J A Fishman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Summary: future directions in antifungal therapy
    J A Fishman
    Harvard Medical School, Transplant Infectious Diseases and Compromised Host Program, Infectious Disease Division and Transplant Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Transpl Infect Dis 4:67-8. 2002
  2. doi request reprint Overview: cytomegalovirus and the herpesviruses in transplantation
    J A Fishman
    Transplant Infectious Disease and Compromised Host Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Transplant 13:1-8; quiz 8. 2013
  3. doi request reprint Transmission of infection with human allografts: essential considerations in donor screening
    Jay A Fishman
    Transplant Infectious Disease Program, Infectious Disease Division, MGH Transplantation Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Clin Infect Dis 55:720-7. 2012
  4. pmc Xenotransplantation-associated infectious risk: a WHO consultation
    Jay A Fishman
    Transplantation Infectious Disease and Compromised Host Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Xenotransplantation 19:72-81. 2012
  5. pmc Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
    Stanley I Martin
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Virol J 3:91. 2006
  6. doi request reprint Infections in immunocompromised hosts and organ transplant recipients: essentials
    Jay A Fishman
    Transplant Center, Transplant Infectious Disease and Compromised Host Service, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Liver Transpl 17:S34-7. 2011
  7. ncbi request reprint Xenotransplantation: infectious risk revisited
    Jay A Fishman
    Transplantation Infectious Disease and Compromised Host Program, Infectious Disease and Transplantation Units, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 4:1383-90. 2004
  8. ncbi request reprint Infection in renal transplant recipients
    Jay A Fishman
    Harvard Medical School, MGH Transplant Center, Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Nephrol 27:445-61. 2007
  9. ncbi request reprint Infection in solid-organ transplant recipients
    Jay A Fishman
    Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 357:2601-14. 2007
  10. ncbi request reprint Clinical cases in transplantation
    J A Fishman
    Harvard Medical School, Transplant Infectious Diseases and Compromised Host Program, Infectious Disease Division and Transplant Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Transpl Infect Dis 4:62-6. 2002

Detail Information

Publications76

  1. ncbi request reprint Summary: future directions in antifungal therapy
    J A Fishman
    Harvard Medical School, Transplant Infectious Diseases and Compromised Host Program, Infectious Disease Division and Transplant Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Transpl Infect Dis 4:67-8. 2002
    ..Preclinical studies and clinical trials will begin to identify candidate therapies for invasive fungal infections in transplantation...
  2. doi request reprint Overview: cytomegalovirus and the herpesviruses in transplantation
    J A Fishman
    Transplant Infectious Disease and Compromised Host Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Transplant 13:1-8; quiz 8. 2013
    ..The syndromes of EBV-associated posttransplant lymphoproliferative disorders (PTLD) and Kaposi's sarcoma remain important complications of immunosuppression. The epidemiology and essential biology of human herpesvirus is reviewed...
  3. doi request reprint Transmission of infection with human allografts: essential considerations in donor screening
    Jay A Fishman
    Transplant Infectious Disease Program, Infectious Disease Division, MGH Transplantation Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Clin Infect Dis 55:720-7. 2012
    ..Research is needed to define the optimal screening assays and the transmissibility of infection with allografts. Approaches are reviewed that may contribute to safety in allograft transplantation...
  4. pmc Xenotransplantation-associated infectious risk: a WHO consultation
    Jay A Fishman
    Transplantation Infectious Disease and Compromised Host Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Xenotransplantation 19:72-81. 2012
    ..This document summarizes approaches to disease surveillance in individual recipients of nonhuman tissues...
  5. pmc Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
    Stanley I Martin
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Virol J 3:91. 2006
    ..Infectious risk in xenotransplantation will be defined by the activity of PERV loci in vivo...
  6. doi request reprint Infections in immunocompromised hosts and organ transplant recipients: essentials
    Jay A Fishman
    Transplant Center, Transplant Infectious Disease and Compromised Host Service, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Liver Transpl 17:S34-7. 2011
    ..d Patients from endemic regions may have parasites (eg, Chagas disease and Leishmania)...
