C D M Fletcher

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Distinctive soft tissue tumors of the head and neck
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mod Pathol 15:324-30. 2002
  2. ncbi The evolving classification of soft tissue tumours: an update based on the new WHO classification
    C D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Histopathology 48:3-12. 2006
  3. ncbi Undifferentiated sarcomas: what to do? And does it matter? A surgical pathology perspective
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ultrastruct Pathol 32:31-6. 2008
  4. ncbi Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors
    W B Ou
    1Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 27:5624-34. 2008
  5. ncbi Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors
    Chandrajit P Raut
    Department of Surgery, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 24:2325-31. 2006
  6. ncbi The role of KIT in the management of patients with gastrointestinal stromal tumors
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital Boston, MA 02115, USA
    Hum Pathol 38:679-87. 2007
  7. ncbi Heterogeneity of kinase inhibitor resistance mechanisms in GIST
    B Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Pathol 216:64-74. 2008
  8. ncbi Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas
    John V Heymach
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
    Clin Cancer Res 10:5732-40. 2004
  9. ncbi Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component--is this dedifferentiated SFT?
    Juan Miguel Mosquera
    Department of Pathology, University Medical Group, Providence, RI, USA
    Am J Surg Pathol 33:1314-21. 2009
  10. ncbi Diagnosis of gastrointestinal stromal tumors: A consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston MA 02115, USA
    Hum Pathol 33:459-65. 2002

Detail Information

Publications93

  1. ncbi Distinctive soft tissue tumors of the head and neck
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mod Pathol 15:324-30. 2002
    ....
  2. ncbi The evolving classification of soft tissue tumours: an update based on the new WHO classification
    C D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Histopathology 48:3-12. 2006
    ....
  3. ncbi Undifferentiated sarcomas: what to do? And does it matter? A surgical pathology perspective
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ultrastruct Pathol 32:31-6. 2008
  4. ncbi Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors
    W B Ou
    1Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 27:5624-34. 2008
    ..These novel findings highlight that PKCtheta warrants clinical evaluation as a potential therapeutic target in GISTs, including those cases containing mutations that confer resistance to KIT/PDGFRA kinase inhibitors...
  5. ncbi Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors
    Chandrajit P Raut
    Department of Surgery, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 24:2325-31. 2006
    ..Surgery has little to offer in the setting of generalized progression...
  6. ncbi The role of KIT in the management of patients with gastrointestinal stromal tumors
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital Boston, MA 02115, USA
    Hum Pathol 38:679-87. 2007
    ..This review examines the role of KIT in the diagnosis and management of patients with GIST...
  7. ncbi Heterogeneity of kinase inhibitor resistance mechanisms in GIST
    B Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Pathol 216:64-74. 2008
    ..Our observations underscore the heterogeneity of clinical TKI resistance, and highlight the therapeutic challenges involved in salvaging patients after clinical progression on TKI monotherapies...
  8. ncbi Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas
    John V Heymach
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
    Clin Cancer Res 10:5732-40. 2004
    ..Correlative studies suggest that VEGF receptor or KIT inhibition was incomplete in at least some cases, providing a possible explanation for the observed lack of activity...
  9. ncbi Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component--is this dedifferentiated SFT?
    Juan Miguel Mosquera
    Department of Pathology, University Medical Group, Providence, RI, USA
    Am J Surg Pathol 33:1314-21. 2009
    ..The p53 and p16 overexpression in the high-grade component is common as in other dedifferentiated lesions, perhaps pertaining to the underlying molecular mechanism...
  10. ncbi Diagnosis of gastrointestinal stromal tumors: A consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston MA 02115, USA
    Hum Pathol 33:459-65. 2002
    ....
  11. ncbi Synovial sarcoma in older patients: clinicopathological analysis of 32 cases with emphasis on unusual histological features
    J A Chan
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Histopathology 43:72-83. 2003
    ..Despite inevitable bias in consultation material, it seems that these cases, when compared with younger age groups, more often show poorly differentiated histology and more often develop at unusual locations...
  12. ncbi Distinctive cytogenetic profile in benign metastasizing leiomyoma: pathogenetic implications
    Marisa R Nucci
    Department of Pathology, Divisions of Women s and Perinatal Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 31:737-43. 2007
    ....
