JAMES FUJIMOTO

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Swept source/Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit
    Bernhard Baumann
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 20:10229-41. 2012
  2. pmc Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers
    Ireneusz Grulkowski
    Department of Electric Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biomed Opt Express 3:2733-51. 2012
  3. pmc In vivo imaging of the rodent eye with swept source/Fourier domain OCT
    Jonathan J Liu
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biomed Opt Express 4:351-63. 2013
  4. pmc Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography
    WooJhon Choi
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e81499. 2013
  5. pmc High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery
    Xingde Li
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, MA, USA
    Arthritis Res Ther 7:R318-23. 2005
  6. ncbi request reprint Optical coherence tomography for ultrahigh resolution in vivo imaging
    James G Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 21:1361-7. 2003
  7. ncbi request reprint Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers
    Desmond C Adler
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139, USA
    Opt Lett 32:626-8. 2007
  8. ncbi request reprint Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s
    Robert Huber
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 31:2975-7. 2006
  9. ncbi request reprint High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo
    Yu Chen
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 12:034008. 2007
  10. ncbi request reprint High-resolution line-scanning optical coherence microscopy
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 32:1971-3. 2007

Research Grants

  1. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2004
  2. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2005
  3. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2005
  4. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2006
  5. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2006
  6. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2007
  7. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2007
  8. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2009
  9. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2009
  10. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2010

Collaborators

Detail Information

Publications81

  1. pmc Swept source/Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit
    Bernhard Baumann
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 20:10229-41. 2012
    ..Enhanced tissue discrimination as well as quantitative measurements of sample properties was demonstrated using the additional contrast and information contained in the PS-OCT images...
  2. pmc Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers
    Ireneusz Grulkowski
    Department of Electric Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biomed Opt Express 3:2733-51. 2012
    ..Swept source OCT with VCSEL technology may be attractive for next generation integrated ophthalmic OCT instruments...
  3. pmc In vivo imaging of the rodent eye with swept source/Fourier domain OCT
    Jonathan J Liu
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biomed Opt Express 4:351-63. 2013
    ..Ultrahigh speed swept source OCT is a promising technique for imaging the rodent eye, proving comprehensive information on the cornea, anterior segment, lens, vitreous, posterior segment, retina and choroid...
  4. pmc Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography
    WooJhon Choi
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e81499. 2013
    ..These results demonstrate the feasibility of ultrahigh speed OCT for in vivo dye-free choriocapillaris and choroidal vasculature imaging, in addition to conventional structural imaging. ..
  5. pmc High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery
    Xingde Li
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, MA, USA
    Arthritis Res Ther 7:R318-23. 2005
    ....
  6. ncbi request reprint Optical coherence tomography for ultrahigh resolution in vivo imaging
    James G Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 21:1361-7. 2003
    ..It is a promising imaging technology because it can provide images of tissue in situ and in real time, without the need for excision and processing of specimens...
  7. ncbi request reprint Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers
    Desmond C Adler
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139, USA
    Opt Lett 32:626-8. 2007
    ..Dynamic measurements of piezoelectric transducer motion and static 3D OCT phase microscopy are demonstrated. Buffered FDML lasers provide excellent displacement sensitivities at extremely high sweep speeds...
  8. ncbi request reprint Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s
    Robert Huber
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 31:2975-7. 2006
    ..Unidirectional sweep rates of 370 kHz over a 100 nm range at a center wavelength of 1300 nm are achieved. High-speed, swept-source OCT is demonstrated at record speeds of up to 370,000 axial scans per second...
  9. ncbi request reprint High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo
    Yu Chen
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 12:034008. 2007
    ..The foregoing observations suggest that OCT can be a useful non-excisional, real-time modality for imaging pathological changes in donor kidney morphology prior to transplantation...
  10. ncbi request reprint High-resolution line-scanning optical coherence microscopy
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 32:1971-3. 2007
    ..The sensitivity of the system is 93 dB with averaging over 30 line scans. En face real time, cellular-level imaging of biological tissues is demonstrated at approximately 2 frames/s...
  11. ncbi request reprint Low-cost, single-mode diode-pumped Cr:Colquiriite lasers
    Umit Demirbas
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:14374-88. 2009
    ..5 nJ pulse energies at approximately 100 MHz repetition rate. Electrical-to-optical conversion efficiencies of 8% in mode-locked operation and 12% in cw operation were achieved...
