James Fox

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Sex hormone influence on hepatitis in young male A/JCr mice infected with Helicobacter hepaticus
    Elizabeth J Theve
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 76:4071-8. 2008
  2. pmc Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice
    Nisanart Charoenlap
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Infect Immun 80:921-8. 2012
  3. pmc Diarrhea as a cause of mortality in a mouse model of infectious colitis
    Diana Borenshtein
    Department of Biological Engineering, Massachusetts Institute of Technology, Massachusetts Avenue, Cambridge, MA 02139, USA
    Genome Biol 9:R122. 2008
  4. ncbi request reprint High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cancer Res 59:4823-8. 1999
  5. ncbi request reprint Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
    Nat Med 6:536-42. 2000
  6. ncbi request reprint C-cell carcinoma (medullary thyroid carcinoma) associated with multiple endocrine neoplasms in a ferret (Mustela putorius)
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Vet Pathol 37:278-82. 2000
  7. pmc Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 72:1116-25. 2004
  8. pmc Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Am J Pathol 171:1520-8. 2007
  9. pmc Inflammation, atrophy, and gastric cancer
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 117:60-9. 2007
  10. doi request reprint Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mucosal Immunol 4:22-30. 2011

Detail Information

Publications115 found, 100 shown here

  1. pmc Sex hormone influence on hepatitis in young male A/JCr mice infected with Helicobacter hepaticus
    Elizabeth J Theve
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 76:4071-8. 2008
    ..hepaticus-induced hepatitis in young male mice, whereas androgen receptor agonism does not worsen disease. This raises the possibility of targeted hormonal therapy in young male patients with childhood-acquired HBV...
  2. pmc Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice
    Nisanart Charoenlap
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Infect Immun 80:921-8. 2012
    ..Collectively, these data suggest that H. cinaedi ahpC not only contributes to protecting the organism against oxidative stress but also alters its pathogenic properties in vivo...
  3. pmc Diarrhea as a cause of mortality in a mouse model of infectious colitis
    Diana Borenshtein
    Department of Biological Engineering, Massachusetts Institute of Technology, Massachusetts Avenue, Cambridge, MA 02139, USA
    Genome Biol 9:R122. 2008
    ..Gene expression in the distal colon was determined prior to infection, and at four and nine days post-inoculation using a whole mouse genome Affymetrix array...
  4. ncbi request reprint High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cancer Res 59:4823-8. 1999
    ..pylori colonization. Furthermore, elevated salt intake may potentiate H. pylori-associated carcinogenesis by inducing proliferation, pit cell hyperplasia, and glandular atrophy...
  5. ncbi request reprint Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
    Nat Med 6:536-42. 2000
    ..Thus, concurrent enteric helminth infection can attenuate gastric atrophy, a premalignant lesion...
  6. ncbi request reprint C-cell carcinoma (medullary thyroid carcinoma) associated with multiple endocrine neoplasms in a ferret (Mustela putorius)
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Vet Pathol 37:278-82. 2000
    ..These findings mimic features observed in human multiple endocrine neoplasia syndromes...
  7. pmc Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 72:1116-25. 2004
    ..jejuni to escape immune surveillance. NF-kappaB-deficient mice should be a useful model to further study the role of CDT and other aspects of C. jejuni pathogenesis...
  8. pmc Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Am J Pathol 171:1520-8. 2007
    ..pylori-infected mice at 19 months pi. These data support a protective role for TFF2 in part by modulating levels of gastric interferon-gamma in the development of H. pylori-associated premalignancy of the distal stomach...
  9. pmc Inflammation, atrophy, and gastric cancer
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 117:60-9. 2007
    ..We also discuss how the increased understanding of the relationship between inflammation and gastric cancer still leaves many questions unanswered regarding recommendations for prevention and treatment...
  10. doi request reprint Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mucosal Immunol 4:22-30. 2011
    ..hepaticus pathogenesis. Delineating targets of H. hepaticus virulence factors could facilitate novel approaches to treating microbially induced lower bowel inflammatory diseases...