  7. ncbi request reprint Xenotransplantation: infectious risk revisited
    Jay A Fishman
    Transplantation Infectious Disease and Compromised Host Program, Infectious Disease and Transplantation Units, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 4:1383-90. 2004
    ..If immunologic hurdles can be overcome, it is reasonable to initiate carefully monitored clinical trials...
  8. ncbi request reprint Infection in renal transplant recipients
    Jay A Fishman
    Harvard Medical School, MGH Transplant Center, Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Nephrol 27:445-61. 2007
    ....
  9. ncbi request reprint Infection in solid-organ transplant recipients
    Jay A Fishman
    Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 357:2601-14. 2007
  10. ncbi request reprint Clinical cases in transplantation
    J A Fishman
    Harvard Medical School, Transplant Infectious Diseases and Compromised Host Program, Infectious Disease Division and Transplant Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Transpl Infect Dis 4:62-6. 2002
    ..These discussions by an expert panel serve to identify areas of controversy and for future research in the care of transplant recipients...
  11. ncbi request reprint Overview: fungal infections in the transplant patient
    J A Fishman
    Harvard Medical School, Transplant Infectious Diseases and Compromised Host Program, Infectious Disease Division, Transplant Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Transpl Infect Dis 4:3-11. 2002
    ..The absence of sensitive diagnostic tools and standardization of antifungal susceptibility testing for the filamentous fungi are identified as major impediments to care in this area...
  12. doi request reprint New technologies for infectious screening of organ donors
    J A Fishman
    Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Transplant Proc 43:2443-5. 2011
    ..Screening of organ donors for potential pathogens cannot completely exclude the risk of disease transmission. The process of donor screening must continue to evolve with advances in diagnostic technologies for infectious diseases...
  13. doi request reprint Organ and tissue safety workshop 2007: advances and challenges
    Jay A Fishman
    Transplant Infectious Disease Program, Massachusetts General Hospital, 55 Fruit Street, GRJ 504, Boston, MA 02114, USA
    Cell Tissue Bank 10:271-80. 2009
    ..Commitment of resources and improved coordination of efforts are required to develop essential tools to enhance safety for allograft recipients...
  14. ncbi request reprint Prevention of infection caused by Pneumocystis carinii in transplant recipients
    J A Fishman
    Infectious Disease Division and Transplantation Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Infect Dis 33:1397-405. 2001
    ..Strategies for the prevention of Pneumocystis infection must be individualized on the basis of a stratification of risk for each patient...
  15. ncbi request reprint Prevention of CMV infection in transplant patients
    J A Fishman
    Transplantation Infectious Disease Program, Infectious Disease Division, Massachusetts General Hospital, Boston 02114, USA
    Transpl Infect Dis 1:35-9. 1999
    ..New vaccines and orally bioavailable antiviral agents will play a significant role in the future care of transplant patients...
  16. ncbi request reprint Smallpox and live-virus vaccination in transplant recipients
    Jay A Fishman
    Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 3:786-93. 2003
    ..In the absence of documented smallpox exposures, immunocompromised hosts should not be vaccinated against smallpox. Planning for bioterrorist events must include consideration of uniquely susceptible hosts...
  17. doi request reprint Infection in organ transplantation: risk factors and evolving patterns of infection
    Jay A Fishman
    Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 504, Boston, MA 02114, USA
    Infect Dis Clin North Am 24:273-83. 2010
    ..In the future, improved assays for microbiologic and immunologic monitoring will allow individualization of prophylactic strategies to reduce the risk of infection in this highly susceptible population...
  18. ncbi request reprint Infection in xenotransplantation
    J A Fishman
    Infectious Disease and Transplantation Units, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Card Surg 16:363-73. 2001
    ..Clinical protocols must be developed so as to enhance the safety of the recipient and of the community-at-large...
  19. ncbi request reprint Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation
    Bernd Gollackner
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Transplantation 75:1841-7. 2003
    ..The activation of porcine (P) cytomegalovirus (PCMV) and baboon (B) CMV infections has been documented in pig-to-primate xenotransplantation. The purpose of this study was to determine the contribution of PCMV and BCMV to CC...