  13. ncbi Soft tissue aneurysmal bone cyst: a clinicopathologic study of five cases
    G Petur Nielsen
    James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Surg Pathol 26:64-9. 2002
    ..Soft tissue aneurysmal bone cyst is an uncommon benign tumor that can be treated by simple excision, and it should be distinguished from a variety of other reactive and neoplastic processes...
  14. ncbi Current management of metastatic gastrointestinal stromal tumor: a case report
    Suzanne George
    Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Adv Hematol Oncol 1:63-4; discussion 65. 2003
  15. ncbi Primary pleuropulmonary synovial sarcoma: reappraisal of a recently described anatomic subset
    Lydia R Essary
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 94:459-69. 2002
    ..Its clinical behavior appears more aggressive, perhaps because of relatively later presentation combined with the difficulty in obtaining a wide surgical margin...
  16. ncbi Molecular correlates of imatinib resistance in gastrointestinal stromal tumors
    Michael C Heinrich
    Division of Hematology Oncology, Department of Pathology, Oregon Health and Science University Cancer Institute, Oregon Health and Science University, Portland, OR, USA
    J Clin Oncol 24:4764-74. 2006
    ..In clinical studies, 75% to 90% of patients with advanced GISTs experience clinical benefit from imatinib. However, imatinib resistance is an increasing clinical problem...
  17. ncbi Predictive value of FIGO and AJCC staging systems in patients with uterine leiomyosarcoma
    Chandrajit P Raut
    Department of Surgery, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States
    Eur J Cancer 45:2818-24. 2009
    ..Neither has been validated in ULMS. We critically evaluated both systems to determine if either identified patient groups with distinct outcomes...
  18. ncbi Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure
    George D Demetri
    Center for Sarcoma and Bone Oncology, Ludwig Center at Dana Farber Harvard Cancer Center, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 15:5902-9. 2009
    ....
  19. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 32-2004. A 68-year-old man with a large retroperitoneal mass
    George D Demetri
    Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, USA
    N Engl J Med 351:1779-87. 2004
  20. ncbi Diagnosis of gastrointestinal stromal tumors: a consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston MA 02115, USA
    Int J Surg Pathol 10:81-9. 2002
    ....
  21. ncbi Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate
    Chandrajit P Raut
    Department of Surgery, Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 17:407-15. 2010
    ..Impact of surgery in IM-resistant patients on second-line sunitinib (SU) is unknown...
  22. ncbi ALK expression in pseudosarcomatous myofibroblastic proliferations of the genitourinary tract
    M S Hirsch
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Histopathology 48:569-78. 2006
    ..The aim of this study was to characterize further the clinicopathological features of these lesions and to examine their relationship to inflammatory myofibroblastic tumour (IMT)...
  23. ncbi Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 32:493-501. 2008
    ..Sclerosing PEComas seem to pursue an indolent clinical course, unless associated with a frankly malignant component. Long-term follow-up will be required to confirm these findings...
  24. ncbi KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications
    Fabiola Medeiros
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 28:889-94. 2004
    ..Notably, some KIT-negative GISTs contain imatinib-sensitive KIT or PDGFRA mutations; therefore, patients with KIT-negative GISTs should not, a priori, be denied imatinib therapy...
  25. ncbi Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors
    Samuel Singer
    Department of Pathology and Surgery, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Oncol 20:3898-905. 2002
    ..The aim of this study was to evaluate the prognostic relevance for KIT mutations in a series of GISTs in which the mutations were evaluated intensively by genomic and cDNA sequencing...
  26. ncbi Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria
    Adrian Mariño-Enríquez
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 34:1122-31. 2010
    ..The available clinical and molecular data support the notion of "homologous" lipoblastic differentiation in dedifferentiated LPS, rather than mixed-type LPS...
  27. ncbi Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    George D Demetri
    Dana-Farber Cancer Institute and Harvard Cancer Center, Boston, MA 02115, USA
    N Engl J Med 347:472-80. 2002
    ..Inhibition of the KIT signal-transduction pathway is a promising treatment for advanced gastrointestinal stromal tumors, which resist conventional chemotherapy...
  28. ncbi Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 32:354-62. 2008
    ..Similar to the cellular, aneurysmal, and atypical variants of FH, deep FH recurs in approximately 20% of cases and may rarely metastasize...
  29. ncbi Immunohistochemistry for beta-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature
    J W Carlson
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Histopathology 51:509-14. 2007
    ..This study aimed to define the prevalence of beta-catenin positivity in desmoid tumours and other morphologically similar spindle cell neoplasms...