  11. ncbi request reprint Novel Helicobacter species isolated from rhesus monkeys with chronic idiopathic colitis
    J G Fox
    Massachusetts Institute of Technology, Cambridge, USA
    J Med Microbiol 50:421-9. 2001
    ..Further microbiological and histological analysis of this chronic idiopathic colitis syndrome in macaques may prove useful in understanding the aetiology and pathogenesis of inflammatory bowel disease in man...
  12. pmc Helicobacter marmotae sp. nov. isolated from livers of woodchucks and intestines of cats
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 40:2513-9. 2002
    ..nov. for these organisms. Further studies are required to ascertain if this novel Helicobacter sp. plays a tumor promotion role in hepadnavirus-associated tumors in woodchucks or causes enterohepatic disease in cats...
  13. pmc Chronic hepatitis, hepatic dysplasia, fibrosis, and biliary hyperplasia in hamsters naturally infected with a novel Helicobacter classified in the H. bilis cluster
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 825, Cambridge, MA 02139, USA
    J Clin Microbiol 47:3673-81. 2009
    ..bilis and closely related Helicobacter spp. play an etiological role in hepatobiliary disease in both animals and humans...
  14. pmc The non-H pylori helicobacters: their expanding role in gastrointestinal and systemic diseases
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Gut 50:273-83. 2002
    ..This review highlights the expanding role that other helicobacters, although not as well known as H pylori, play in gastrointestinal and systemic disease in humans...
  15. ncbi request reprint Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 63:942-50. 2003
    ..This study highlights the importance of using both genders to investigate the pathogenesis of H. pylori...
  16. pmc A novel urease-negative Helicobacter species associated with colitis and typhlitis in IL-10-deficient mice
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 67:1757-62. 1999
    ..The mouse model of helicobacter-associated intestinal inflammation should prove valuable in understanding how specific microbial antigens influence a complex disease process...
  17. pmc Comparison of methods of identifying Helicobacter hepaticus in B6C3F1 mice used in a carcinogenesis bioassay
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Clin Microbiol 36:1382-7. 1998
    ..This study confirms the widespread prevalence of H. hepaticus in mice, its potential to confound experimental results, and the need to include diagnostic testing for H. hepaticus in a murine health monitoring program...
  18. pmc Isolation and characterization of a novel helicobacter species, "Helicobacter macacae," from rhesus monkeys with and without chronic idiopathic colitis
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Clin Microbiol 45:4061-3. 2007
    ..All eight strains of H. macacae had 99.5% identical 16S rRNA sequences...
  19. pmc Helicobacter canadensis sp. nov. isolated from humans with diarrhea as an example of an emerging pathogen
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 38:2546-9. 2000
    ..fennelliae, and H. cinaedi. This finding highlights the importance of careful molecular analysis in addition to standard biochemical tests in identifying the increasing number of Helicobacter spp. isolated from humans and animals...
  20. pmc Helicobacter bilis: bacterial provocateur orchestrates host immune responses to commensal flora in a model of inflammatory bowel disease
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16, Room 825C, Cambridge, MA 02139, USA
    Gut 56:898-900. 2007
  21. pmc Helicobacter anseris sp. nov. and Helicobacter brantae sp. nov., isolated from feces of resident Canada geese in the greater Boston area
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 16, Rm 825C, Cambridge, MA 02139, USA
    Appl Environ Microbiol 72:4633-7. 2006
    ..Whether these two novel helicobacters pose a zoonotic risk, similar to other enteric helicobacters (e.g., H. canadensis, previously isolated from diarrheic and bacteremic humans and from geese in Europe), will require further studies...
  22. ncbi request reprint Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Gastroenterology 114:755-63. 1998
    ..Because several Helicobacter sp. colonize the livers of animals and induce hepatitis, the aim of this study was to determine whether Helicobacter infection was associated with cholecystitis in humans...
  23. ncbi request reprint Veterinarians in biomedical research: a perilous future?
    James G Fox
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 16 825C, Cambridge, MA 02139, USA
    J Vet Med Educ 32:301-5. 2005
  24. ncbi request reprint Cholangiohepatitis and inflammatory bowel disease induced by a novel urease-negative Helicobacter species in A/J and Tac:ICR:HascidfRF mice
    N H Shomer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Exp Biol Med (Maywood) 226:420-8. 2001
    ..These results provide a new model of IBD and cholangio-hepatitis associated with a specific urease-negative, novel H. species...
