Affiliation: Massachusetts General Hospital
- A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neuronsJonathan W Francis
Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
Brain Res 995:84-96. 2004..While these studies indicate that SDT may not be useful for SMA therapy, the use of the TTC:DTx fusion construct to deliver other passenger proteins to the neuronal cytosol should not be ruled out...
- Survival motor neuron protein in the nucleolus of mammalian neuronsKaren A Wehner
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
Brain Res 945:160-73. 2002..These studies raise the possibility that SMN may serve a function in rRNA maturation/ribosome synthesis similar to its role in spliceosome biogenesis...
- The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron proteinPhilip J Young
Department of Veterinary Pathobiology, 210 Connaway Hall, University of Missouri, Columbia, MO 65211, USA
Brain Res Mol Brain Res 119:37-49. 2003..Anti-sense RNA experiments, however, demonstrate that EWS does not mediate the nuclear distribution of SMN or other Cajal body components...
- Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in miceSusanna C Benn
Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurochem 95:1118-31. 2005..These results indicate that TTC may serve as a useful prototype for development as a non-viral vehicle for improving delivery of therapeutic proteins to the CNS...
- A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in miceKristin E Larsen
Columbia University, Department of Neurology, New York, NY 10032, and Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
Brain Res 1120:1-12. 2006..These results indicate that TTC can serve as a non-viral vehicle to substantially improve the delivery of functionally active growth factors to motor neurons in the mammalian CNS...