  30. ncbi Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases
    Mark R Carter
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 30:300-9. 2006
    ..Purely spindled/sarcomatoid tumors have a significantly lower rate of nodal metastases than conventional ductal and lobular breast carcinomas...
  31. ncbi Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:1813-24. 2007
    ..Despite the relative rarity of carcinomas in the pediatric population, myoepithelial carcinoma seems to be disproportionately common among children and often has an aggressive clinical course...
  32. ncbi Primary cutaneous PEComa: distinctive clear cell lesions of skin
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 32:608-14. 2008
    ..Primary cutaneous PEComas are rare and thus far apparently benign cutaneous tumors. Accurate recognition of this entity is essential because of potential misdiagnosis as malignant tumors, especially malignant melanoma...
  33. ncbi Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases
    Eleanor Chen
    Department of Pathology, Brigham and Women s Hospital, Harvard University Medical School, Boston, MA, USA
    Am J Surg Pathol 34:707-14. 2010
    ..Overexpression of p16 in the atypical cells and sarcomatous component suggests a possible underlying molecular mechanism...
  34. ncbi Myxoid dermatofibrosarcoma protuberans: a rare variant analyzed in a series of 23 cases
    Julie D R Reimann
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:1371-7. 2007
    ..In summary, these low-grade lesions are clinically similar to typical DFSP, but their unusual morphology is easily confused with a variety of other tumor types...
  35. ncbi Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases
    Alessandra F Nascimento
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 31:99-105. 2007
    ..Its natural history seems more aggressive than usual high-grade MFS, with approximately 70% local recurrence and 50% metastases, even within a relatively short follow-up period...
  36. ncbi Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:437-46. 2009
    ..DOG1.1 is also a sensitive marker for unusual GIST subgroups lacking KIT or PDGFRA mutations. In tumors that are negative for both KIT and DOG1.1, mutational screening may be required to confirm the diagnosis of GIST...
  37. ncbi Criteria for malignancy in nonvisceral smooth muscle tumors
    Jason L Hornick
    Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
    Ann Diagn Pathol 7:60-6. 2003
    ..Distinct criteria for assessing malignancy should be applied to smooth muscle tumors at each of these locations...
  38. ncbi Spindle cell rhabdomyosarcoma in adults
    Alessandra F Nascimento
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:1106-13. 2005
    ..Specifically, it appears to be most common in the head and neck region, and although only limited follow-up is available so far, these lesions appear to have a more aggressive clinical course in adults...
  39. ncbi PDGFRA activating mutations in gastrointestinal stromal tumors
    Michael C Heinrich
    Department of Medicine, Department of Pathology, Oregon Health and Science University Cancer Institute and Portland VA Medical Center, Portland, OR 97201, USA
    Science 299:708-10. 2003
    ..Thus, KIT and PDGFRA mutations appear to be alternative and mutually exclusive oncogenic mechanisms in GISTs...
  40. ncbi Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution
    Jason L Hornick
    Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
    Am J Clin Pathol 117:188-93. 2002
    ..Since treatment eligibility for selective tyrosine kinase inhibitors such as STI571 hinges on positive immunostaining, standardization and reproducibility of meaningful results are critically important...
  41. ncbi Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:542-50. 2009
    ..Immunostaining for INI1 can be used to confirm the diagnosis of ES in the appropriate context. Loss of INI1 expression may also be helpful to distinguish epithelioid MPNST from metastatic melanoma in a subset of cases...
  42. ncbi Ischemic fasciitis: analysis of 44 cases indicating an inconsistent association with immobility or debilitation
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 32:1546-52. 2008
    ..Recognition of this distinct entity as a reactive process, by no means always associated with debilitation, is essential to avoid confusion with soft tissue sarcomas...
  43. ncbi Gastrointestinal stromal tumors
    Bernadette Liegl-Atzwanger
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Virchows Arch 456:111-27. 2010
    ..This review focuses on GIST pathogenesis, morphologic evaluation, promising new immunohistochemical markers, risk assessment, the role of molecular analysis, and the increasing problem of secondary imatinib resistance and its mechanisms...
  44. ncbi Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after tyrosine kinase inhibitor therapy: a novel form of tumor progression
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:218-26. 2009
    ..The rhabdomyoblastic differentiation can represent a diagnostic pitfall. The molecular mechanisms for this form of TKI-resistant clonal evolution remain to be determined...