  25. pmc Helicobacter cetorum sp. nov., a urease-positive Helicobacter species isolated from dolphins and whales
    C G Harper
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 40:4536-43. 2002
    ..Further studies are necessary to determine the role of H. cetorum in the development of gastric ulcers and gastritis of cetaceans. This is the first description and formal naming of a novel Helicobacter species from a marine mammal...
  26. ncbi request reprint Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Boston, USA
    Gastroenterology 110:155-66. 1996
    ..To analyze host genetic factors and the influence of Helicobacter on cell proliferation, we used an inbred and p53 hemizygous mouse model of Helicobacter felis-induced gastritis...
  27. ncbi request reprint Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alphabeta mutant mice
    E Y Chin
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge 02139, USA
    Comp Med 50:586-94. 2000
    ..Infection with H. hepaticus is sufficient to cause chronic proliferative intestinal inflammation in TCR alphabeta mutant mice. However, H. hepaticus infection is not necessary for intestinal disease in TCR alpha-/- mice...
  28. pmc Coinfection of enteric Helicobacter spp. and Campylobacter spp. in cats
    Z Shen
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    J Clin Microbiol 39:2166-72. 2001
    ..The clinical relevance of enteric Helicobacter and Campylobacter coinfection in cats will require further studies...
  29. pmc Molecular evidence of Helicobacter cinaedi organisms in human gastric biopsy specimens
    J A Pena
    Northeastern University, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Clin Microbiol 40:1511-3. 2002
    ..Although these organisms were previously associated with extragastric infections, the roles of these organisms in the pathogenesis of chronic gastritis or peptic ulcer disease remain unclear...
  30. pmc Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice
    Z Shen
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Infect Immun 77:2508-16. 2009
    ..These results indicate that WT(Hc) can be used to model inflammatory bowel disease in IL-10(-/-) mice and that CDT contributes to the virulence of H. cinaedi...
  31. ncbi request reprint A small animal model of human Helicobacter pylori active chronic gastritis
    A Lee
    Division of Comparative Medicine, Massachusetts Institute of Technology, Boston
    Gastroenterology 99:1315-23. 1990
    ..This is the first animal model of bacterial gastritis to be described that shows progression from acute inflammation to persistent acute on chronic inflammation (active chronic) as is seen in human infection with H. pylori...
  32. ncbi request reprint Long-term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 mice
    M T Whary
    Massachusetts Institute of Technology, Cambridge 02139, USA
    Comp Med 51:413-7. 2001
    ..hepaticus in the cecum, compared with those of hepatitis-resistant C57BL/6 mice. Host responses of A/JCr mice that limit cecal colonization with H. hepaticus may have important roles in the pathogenesis of hepatic lesions...
  33. pmc Development of a PCR-restriction fragment length polymorphism assay using the nucleotide sequence of the Helicobacter hepaticus urease structural genes ureAB
    Z Shen
    Divisions of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 36:2447-53. 1998
    ..hepaticus has urease structural genes which are homologous to those of the gastric Helicobacter species and that these gene sequences can be used in a PCR and RFLP assay for diagnosis of this important murine pathogen...
  34. ncbi request reprint Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp
    C C Chien
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Med Microbiol 49:525-34. 2000
    ..Cdt caused cell cycle arrest at G2/M phase as measured by flow cytometry. The results demonstrated the presence of a toxin in these Helicobacter spp. belonging to the family of Cdt...
  35. ncbi request reprint Mice carrying a truncated Apc gene have diminished gastric epithelial proliferation, gastric inflammation, and humoral immunity in response to Helicobacter felis infection
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02138, USA
    Cancer Res 57:3972-8. 1997
    ....
  36. pmc Failure of surface ring mutant strains of Helicobacter mustelae to persistently infect the ferret stomach
    M M Patterson
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Infect Immun 71:2350-5. 2003
    ..Scant colonization by the Hsr-negative H. mustelae strain at the end of the 18-week study, despite initial successful colonization, indicates an inability of the mutant to persist, perhaps due to a specific host response...
