Christopher Alexander French

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc NSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital
    Cancer Discov 4:928-41. 2014
  2. pmc The importance of diagnosing NUT midline carcinoma
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Head Neck Pathol 7:11-6. 2013
  3. doi request reprint Pathogenesis of NUT midline carcinoma
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 7:247-65. 2012
  4. pmc NUT midline carcinoma
    Christopher Alexander French
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Genet Cytogenet 203:16-20. 2010
  5. ncbi request reprint BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 63:304-7. 2003
  6. ncbi request reprint Demystified molecular pathology of NUT midline carcinomas
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Pathol 63:492-6. 2010
  7. ncbi request reprint Midline carcinoma of children and young adults with NUT rearrangement
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Clin Oncol 22:4135-9. 2004
  8. doi request reprint NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract
    Edward B Stelow
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    Am J Surg Pathol 32:828-34. 2008
  9. ncbi request reprint Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas)
    Edward B Stelow
    Department of Pathology, University of Virginia, Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Adv Anat Pathol 16:92-6. 2009
  10. doi request reprint BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findings
    Benjamin A Nelson
    Department of Pediatrics, Pulmonary Division, Massachusetts General Hospital, Boston, MA, USA
    J Thorac Imaging 25:W93-6. 2010

Research Grants

  1. T(15;19) in Aggressive Pediatric Carcinoma
    Christopher French; Fiscal Year: 2006
  2. Pathogenesis of NUT-Rearranged Carcinoma
    Christopher French; Fiscal Year: 2007
  3. Pathogenesis of NUT-Rearranged Carcinoma
    Christopher French; Fiscal Year: 2009
  4. Pathogenesis of NUT-Rearranged Carcinoma
    Christopher A French; Fiscal Year: 2010
  5. Pathogenesis of NUT-Rearranged Carcinoma
    Christopher A French; Fiscal Year: 2010