  45. ncbi Malignant myopericytoma: expanding the spectrum of tumours with myopericytic differentiation
    M E McMenamin
    Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
    Histopathology 41:450-60. 2002
    ..Available data indicate that malignant myopericytomas are associated with aggressive clinical behaviour...
  46. ncbi PEComa: what do we know so far?
    J L Hornick
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Histopathology 48:75-82. 2006
    ..This review examines the members of the PEComa family, with an emphasis on lesions arising outside of the kidney, lung and liver, and discusses preliminary evidence for pathological features that might predict malignant behaviour...
  47. ncbi KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance
    M J Zhu
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Oncogene 26:6386-95. 2007
    ....
  48. ncbi Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity
    T-J Browne
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Histopathology 48:453-61. 2006
    ....
  49. ncbi Insulin receptor activation in solitary fibrous tumours
    Y Li
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Pathol 211:550-4. 2007
    ..The aetiological relevance of IGF-2 is supported by expression of IR-A, the IR isoform with high affinity for IGF-2, in all SFTs. Our studies suggest that IR activation plays an oncogenic role in SFTs...
  50. ncbi Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas
    Cheryl M Coffin
    Department of Pathology, Primary Children s Medical Center and University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Surg Pathol 31:410-6. 2007
    ..The proportion of sporadic GAFs that have APC mutation remains to be determined...
  51. ncbi Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases
    Cheryl M Coffin
    Department of Pathology, Division of Pediatric Pathology, University of Utah School of Medicine, Primary Children s Medical Center, Salt Lake City, UT 84113, USA
    Am J Surg Pathol 31:509-20. 2007
    ..Other proliferative, apoptotic, and prognostic markers did not correlate well with morphology or outcome. Thus, ALK reactivity may be a favorable prognostic indicator in IMT and abdominopelvic IMTs recur more frequently...
  52. ncbi Meningothelial proliferations in mature cystic teratoma of the ovary: evidence for the common presence of cranially derived tissues paralleling anterior embryonic plate development. An analysis of 25 consecutive cases
    Eleanor Chen
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 34:1014-8. 2010
    ....
  53. ncbi Calcifying fibrous 'pseudotumor': clinicopathologic study of 15 cases and analysis of its relationship to inflammatory myofibroblastic tumor
    Alessandra F Nascimento
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Surg Pathol 10:189-96. 2002
    ..quot; There is no convincing evidence to support an association between CFP and IMT...
  54. ncbi Cellular neurothekeoma: detailed characterization in a series of 133 cases
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 31:329-40. 2007
    ..Atypical histologic features (including pleomorphism, infiltration of subcutis, and a high mitotic rate) seem to have no clinical significance...
  55. ncbi The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas
    Alessandra F Nascimento
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 31:1363-70. 2007
    ..Differentiation between neurofibroma and schwannoma in cases with overlapping cytoarchitectural features should not be based solely on the presence or absence of NFP-positive axons within a given tumor...
  56. ncbi Angiosarcoma arising in hemangioma/vascular malformation: report of four cases and review of the literature
    Sabrina Rossi
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA
    Am J Surg Pathol 26:1319-29. 2002
    ..All cases were positive for at least two endothelial markers (CD31, CD34, VWF) and negative for the epithelial markers (EMA, AE1/AE3, Pan-keratin). Possible mechanisms for this exceptional phenomenon are discussed...
  57. ncbi Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features
    Jason L Hornick
    Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:845-58. 2005
    ..Atypical histologic features (including scattered pleomorphic cells and infiltrative margins) seem to have no clinical significance and appear to be akin to those seen in ancient schwannoma and atypical (bizarre) neurofibroma...
  58. ncbi Microcystic/reticular schwannoma: a distinct variant with predilection for visceral locations
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 32:1080-7. 2008
    ..Recognition of this distinct entity is essential to avoid confusion with malignant tumors, especially in the gastrointestinal and upper respiratory tracts...
  59. ncbi Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters
    Jason L Hornick
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 27:1183-96. 2003
    ..Although the majority of morphologically benign or low-grade myoepithelial neoplasms of soft tissue behave in a benign fashion, there is an approximate 20% risk for local recurrence...