  37. pmc Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice
    S E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1027-32. 2009
    ..Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis...
  38. pmc Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora
    M T Whary
    Division of Comparative Medicine, Massachusette Institute of Technology, 77 Massachusetts Avenue, Bldg 16 825A, Cambridge, MA 02139, USA
    Infect Immun 74:6615-23. 2006
    ..trogontum (with or without H. rodentium) induces a rapid-onset, erosive to ulcerative typhlocolitis which impacts the normal anaerobic flora of the colon and increases the risk of sepsis...
  39. ncbi request reprint Progressive proliferative and dysplastic typhlocolitis in aging syrian hamsters naturally infected with Helicobacter spp.: a spontaneous model of inflammatory bowel disease
    P R Nambiar
    Prashant R Nambiar, Division of Comparative Medicine, Massachusetts Institute of Technology, Building 16 849, Cambridge, MA 02139, USA
    Vet Pathol 43:2-14. 2006
    ..Thus, lesions in the distal portion of the large bowel of aging hamsters naturally colonized with Helicobacter spp. warrants developing the hamster as an animal model of IBD and potentially IBD-related cancer...
  40. doi request reprint Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Gut 59:88-97. 2010
    ..Recently, gut microbes have been implicated in multisystemic diseases including obesity and diabetes. Here, the hypothesis that specific intestinal bacteria promote liver cancer was tested in chemical and viral transgenic mouse models...
  41. ncbi request reprint Gastritis-associated adenocarcinoma and intestinal metaplasia in a Syrian hamster naturally infected with Helicobacter species
    P R Nambiar
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Vet Pathol 42:386-90. 2005
    ..This is a first report of gastric adenocarcinoma in helicobacter-infected hamsters. Syrian hamsters appear suitable as potential model for studying development of helicobacter-associated gastric adenocarcinomas...
  42. doi request reprint Staphylococcal meningoencephalitis, nematodiasis, and typhlocolitis in a squirrel monkey (Saimiri sciureus)
    A Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Med Primatol 38:377-81. 2009
    ..Seizures were observed in a 16-year old male Guyanese squirrel monkey with a history of inappetence and weakness...
  43. ncbi request reprint Hepatobiliary inflammation, neoplasia, and argyrophilic bacteria in a ferret colony
    A Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Vet Pathol 39:173-9. 2002
    ..The clustering of severe hepatic disease in these cohabitating ferroes suggests a possible infectious etiology. The role of Helicobacter species and other bacteria in hepatitis and/or neoplasia in ferrets requires further study...
  44. ncbi request reprint Bacterial infection promotes colon tumorigenesis in Apc(Min/+) mice
    J V Newman
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Infect Dis 184:227-30. 2001
    ..rodentium-induced hyperplasia occurs. These data demonstrate that bacterial infection promotes colon tumor formation in genetically susceptible mice...
  45. ncbi request reprint Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 29:279-87. 2000
    ..pylori prevention and eradication...
  46. pmc Proliferative enterocolitis associated with dual infection with enteropathogenic Escherichia coli and Lawsonia intracellularis in rabbits
    D B Schauer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Clin Microbiol 36:1700-3. 1998
    ..Dual infection with these two pathogens in rabbits has not been previously reported and may have contributed to the unusually high mortality observed in this outbreak...
  47. pmc Experimental Helicobacter pylori infection induces antral gastritis and gastric mucosa-associated lymphoid tissue in guinea pigs
    N H Shomer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 66:2614-8. 1998
    ..pylori-infected humans. The H. pylori-infected guinea pig should prove useful in modeling the interaction of helicobacter and vitamin C in gastric carcinogenesis...
  48. pmc Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora
    N H Shomer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Infect Immun 65:4858-64. 1997
    ..bilis causes IBD in scid mice with defined flora. This result both confirms a pathogenic role for H. bilis in mice and provides a new model relating a specific microbial agent and IBD...
  49. ncbi request reprint Typhlocolitis in NF-kappa B-deficient mice
    S Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 166:1443-7. 2001
    ..T cell development in NF-kappaB-deficient mice was normal. These data indicate that p50 and p65 subunits of NF-kappaB have an unexpected role in inhibiting the development of colitis...
