Rajesh Gandhi

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Residual plasma viraemia and infectious HIV-1 recovery from resting memory CD4 cells in patients on antiretroviral therapy: results from ACTG A5173
    Rajesh T Gandhi
    Massachusetts General Hospital and Ragon Institute, Boston, MA, USA
    Antivir Ther 18:607-13. 2013
  2. pmc No effect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy
    Rajesh T Gandhi
    Division of Infectious Diseases and Ragon Institute, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 59:229-35. 2012
  3. pmc No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 201:293-6. 2010
  4. pmc A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy
    Rajesh T Gandhi
    Massachusetts General Hospital, 55 Fruit St, GRJ 504, Boston, MA 02114, United States
    Vaccine 27:6088-94. 2009
  5. ncbi request reprint Immunologic control of HIV-1
    Rajesh T Gandhi
    Partners AIDS Research Center and Infectious Diseases Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Med 53:149-72. 2002
  6. ncbi request reprint Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: results from ACTG 384
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 42:426-34. 2006
  7. ncbi request reprint Response to hepatitis B vaccine in HIV-1-positive subjects who test positive for isolated antibody to hepatitis B core antigen: implications for hepatitis B vaccine strategies
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 191:1435-41. 2005
  8. ncbi request reprint Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus
    Rajesh T Gandhi
    Infectious Diseases Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 37:1693-8. 2003
  9. ncbi request reprint Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection
    Rajesh T Gandhi
    Partners AIDS Research Center and Infectious Diseases Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02114, USA
    Curr Opin Immunol 14:487-94. 2002
  10. ncbi request reprint Isolated antibody to hepatitis B core antigen in human immunodeficiency virus type-1-infected individuals
    Rajesh T Gandhi
    Infectious Diseases Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 36:1602-5. 2003

Research Grants

  1. Induction of HIV-specific Immune Responses
    Rajesh Gandhi; Fiscal Year: 2007
  2. MECHANISMS OF T CELL APOPTOSIS DURING HIV1 INFECTION
    Rajesh Gandhi; Fiscal Year: 2002
  3. Induction of HIV-specific Immune Responses
    Rajesh Gandhi; Fiscal Year: 2009
  4. Induction of HIV-specific Immune Responses
    Rajesh T Gandhi; Fiscal Year: 2010

