Research Topics
Species | J P FormanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Effect of vitamin D supplementation on blood pressure in blacksJohn P Forman
Renal Division and Kidney Clinical Research Institute, Brigham and Women s Hospital, 41 Ave Louis Pasteur, Suite 120, Boston, MA 02115, USA
Hypertension 61:779-85. 2013....- Association between sodium intake and change in uric acid, urine albumin excretion, and the risk of developing hypertensionJohn P Forman
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circulation 125:3108-16. 2012.... 
Diabetes and lipid screening among patients in primary care: a cohort studySheryl L Rifas-Shiman
Obesity Prevention Program, Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, 133 Brookline Avenue, 6th Floor, Boston, Massachusetts 02215, USA
BMC Health Serv Res 8:25. 2008..Data on compliance with these guidelines are scarce. The purpose of this study was to assess rates of diabetes and lipid screening in primary care according to demographic variables and weight status...- Urinary melatonin and risk of incident hypertension among young womenJohn P Forman
Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Hypertens 28:446-51. 2010..However, whether lower physiologic levels of melatonin are an independent risk factor for the development of hypertension has never been reported... - Higher levels of albuminuria within the normal range predict incident hypertensionJohn P Forman
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 19:1983-8. 2008..The definition of normal albumin excretion should be reevaluated... 
Renin-angiotensin system polymorphisms and risk of hypertension: influence of environmental factorsJohn P Forman
Renal Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Clin Hypertens (Greenwich) 10:459-66. 2008..These data suggest that demographic and dietary factors may influence the associations between RAS polymorphisms and hypertension and could explain heterogeneity in prior studies...- Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humansJohn P Forman
Renal Division and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Hypertension 55:1283-8. 2010..These data suggest that low plasma 25-hydroxyvitamin D levels may result in upregulation of the RAS in otherwise healthy humans... - Plasma uric acid level and risk for incident hypertension among menJohn P Forman
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Am Soc Nephrol 18:287-92. 2007..24; 95% CI 0.93 to 1.66). In conclusion, no independent association between UA level and risk for incident hypertension was found among older men... - Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young womenJohn P Forman
Department of Medicine, Renal Division and Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachussetts, USA
Hypertension 52:828-32. 2008..7% of the study population) had a multivariable odds ratio of 1.47 (95% CI: 1.10 to 1.97). Plasma 25(OH)D levels are inversely and independently associated with the risk of developing hypertension... - Fructose and vitamin C intake do not influence risk for developing hypertensionJohn P Forman
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 3rd Floor, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 20:863-71. 2009..02 (0.91 to 1.14) in Nurses' Health Study 2, and 1.06 (0.97 to 1.15) in Health Professionals Follow-up Study. In conclusion, fructose and vitamin C intake do not substantially influence the risk for developing hypertension... - Uric acid and insulin sensitivity and risk of incident hypertensionJohn P Forman
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 169:155-62. 2009..Corresponding circulating biomarkers are associated with risk of hypertension, but because these factors may be interrelated, whether they independently affect risk is unknown... - Diet and lifestyle risk factors associated with incident hypertension in womenJohn P Forman
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
JAMA 302:401-11. 2009..Hypertension is an important preventable risk factor for death among women. While several modifiable risk factors have been identified, their combined risk and distribution in the population have not been assessed... - Plasma 25-hydroxyvitamin D levels and risk of incident hypertensionJohn P Forman
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hypertension 49:1063-9. 2007..31 (95% CI: 2.03 to 2.63) in men and 1.57 (95% CI: 1.44 to 1.72) in women. Plasma 25(OH)D levels are inversely associated with risk of incident hypertension... - Racial differences in renal vascular response to angiotensin blockade with captopril or candesartanJohn P Forman
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Hypertens 25:877-82. 2007..We compared the renal vascular response to captopril and candesartan among nondiabetic, normotensive black and white participants to explore angiotensin-converting enzyme-independent generation of angiotensin II... - Folate intake and the risk of incident hypertension among US womenJohn P Forman