  50. pmc Isolation of Helicobacter cinaedi from the colon, liver, and mesenteric lymph node of a rhesus monkey with chronic colitis and hepatitis
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 39:1580-5. 2001
    ..This is the first observation of H. cinaedi associated with active hepatitis and colitis in a nonhuman primate...
  51. pmc Chronic active hepatitis induced by Helicobacter hepaticus in the A/JCr mouse is associated with a Th1 cell-mediated immune response
    M T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 66:3142-8. 1998
    ..i. The characterization of a cell-mediated Th1 immune response to H. hepaticus infection in the A/JCr mouse should prove valuable as a model for experimental regimens which manipulate the host response to Helicobacter...
  52. pmc Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 39:2598-602. 2001
    ..hepaticus DNA. Therefore, this assay can be used with high sensitivity and specificity to quantify H. hepaticus in experimentally infected mouse models as well as in naturally infected mice...
  53. ncbi request reprint Genomic characterization of Helicobacter hepaticus: ordered cosmid library and comparative sequence analysis
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    FEMS Microbiol Lett 204:147-53. 2001
    ..jejuni; (2) significant genomic alterations exist between H. hepaticus and H. pylori, including gene organization, protein sequences and GC content, probably in part due to specific adaptation to distinct ecological niches...
  54. ncbi request reprint Gastric dilatation syndrome associated with chronic nephropathy, hypergastrinemia, and gastritis in mice exposed to high levels of environmental antigens
    A Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Comp Med 51:262-7. 2001
    ..009), compared with control (60.77 +/- 8.39 pM) mice. Gastric dilatation syndrome is associated with chronic nephropathy, hypergastrinemia, and gastritis in surveillance mice exposed to high levels of environmental antigens...
  55. pmc Characterization of proteins in the outer membrane preparation of a murine pathogen, Helicobacter bilis
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 69:3502-6. 2001
    ..These results indicate that H. bilis has a conserved, unique OMP protein profile that is distinct from those of H. pylori...
  56. ncbi request reprint Clusters of lymphoma in ferrets
    S E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cancer Invest 14:225-30. 1996
    ..None of the cluster ferrets were seropositive for FeLV p27 antigen using a monoclonal ELISA. Infection with a novel ferret virus is suspected, but an etiological agent has not yet been identified...
  57. pmc Coinfection with Enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori-induced gastric pathology in C57BL/6 mice
    Zhongming Ge
    Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Infect Immun 79:3861-71. 2011
    ..pylori-induced gastric pathology in C57BL/6 mice. This modulation was related to the variable effects of EHS on gastric interleukin 17 (IL-17) responses to H. pylori infection...
  58. pmc 17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice
    Alexander Sheh
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Cancer Prev Res (Phila) 4:1426-35. 2011
    ..01). Prevention of H. pylori-induced gastric cancer by E2 and TAM may be mediated by estrogen signaling and is associated with decreased CXCL1, decreased neutrophil counts, and downregulation of oncogenic pathways...
  59. pmc Campylobacter troglodytis sp. nov., isolated from feces of human-habituated wild chimpanzees (Pan troglodytes schweinfurthii) in Tanzania
    Taranjit Kaur
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Appl Environ Microbiol 77:2366-73. 2011
    ..troglodytis genomovar. Further studies are required to determine whether the organism is pathogenic to chimpanzees and whether this novel Campylobacter colonizes humans and causes enteric disease...
  60. ncbi request reprint Prolactin-secreting pituitary adenomas with mammary dysplasia in New Zealand white rabbits
    N S Lipman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139
    Lab Anim Sci 44:114-20. 1994
    ..The cystic dilations extended into and included the teat canal producing the gross appearance. Prolactin-secreting acidophil adenomas have not been previously reported in the rabbit, and the association with mammary dysplasia is unique...
  61. ncbi request reprint Identification of a DNA segment in ferret Aleutian disease virus similar to a hypervariable capsid region of mink Aleutian disease parvovirus
    M Saifuddin
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, USA
    Arch Virol 141:1329-36. 1996
    ....