Detail Information

Publications36

  1. pmc Residual plasma viraemia and infectious HIV-1 recovery from resting memory CD4 cells in patients on antiretroviral therapy: results from ACTG A5173
    Rajesh T Gandhi
    Massachusetts General Hospital and Ragon Institute, Boston, MA, USA
    Antivir Ther 18:607-13. 2013
    ..In HIV-1-infected patients receiving antiretroviral therapy (ART), the relationship between residual viraemia and ex vivo recovery of infectious virus from latently infected CD4 cells is uncertain...
  2. pmc No effect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy
    Rajesh T Gandhi
    Division of Infectious Diseases and Ragon Institute, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 59:229-35. 2012
    ..Adding an additional potent agent, such as raltegravir, to effective ART in patients with low-level residual viremia may reveal whether there is ongoing HIV-1 replication...
  3. pmc No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 201:293-6. 2010
    ..The stability of the latent reservoir despite intensive therapy suggests that new strategies are needed to eradicate HIV-1 from this reservoir. (ClinicalTrials.gov identifier: NCT00051831 .)...
  4. pmc A randomized therapeutic vaccine trial of canarypox-HIV-pulsed dendritic cells vs. canarypox-HIV alone in HIV-1-infected patients on antiretroviral therapy
    Rajesh T Gandhi
    Massachusetts General Hospital, 55 Fruit St, GRJ 504, Boston, MA 02114, United States
    Vaccine 27:6088-94. 2009
    ..New methods to enhance the immunogenicity and antiviral efficacy of DC-based vaccines for HIV-1 infection are needed...
  5. ncbi request reprint Immunologic control of HIV-1
    Rajesh T Gandhi
    Partners AIDS Research Center and Infectious Diseases Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Med 53:149-72. 2002
    ..Based on this understanding of the immunologic correlates of control of HIV-1, exciting new immunotherapeutic strategies for HIV-1 infection are being designed and tested...
  6. ncbi request reprint Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: results from ACTG 384
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 42:426-34. 2006
    ..To assess the effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy (ART)...
  7. ncbi request reprint Response to hepatitis B vaccine in HIV-1-positive subjects who test positive for isolated antibody to hepatitis B core antigen: implications for hepatitis B vaccine strategies
    Rajesh T Gandhi
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 191:1435-41. 2005
    ..Development of an anamnestic response after vaccination would suggest previous hepatitis B virus (HBV) infection, in which case vaccination is not necessary...
  8. ncbi request reprint Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus
    Rajesh T Gandhi
    Infectious Diseases Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 37:1693-8. 2003
    ..Moreover, it suggests that, despite initially impaired viral fitness, a transmitted HIV-1 isolate with multiple drug resistance mutations can evolve to develop increased RC and significant pathogenicity...
  9. ncbi request reprint Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection
    Rajesh T Gandhi
    Partners AIDS Research Center and Infectious Diseases Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02114, USA
    Curr Opin Immunol 14:487-94. 2002
    ..Although viral escape from the immune system is an important challenge, new strategies for therapeutic and preventative HIV-1 vaccination are being vigorously pursued in human trials...
  10. ncbi request reprint Isolated antibody to hepatitis B core antigen in human immunodeficiency virus type-1-infected individuals
    Rajesh T Gandhi
    Infectious Diseases Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 36:1602-5. 2003
    ..A screening strategy that tests only for HBsAg and anti-HBs in HIV-1-infected patients will miss a large number of individuals with isolated anti-HBc...
  11. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
    ..Together, these data indicate that viral escape from CD8+ T cell responses occurs during human HCV infection and that acute immune selection pressure is of sufficient magnitude to influence HCV evolution...
  12. ncbi request reprint A therapeutic HIV vaccine: how good is good enough?
    Rochelle P Walensky
    Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, MA 02114, USA
    Vaccine 22:4044-53. 2004
    ..91 months (cost-effectiveness ratio US$ 45,500/QALY). Even modestly effective therapeutic HIV vaccines may produce small but meaningful increases in life expectancy and compare favorably to alternative uses of scarce HIV care resources...
  13. doi request reprint Antiretroviral therapy-associated toxicities in the resource-poor world: the challenge of a limited formulary
    Richard A Murphy
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 196:S449-56. 2007
    ....
  14. pmc Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384
    Gregory K Robbins
    Infectious Diseases Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Infect Dis 48:350-61. 2009
    ..Whether the baseline CD4 cell count affects reconstitution of immune cell subsets has not been well characterized...
  15. doi request reprint Clozapine use in HIV-infected schizophrenia patients: a case-based discussion and review
    Shamim Hashemi Nejad
    Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychosomatics 50:626-32. 2009
    ..However, 20% to 30% of patients with schizophrenia are refractory to first-line antipsychotics...
  16. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
    ..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection...
  17. pmc Update on human immunodeficiency virus (HIV)-2 infection
    Omobolaji T Campbell-Yesufu
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Infect Dis 52:780-7. 2011
    ..In this review, we present information on recent clinical advances in our understanding of HIV-2 infection and highlight remaining diagnostic and therapeutic challenges...
  18. ncbi request reprint Hepatitis C in schizophrenia: screening experience in a community-dwelling clozapine cohort
    Oliver Freudenreich
    Massachusetts General Hospital Schizophrenia Program, Freedom Trail Clinic, the Division of Infectious Diseases and Partners AIDS Research Center, and Harvard Medical School, Boston, MA 02114, USA