  12. pmc Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second
    Benjamin Potsaid
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Express 16:15149-69. 2008
    ....
  13. pmc Frequency comb swept lasers
    Tsung Han Tsai
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:21257-70. 2009
    ..The design and operation principles of FC swept lasers are discussed and designs for short cavity lasers for OCT and interferometric measurement applications are proposed...
  14. pmc High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe
    Aaron D Aguirre
    Research Laboratory of Electronics and Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 USA
    Opt Express 18:4222-39. 2010
    ..Finally, the system design is demonstrated with a miniaturized piezoelectric fiber-scanning probe which can be adapted for laparoscopic and endoscopic imaging applications...
  15. ncbi request reprint Speckle reduction in optical coherence tomography images by use of a spatially adaptive wavelet filter
    Desmond C Adler
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 29:2878-80. 2004
    ..A single parameter controls the degree of noise reduction. When this filter is applied to ophthalmic OCT images, signal-to-noise ratio improvements of >7 dB are attained, with a sharpness reduction of <3%...
  16. ncbi request reprint Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography
    Desmond C Adler
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 16:4376-93. 2008
    ..This technique represents a new method for detecting gold nanoparticle contrast agents with excellent signal-to-noise performance at high speeds using OCT...
  17. pmc Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Invest Ophthalmol Vis Sci 49:5103-10. 2008
    ..To investigate methods for visualization of the retina, choroid, and optic nerve using high-density sampling enabled by improved imaging speed...
  18. pmc Three-dimensional endomicroscopy of the human colon using optical coherence tomography
    Desmond C Adler
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:784-96. 2009
    ..This clinical pilot study demonstrates the potential of 3D-OCT for distinguishing normal from pathologic colorectal tissue, assessing endoscopic therapies and healing progression...
  19. ncbi request reprint Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography
    Pei Lin Hsiung
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02215, USA
    Radiology 244:865-74. 2007
    ..OCT is potentially useful for visualization of breast lesions at a resolution greater than that of currently available clinical imaging methods...
  20. ncbi request reprint Effect of tissue preservation on imaging using ultrahigh resolution optical coherence tomography
    Pei Lin Hsiung
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 10:064033. 2005
    ..DMEM maintains tissue structure and optical scattering characteristics close to in vivo conditions up to 4 to 6 h after excision and best preserved tissue optical properties when compared to in vivo imaging...
  21. ncbi request reprint Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Express 16:2469-85. 2008
    ..Enhanced classification of image features using UHR-OCT promises to help in the computer-aided diagnosis of GI diseases...
  22. pmc Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography
    Maciej Wojtkowski
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 112:1734-46. 2005
    ..To demonstrate high-speed, ultrahigh-resolution, 3-dimensional optical coherence tomography (3D OCT) and new protocols for retinal imaging...
  23. pmc Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy
    Aaron D Aguirre
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:016025. 2010
    ..OCT provided complementary information through assessment of tissue architectural features over a larger field of view. OCM may provide a complementary imaging modality to standard OCT approaches for endoscopic microscopy...
  24. ncbi request reprint Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines
    Pei Lin Hsiung
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Gastrointest Endosc 62:561-74. 2005
    ..This study investigates ultrahigh-resolution and three-dimensional OCT for ex vivo imaging of the large and small intestines and correlates images with histology...
  25. pmc Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation
    Yu Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Neurosci Methods 178:162-73. 2009
    ..OCT is a promising a new technology which provides complementary information to OISI for functional neuroimaging...
  26. ncbi request reprint High-resolution imaging of progressive articular cartilage degeneration
    Samuel B Adams
    Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02139, USA
    J Orthop Res 24:708-15. 2006
    ....
  27. ncbi request reprint High-speed path-length scanning with a multiple-pass cavity delay line
    Pei Lin Hsiung
    Department of Electrical Engineering and Computer Science and the Research Laboratory of Electronics, Massachusetts Institute of Technology, Building 36 345, 50 Vassar Street, Cambridge, Massachusetts 01239, USA
    Appl Opt 42:640-8. 2003
    ..Real-time optical coherence tomography imaging with 500 pixel images at four frames/s is performed. Using a Cr:forsterite laser source, we obtained axial image resolutions of 6 microm with 92-dB sensitivity...
  28. pmc Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration
    Yueli Chen
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:4046-60. 2009
    ..These cases provide representative volumetric datasets of well-documented AMD pathologies which could be used for the development of visualization and imaging processing methods and algorithms...
