Dahlene N Fusco

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Non-oral treatment with ivermectin for disseminated strongyloidiasis
    Dahlene N Fusco
    Division of Infectious Diseases, and Department of Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, USA
    Am J Trop Med Hyg 83:879-83. 2010
  2. doi request reprint Novel therapies for hepatitis C: insights from the structure of the virus
    Dahlene N Fusco
    Gastroenterology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Annu Rev Med 63:373-87. 2012
  3. pmc SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication
    Run Xuan Shao
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Antiviral Res 97:101-7. 2013
  4. pmc A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus
    Hong Zhao
    Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
    J Hepatol 56:326-33. 2012
  5. pmc A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication
    Dahlene N Fusco
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 144:1438-49, 1449.e1-9. 2013
  6. pmc Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling
    Kattareeya Kumthip
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 86:8581-91. 2012
  7. pmc IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway
    Leiliang Zhang
    Gastrointestinal Unit, Department of Medicine, Warren 1007, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hepatol 55:289-98. 2011
  8. pmc Effect of linezolid on clinical severity and pulmonary cytokines in a murine model of influenza A and Staphylococcus aureus coinfection
    Xinyan Liu
    Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 8:e57483. 2013

Collaborators

  • Hong Zhao
  • Leiliang Zhang
  • Abraham L Brass
  • Lei Zhao
  • Kattareeya Kumthip
  • Xinyan Liu
  • Run Xuan Shao
  • Kaku Goto
  • Nikolaus Jilg
  • Du Cheng
  • Raymond T Chung
  • Lee F Peng
  • Zhi Hong
  • Yaling He
  • Genovefa A Papanicolaou
  • Kun Xiao
  • Julie R White
  • Wen Chi Chen
  • Chansom Pantip
  • Esperance A Schaefer
  • Amornrat O'Brien
  • Satawat Thongsawat
  • Wenyu Lin
  • Niwat Maneekarn
  • Pattranuch Chusri

Detail Information

Publications8

  1. pmc Non-oral treatment with ivermectin for disseminated strongyloidiasis
    Dahlene N Fusco
    Division of Infectious Diseases, and Department of Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, USA
    Am J Trop Med Hyg 83:879-83. 2010
    ..Obtaining subcutaneous ivermectin and dosing it appropriately is a challenge. These cases underscore the need for improved access to subcutaneous ivermectin and more pharmacological data to guide use of this treatment approach...
  2. doi request reprint Novel therapies for hepatitis C: insights from the structure of the virus
    Dahlene N Fusco
    Gastroenterology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Annu Rev Med 63:373-87. 2012
    ..This review provides a guide to HCV drugs in various stages of development, including an introduction to their mechanism of action, state of clinical development, efficacy, and side effects...
  3. pmc SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication
    Run Xuan Shao
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Antiviral Res 97:101-7. 2013
    ..Knockdown of SOCS1 alone with specific shRNA enhanced the antiviral effect of IFN compared with negative control. Thus, SOCS1 acts as a suppressor of type I IFN function against HCV...
  4. pmc A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus
    Hong Zhao
    Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
    J Hepatol 56:326-33. 2012
    ..The precise mechanisms by which IFN exerts its antiviral effect against HCV have not yet been elucidated. We sought to identify host genes that mediate the antiviral effect of IFN-α by conducting a whole-genome siRNA library screen...
  5. pmc A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication
    Dahlene N Fusco
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 144:1438-49, 1449.e1-9. 2013
    ..In contrast to candidate approaches based on analyses of messenger RNA (mRNA) expression, identification of IEGs requires a broad functional approach...
  6. pmc Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling
    Kattareeya Kumthip
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 86:8581-91. 2012
    ..We propose a model in which the binding of the C-terminal region of NS5A to STAT1 leads to decreased levels of P-STAT1, ISRE signaling, and ISG transcription and, ultimately, to preferential GT1 resistance to IFN treatment...
  7. pmc IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway
    Leiliang Zhang
    Gastrointestinal Unit, Department of Medicine, Warren 1007, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hepatol 55:289-98. 2011
    ..We sought to determine whether IL28B was capable of inhibiting HCV replication and to determine the pathway by which IL28B exhibits anti-HCV activity...
  8. pmc Effect of linezolid on clinical severity and pulmonary cytokines in a murine model of influenza A and Staphylococcus aureus coinfection
    Xinyan Liu
    Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 8:e57483. 2013
    ..Linezolid has immunomodulatory properties. We report on the effects of the three antibiotics on microbial clearance, pulmonary cytokines and clinical course in a murine model of influenza and MRSA coinfection...