Leonid Gaidukov

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    BMC Clin Pharmacol 9:18. 2009
  2. ncbi ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 49:532-8. 2010
  3. ncbi The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    J Lipid Res 47:2492-502. 2006
  4. ncbi High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 44:11843-54. 2005
  5. ncbi The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Lipid Res 48:1637-46. 2007
  6. ncbi The 'evolvability' of promiscuous protein functions
    Amir Aharoni
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 37:73-6. 2005
  7. ncbi Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
    Amir Aharoni
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 101:482-7. 2004

Collaborators

  • Dan S Tawfik
  • Amir Aharoni
  • Cintia Roodveldt
  • Olga Khersonsky
  • Stephen McQ Gould
  • Israel Silman
  • Lilly Toker
  • Shai Yagur

Detail Information

Publications7

  1. ncbi In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    BMC Clin Pharmacol 9:18. 2009
    ..This work addresses the feasibility of in vivo administration of rePON1, and its HDL complex, as a potentially therapeutic agent dubbed BL-3050...
  2. ncbi ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 49:532-8. 2010
    ....
  3. ncbi The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    J Lipid Res 47:2492-502. 2006
    ....
  4. ncbi High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 44:11843-54. 2005
    ..Overall, the results indicate the high stability, selectivity, and catalytic proficiency of PON1 when anchored onto apoA-I HDL, toward lactone substrates, and lipophilic lactones in particular...
  5. ncbi The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Lipid Res 48:1637-46. 2007
    ..80). These new tests indicate the levels and activity of PON1 in a physiologically relevant context as well as the levels and quality of the HDL particles with which the enzyme is associated...
  6. ncbi The 'evolvability' of promiscuous protein functions
    Amir Aharoni
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 37:73-6. 2005
    ..Thus, an evolving protein can initially acquire increased fitness for a new function without losing its original function. Gene duplication and the divergence of a completely new protein may then follow...
  7. ncbi Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
    Amir Aharoni
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 101:482-7. 2004
    ..Analysis of the newly evolved variants provides insights into the evolutionary relationships between different family members...