  20. pmc Activation of cytomegalovirus in pig-to-primate organ xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Virol 76:4734-40. 2002
    ..The observation of graft injury by PCMV demonstrates that CMV will be an important pathogen in immunosuppressed xenograft recipients. Strategies must be developed to exclude CMV from porcine organ donors...
  21. pmc Viral infection induces de novo lesions of coronary allograft vasculopathy through a natural killer cell-dependent pathway
    J A Graham
    Transplantation Research Division, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 9:2479-84. 2009
    ..These data also suggest that virus-induced CAV can develop via an NK-cell-dependent pathway in the absence of T- and B-lymphocytes...
  22. ncbi request reprint GalT-KO pigs: is the cup half empty or half full?
    David H Sachs
    Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Transplantation 84:12-4. 2007
  23. ncbi request reprint Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Transplant 3:1057-64. 2003
    ..GCV and other antiviral agents have limited activities against PCMV in vitro. Breeding of PCMV-free xenograft donors may be necessary to prevent PCMV infections in clinical trials...
  24. pmc Results of gal-knockout porcine thymokidney xenografts
    A D Griesemer
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 9:2669-78. 2009
    ..These results show that xenogeneic thymus transplantation can support early primate thymopoiesis, which in turn may induce T-cell tolerance to solid organ xenografts...
  25. ncbi request reprint Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen
    Kenji Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA
    Am J Transplant 4:363-72. 2004
    ..The treatment regimen was effective in maintaining low anti-Gal Ab levels and in delaying or preventing AHXR. The combination of costimulatory blockade and heparin with Tx of a Gal-negative pig organ may prolong graft survival further...
  26. ncbi request reprint Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation
    Nicolas J Mueller
    Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Infect Dis 189:1628-33. 2004
    ..Control immunosuppressed swine coinfected with PCMV and PLHV-1 had activation of PCMV but not PLHV-1. PCMV, but not PLHV-1, is activated in solid-organ xenotransplantation...
  27. ncbi request reprint Infection and xenotransplantation. Developing strategies to minimize risk
    J A Fishman
    Infectious Disease Unit, Massachusetts General Hospital, Boston, USA
    Ann N Y Acad Sci 862:52-66. 1998
    ....
  28. ncbi request reprint Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons
    F J M F Dor
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Transplant Proc 37:489-90. 2005
    ..Function of a pig organ in a baboon for a period approaching 6 months has not been reported previously and lends encouragement that the barriers to xenotransplantation will be overcome, but TM requires investigation...
  29. ncbi request reprint Salvage therapy with voriconazole for invasive fungal infections in patients failing or intolerant to standard antifungal therapy
    L R Baden
    Division of Infectious Diseases, Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA 02215, USA
    Transplantation 76:1632-7. 2003
    ..Invasive fungal infections (IFI), particularly those caused by Aspergillus and other angioinvasive molds, are associated with an excessive mortality despite therapy...
  30. ncbi request reprint BK virus in solid organ transplant recipients: an emerging syndrome
    E Mylonakis
    Infectious Disease Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Transplantation 72:1587-92. 2001
    ..Current, treatment of immunosuppressed patients with polyomavirus viruria is largely supportive and directed toward minimizing immunosuppression. Improved diagnostic tools and antiviral therapies are needed for polyomavirus infections...
  31. doi request reprint International consensus guidelines on the management of cytomegalovirus in solid organ transplantation
    Camille N Kotton
    Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 89:779-95. 2010
    ....
  32. ncbi request reprint Cytomegalovirus in transplantation - challenging the status quo
    Jay A Fishman
    Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Transplant 21:149-58. 2007
    ..Each approach has advantages and disadvantages in terms of efficacy, costs, and side effects. Standards of care for prophylaxis have not been established...
  33. ncbi request reprint Viral infection in the renal transplant recipient
    Camille N Kotton
    Transplant Infectious Disease and Compromised Host Service, Infectious Disease Division, Massachusetts General Hospital, 55 Fruit Street GRJ 504, Boston, MA 02114, USA
    J Am Soc Nephrol 16:1758-74. 2005
    ..Studies of viral latency, reactivation, and the cellular effects of viral infection will provide clues for future strategies in prevention and treatment of viral infections...
