Rebecca C Fry

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint DNA damage and stress transcripts in Saccharomyces cerevisiae mutant sgs1
    Rebecca C Fry
    Department of Biological Engineering, Massachusetts Institute of Technology, 56 211, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mech Ageing Dev 124:839-46. 2003
  2. ncbi request reprint Genome-wide responses to DNA-damaging agents
    Rebecca C Fry
    Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Microbiol 59:357-77. 2005
  3. pmc The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA
    Rebecca C Fry
    Department of Biological Engineering, Massachusetts Institute of Technology, NE47 277, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    BMC Genomics 7:313. 2006
  4. pmc Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-a
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave 16 825, Cambridge, MA 02139, USA
    Infect Immun 76:1866-76. 2008
  5. pmc Identification of novel human damage response proteins targeted through yeast orthology
    J Peter Svensson
    Biological Engineering Department, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e37368. 2012
  6. pmc Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae
    Rachel L Erlich
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    PLoS ONE 3:e3717. 2008
  7. pmc Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance
    J Peter Svensson
    Biological Engineering Department, Center for Environmental Health Sciences, Biology Department, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    BMC Syst Biol 5:157. 2011
  8. pmc Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates
    Ivan Rusyn
    Center for Environmental Health Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 2:e1252. 2007
  9. doi request reprint Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency
    Sijin Liu
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Br J Haematol 143:129-37. 2008
  10. pmc Genomic predictors of interindividual differences in response to DNA damaging agents
    Rebecca C Fry
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 22:2621-6. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint DNA damage and stress transcripts in Saccharomyces cerevisiae mutant sgs1
    Rebecca C Fry
    Department of Biological Engineering, Massachusetts Institute of Technology, 56 211, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mech Ageing Dev 124:839-46. 2003
    ..Our comparative analysis of the genome-wide expression response of SGS1 deletion, stress and DNA damage indicates parallel transcriptional responses to cellular insult and aging in yeast...
  2. ncbi request reprint Genome-wide responses to DNA-damaging agents
    Rebecca C Fry
    Biological Engineering Division and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Microbiol 59:357-77. 2005
    ..This review highlights many of the studies that detail genome-wide responses to DNA-damaging agents and examines how these datasets have been used to build a systems view of cellular responses to damage...
  3. pmc The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA
    Rebecca C Fry
    Department of Biological Engineering, Massachusetts Institute of Technology, NE47 277, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    BMC Genomics 7:313. 2006
    ..The genome-wide responses were compared to those induced by the non-selective oxidant gamma-radiation...
  4. pmc Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-a
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave 16 825, Cambridge, MA 02139, USA
    Infect Immun 76:1866-76. 2008
    ..The use of AB6F1 and B6AF1 mice, as well as genetically engineered mice, on a C57BL/6 background will allow studies investigating the role of chronic microbial hepatitis and steatohepatitis in the pathogenesis of liver cancer...
  5. pmc Identification of novel human damage response proteins targeted through yeast orthology
    J Peter Svensson
    Biological Engineering Department, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e37368. 2012
    ..In summary, we show that damage recovery proteins in humans can be identified through homology to S. cerevisiae and that many of the same pathways are represented among the toxicity modulators...
  6. pmc Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae
    Rachel L Erlich
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    PLoS ONE 3:e3717. 2008
    ..Anc1's role in the PRR pathway, as well as its role in suppressing triplet repeats, point to a possible mechanism for a protein of potential medical interest...
  7. pmc Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance
    J Peter Svensson
    Biological Engineering Department, Center for Environmental Health Sciences, Biology Department, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    BMC Syst Biol 5:157. 2011
    ..Analysis of global transcriptional and phenotypic responses in the yeast S. cerevisiae provides means to identify pathways of damage recovery upon toxic exposure...
  8. pmc Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates
    Ivan Rusyn
    Center for Environmental Health Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 2:e1252. 2007
    ..Taken together, these results suggest that a branch point exists in the current model for DNA damage-signaled transcription in S. cerevisiae...
  9. doi request reprint Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency
    Sijin Liu
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Br J Haematol 143:129-37. 2008
    ..Our results indicate that HRI confers adaptive gene expression in developing erythroblasts during iron deficiency through maintaining Gata1/Fog1 expression...
  10. pmc Genomic predictors of interindividual differences in response to DNA damaging agents
    Rebecca C Fry
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 22:2621-6. 2008
    ..Many proteins encoded by these genes are interconnected in cellular networks related to human cancer and tumorigenesis...
  11. ncbi request reprint Hepatocellular carcinoma associated with liver-gender disruption in male mice
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 67:11536-46. 2007
    ..This model introduces a novel mechanism of inflammation-associated carcinogenesis consistent with male-predominant HCC risk...
  12. pmc Diarrhea as a cause of mortality in a mouse model of infectious colitis
    Diana Borenshtein
    Department of Biological Engineering, Massachusetts Institute of Technology, Massachusetts Avenue, Cambridge, MA 02139, USA
    Genome Biol 9:R122. 2008
    ..Gene expression in the distal colon was determined prior to infection, and at four and nine days post-inoculation using a whole mouse genome Affymetrix array...
  13. pmc Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers
    Rebecca C Fry
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 3:e207. 2007
    ..These studies clearly demonstrate the robust impact of a mother's arsenic consumption on fetal gene expression as evidenced by transcript levels in newborn cord blood...
  14. pmc 17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice
    Alexander Sheh
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Cancer Prev Res (Phila) 4:1426-35. 2011
    ..01). Prevention of H. pylori-induced gastric cancer by E2 and TAM may be mediated by estrogen signaling and is associated with decreased CXCL1, decreased neutrophil counts, and downregulation of oncogenic pathways...
  15. ncbi request reprint Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes
    Albert J Hwa
    Department of Mechanical Engineering, MIT, 77 Mass Ave, Cambridge, MA 02139, USA
    FASEB J 21:2564-79. 2007
    ..Global transcriptional profiling did not reveal profound changes between 2D and 3D cultures in expression of most canonical angiogenic factors but suggested changes in several pathways related to endothelial cell function...
  16. ncbi request reprint Comparative modeling and analysis of microfluidic and conventional DNA microarrays
    James A Benn
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Anal Biochem 348:284-93. 2006
    ..Consistent with the theoretical model, the microfluidic microarray demonstrated the ability to print DNA probes in less than 1 min and to detect 10-pM target concentrations with hybridization times in less than 5 min...
  17. ncbi request reprint Hepatic temporal gene expression profiling in Helicobacter hepaticus-infected A/JCr mice
    Samuel R Boutin
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:678-93. 2004
    ....
  18. ncbi request reprint Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses
    Richard P Beyer
    University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    Toxicol Sci 99:326-37. 2007
    ..We show that phenotypic anchoring of gene expression data is required for biologically meaningful analysis of toxicogenomic experiments...
  19. ncbi request reprint Standardizing global gene expression analysis between laboratories and across platforms
    Theodore Bammler
    Nat Methods 2:351-6. 2005
    ..These findings indicate that microarray results can be comparable across multiple laboratories, especially when a common platform and set of procedures are used...