Research Topics
| J J GagneSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Active safety monitoring of new medical products using electronic healthcare data: selecting alerting rulesJoshua J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
Epidemiology 23:238-46. 2012..These systems will rely on algorithms to generate alerts about potential safety concerns...
Active safety monitoring of newly marketed medications in a distributed data network: application of a semi-automated monitoring systemJ J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Clin Pharmacol Ther 92:80-6. 2012..3 cases per 1,000 person-years (95% CI: -0.5, 1.0). In a setting in which false positivity is a major concern, the system did not generate alerts for the three drug-outcome pairs...- An event-based approach for comparing the performance of methods for prospective medical product monitoringJoshua J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Pharmacoepidemiol Drug Saf 21:631-9. 2012..Little attention has been given to how to compare methods in this setting... - Design considerations in an active medical product safety monitoring systemJoshua J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
Pharmacoepidemiol Drug Saf 21:32-40. 2012..The cohort approach generally is preferred in other situations and particularly when timing of exposure or outcome is uncertain because cohort approaches are less vulnerable to biases resulting from misclassification... - Antidepressants and fracture risk in older adults: a comparative safety analysisJ J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Clin Pharmacol Ther 89:880-7. 2011..Although SSRI use was associated with the highest rate of fractures, variation in fracture risk across specific antidepressant medications did not depend on affinity for serotonin transport receptors... - A combined comorbidity score predicted mortality in elderly patients better than existing scoresJoshua J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
J Clin Epidemiol 64:749-59. 2011..To develop and validate a single numerical comorbidity score for predicting short- and long-term mortality, by combining conditions in the Charlson and Elixhauser measures... - Refilling and switching of antiepileptic drugs and seizure-related eventsJ J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Pharmacol Ther 88:347-53. 2010..19 (95% CI 0.35-3.99). Refilling the same AED prescription was associated with an elevated risk of seizure-related events whether or not the refill involved switching from a brand-name to a generic product... - Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysisJoshua J Gagne
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Neurology 74:995-1002. 2010..We tested the hypothesis that anti-inflammatory drugs reduce PD incidence and that there are differential effects by type of anti-inflammatory, duration of use, or intensity of use... - Health advisories and patterns of patient monitoring among new users of antidepressant medicationsJoshua J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Suite 3030, 1620 Tremont St, Boston, MA 02120, USA
J Clin Psychopharmacol 29:590-4. 2009..We sought to identify patterns of patient monitoring after antidepressant initiation in British Columbia before and after issuance of health advisories... - Aprotinin and the risk of death and renal dysfunction in patients undergoing cardiac surgery: a meta-analysis of epidemiologic studiesJoshua J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
Pharmacoepidemiol Drug Saf 18:259-68. 2009..A meta-analysis was conducted to summarize results and explain variation of published epidemiologic studies on risks of renal dysfunction and death associated with aprotinin... - Seizure outcomes following the use of generic versus brand-name antiepileptic drugs: a systematic review and meta-analysisAaron S Kesselheim
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
Drugs 70:605-21. 2010..In the absence of better data, physicians may want to consider more intensive monitoring of high-risk patients taking AEDs when any switch occurs... - Assessing the comparative effectiveness of newly marketed medications: methodological challenges and implications for drug developmentS Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Clin Pharmacol Ther 90:777-90. 2011.... - Confounder summary scores when comparing the effects of multiple drug exposuresSuzanne M Cadarette
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Pharmacoepidemiol Drug Saf 19:2-9. 2010..We compared three analytic strategies to control for confounding based on measured variables: conventional multivariable, exposure propensity score (EPS), and disease risk score (DRS)...