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
JAMA 293:320-9. 2005..Folate has important beneficial effects on endothelial function, but there is limited information about folate intake and risk of incident hypertension... - Non-narcotic analgesic dose and risk of incident hypertension in US womenJohn P Forman
Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Hypertension 46:500-7. 2005..Because acetaminophen and nonsteroidal anti-inflammatory drugs are commonly used, they may contribute to the high prevalence of hypertension in the United States... - Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studiesJohn P Forman
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Hypertension 46:676-82. 2005..We conclude that higher intake of vitamin D is not associated with a lower risk of incident hypertension... - 'Hypertension' and 'microalbuminuria': the bell tolls for theeJ P Forman
Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 69:22-8. 2006..We propose that the medical community consider abandoning the terms 'hypertension' and 'microalbuminuria' in favor of 'blood pressure-associated' and 'albuminuria-associated' disease... - Frequency of analgesic use and risk of hypertension among menJohn P Forman
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 167:394-9. 2007..To our knowledge, the association between the use of these analgesics, particularly acetaminophen, and the risk of hypertension among men has not been extensively studied... - Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertensionA Vaidya
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
J Hum Hypertens 25:672-8. 2011..Future studies to evaluate the effect of vitamin D supplementation on vascular RAS activity in obesity are needed... - Genetic polymorphisms and the risk of accelerated renal function decline in womenCynthia Cooper Worobey
Renal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 4:e4787. 2009..Reduced glomerular filtration rate is an important predictor of cardiovascular disease and death. Genetic polymorphisms, particularly in genes involved in the renin-angiotensin system (RAS), may influence the rate of renal function decline... - Physical activity and albuminuriaEmily S Robinson
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women sHospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Epidemiol 171:515-21. 2010..61 (95% CI: 0.37, 0.99), and for those in the highest quintile of walking compared with the lowest quintile, it was 0.69 (95% CI: 0.47, 1.02). Greater physical activity is associated with a lower ACR in nondiabetic women... - Plasma resistin levels associate with risk for hypertension among nondiabetic womenLuxia Zhang
Channing Laboratory, Department of Medicine, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 21:1185-91. 2010..In conclusion, higher plasma resistin levels independently associate with an increased risk for incident hypertension among women without diabetes... - The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertensionAnand Vaidya
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Clin Endocrinol (Oxf) 74:294-9. 2011..Both resistin and vitamin D have been associated with the renin-angiotensin-aldosterone system (RAAS). We investigated the association between resistin and the RAAS, and resistin and vitamin D under controlled dietary sodium conditions... - Primary care management of chronic kidney diseaseAdrienne S Allen
Division of General Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Gen Intern Med 26:386-92. 2011..Chronic kidney disease (CKD) causes substantial morbidity and mortality; however, there are limited data to comprehensively assess quality of care in this area... - Determinants of plasma parathyroid hormone levels in young womenJulie M Paik
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 5th Floor, 181 Longwood Avenue, Boston, MA, 02115, USA
Calcif Tissue Int 87:211-7. 2010..Additional research is needed to elucidate the mechanisms whereby smoking, vitamin A, and phosphorus affect PTH and to examine how body size and season may affect PTH independent of 25(OH)D... - Sugar-sweetened beverages and chronic diseaseGary C Curhan
Channing Laboratory and Renal Division, Department of Medicine, Boston, Massachusetts 02115, USA
Kidney Int 77:569-70. 2010..Nevertheless, given their demonstrated adverse health associations and the lack of any health benefit, the evidence favors minimization of sugar-sweetened beverage intake... - Plasma prolactin level and risk of incident hypertension in postmenopausal womenLuxia Zhang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Hypertens 28:1400-5. 2010..Laboratory and cross-sectional human studies suggest a potential role for prolactin in the pathogenesis of hypertension; however, the prospective association between prolactin and hypertension has not been previously reported... - Diet-dependent net acid load and risk of incident hypertension in United States womenLuxia Zhang
