Robert Fuhlbrigge

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc CD43 is a ligand for E-selectin on CLA+ human T cells
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 107:1421-6. 2006
  2. ncbi request reprint Adhesion molecules in cutaneous immunity
    Robert C Fuhlbrigge
    Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Eugene Braunwald Research Center, Boston, MA 02115, USA
    Semin Immunopathol 29:45-57. 2007
  3. pmc Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:148-157.e3. 2008
  4. doi request reprint Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay
    Robert Sackstein
    Department of Dermatology and Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Mailstop HIM, Room 671, Boston, MA, 02115, USA
    Methods Mol Biol 536:343-54. 2009
  5. ncbi request reprint Meeting report of immunology and skin disease: new perspectives
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, Boston, Massachusetts 02115, USA
    J Invest Dermatol 127:1838-41. 2007
  6. ncbi request reprint The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions
    Robert Sackstein
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 341:217-26. 2006
  7. ncbi request reprint The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors
    Kazuki Hirahara
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:4488-94. 2006
  8. ncbi request reprint E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system
    Benjamin F Chong
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 172:1575-81. 2004
  9. pmc Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking
    Suresh Koduru
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:16252-6. 2010
  10. ncbi request reprint Increased CCR4 expression in cutaneous T cell lymphoma
    Katalin Ferenczi
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 119:1405-10. 2002

Collaborators

Detail Information

Publications22

  1. pmc CD43 is a ligand for E-selectin on CLA+ human T cells
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 107:1421-6. 2006
    ..The identification and characterization of CD43 as a T-cell E-selectin ligand distinct from PSGL-1 expands the role of CD43 in the regulation of T-cell trafficking and provides new targets for the modulation of immune functions in skin...
  2. ncbi request reprint Adhesion molecules in cutaneous immunity
    Robert C Fuhlbrigge
    Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Eugene Braunwald Research Center, Boston, MA 02115, USA
    Semin Immunopathol 29:45-57. 2007
    ..In this review, we discuss current understanding of the regulation and function of adhesion molecules in cutaneous immune surveillance and their relevance to the immunopathology of inflammatory skin disease...
  3. pmc Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:148-157.e3. 2008
    ....
  4. doi request reprint Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay
    Robert Sackstein
    Department of Dermatology and Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Mailstop HIM, Room 671, Boston, MA, 02115, USA
    Methods Mol Biol 536:343-54. 2009
    ..This method thus allows for the identification, within a complex mixture and without prior isolation or purification, of both known and previously uncharacterized adhesion molecules operational under dynamic conditions...
  5. ncbi request reprint Meeting report of immunology and skin disease: new perspectives
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, Boston, Massachusetts 02115, USA
    J Invest Dermatol 127:1838-41. 2007
  6. ncbi request reprint The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions
    Robert Sackstein
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 341:217-26. 2006
    ..Thus, this method allows for the identification, within a complex mixture and without previous isolation or purification, of both known and novel adhesion molecules capable of binding under shear conditions...
  7. ncbi request reprint The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors
    Kazuki Hirahara
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:4488-94. 2006
    ..Therefore, the majority of true circulating Treg express functional skin-homing receptors, and human Treg may regulate local immune responses in normal human skin...
  8. ncbi request reprint E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system
    Benjamin F Chong
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 172:1575-81. 2004
    ..Coexpression of these molecules on blood vessels in noninflamed skin provides the basis for a model of cutaneous immunosurveillance system active in the absence of pathologic inflammation...
  9. pmc Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking
    Suresh Koduru
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:16252-6. 2010
    ....
  10. ncbi request reprint Increased CCR4 expression in cutaneous T cell lymphoma
    Katalin Ferenczi
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 119:1405-10. 2002
    ..These data may explain, in part, why these T cells accumulate in the skin, a diagnostic feature of cutaneous T cell lymphomas...
  11. ncbi request reprint T-cell distribution and adhesion receptor expression in metastatic melanoma
    Carsten Weishaupt
    Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Cancer Res 13:2549-56. 2007
    ..To kill tumor, antigen-specific CTL must efficiently target and enter tumor tissue. The purpose of this study was to examine the pathway of leukocyte migration to metastatic melanoma...
  12. ncbi request reprint Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 168:5645-51. 2002
    ....
  13. pmc Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice
    Teresa Bianchi
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 182:4665-74. 2009
    ..Taken together, controlled skin homing of T cells is critical for the maintenance of peripheral immune tolerance to epidermal self-Ags...
  14. ncbi request reprint WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha
    Maria Dolores Gallego
    Division of Immunology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Int Immunol 18:221-32. 2006
    ..These results suggest that WASP and WIP are not essential for T lymphocyte rolling and adhesion, but play important and partially redundant roles in T cell chemotaxis in vitro and homing in vivo and function downstream of small GTPases...
  15. pmc Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus
    Tian Tian
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:70-8. 2009
    ....
  16. ncbi request reprint The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo
    Pilar Alcaide
    Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Invest Dermatol 127:1964-72. 2007
    ..These results demonstrate that both PSGL-1 and CD43 are major E-selectin ligands and are likely to be important during leukocyte recruitment in the development of inflammatory reactions...
  17. pmc Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arch Dermatol Res 302:453-9. 2010
    ..These data suggest that the diversity of the T cell repertoire can be recovered after successful treatment of even advanced CTCL...
  18. ncbi request reprint Clinical effects and safety of rituximab for treatment of refractory pediatric autoimmune diseases
    Moussa El-Hallak
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Pediatr 150:376-82. 2007
    ..To evaluate the safety, tolerability, and clinical effects of rituximab, an anti-CD20 monoclonal antibody, in the treatment of severe pediatric autoimmune diseases...
  19. pmc Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Suite 672, Boston, MA 02115, USA
    J Virol 79:7363-70. 2005
    ....
  20. ncbi request reprint Immune surveillance in the skin: mechanisms and clinical consequences
    Thomas S Kupper
    Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 4:211-22. 2004
  21. ncbi request reprint Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1
    Gunther G Pendl
    Institute of Cell Biology, ZMBE, University of Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Blood 99:946-56. 2002
    ..Thus, fucosylated ligands of the endothelial selectins, determined in part by Fuc-TIV, and independent of PSGL-1, are required for extravasation of DCs into sites of cutaneous inflammation...
  22. ncbi request reprint Rituximab therapy for multisystem autoimmune diseases in pediatric patients
    Bryce A Binstadt
    Rheumatology Program, Division of Immunology, Children s Hospital Boston, Massachusetts 02115, USA
    J Pediatr 143:598-604. 2003
    ..To evaluate the effects of rituximab (anti-CD20 monoclonal antibody) on the disease course in pediatric patients with multisystem autoimmune diseases...

Research Grants10

  1. REGULATION OF T CELL SKIN SPECIFIC HOMING VIA PSGL1
    Robert Fuhlbrigge; Fiscal Year: 2003
    ..This application thus represents a comprehensive career development plan and research proposal suitable to advance the career of this young investigator. ..
  2. Structure Function Analysis of T Cell E-Selectin Ligands
    Robert Fuhlbrigge; Fiscal Year: 2007
    ..abstract_text> ..
  3. Structure Function Analysis of T Cell E-Selectin Ligands
    Robert Fuhlbrigge; Fiscal Year: 2006
    ..abstract_text> ..
  4. Analysis of Class II MHC and CD1d antigen presentation pathways in skin-derived d
    Robert C Fuhlbrigge; Fiscal Year: 2010
    ..The possible involvement of CD1d to immune responses originating in the skin will be investigated in CD1d- yellow fluorescent protein knock-in mice. ..