine cohort
    Oliver Freudenreich
    Massachusetts General Hospital Schizophrenia Program, Freedom Trail Clinic, the Division of Infectious Diseases and Partners AIDS Research Center, and Harvard Medical School, Boston, MA 02114, USA
    Psychosomatics 48:405-11. 2007
    ..However, clinical experience treating HCV in schizophrenia patients is limited; in this cohort, 2 years after screening, no patient had received interferon/ribavirin treatment...
  6. doi Antiretroviral therapy-associated toxicities in the resource-poor world: the challenge of a limited formulary
    Richard A Murphy
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 196:S449-56. 2007
    ....
  7. pmc Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384
    Gregory K Robbins
    Infectious Diseases Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Infect Dis 48:350-61. 2009
    ..Whether the baseline CD4 cell count affects reconstitution of immune cell subsets has not been well characterized...
  8. pmc A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy
    Rajesh T Gandhi
    Massachusetts General Hospital, 55 Fruit St, GRJ 504, Boston, MA 02114, United States
    Vaccine 27:6088-94. 2009
    ..New methods to enhance the immunogenicity and antiviral efficacy of DC-based vaccines for HIV-1 infection are needed...
  9. doi Clozapine use in HIV-infected schizophrenia patients: a case-based discussion and review
    Shamim Hashemi Nejad
    Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychosomatics 50:626-32. 2009
    ..However, 20% to 30% of patients with schizophrenia are refractory to first-line antipsychotics...
  10. pmc No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 201:293-6. 2010
    ..The stability of the latent reservoir despite intensive therapy suggests that new strategies are needed to eradicate HIV-1 from this reservoir. (ClinicalTrials.gov identifier: NCT00051831 .)...
  11. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
    ..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection...
  12. ncbi Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection
    Rajesh T Gandhi
    Partners AIDS Research Center and Infectious Diseases Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02114, USA
    Curr Opin Immunol 14:487-94. 2002
    ..Although viral escape from the immune system is an important challenge, new strategies for therapeutic and preventative HIV-1 vaccination are being vigorously pursued in human trials...
  13. ncbi Response to hepatitis B vaccine in HIV-1-positive subjects who test positive for isolated antibody to hepatitis B core antigen: implications for hepatitis B vaccine strategies
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 191:1435-41. 2005
    ..Development of an anamnestic response after vaccination would suggest previous hepatitis B virus (HBV) infection, in which case vaccination is not necessary...
  14. pmc Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
    Arthur Y Kim
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 3:e492. 2006
    ..Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection...
  15. ncbi Isolated antibody to hepatitis B core antigen in human immunodeficiency virus type-1-infected individuals
    Rajesh T Gandhi
    Infectious Diseases Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 36:1602-5. 2003
    ..A screening strategy that tests only for HBsAg and anti-HBs in HIV-1-infected patients will miss a large number of individuals with isolated anti-HBc...
  16. ncbi Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: results from ACTG 384
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 42:426-34. 2006
    ..To assess the effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy (ART)...
  17. ncbi Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus
    Rajesh T Gandhi
    Infectious Diseases Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 37:1693-8. 2003
    ..Moreover, it suggests that, despite initially impaired viral fitness, a transmitted HIV-1 isolate with multiple drug resistance mutations can evolve to develop increased RC and significant pathogenicity...
  18. ncbi A therapeutic HIV vaccine: how good is good enough?
    Rochelle P Walensky
    Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, MA 02114, USA
    Vaccine 22:4044-53. 2004
    ..91 months (cost-effectiveness ratio US$ 45,500/QALY). Even modestly effective therapeutic HIV vaccines may produce small but meaningful increases in life expectancy and compare favorably to alternative uses of scarce HIV care resources...
  19. pmc Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection
    Cheryl L Day
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 76:12584-95. 2002
    ..Moreover, these data provide important parameters for evaluation of candidate HCV vaccines, and provide rationale for immunotherapy in chronic HCV infection...
  20. pmc A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, and Harvard University Center for AIDS Research, Boston, MA 02129, USA
    J Exp Med 204:2813-24. 2007
    ....
  21. doi Fatigue in psychiatric HIV patients: a pilot study of psychological correlates
    Johanna Paddison
    Division of Psychiatry and Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychosomatics 50:455-60. 2009
    ..Even though viral management of HIV infection is now more effective, clinical observations suggest that fatigue remains a problem for a substantial proportion of patients...
  22. ncbi Antiretroviral rounds. Three diseases, one patient
    Margaret Koziel
    Harvard Medical School, Boston, Massachusetts, USA
    AIDS Clin Care 17:50-1. 2005
  23. doi HIV Online Provider Education (HOPE): the internet as a tool for training in HIV medicine
    Aurora D Kiviat
    Infectious Diseases Unit and Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 196:S512-5. 2007
    ..This online program may be a model for other efforts to provide education to health care providers treating HIV-infected patients in the developing world...
  24. pmc Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy
    Marco A Lima
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    J Virol 81:3361-8. 2007
    ..Immunotherapies aiming at increasing the cellular immune response against JCV may be valuable in the treatment of HIV+ individuals with PML...