Detail Information

Publications16

  1. pmc NSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital
    Cancer Discov 4:928-41. 2014
    ..We find further that NSD3 is required for the blockade of differentiation in BRD4-NUT-expressing NMCs. These findings identify NSD3 as a novel critical oncogenic component and potential therapeutic target in NMC...
  2. pmc The importance of diagnosing NUT midline carcinoma
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Head Neck Pathol 7:11-6. 2013
    ..The emergence of these promising targeted therapies gives hope that NMC may one day be effectively treated and provides a strong rationale for diagnostic testing for NMC...
  3. doi request reprint Pathogenesis of NUT midline carcinoma
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 7:247-65. 2012
    ..These insights provide a rationale for targeted therapy of NMC, which is almost uniformly refractory to conventional chemotherapy and radiotherapy...
  4. pmc NUT midline carcinoma
    Christopher Alexander French
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cancer Genet Cytogenet 203:16-20. 2010
    ..There still is no effective treatment for NMC, there are no guidelines, and current approaches to treatment are based on discussions among a few oncologists who each have had a single experience treating this disease...
  5. ncbi request reprint BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 63:304-7. 2003
    ..Very few fusion oncogenes have been identified in epithelial tumors, and BRD4-NUT is the first fusion oncogene mechanism identified in a highly lethal form of carcinoma...
  6. ncbi request reprint Demystified molecular pathology of NUT midline carcinomas
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Pathol 63:492-6. 2010
    ..NMC is diagnosed by detection of NUT rearrangement by fluorescence in situ hybridisation or reverse transcriptase PCR. Due its rarity and lack of characteristic histological features, most cases of NMC currently go unrecognised...
  7. ncbi request reprint Midline carcinoma of children and young adults with NUT rearrangement
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Clin Oncol 22:4135-9. 2004
    ..We sought to amass a more definitive series of tumors with NUT and/or BRD4 gene rearrangements and to determine distinct clinicopathologic features...
  8. doi request reprint NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract
    Edward B Stelow
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    Am J Surg Pathol 32:828-34. 2008
    ..The histologic features of these tumors are described in detail...
  9. ncbi request reprint Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas)
    Edward B Stelow
    Department of Pathology, University of Virginia, Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Adv Anat Pathol 16:92-6. 2009
    ..Our current understanding of the molecular pathogenesis of the disease is also discussed, along with the differential diagnosis for undifferentiated or poorly differentiated malignancy of the upper aerodigestive tract...
  10. doi request reprint BRD4-NUT carcinoma of the mediastinum in a pediatric patient: multidetector computed tomography imaging findings
    Benjamin A Nelson
    Department of Pediatrics, Pulmonary Division, Massachusetts General Hospital, Boston, MA, USA
    J Thorac Imaging 25:W93-6. 2010
    ....
  11. doi request reprint The cytologic features of NUT midline carcinoma
    Andrew M Bellizzi
    Department of Pathology, The Ohio State University Medical Center, Columbus, Ohio, USA
    Cancer 117:508-15. 2009
    ..Although the tumor was originally noted in young persons, we have subsequently identified 5 adult cases. To our knowledge, the cytology of NMC has not been systematically described...
  12. ncbi request reprint Applications of fluorescence in situ hybridization in cytopathology: a review
    Andre M Oliveira
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Acta Cytol 49:587-94. 2005
    ..Furthermore, due to its feasibility for virtually all types of cytologic specimens, a new and exciting era in both investigative and clinical cytopathology is expected...
  13. ncbi request reprint The role of chromosomal translocation (15;19) in the carcinoma of the upper aerodigestive tract in children
    Reza Rahbar
    Department of Otolaryngology, Children s Hospital, Boston, MA 02115, USA
    Otolaryngol Head Neck Surg 129:698-704. 2003
    ..To further evaluate the role of chromosomal translocation (15;19) in the presentation of the carcinoma (CA) of the upper aerodigestive tract...
  14. pmc Genetic and biological subgroups of low-stage follicular thyroid cancer
    Christopher A French
    Division of Endocrinology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 162:1053-60. 2003
    ..The findings support a model in which separate genetic alterations initiate distinct pathways of oncogenesis in thyroid carcinoma subtypes...
  15. doi request reprint Molecular detection of PPAR gamma rearrangements and thyroid carcinoma in preoperative fine-needle aspiration biopsies
    Christopher A French
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Endocr Pathol 19:166-74. 2008
    ..The application of specific mutations to preoperative diagnosis of thyroid carcinoma is predicted to improve the accuracy and reduce the costs of treating patients with thyroid tumors...
  16. ncbi request reprint Successful treatment of a child with t(15;19)-positive tumor
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Pediatr Blood Cancer 49:1015-7. 2007
    ..More importantly, our results also demonstrate that at least some patients with t(15;19)-positive tumors may be successfully treated...

Research Grants6

  1. T(15;19) in Aggressive Pediatric Carcinoma
    Christopher French; Fiscal Year: 2006
    ..These studies will also reveal the range of primary sites from which t(15;19)+ carcinomas arise. ..
  2. Pathogenesis of NUT-Rearranged Carcinoma
    Christopher French; Fiscal Year: 2007
    ..3. To identify the transcriptional targets of BRD4-NUT1 that are responsible for the blockade of differentiation in BRD4-NUT1 carcinoma cells. ..
  3. Pathogenesis of NUT-Rearranged Carcinoma
    Christopher French; Fiscal Year: 2009
    ..3. To identify the transcriptional targets of BRD4-NUT1 that are responsible for the blockade of differentiation in BRD4-NUT1 carcinoma cells. ..
  4. Pathogenesis of NUT-Rearranged Carcinoma
    Christopher A French; Fiscal Year: 2010
    ..3. To identify the transcriptional targets of BRD4-NUT1 that are responsible for the blockade of differentiation in BRD4-NUT1 carcinoma cells. ..
  5. Pathogenesis of NUT-Rearranged Carcinoma
    Christopher A French; Fiscal Year: 2010
    ..3. To identify the transcriptional targets of BRD4-NUT1 that are responsible for the blockade of differentiation in BRD4-NUT1 carcinoma cells. ..