  62. ncbi request reprint Parvovirus-associated syndrome (Aleutian disease) in two ferrets
    L S Palley
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139
    J Am Vet Med Assoc 201:100-6. 1992
    ..We present the clinical and laboratory findings associated with Aleutian disease in 2 domestic ferrets, one with the chronic wasting form of the disease and one with the central nervous system form...
  63. ncbi request reprint Practical venipuncture techniques for the ferret
    G Otto
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139
    Lab Anim 27:26-9. 1993
    ..Using these methods it is possible to repeatedly sample moderate volumes of blood and to perform intravenous injections in both conscious and sedated ferrets...
  64. ncbi request reprint Mice lacking inducible nitric oxide synthase develop spontaneous hypercholesterolaemia and aortic atheromas
    M Ihrig
    Division of Comparative Medicine, Massachusetts Institute of Technology, Building 16 825, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Atherosclerosis 156:103-7. 2001
    ....
  65. ncbi request reprint Helicobacter hepaticus catalase shares surface-predicted epitopes with mammalian catalases
    Essam J Alyamani
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 01225, USA
    Microbiology 153:1006-16. 2007
    ..hepaticus catalase. Catalases are highly conserved enzymes in bacteria and mammals that may contribute to autoimmune responses in animals infected with catalase-producing pathogens...
  66. pmc Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis
    Chung Wei Lee
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Infect Immun 75:2699-707. 2007
    ..pylori-mediated inflammation and in regulatory effects between wt T(R) and IL-10(-/-) T(R) cells suggest that IL-10 expression by wt T(R) cells is important to regulatory suppression of gastric inflammation...
  67. ncbi request reprint Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma
    Theofilos Poutahidis
    Division of Comparative Medicine
    Carcinogenesis 28:2614-23. 2007
    ..These data provide insights into etiopathogenesis of inflammation-associated epithelial invasion and maintenance of epithelial homeostasis...
  68. ncbi request reprint Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice
    Masahiro Ohtani
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825C, Cambridge, MA 02139, USA
    Carcinogenesis 28:2597-604. 2007
    ..These results demonstrate a protective effect of E2 in H.pylori-induced gastric cancer in a mouse model...
  69. ncbi request reprint Swedish moist snuff accelerates gastric cancer development in Helicobacter pylori-infected wild-type and gastrin transgenic mice
    Bjorn Stenstrom
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, NO 7006 Norway
    Carcinogenesis 28:2041-6. 2007
    ..We suggest that snus is a potential gastric carcinogen in mice. The development of CIS was associated with increased rates of the epithelial cell proliferation and apoptosis, common features of gastric carcinogenesis...
  70. ncbi request reprint Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice
    Claude M Nagamine
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 122:832-8. 2008
    ..The AOM-induced adenomas were predominantly exophytic and nodular or polypoid and localized to the distal colon. These results suggest that H. hepaticus promotes AOM-induced tumorigenesis in the BALB/c-IL10 null mouse...
  71. pmc Development of fatal colitis in FVB mice infected with Citrobacter rodentium
    Diana Borenshtein
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Infect Immun 75:3271-81. 2007
    ....
  72. pmc Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
    Shuiping Tu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cancer Cell 14:408-19. 2008
    ..These results demonstrate that pathologic elevation of a single proinflammatory cytokine may be sufficient to induce neoplasia and provide a direct link between IL-1beta, MDSCs, and carcinogenesis...
  73. pmc Modulation of acute diarrheal illness by persistent bacterial infection
    Megan E McBee
    Department of Biological Engineering, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 76:4851-8. 2008
    ..This new model of polymicrobial infection provides insight into the mechanism by which subclinical infection can exacerbate morbidity due to an unrelated self-limiting infection...
  74. pmc Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Microbes Infect 10:726-33. 2008
    ..05) at 13 WPI. These results demonstrate that genes in the HHGI1 contribute to the pathogenicity of H. hepaticus, at least in part via up-regulation of proinflammatory mediators IFN-gamma, TNF-alpha and IL-17a...
  75. pmc c-Rel is essential for the development of innate and T cell-induced colitis
    Yanyan Wang
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 180:8118-25. 2008
    ..Thus, c-Rel plays a critical role in regulating the innate inflammatory response to microflora within the lower bowel, likely through its ability to modulate expression of IL-12/23 family members...