Channing Laboratory Renal Division, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
Hypertension 54:751-5. 2009..In conclusion, a high diet-dependent net acid load is independently associated with a higher risk of incident hypertension... - Post-menopausal hormone use and albuminuriaEmily L Schopick
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Nephrol Dial Transplant 24:3739-44. 2009..Post-menopausal hormone use may influence the renin-angiotensin system and renal endothelial function, impacting albumin excretion. The association between post-menopausal hormone use and albuminuria is not well defined... - Serum anion gap and blood pressure in the national health and nutrition examination surveyEric N Taylor
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hypertension 50:320-4. 2007..73 m(2). The anion gap is independently associated with higher blood pressure. Further research is needed to elucidate the relation between organic acid and hypertension... - Parathyroid hormone and the risk of incident hypertensionEric N Taylor
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Hypertens 26:1390-4. 2008..We conducted a prospective study to examine the association between plasma intact parathyroid hormone levels and the subsequent risk of developing hypertension... - Risk of target lesion revascularization after coronary stenting in patients with and without chronic kidney diseaseDavid Charytan
Department of Medicine, Brigham and Women s Hospital, Renal Division, Clinical Biometrics, 1 Brigham Circle, 3rd Floor, Boston, MA 02115, USA
Nephrol Dial Transplant 22:2578-85. 2007..Whether mild to moderate chronic kidney disease (CKD) is associated with a similarly increased need for short or long-term target lesion revascularization (TLR) following coronary stenting is uncertain... - Significance of anticardiolipin antibodies on short and long term allograft survival and function following kidney transplantationJohn P Forman
Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Am J Transplant 4:1786-91. 2004..A positive ACA titer prior to kidney transplantation was not associated with inferior renal outcomes after transplantation, although more research is required to address the prognostic significance of very high ACA titers... - Association of prevalent hypertension with 24-hour urinary excretion of calcium, citrate, and other factorsEric N Taylor
Renal Division, Department of Medicine, Brigham Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Kidney Dis 47:780-9. 2006..It has been proposed that increased urinary calcium excretion is a central feature of essential hypertension. Metabolic acidosis also may be associated with hypertension and decreases urinary citrate levels... - Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospitalBenjamin D Humphreys
Department of Medicine, Renal Division, Brigham and Women s Hospital, Boston, MA, USA
Am J Kidney Dis 46:143-6. 2005.... - Vitamin C intake and serum uric acid concentration in menXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA
J Rheumatol 35:1853-8. 2008..We examined associations between vitamin C intake and serum uric acid in men in a population-based study... - Dietary fatty acids and the risk of hypertension in middle-aged and older womenLu Wang
900 Commonwealth Ave East, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Hypertension 56:598-604. 2010.... - Hepatitis C, acute humoral rejection, and renal allograft survivalJohn P Forman
Department of Medicine, Brigham and Women's Hospital/Renal Division, 75 Francis Street, MRB-4, Boston, MA 02115, USA
J Am Soc Nephrol 15:3249-55. 2004..After adjusting for these confounding factors, the association between HCV Ab positivity and renal allograft loss was notably attenuated and no longer statistically significant... - CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivoAkira Yamada
Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:1357-64. 2005..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory... - Hemofiltration and the prevention of radiocontrast-agent-induced nephropathyJohn P Forman
N Engl J Med 350:836-8; author reply 836-8. 2004
Research Grants
- Folic Acid Intake and Risk of HypertensionJohn Forman; Fiscal Year: 2004..Subsequently, the risk of hypertension will be analyzed in > 2000 men and women genotyped for eNOS, and > 7000 men and women genotyped for MTHFR. Interaction with folate will be analyzed. ..
- Novel Risk Factors For HypertensionJohn Forman; Fiscal Year: 2007..D., Sc.D., a well-known epidemiologist with an interest in HTN. This project proposal will provide the foundation for the candidate's future career as an independent and successful clinical scientist in HTN research. (End of Abstract) ..