  34. ncbi request reprint Prevention of infection in adult travelers after solid organ transplantation
    Camille Nelson Kotton
    Transplant Infectious Disease and Compromised Host Program, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 5:8-14. 2005
    ..This review considers risks of international travel to adult solid organ transplant recipients and the use of vaccines and prophylactic agents in this population...
  35. ncbi request reprint Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 504, Boston, MA 02114, USA
    Transplantation 78:1449-53. 2004
    ..Activation of porcine cytomegalovirus (PCMV) in pig-to-baboon xenotransplantation is associated with xenograft injury and possibly an increased incidence of consumptive coagulopathy (CC)...
  36. doi request reprint What's new and what's hot? Basic science at the American Transplant Congress 2012
    J A Fishman
    Transplant Infectious Disease and Compromised Host Program, MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Transplant 13:275-80. 2013
    ..The impact of the microbiome, of vaccines, and of antimicrobial therapies on immune memory and reconstitution after lymphocyte depletion is beginning to be defined...
  37. pmc Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model
    J A Fishman
    Infectious Disease Unit, Massachusetts General Hospital, Boston
    Antimicrob Agents Chemother 37:1543-6. 1993
    ..Studies in immunosuppressed mice demonstrated the efficacy of teniposide against P. carinii pneumonia, but successful administration of teniposide was schedule dependent with significant toxicity at therapeutic dosages...
  38. doi request reprint Central nervous system involvement in cryptococcal infection in individuals after solid organ transplantation or with AIDS
    J A Davis
    Transplant Infectious Disease Program, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Transpl Infect Dis 11:432-7. 2009
    ..Cryptococcus neoformans is an important pathogen of immunocompromised hosts. Manifestations of cryptococcal infection have not been compared between populations based on the nature of the underlying immune deficiencies...
  39. ncbi request reprint Asymptomatic pulmonary cryptococcosis in solid organ transplantation: report of four cases and review of the literature
    N J Mueller
    Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Transpl Infect Dis 5:140-3. 2003
    ..Prolonged therapy may be used to reduce the risk of progression and dissemination during periods of intensified immune suppression...
  40. ncbi request reprint Postmenopausal tubo-ovarian abscess due to Pseudomonas aeruginosa in a renal transplant patient: a case report and review of the literature
    J El Khoury
    Infectious Disease Division, GRJ 504, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Transplantation 72:1241-4. 2001
    ..8% with abdominal surgery, and 32% with surgery and antimicrobial therapy. CONCLUSION: This report illustrates the muted presentation and atypical microbiology of gynecologic infection in an organ transplant recipient...
  41. doi request reprint Infectious complications of antilymphocyte therapies in solid organ transplantation
    Nicolas C Issa
    Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Infect Dis 48:772-86. 2009
    ....
  42. ncbi request reprint Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
    Kenji Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, 13th Street, Boston, Massachusetts 02129, USA
    Nat Med 11:29-31. 2005
    ..There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies...
  43. ncbi request reprint Risk factors for the development of post-transplant lymphoproliferative disorder in a large animal model
    Patricia S Cho
    Transplantation Biology Research Center, Massachusetts Genral Hospital Harvard Medical School, Boston, MA, USA
    Am J Transplant 4:1274-82. 2004
    ..The availability of a preclinical large-animal model with similarities to PTLD of humans may allow studies of the pathogenesis and treatment of that disorder...
  44. pmc HLA-mismatched renal transplantation without maintenance immunosuppression
    Tatsuo Kawai
    Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 358:353-61. 2008
    ....
  45. doi request reprint Disseminated Mycobacterium kansasii infection with hepatic abscesses in a renal transplant recipient
    P Kaur
    Transplant Infectious Disease and Immunocompromised Host Program, Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Transpl Infect Dis 13:531-5. 2011
    ..This case report describes a recent renal transplant recipient with disseminated M. kansasii infection presenting with hepatic abscesses, with discussion of clinical management issues and strategies, and a review of the literature...