  76. pmc DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
    Lisiane B Meira
    Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 118:2516-25. 2008
    ..These data demonstrate that the repair of DNA lesions formed by RONS during chronic inflammation is important for protection against colon carcinogenesis...
  77. pmc Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice
    Chung Wei Lee
    Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 68:3540-8. 2008
    ..pylori eradication prevented gastric cancer to the greatest extent when antibiotics are given at an early point of infection, but that eradication therapy given at a later time point delayed the development of severe dysplastic lesions...
  78. pmc Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse
    Claude M Nagamine
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Infect Immun 76:2758-66. 2008
    ..5% versus 1.7%, respectively). The data suggest that H. hepaticus, which is present in many research colonies, promotes colon tumorigenesis in the BALB-RagMin mouse and that it has the potential to confound colon tumorigenesis studies...
  79. pmc Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-a
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave 16 825, Cambridge, MA 02139, USA
    Infect Immun 76:1866-76. 2008
    ..The use of AB6F1 and B6AF1 mice, as well as genetically engineered mice, on a C57BL/6 background will allow studies investigating the role of chronic microbial hepatitis and steatohepatitis in the pathogenesis of liver cancer...
  80. pmc Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy
    Chung Wei Lee
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 122:1068-76. 2008
    ..pylori-induced premalignant gastric lesions. In addition, less severe gastric lesions in H.pylori infected gulo(-/-) mice supplemented with low vitamin C correlated with an attenuated Th1 inflammatory response...
  81. doi request reprint Intravenous Shiga toxin 2 promotes enteritis and renal injury characterized by polymorphonuclear leukocyte infiltration and thrombosis in Dutch Belted rabbits
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave 16 873, Cambridge, MA 02139, USA
    Microbes Infect 10:650-6. 2008
    ..04), and tissue plasminogen activator (P<0.05). Circulating Stx2 promoted dose-dependent enteritis and renal injury characterized by inflammation and impaired fibrinolysis leading to thrombosis...
  82. pmc Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building Rm 226, Worcester, MA 01605, USA
    Infect Immun 75:471-80. 2007
    ..Our studies suggest that TFF2 not only controls gastrointestinal repair but also regulates mononuclear cell inflammatory responses...
  83. ncbi request reprint Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B
    Michal F Tomczak
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:7332-9. 2006
    ..These results suggest that the absence of the p50/p105 subunit of NF-kappaB within hemopoietic cells of the innate immune system interferes with the ability of IL-10 to suppress inflammatory gene expression and Hh-induced colitis...
  84. ncbi request reprint Natural and experimental Helicobacter infections
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Comp Med 54:128-58. 2004
    ..Current recommendations for deriving and managing helicobacter-free animal colonies for research are provided...
  85. pmc Spatial distribution and stability of the eight microbial species of the altered schaedler flora in the mouse gastrointestinal tract
    Ramahi B Sarma-Rupavtarm
    Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Appl Environ Microbiol 70:2791-800. 2004
    ....
  86. pmc In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants
    Vincent B Young
    Department of Microbiology and Molecular Genetics, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Infect Immun 72:2521-7. 2004
    ..However, a CDT-negative H. hepaticus mutant had a significantly diminished capacity to induce lesions in this murine model of inflammatory bowel disease...
  87. ncbi request reprint Isolation and characterization of novel Helicobacter spp. from the gastric mucosa of harp seals Phoca groenlandica
    Claudia G Harper
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16, Room 825C, Cambridge, Massachusetts 02139, USA
    Dis Aquat Organ 57:1-9. 2003
    ..may play a role in the etiopathogenesis of gastrointestinal diseases in pinnipeds. To our knowledge, this represents the first isolation and characterization of a novel Helicobacter spp. from pinnipeds...
  88. pmc Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15830-5. 2003
    ....
  89. ncbi request reprint NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40
    Michal F Tomczak
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 171:1484-92. 2003
    ..These results suggest that inhibition of H. hepaticus-induced IL-12 p40 expression by NF-kappaB subunits is critical to preventing colonic inflammation in response to inflammatory microflora...