  60. ncbi Sclerosing paraganglioma: report of 19 cases of an unusual variant of neuroendocrine tumor that may be mistaken for an aggressive malignant neoplasm
    Jose Antonio Plaza
    Department of Pathology, Ohio State University Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA
    Am J Surg Pathol 30:7-12. 2006
    ..Sclerosing paraganglioma should be included in the differential diagnosis of sclerosing lesions of the head and neck region and mediastinum. Appropriate immunohistochemical stains may be of aid for establishing the correct diagnosis...
  61. ncbi Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group
    Giovanni Tallini
    Department of Pathology, Yale University School of Medicine, New Haven, USA
    J Pathol 196:194-203. 2002
    ..They are associated with malignancy/tumour grade as well as with specific diagnoses in many cases, and can therefore be of potential value for tumour typing...
  62. ncbi Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 33:1554-61. 2009
    ..Hybrid schwannoma/perineuriomas have no evident association with neurofibromatosis and rarely recur. The pathogenetic basis of the dual pattern of differentiation in these lesions remains poorly understood at this time...
  63. ncbi Liposarcoma subtypes: identification with computed tomography and ultrasound-guided percutaneous needle biopsy
    Paul Nikolaidis
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur Radiol 15:383-9. 2005
    ..Although these data cannot be extrapolated to primary diagnosis of liposarcoma, they are important for screening and subtyping of possible recurrence...
  64. ncbi A multi-institutional survey of critical diagnoses (critical values) in surgical pathology and cytology
    Telma C Pereira
    Department of Pathology, Allegheny General Hospital, Drexel University College of Medicine, Pittsburgh, PA, USA
    Am J Clin Pathol 130:731-5. 2008
    ..A few respondents expressed concern about medicolegal implications. Based on the results of this survey, an ADASP committee has developed national guidelines for CDs (CVs) in surgical pathology and cytology...
  65. ncbi Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases
    Sebastien de Feraudy
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 34:1377-81. 2010
    ..In summary, intradermal nodular fasciitis occurs most commonly on the limbs and trunk of young adults, shows morphologic features similar to nodular fasciitis at conventional sites and should not be confused with sarcoma...
  66. ncbi Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic
    Alessandra F Nascimento
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 32:1896-904. 2008
    ..In this large series, there is no correlation between histologic grade and patient outcome, more in line with angiosarcomas at other sites...
  67. ncbi Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
    Anette Duensing
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Oncogene 23:3999-4006. 2004
    ....
  68. ncbi Reactive angioendotheliomatosis: a study of 15 cases demonstrating a wide clinicopathologic spectrum
    Mairin E McMenamin
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 26:685-97. 2002
    ..This study suggests that RAE has a broader clinicopathologic spectrum than previously described. The pathogenesis of this rare disorder is unknown, but it is likely that immunologic factors play a role...
  69. ncbi Distinctive dermal clear cell mesenchymal neoplasm: clinicopathologic analysis of five cases
    Alexander J F Lazar
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Dermatopathol 26:273-9. 2004
    ..These tumors appear to be mesenchymal in nature, but their precise line of differentiation is unknown. Recognition of these lesions is important to avoid confusion with better-known malignant neoplasms...
  70. ncbi Cutaneous epithelioid angiomatous nodule: a distinct lesion in the morphologic spectrum of epithelioid vascular tumors
    Thomas Brenn
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Dermatopathol 26:14-21. 2004
    ..It differs from conventional epithelioid hemangioma both in its clinical presentation with predominant involvement of trunk and extremities as well as its histologic features, which more closely resemble epithelioid angiosarcoma...
  71. ncbi Primitive nonneural granular cell tumors of skin: clinicopathologic analysis of 13 cases
    Alexander J F Lazar
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:927-34. 2005
    ..These cutaneous granular tumors do not appear to be neural or Schwannian in nature, but their precise line of differentiation is unknown...
  72. ncbi Atypical fibrous histiocytoma of the skin: clinicopathologic analysis of 59 cases with evidence of infrequent metastasis
    Steven Kaddu
    Department of Pathology, Brigham and Women's Hospital, Bosston, MA 02115, USA
    Am J Surg Pathol 26:35-46. 2002
    ..However, similar to the cellular and aneurysmal variants of fibrous histiocytoma, atypical fibrous histiocytoma shows a higher tendency to recur locally than ordinary fibrous histiocytoma and may rarely metastasize...
  73. ncbi Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033
    Charles D Blanke
    Oregon Health and Science University Cancer Institute, 3181 SW Sam Jackson Park Rd, L 586, Portland, OR 97239, USA
    J Clin Oncol 26:626-32. 2008
    ....