  29. pmc High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 113:2054.e1-14. 2006
    ..To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies...
  30. pmc Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair
    Tony H Ko
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 111:2033-43. 2004
    ....
  31. pmc Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Invest Ophthalmol Vis Sci 49:1571-9. 2008
    ..To visualize, quantitatively assess, and interpret outer retinal morphology by using high-speed, ultrahigh-resolution (UHR) OCT...
  32. pmc Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Invest Ophthalmol Vis Sci 47:5522-8. 2006
    ..To demonstrate high-speed, ultrahigh-resolution optical coherence tomography (OCT) for noninvasive, in vivo, three-dimensional imaging of the retina in rat and mouse models...
  33. pmc Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy
    Chao Zhou
    Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:016001. 2010
    ..With further development of needle-based imaging probes, OCT and OCM could be promising techniques to use for the screening of thyroid nodules and to improve the diagnostic specificity of fine needle aspiration evaluation...
  34. pmc Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells
    Chao Zhou
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Opt Lett 35:700-2. 2010
    ..This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells...
  35. doi request reprint Low-cost cavity-dumped femtosecond Cr:LiSAF laser producing >100 nJ pulses
    Umit Demirbas
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 35:607-9. 2010
    ..At higher dumping rates of up to 1 MHz, reduced pulse energies of 62 nJ could be generated. Two-photon absorption in the saturable absorber mirror limits pulse durations, while Q-switching instabilities limit pulse energy extraction...
  36. pmc Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology
    Tony H Ko
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 112:1922.e1-15. 2005
    ....
  37. pmc Ultrahigh-resolution optical coherence tomography of surgically closed macular holes
    Tony H Ko
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Mass, USA
    Arch Ophthalmol 124:827-36. 2006
    ..To evaluate retinal anatomy using ultrahigh-resolution optical coherence tomography (OCT) in eyes after successful surgical repair of full-thickness macular hole...
  38. doi request reprint High-resolution optical coherence tomography imaging of the living kidney
    Peter M Andrews
    Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Lab Invest 88:441-9. 2008
    ..We conclude that OCT represents an exciting new approach to visualize, in real-time, pathological changes in the living kidney in a non-invasive fashion. Possible clinical applications are discussed...
  39. pmc Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography
    Larry Kagemann
    University of Pittsburgh School of Medicine, Department of Ophthalmology, Ophthalmology and Visual Sciences Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213, USA
    J Biomed Opt 12:041212. 2007
    ..0217) (mean+/-standard deviation). A difference between arterial and venous blood saturation was detected. This suggests that retinal oximetry may possibly be added as a metabolic measurement in structural imaging devices...
  40. pmc Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability
    Michelle L Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 49:2315-21. 2008
    ..To investigate the effect on optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness measurements of varying the standard 3.4-mm-diameter circle location...
  41. ncbi request reprint Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies
    Maciej Szkulmowski
    Nicolaus Copernicus University, Institute of Physics, ul Grudziadzka 5 7, PL 87 100 Torun, Poland
    J Biomed Opt 12:041207. 2007
    ..Operator intervention is required to assess the quality of segmentation. Thickness and distance maps from the segmented layers and their analysis are presented for healthy and pathological retinas...
  42. pmc Photoreceptor disruption secondary to posterior vitreous detachment as visualized using high-speed ultrahigh-resolution optical coherence tomography
    Andre J Witkin
    New England Eye Center, Tufts New England Medical Center, Tufts University, 750 Washington St, Boston, MA 02111, USA
    Arch Ophthalmol 125:1579-80. 2007
  43. ncbi request reprint State-of-the-art retinal optical coherence tomography
    Wolfgang Drexler
    Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, CF24 4LU, Wales, United Kingdom
    Prog Retin Eye Res 27:45-88. 2008
    ..Functional OCT promises to enable the differentiation of retinal pathologies via localized, functional retinal response or metabolic properties. These advances promise to have a powerful impact on fundamental as well as clinical studies...
  44. ncbi request reprint Retinal response of Macaca mulatta to picosecond laser pulses of varying energy and spot size
    William P Roach
    Air Force Research Laboratory, Human Effectiveness Directorate, Optical Radiation Branch, Building 803, 8262 Hawks Road, Brooks Air Force Base, Texas 78253 5214, USA
    J Biomed Opt 9:1288-96. 2004
    ..Spot-size dependence should be considered when comparing studies of retinal effects or when pursuing a specific retinal effect from ultrashort laser pulses...