  90. pmc Comparison of diagnostic techniques for Helicobacter cetorum infection in wild Atlantic bottlenose dolphins (Tursiops truncatus)
    Claudia G Harper
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 41:2842-8. 2003
    ..cetorum, and results indicate there is at least a 50% prevalence of H. cetorum infection in these dolphins...
  91. pmc The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:7901-6. 2003
    ....
  92. ncbi request reprint Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Gastroenterology 124:1879-90. 2003
    ..We examined the effects of an H. pylori cancer-associated determinant (cagE), IL-1beta, and host gender in a transgenic hypergastrinemic (INS-GAS) murine model of gastric carcinogenesis...
  93. ncbi request reprint Helicobacter pylori infection and high dietary salt independently induce atrophic gastritis and intestinal metaplasia in commercially available outbred Mongolian gerbils
    Ingrid L Bergin
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Dig Dis Sci 48:475-85. 2003
    ..pylori-infected animals, these lesions were present without concurrent gastric inflammation. The outbred Mongolian gerbil therefore provides an excellent animal model for the study of several gastric cancer risk factors...
  94. ncbi request reprint A naturally occurring rabbit model of enterohemorrhagic Escherichia coli-induced disease
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Infect Dis 186:1682-6. 2002
    ..Our findings provide evidence for a naturally occurring animal model of EHEC-induced systemic disease that closely resembles human HUS...
  95. ncbi request reprint Gastric cancer: laboratory bench to clinic
    JeanMarie Houghton
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical Center, NRB Second Floor, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Gastroenterol Hepatol 17:495-502. 2002
    ..Identifying potentially removable factors (in addition to H. pylori infection) in the acquisition and progression of neoplastic disease may provide targets for early intervention and prevention strategies...
  96. ncbi request reprint Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pylori
    Sebastian Suerbaum
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Germany
    Int J Syst Evol Microbiol 52:437-9. 2002
    ..nemestrinae ATCC 49396T is really a strain of H. pylori and that H. nemestrinae Bronsdon et al. 1991 is a junior heterotypic synonym of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989...
  97. pmc Identification of novel Helicobacter spp. from a beluga whale
    Claudia M G Harper
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Appl Environ Microbiol 68:2040-3. 2002
    ..Esophageal and forestomach ulcers were noted on endoscopy. This is the first report of novel Helicobacter spp. being identified from whales...
  98. ncbi request reprint Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin
    Marina Aspholm-Hurtig
    Department of Odontology, Section of Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 305:519-22. 2004
    ....
  99. ncbi request reprint Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice
    Sachiyo Nomura
    Nashville VA Medical Center and the Department of Surgery, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Tennessee, USA
    Gastroenterology 127:582-94. 2004
    ..To examine the relationship of SPEM to the neoplastic process in the H. felis -infected C57BL/6 mouse, we have now studied the association of SPEM-related transcripts with preneoplasia...
  100. ncbi request reprint Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections
    Calin Stoicov
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 173:3329-36. 2004
    ..These data demonstrate the profound interactions between the immune response to unrelated organisms, and suggest these types of interactions my impact clinical disease...
  101. ncbi request reprint Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 66:7395-400. 2006
    ..The possibility that dysregulated gut microbial infections in humans may lead to cancer in anatomically distant organs, such as breast, highlights the need for novel immune-based strategies in cancer prevention and treatment...

Research Grants41

  1. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  2. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  3. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  4. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  5. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2007
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  6. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2007
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. ..
  7. BIOMEDICAL RESEARCH TRAINING FOR VETERINARY SCIENTISTS
    James Fox; Fiscal Year: 2007
    ..These students will spend a summer in the same research environment in which the postdoctoral fellows conduct their research. ..
  8. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2004
    ....
  9. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 1999
    ..Thirdly, the choice of virulence factors ot be tested in vivo will in part be determined by in vitro assays as well as screening H. pylori isogenic mutants in a mouse model, recently developed in our laboratory. ..
  10. HELIOBACTER INDUCED HEPATITIS AND TUMORIGENESIS
    James Fox; Fiscal Year: 2003
    ..hepaticus at different stages of infection. ..