JONATHAN FRANCIS

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neurons
    Jonathan W Francis
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
    Brain Res 995:84-96. 2004
  2. ncbi request reprint Survival motor neuron protein in the nucleolus of mammalian neurons
    Karen A Wehner
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Brain Res 945:160-73. 2002
  3. ncbi request reprint The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein
    Philip J Young
    Department of Veterinary Pathobiology, 210 Connaway Hall, University of Missouri, Columbia, MO 65211, USA
    Brain Res Mol Brain Res 119:37-49. 2003
  4. ncbi request reprint Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice
    Susanna C Benn
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 95:1118-31. 2005
  5. ncbi request reprint A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice
    Kristin E Larsen
    Columbia University, Department of Neurology, New York, NY 10032, and Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
    Brain Res 1120:1-12. 2006

Research Grants

Collaborators

  • Johanna C vanderSpek
  • P S Fishman
  • David L Sulzer
  • Susanna C Benn
  • Philip J Young
  • Kristin E Larsen
  • Robert H Brown
  • Ilknur Ay
  • Ru Ju Chian
  • R Blake Pepinsky
  • Samuel A Celia
  • Christian L Lorson
  • Karen A Wehner
  • Kester A Phillips
  • Mary P Remington
  • Dinah Sah
  • Meiqin Liu
  • Joshua Ross
  • Paul Carmillo
  • Michelle Bejarano
  • Elena Bastia
  • Elliot J Androphy
  • Diane Lince
  • Keith Coon
  • Youngseon Kim
  • Susan J Baserga
  • Laura Ayala
  • Betsy A Hosler

Detail Information

Publications5

  1. ncbi request reprint A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neurons
    Jonathan W Francis
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
    Brain Res 995:84-96. 2004
    ..While these studies indicate that SDT may not be useful for SMA therapy, the use of the TTC:DTx fusion construct to deliver other passenger proteins to the neuronal cytosol should not be ruled out...
  2. ncbi request reprint Survival motor neuron protein in the nucleolus of mammalian neurons
    Karen A Wehner
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Brain Res 945:160-73. 2002
    ..These studies raise the possibility that SMN may serve a function in rRNA maturation/ribosome synthesis similar to its role in spliceosome biogenesis...
  3. ncbi request reprint The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein
    Philip J Young
    Department of Veterinary Pathobiology, 210 Connaway Hall, University of Missouri, Columbia, MO 65211, USA
    Brain Res Mol Brain Res 119:37-49. 2003
    ..Anti-sense RNA experiments, however, demonstrate that EWS does not mediate the nuclear distribution of SMN or other Cajal body components...
  4. ncbi request reprint Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice
    Susanna C Benn
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 95:1118-31. 2005
    ..These results indicate that TTC may serve as a useful prototype for development as a non-viral vehicle for improving delivery of therapeutic proteins to the CNS...
  5. ncbi request reprint A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice
    Kristin E Larsen
    Columbia University, Department of Neurology, New York, NY 10032, and Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
    Brain Res 1120:1-12. 2006
    ..These results indicate that TTC can serve as a non-viral vehicle to substantially improve the delivery of functionally active growth factors to motor neurons in the mammalian CNS...

Research Grants7

  1. Non-viral Delivery of Neurotrophic Factors to the CNS
    JONATHAN FRANCIS; Fiscal Year: 2005
    ..als). ..
  2. Non-viral Delivery of Neurotrophic Factors to the CNS
    JONATHAN FRANCIS; Fiscal Year: 2007
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