  45. pmc Comparison of optic disc margin identified by color disc photography and high-speed ultrahigh-resolution optical coherence tomography
    Anita Manassakorn
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Ophthalmol 126:58-64. 2008
    ..To determine the correspondence between optic disc margins evaluated using disc photography (DP) and optical coherence tomography (OCT)...
  46. pmc High-speed, ultrahigh resolution optical coherence tomography of the retina in Hunter syndrome
    Michael K Yoon
    New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA
    Ophthalmic Surg Lasers Imaging 38:423-8. 2007
    ..Optical coherence tomography could be used as a diagnostic modality to monitor patients with Hunter syndrome and to detect subclinical forms of disease...
  47. pmc Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography
    Tarkan Mumcuoglu
    University of Pittsburgh Medical Center Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ophthalmology 115:782-789.e2. 2008
    ..To test if improving optical coherence tomography (OCT) resolution and scanning speed improves the visualization of glaucomatous structural changes as compared with conventional OCT...
  48. ncbi request reprint Ultrahigh resolution optical coherence tomography in macular dystrophy
    Matthias G Wirtitsch
    Department of Ophthalmology, Medical University of Vienna, Wahringer Strasse 13, 1090 Vienna, Austria
    Am J Ophthalmol 140:976-983. 2005
    ..To visualize and investigate intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR OCT)...
  49. pmc Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography
    Lelia A Paunescu
    New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA
    Ophthalmology 113:48-57. 2006
    ....
  50. pmc Photoreceptor atrophy in acute posterior multifocal placoid pigment epitheliopathy demonstrated by optical coherence tomography
    Tina A Scheufele
    New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, MA 02111, USA
    Retina 25:1109-12. 2005
  51. pmc Macular segmentation with optical coherence tomography
    Hiroshi Ishikawa
    UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, PA 15213, USA
    Invest Ophthalmol Vis Sci 46:2012-7. 2005
    ..Dublin, CA) scan images and to test its performance in discriminating normal from glaucomatous eyes in comparison with conventional circumpapillary nerve fiber layer (cpNFL) thickness measurement...
  52. ncbi request reprint Monitoring osteoarthritis in the rat model using optical coherence tomography
    Nirlep A Patel
    Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    IEEE Trans Med Imaging 24:155-9. 2005
    ....
  53. pmc Ultrahigh-resolution optical coherence tomography in glaucoma
    Gadi Wollstein
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Ophthalmology 112:229-37. 2005
    ..We investigated a new ultrahigh-resolution OCT (UHR-OCT) imaging system in glaucoma patients and compared the findings with those obtained by conventional-resolution OCT...
  54. ncbi request reprint Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography
    Erdem Ergun
    Department of Ophthalmology, General Hospital of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 46:310-6. 2005
    ..To assess photoreceptor morphology in patients with Stargardt's disease and fundus flavimaculatus using ultrahigh-resolution optical coherence tomography (UHR-OCT) and correlate it with visual acuity (VA)...
  55. pmc Stage 0 macular holes: observations by optical coherence tomography
    Annie Chan
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111 1533, USA
    Ophthalmology 111:2027-32. 2004
    ....
  56. pmc Wavelength independence and interdevice variability of optical coherence tomography
    Stefanie G Schuman
    New England Eye Center SGS, Tufts School of Medicine, Boston, USA
    Ophthalmic Surg Lasers Imaging 35:316-20. 2004
    ..Comparison of nerve fiber layer (NFL) thickness and macular retinal thickness measurements in two different commercial optical coherence tomography (OCT) machines with the same and different super luminescent diode lasers (SLDs)...
  57. ncbi request reprint Optical coherence tomography (OCT) macular and peripapillary retinal nerve fiber layer measurements and automated visual fields
    Gadi Wollstein
    UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 138:218-25. 2004
    ..To investigate the structure-function relationship between optical coherence tomography (OCT) macular retinal and peripapillary nerve fiber layer (NFL) thickness and automated visual field (VF) findings...
  58. pmc Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
    ..A2, Carl Zeiss Meditec Inc., Dublin, CA) was investigated. The nerve fiber layer (NFL) thickness, macula thickness map, and optic nerve head (ONH) parameters in normal eyes were studied...