    Psychosomatics 48:405-11. 2007
    ..However, clinical experience treating HCV in schizophrenia patients is limited; in this cohort, 2 years after screening, no patient had received interferon/ribavirin treatment...
  19. pmc Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
    Arthur Y Kim
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 3:e492. 2006
    ..Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection...
  20. pmc Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy
    Angela Marzocchetti
    Div of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Virology 383:173-7. 2009
    ..JCV peptide-loaded DC elicited a stronger CTL expansion in 13/15 responders. DC can induce a potent JCV-specific CTL response in vitro, and may constitute a promising approach for PML immunotherapy...
  21. pmc A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, and Harvard University Center for AIDS Research, Boston, MA 02129, USA
    J Exp Med 204:2813-24. 2007
    ....
  22. pmc Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection
    Cheryl L Day
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 76:12584-95. 2002
    ..Moreover, these data provide important parameters for evaluation of candidate HCV vaccines, and provide rationale for immunotherapy in chronic HCV infection...
  23. doi request reprint Fatigue in psychiatric HIV patients: a pilot study of psychological correlates
    Johanna Paddison
    Division of Psychiatry and Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychosomatics 50:455-60. 2009
    ..Even though viral management of HIV infection is now more effective, clinical observations suggest that fatigue remains a problem for a substantial proportion of patients...
  24. ncbi request reprint Antiretroviral rounds. Three diseases, one patient
    Margaret Koziel
    Harvard Medical School, Boston, Massachusetts, USA
    AIDS Clin Care 17:50-1. 2005
  25. doi request reprint HIV Online Provider Education (HOPE): the internet as a tool for training in HIV medicine
    Aurora D Kiviat
    Infectious Diseases Unit and Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Infect Dis 196:S512-5. 2007
    ..This online program may be a model for other efforts to provide education to health care providers treating HIV-infected patients in the developing world...
  26. pmc Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy
    Marco A Lima
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    J Virol 81:3361-8. 2007
    ..Immunotherapies aiming at increasing the cellular immune response against JCV may be valuable in the treatment of HIV+ individuals with PML...
  27. pmc Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy
    Georg M Lauer
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Virol 79:12979-88. 2005
    ..These data suggest that broad CD8(+) T-cell responses alone may be insufficient to contain HCV replication, and also that early therapy is effective independent of such responses...
  28. ncbi request reprint Low prevalence of ongoing hepatitis B viremia in HIV-positive individuals with isolated antibody to hepatitis B core antigen
    Rajesh T Gandhi
    J Acquir Immune Defic Syndr 34:439-41. 2003
  29. ncbi request reprint HIV notes from the 40th annual meeting of the Infectious Diseases Society of America
    Emily J Erbelding
    Hopkins HIV Rep 14:6-7. 2002
  30. ncbi request reprint Hepatic steatosis is associated with fibrosis, nucleoside analogue use, and hepatitis C virus genotype 3 infection in HIV-seropositive patients
    Barbara H McGovern
    HIV HCV Co infection Clinic, Lemuel Shattuck Hospital, Jamaica Plain, Jamaica Plain, MA 02494, USA
    Clin Infect Dis 43:365-72. 2006
    ....
  31. ncbi request reprint Managing symptomatic drug-induced liver injury in HIV-hepatitis C virus-coinfected patients: a role for interferon
    Barbara H McGovern
    Lemuel Shattuck Hospital, Jamaica Plain, MA 02130, USA
    Clin Infect Dis 45:1386-92. 2007
    ..We hypothesized that interferon (IFN) would induce biochemical improvement through its anti-inflammatory properties and thereby facilitate the reintroduction of antiretroviral therapy (ART) in patients with DILI...
  32. ncbi request reprint Cirrhosis is associated with low CD4+ T cell counts: implications for HIV-infected patients with liver disease
    Rajesh T Gandhi
    Clin Infect Dis 44:438-40. 2007
  33. ncbi request reprint Immune-based therapy in HIV
    Rajesh T Gandhi
    Hopkins HIV Rep 15:4. 2003
  34. pmc Quantitative effect of suboptimal codon usage on translational efficiency of mRNA encoding HIV-1 gag in intact T cells
    Kholiswa C Ngumbela
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa
    PLoS ONE 3:e2356. 2008
    ..Although gag codon optimization is widely used in DNA vectors and experimental vaccines, the actual effect of altered codon usage on gag translational efficiency has not been quantified...
  35. ncbi request reprint Raltegravir, a new HIV integrase inhibitor
    Rajesh T Gandhi
    AIDS Clin Care 19:105. 2007
    ..Because raltegravir inhibits a novel viral target, even HIV that is resistant to other antiretroviral-medication classes is sensitive to this drug...
  36. ncbi request reprint Guideline watch. New guidelines on treating chronic hepatitis B and C in HIV-coinfected patients
    Rajesh T Gandhi
    AIDS Clin Care 17:65. 2005

Research Grants6

  1. Induction of HIV-specific Immune Responses
    Rajesh Gandhi; Fiscal Year: 2007
    ..By understanding the mechanisms by which immune responses against HIV can be augmented, this may lead to improved ways of treating this disease and may help in developing a vaccine to prevent this infection. ..
  2. MECHANISMS OF T CELL APOPTOSIS DURING HIV1 INFECTION
    Rajesh Gandhi; Fiscal Year: 2002
    ....
  3. Induction of HIV-specific Immune Responses
    Rajesh Gandhi; Fiscal Year: 2009
    ..By understanding the mechanisms by which immune responses against HIV can be augmented, this may lead to improved ways of treating this disease and may help in developing a vaccine to prevent this infection. ..
  4. Induction of HIV-specific Immune Responses
    Rajesh T Gandhi; Fiscal Year: 2010
    ..By understanding the mechanisms by which immune responses against HIV can be augmented, this may lead to improved ways of treating this disease and may help in developing a vaccine to prevent this infection. ..