  46. ncbi request reprint Outcome of kidney transplantation using expanded criteria donors and donation after cardiac death kidneys: realities and costs
    R F Saidi
    Department of Surgery, Transplantation Unit, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 7:2769-74. 2007
    ..Revised reimbursement guidelines will be required for centers that utilize these organs...
  47. ncbi request reprint Posttransplantation lymphoproliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: similarity to human PTLD and association with a porcine gammaherpesvirus
    C A Huang
    Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    Blood 97:1467-73. 2001
    ..The availability of this reproducible large-animal model of PTLD may facilitate the development and testing of diagnostic and therapeutic approaches for prevention or treatment of PTLD in the clinical setting...
  48. ncbi request reprint Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Xenotransplantation 12:59-62. 2005
    ..MATERIAL and..
  49. ncbi request reprint Primary infection with cytomegalovirus in ulcerative colitis
    Stanley I Martin
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Dig Dis Sci 51:2184-7. 2006
  50. ncbi request reprint Combination antiviral therapy for ganciclovir-resistant cytomegalovirus infection in solid-organ transplant recipients
    Eleftherios Mylonakis
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA, 02114, USA
    Clin Infect Dis 34:1337-41. 2002
    ..Larger studies are needed to identify the patients who are most likely to benefit from this regimen...
  51. ncbi request reprint Cytomegalovirus pneumonia in transplant recipients
    Michael G Ison
    Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Chest Med 26:691-705, viii. 2005
    ..Invasive procedures are often required for the optimal management of such infections. The use of sensitive and quantitative assays have greatly improved the outcomes of CMV infection...
  52. pmc Use of induced sputum specimens for microbiologic diagnosis of infections due to organisms other than Pneumocystis carinii
    J A Fishman
    Infectious Disease Unit, Massachusetts General Hospital, Boston
    J Clin Microbiol 32:131-4. 1994
    ..The use of induced sputum samples for the diagnosis of other infections may not be necessary when routine sputum specimens are available...
  53. ncbi request reprint Surfactant protein-A reduces binding and phagocytosis of pneumocystis carinii by human alveolar macrophages in vitro
    H Koziel
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Respir Cell Mol Biol 18:834-43. 1998
    ..These data suggest that increased levels of SP-A may contribute to the pathogenesis of P. carinii pneumonia through binding to the surface of the organism and interfering with AM recognition of this opportunistic pulmonary pathogen...
  54. ncbi request reprint Linezolid in the treatment of vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: report of a multicenter compassionate-use trial
    J El-Khoury
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Transpl Infect Dis 5:121-5. 2003
    ..Linezolid appears to be a safe and effective treatment option for VRE, even in the presence of bacteremia, and may lead to decreased mortality in solid organ transplant recipients with VRE infection...
  55. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-2004. A 58-year-old man with acute myeloid leukemia and Fever after chemotherapy
    Jay A Fishman
    Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, USA
    N Engl J Med 350:1339-47. 2004
  56. ncbi request reprint Gene expression of porcine lymphotrophic herpesvirus-1 in miniature Swine with posttransplant lymphoproliferative disorder
    Karen Doucette
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Transplantation 83:87-90. 2007
    ..This model provides insights into the pathogenesis of PTLD and, by extension, potential diagnostic and therapeutic tools for human EBV-associated PTLD...
  57. ncbi request reprint Posttransplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swine
    Frank J M F Dor
    Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149, 13th Street, Boston, MA 02129, USA
    Transplantation 78:286-91. 2004
    ..PTLD can occur after allogeneic SpTx in swine. This model may be useful in studies of the pathogenesis of PTLD...
  58. pmc Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice
    Yong Guang Yang
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 114:695-700. 2004
    ....
  59. doi request reprint Case records of the Massachusetts General Hospital. Case 11-2008. A 45-year-old man with changes in mental status after liver transplantation
    Jay A Fishman
    Massachusetts General Hospital Transplant Center, Harvard Medical School, Boston, USA
    N Engl J Med 358:1604-13. 2008
  60. pmc Absence of replication of porcine endogenous retrovirus and porcine lymphotropic herpesvirus type 1 with prolonged pig cell microchimerism after pig-to-baboon xenotransplantation
    Nicolas C Issa
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Virol 82:12441-8. 2008
    ..Viral detection appeared to be due to persistent pig cell microchimerism. There was no evidence of productive infection in recipient baboons for up to 6 months of xenograft function...