  59. pmc Optical coherence tomography disc assessment in optic nerves with peripapillary atrophy
    Edward Lai
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Ophthalmic Surg Lasers Imaging 34:498-504. 2003
    ..Optical coherence tomography (OCT) is able to determine the optic disc margin automatically. The aim of this study was to investigate the accuracy of the automatic OCT optic nerve head measurements in the presence of peripapillary atrophy...
  60. ncbi request reprint Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy
    Joel S Schuman
    New England Eye Center, Tufts School of Medicine, Boston, Massachusetts 02111, USA
    Am J Ophthalmol 135:504-12. 2003
    ....
  61. ncbi request reprint Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)
    Susanne D Giattina
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Cardiol 107:400-9. 2006
    ..Collagen is birefringent, meaning that different polarization states travel through it at different velocities...
  62. pmc Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography
    Annie Chan
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass 02111 1533, USA
    Arch Ophthalmol 124:193-8. 2006
    ..To report normal macular thickness measurements in healthy eyes using the latest commercially available optical coherence tomography (OCT) mapping software, version 3.0, from the Stratus OCT (OCT3)...
  63. pmc In vivo corneal high-speed, ultra high-resolution optical coherence tomography
    Viki Christopoulos
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop St, Suite 827, Pittsburgh, PA 15213, USA
    Arch Ophthalmol 125:1027-35. 2007
    ..To introduce new corneal high-speed, ultra-high-resolution optical coherence tomography (hsUHR-OCT) technology that improves the evaluation of complicated and uncomplicated cataract, corneal, and refractive surgical procedures...
  64. pmc Optical coherence tomography and histologic measurements of nerve fiber layer thickness in normal and glaucomatous monkey eyes
    Joel S Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Sciences Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 48:3645-54. 2007
    ....
  65. pmc Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning
    Michelle L Gabriele
    University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 48:3154-60. 2007
    ..To determine the retinal nerve fiber layer (RNFL) thickness profile in the peripapillary region of healthy eyes...
  66. pmc High-speed ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy
    Julio A Rodriguez-Padilla
    Tufts New England Medical Center, Tufts University, Boston, MA 02111, USA
    Arch Ophthalmol 125:775-80. 2007
    ..To compare structural changes in the retina seen on high-speed ultra-high-resolution optical coherence tomography (hsUHR-OCT) with multifocal electroretinography (mfERG) and automated visual fields in patients receiving hydroxychloroquine...
  67. pmc Microstructural abnormalities in MEWDS demonstrated by ultrahigh resolution optical coherence tomography
    My Hanh T Nguyen
    New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA
    Retina 27:414-8. 2007
    ..Ultrahigh resolution optical coherence tomography (UHR-OCT), capable of high resolution in vivo imaging, offers a unique opportunity to visualize retinal microstructure in the disease...
  68. pmc Peripapillary schisis in glaucoma patients with narrow angles and increased intraocular pressure
    Malik Y Kahook
    UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 143:697-9. 2007
    ..To describe two cases of peripapillary retinal schisis in patients with glaucoma without evidence of optic nerve pits, pseudopits, or X-linked retinoschisis...
  69. pmc Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases
    Andre J Witkin
    New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts 0211, USA
    Am J Ophthalmol 142:945-52. 2006
    ..To assess photoreceptor integrity in patients with retinitis pigmentosa (RP) and related diseases using ultra-high resolution optical coherence tomography (UHR-OCT) and to correlate foveal photoreceptor loss with visual acuity...
  70. ncbi request reprint Ultrahigh resolution optical coherence tomography of macular holes
    Christoph Scholda
    Department of Ophthalmology, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria
    Retina 26:1034-41. 2006
    ....
  71. pmc Persistence of Cloquet's canal in normal healthy eyes
    Larry Kagemann
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 142:862-4. 2006
    ..Optic nerve head (ONH) structural imaging with state-of-the-art, high-speed, ultra-high-resolution optical coherence tomography (hsUHR-OCT)...
  72. pmc Quantification of photoreceptor layer thickness in normal eyes using optical coherence tomography
    Annie Chan
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111 1533, USA
    Retina 26:655-60. 2006
    ..Dublin, CA) and from the ultrahigh resolution OCT (UHR-OCT) prototype...