  74. ncbi Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    Michael C Heinrich
    R and D 19 3710 SW US Veterans Hospital Rd, Portland, OR 97207, USA
    J Clin Oncol 21:4342-9. 2003
    ..The relationship between mutations in these kinases and clinical response to imatinib was examined in a group of patients with advanced GIST...
  75. ncbi Soft tissue sarcomas of adults: state of the translational science
    Ernest C Borden
    The Cleveland Clinic Foundation, Cleveland, Ohio, 44195, USA
    Clin Cancer Res 9:1941-56. 2003
    ..Finally, multicenter, coordinated trials, such as those that occurred with assessment of imatinib mesylate in metastatic gastrointestinal stromal tumors, will assure the most rapid reductions in morbidity and mortality...
  76. ncbi Testing for KIT (CD117) in gastrointestinal stromal tumors: another HercepTest?
    Christopher D M Fletcher
    Appl Immunohistochem Mol Morphol 10:197-8. 2002
  77. ncbi Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 62:3980-4. 2002
    ..Furthermore, our results point to specific areas of the genome harboring genes that may influence the metastatic potential of sarcoma cells...
  78. ncbi Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma)
    Jo Van Dorpe
    Department of Pathology, , Leuven Catholic University, Minderbroederstraat 12, 3000 Leuven, Belgium
    Virchows Arch 440:485-90. 2002
    ....
  79. ncbi Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12)
    Anna Dahlén
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Am J Pathol 164:1645-53. 2004
    ....
  80. ncbi The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 40:218-28. 2004
    ..The results indicated that FUS/CREB3L2 is specifically associated with LGFMS and that RT-PCR or FISH analysis may be useful for the differential diagnosis...
  81. ncbi Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Lab Invest 85:408-15. 2005
    ..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion...
  82. ncbi Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978-2001: An analysis of 26,758 cases
    Jorge R Toro
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7231, USA
    Int J Cancer 119:2922-30. 2006
    ..Incidence patterns of STS varied markedly by histologic type, supporting the notion that these tumors may be etiologically distinct...
  83. ncbi NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)--update of the NCCN clinical practice guidelines
    George D Demetri
    J Natl Compr Canc Netw 5:S1-29; quiz S30. 2007
    ....
  84. ncbi Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT
    Charles D Blanke
    Oregon Health and Science University Cancer Center and Portland Veterans Affairs Hospital, Portland, OR, USA
    J Clin Oncol 26:620-5. 2008
    ..We conducted a long-term analysis of patients treated on the trial, including patients followed during an extension phase, to evaluate survival, patterns of failure, and potential prognostic factors, including tumor mutational status...
  85. ncbi Challenges in oncology. Case 4. Response of metastatic gastrointestinal stromal tumor including CNS involvement to imatinib mesylate (STI-571)
    B Jay Brooks
    Ochsner Clinic Foundation, Baton Rouge, LA, USA
    J Clin Oncol 20:870-2. 2002
  86. ncbi Molecular prognostication for soft tissue sarcomas: are we ready yet?
    Andre M Oliveira
    J Clin Oncol 22:4031-4. 2004
  87. ncbi Clinicopathologic correlations in gastrointestinal stromal tumors
    Christopher D M Fletcher
    Hum Pathol 33:455. 2002
  88. ncbi Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis
    Kay Savage
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 13:90-101. 2007
    ....
  89. ncbi Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 35:340-52. 2002
    ....
  90. ncbi Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia
    Clelia Tiziana Storlazzi
    Department of Clinical Genetics, Lund University Hospital, 221 85 Lund, Sweden
    Int J Oncol 23:67-71. 2003
    ..Furthermore, the present data strongly imply that it is the composition of the rings rather than the ring chromosome formation as such that causes the genetic instability and nuclear atypia frequently seen in ALTs...
  91. ncbi Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors
    Brian P Rubin
    Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Arch Pathol Lab Med 130:1616-29. 2006
  92. ncbi The significance of KIT (CD117) in gastrointestinal stromal tumors
    Jason L Hornick
    Int J Surg Pathol 12:93-7. 2004
  93. ncbi Congenital hand lesion
    Eduardo Calonje
    Department of Histopathology, St. John's Institute of Dermatology, St. Thomas' Hospital, London, United Kingdom
    Am J Dermatopathol 29:588-90. 2007