  61. pmc Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients
    Martin Rodriguez
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 504, Boston, MA 02114, USA
    Clin Microbiol Rev 17:770-82, table of contents. 2004
    ..The risk for PCP varies based on individual immune defects, regional differences, and immunosuppressive regimens. Prophylactic strategies must be linked to an ongoing assessment of the patient's risk for disease...
  62. ncbi request reprint Nontuberculous mycobacterial infection in hematopoietic stem cell and solid organ transplant recipients
    Karen Doucette
    Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Infect Dis 38:1428-39. 2004
    ..Issues involved in the management of NTM disease in transplant recipients are characterized by a case of disseminated infection due to Mycobacterium avium complex in a lung transplant recipient, with a review of the relevant literature...
  63. ncbi request reprint Failure of low-dose atovaquone prophylaxis against Pneumocystis jiroveci infection in transplant recipients
    Martin Rodriguez
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 38:e76-8. 2004
    ..We report 2 cases of prophylaxis failure in patients receiving low-dose atovaquone. We discuss the use of atovaquone as an alternative agent for prophylaxis in transplant recipients...
  64. doi request reprint Case records of the Massachusetts General Hospital. Case 18-2008. A 68-year-old man with headache and visual changes after liver transplantation
    Margaret Seton
    Rheumatology, Allergy, and Immunology Division and Rheumatology Unit, Massachusetts General Hospital, USA
    N Engl J Med 358:2619-28. 2008
  65. ncbi request reprint BK nephropathy: what is the role of antiviral therapy?
    Jay A Fishman
    Am J Transplant 3:99-100. 2003
  66. ncbi request reprint Presentation of the PATH Alliance registry for prospective data collection and analysis of the epidemiology, therapy, and outcomes of invasive fungal infections
    David L Horn
    Division of Infectious Diseases, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Diagn Microbiol Infect Dis 59:407-14. 2007
    ..As enrollment continues, additional data will be analyzed and published, which will provide valuable information concerning the epidemiology, therapy, and outcomes of IFIs...
  67. ncbi request reprint BK virus nephropathy--polyomavirus adding insult to injury
    Jay A Fishman
    N Engl J Med 347:527-30. 2002
  68. ncbi request reprint Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  69. ncbi request reprint Transplantation for patients infected with human immunodeficiency virus: no longer experimental but not yet routine
    Jay A Fishman
    J Infect Dis 188:1405-11. 2003
  70. ncbi request reprint Herpesvirus infections in xenotransplantation: pathogenesis and approaches
    Nicolas J Mueller
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Xenotransplantation 11:486-90. 2004
    ....
  71. doi request reprint Informing candidates for transplantation about donor risk factors
    Jay A Fishman
    N Engl J Med 359:1182; author reply 1182-3. 2008
  72. ncbi request reprint How should we evaluate organ donors with active or prior infections?
    Nicolas J Mueller
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Switzerland
    J Hepatol 45:507-13. 2006
  73. ncbi request reprint Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt
    Elias J Anaissie
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Clin Infect Dis 43:1031-9. 2006
  74. ncbi request reprint Pre-screening of miniature swine may reduce the risk of transmitting human tropic recombinant porcine endogenous retroviruses
    Ralph D Hector
    Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Bearsden, Glasgow, UK
    Xenotransplantation 14:222-6. 2007
    ..It has been suggested that these recombinants are exogenous and/or driven by one or more critical loci present in the pig genome...
  75. ncbi request reprint SARS, xenotransplantation and bioterrorism: preventing the next epidemic
    Jay A Fishman
    Am J Transplant 3:909-12. 2003
  76. pmc Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature Swine
    James C Wood
    Immerge BioTherapeutics Inc, Cambridge, Massachusetts 02139, USA
    J Virol 78:2494-501. 2004
    ..Such animals were identified within the miniature swine herd and may further enhance the safety of clinical xenotransplantation...