  73. pmc Ultrahigh-resolution optical coherence tomography in patients with decreased visual acuity after retinal detachment repair
    Lisa S Schocket
    New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA
    Ophthalmology 113:666-72. 2006
    ..To assess microstructural changes in the retina that may explain incomplete visual recovery after anatomically successful repair of rhegmatogenous retinal detachments (RD) using ultrahigh-resolution optical coherence tomography (UHR OCT)...
  74. pmc Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study
    Andre J Witkin
    New England Eye Center, Tufts New England Medical Center, Tufts University, Boston, Massachusetts 02111, USA
    Ophthalmology 113:388-97. 2006
    ....
  75. pmc Ultra-high resolution optical coherence tomography of retinal pigment epithelial tear following blunt trauma
    Annie Chan
    Arch Ophthalmol 124:281-3. 2006
  76. ncbi request reprint Optical coherence tomography measurement of nerve fiber layer thickness and the likelihood of a visual field defect
    Zinaria Y Williams
    New England Eye Center, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Ophthalmol 134:538-46. 2002
    ..To determine if optical coherence tomography (OCT) measurements of nerve fiber layer (NFL) thickness can be used to predict the presence of visual field defects (VFD) associated with glaucoma...

Research Grants29

  1. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2004
    ..If successful, this research will develop new imaging technology with applications in gastrointestinal endoscopy as well as the detection of a wide range of early neoplastic changes. ..
  2. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2005
    ..These advances promise to help elucidate disease pathogenesis, provide more sensitive and earlier diagnosis of disease, as well as more accurate monitoring of disease progression and response to therapy. ..
  3. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2005
    ..If successful, this research will develop new imaging technology with applications in gastrointestinal endoscopy as well as the detection of a wide range of early neoplastic changes. ..
  4. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2006
    ..If successful, this research will develop new imaging technology with applications in gastrointestinal endoscopy as well as the detection of a wide range of early neoplastic changes. ..
  5. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2006
    ..These advances promise to help elucidate disease pathogenesis, provide more sensitive and earlier diagnosis of disease, as well as more accurate monitoring of disease progression and response to therapy. ..
  6. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2007
    ..If successful, this research will develop new imaging technology with applications in gastrointestinal endoscopy as well as the detection of a wide range of early neoplastic changes. ..
  7. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2007
    ..These advances promise to help elucidate disease pathogenesis, provide more sensitive and earlier diagnosis of disease, as well as more accurate monitoring of disease progression and response to therapy. ..
  8. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2009
    ..If successful, the proposed research will develop and demonstrate new imaging technology which will augment gastrointestinal endoscopy and open the door for improved detection of a wide range of neoplasias. ..
  9. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2009
    ..These advances promise to help elucidate disease pathogenesis, provide more sensitive and earlier diagnosis of disease, as well as more accurate monitoring of disease progression and response to therapy. ..
  10. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2010
    ..Age related macular degeneration and glaucoma are leading causes of blindness. ..
  11. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2004
    ....
  12. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2003
    ..Develop OCT as a low cost screening technique for Barrett's esophagus. Taken together, these studies will provide new imaging tools for oncology research and also develop new clinical diagnostic and screening techniques. ..
  13. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2003
    ....
  14. NOVEL OPTICAL DIAGNOSTICS AND SHORT PULSE LASER SURGERY
    JAMES FUJIMOTO; Fiscal Year: 1999
    ....
  15. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 1999
    ..Taken together, these studies hold the promise of developing a new imaging diagnostic which could be a powerful tool in the diagnosis and prevention of malignancy. ..
  16. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2000
    ....
  17. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2000
    ..Develop OCT as a low cost screening technique for Barrett's esophagus. Taken together, these studies will provide new imaging tools for oncology research and also develop new clinical diagnostic and screening techniques. ..
  18. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2001
    ..Develop OCT as a low cost screening technique for Barrett's esophagus. Taken together, these studies will provide new imaging tools for oncology research and also develop new clinical diagnostic and screening techniques. ..
  19. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2001
    ....
  20. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2002
    ....
  21. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2002
    ..Develop OCT as a low cost screening technique for Barrett's esophagus. Taken together, these studies will provide new imaging tools for oncology research and also develop new clinical diagnostic and screening techniques. ..
  22. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2010
    ..If successful, the proposed research will develop and demonstrate new imaging technology which will augment gastrointestinal endoscopy and open the door for improved detection of a wide range of neoplasias. ..