Research Topics
Species | N D FisherSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Body mass index and angiotensin-dependent control of the renal circulation in healthy humansSofia B Ahmed
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Hypertension 46:1316-20. 2005..Weight loss should be considered in the overweight or obese patient for renal protection...- The state and responsiveness of the renin-angiotensin-aldosterone system in patients with type II diabetes mellitusD A Price
Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
Am J Hypertens 12:348-55. 1999..The infrequency of a low renin state, and the inappropriately high renin levels on a high salt intake, provide a rational basis for pharmacologic interruption of the renin system to treat patients with type II diabetes... - Familial factors in the antihypertensive response to lisinoprilN K Hollenberg
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Hypertens 14:218-23. 2001..Although it is widely recognized that there are familial elements in the pathogenesis of hypertension, remarkably little is known about the influence of family history on response to specific antihypertensive agents... - Familial aggregation of low-renin hypertensionNaomi D L Fisher
Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass 02115, USA
Hypertension 39:914-8. 2002..Familial determinants, which are probably but not definitely genetic, contribute to the low-renin hypertension state... - Renal perfusion in blacks: alterations caused by insuppressibility of intrarenal renin with saltDeborah A Price
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
Hypertension 40:186-9. 2002..The mechanism involved may contribute to the increased susceptibility to renal injury in blacks... - Habitual flavonoid intake and endothelial function in healthy humansNaomi D L Fisher
Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
J Am Coll Nutr 31:275-9. 2012..Our study was designed to test the hypothesis that this variation is determined in large part by a person's habitual dietary intake of flavonoids... - Adrenal response to angiotensin II in black hypertension: lack of sexual dimorphismN D Fisher
Departments of Medicine and Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
Hypertension 38:373-8. 2001..Mechanisms protecting against a blunted adrenal response to Ang II in young white women are absent in blacks. These differences may contribute to the markedly increased prevalence of hypertension in young black women... - Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humansNaomi D L Fisher
Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
J Hypertens 21:2281-6. 2003..Cocoa can contain extraordinary concentrations of flavanols, a flavonoid subclass shown to activate nitric oxide synthase in vitro... - Is there a future for renin inhibitors?N D Fisher
Departments of Radiology and Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, MA, USA
Expert Opin Investig Drugs 10:417-26. 2001..We believe that the potential of renin inhibition in human therapy has been under estimated and still shows substantial promise... - Flavanols for cardiovascular health: the science behind the sweetnessNaomi D L Fisher
Departments of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Hypertens 23:1453-9. 2005..CONCLUSIONS: Evidence is mounting to support cardiovascular health benefits from the consumption of flavanol-rich cocoa. This review hopes to illuminate sound scientific principles by which future research in the field can be guided... - Cocoa flavanols and brain perfusionNaomi D L Fisher
Department of Internal Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
J Cardiovasc Pharmacol 47:S210-4. 2006..With the modalities of transcranial Doppler and MRI, we have the capabilities of analyzing the potential benefits of flavanols on brain perfusion and, subsequently, on cognition... - Aging and vascular responses to flavanol-rich cocoaNaomi D L Fisher
Department of Medicine, Harvard Medical School and the Brigham and Women s Hospital, Boston, Massachusetts, USA
J Hypertens 24:1575-80. 2006..We have previously shown that flavanol-rich cocoa induced peripheral vasodilation, improving endothelial function via a nitric oxide (NO)-dependent mechanism... 
Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humansNaomi D L Fisher
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circulation 117:3199-205. 2008..We predicted that blockade with the direct oral renin inhibitor aliskiren would produce renal vascular responses exceeding those induced by angiotensin-converting enzyme inhibitors and angiotensin receptor blockers...- Renin inhibitorsNaomi D L Fisher
Division of Endocrinology, Diabetes and Hypertension, Hypertension Services, Brigham and Women s Hospital, Boston, MA, USA
J Clin Hypertens (Greenwich) 13:662-6. 2011..Increases in serum potassium >5.5 meq/L were infrequent in patients with essential hypertension treated with aliskiren alone (0.9% compared with 0.6% with placebo)... - Hyperglycemia and angiotensin-mediated control of the renal circulation in healthy humansS Y Osei
Department of Medicine and Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Hypertension 33:559-64. 1999..PRA did not change with hyperglycemia. Enhancement of renal vasodilation during hyperglycemia by captopril without alteration of PRA suggests activation of the intrarenal renin angiotensin system... - Renal perfusion and function in healthy African AmericansD A Price
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Kidney Int 59:1037-43. 2001..Despite their increased risk of nephropathy, remarkably little is known about renal perfusion and function in healthy African Americans... - Altered adrenal sensitivity to angiotensin II in low-renin essential hypertensionN D Fisher
Departments of Medicine and Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass 02115, USA
Hypertension 34:388-94. 1999..The factors that mediate enhanced adrenal response to Ang II with sodium restriction may be defective, suggesting the existence of alternative physiological mechanisms for sodium homeostasis in the low-renin state... - Renal response to captopril reflects state of local renin system in healthy humansN D Fisher
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Kidney Int 56:635-41. 1999..In this study we tested the hypothesis that variation in the renal vasodilator response to ACE inhibition in healthy humans reflected the variation in angiotensin-mediated renal vasoconstriction provoked by a low-salt diet... - Salt intake and non-ACE pathways for intrarenal angiotensin II generation in manN K Hollenberg
Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Renin Angiotensin Aldosterone Syst 2:14-8. 2001.... - Age, gender, and non-modulation. A sexual dimorphism in essential hypertensionN D Fisher
Department of Medicine, Harvard Medical School, Boston, Mass, USA
Hypertension 29:980-5. 1997..This "override" of genotype, manifest by a very low frequency of non-modulation in young women, may participate in their known protection against cardiovascular disease... - Renal hemodynamic response to an angiotensin II antagonist, eprosartan, in healthy menD A Price
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
Hypertension 30:240-6. 1997..Thus, eprosartan probably exerted its effect via the angiotensin receptor. More complete blockade of the renin system can be achieved by pharmacological interruption at this level, a finding that could have therapeutic implications... - Effect of ACE inhibition on pressor, renal vascular, and adrenal responses to infusion of angiotensin I in normal subjects eating a low-salt dietN K Hollenberg
Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Am J Hypertens 13:498-503. 2000..Under the conditions of this study, ACE inhibition led to nonuniform changes in the response to exogenous Ang I, suggesting intrarenal conversion of Ang I to Ang II... - The paradox of the low-renin state in diabetic nephropathyD A Price
Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 10:2382-91. 1999..This increase could account for suppressed circulating renin, the exaggerated renal vasodilator response to irbesartan, and the therapeutic effectiveness of interrupting the renin system in diabetic nephropathy... - Effects of gender and genotype on the phenotypic expression of nonmodulating essential hypertensionG H Williams
Endocrine Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Kidney Int 57:1404-7. 2000..This suggests that the expression of the nonmodulating phenotype, presumably secondary to changes in the expression of the angiotensinogen gene, is modulated by female sex hormones... - Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitusM C Lansang
Department of Medicine, Brigham and Women's Hospital, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
Kidney Int 59:1432-8. 2001..The high correlation between the renal hemodynamic response to captopril and to candesartan indicates that reduced angiotensin II formation is the main mechanism of action of the ACE inhibitor... - Prorenin and angiotensin-dependent renal vasoconstriction in type 1 and type 2 diabetesAna R Stankovic
Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
J Am Soc Nephrol 17:3293-9. 2006.... - Gender and the renal nitric oxide synthase system in healthy humansSofia B Ahmed
Department of Medicine, University of Calgary, Calgary, Alberta, Canada
Clin J Am Soc Nephrol 2:926-31. 2007..Animal models suggest that the renal vasculature of men may be significantly more dependent on nitric oxide than that of women... - Short- and long-term glycaemic control and the state of the renin system in type 1 diabetes mellitusRadomir D Stevanovic
Department of Medicine, Saint Mary s Hospital, Waterbury, CT 06706, USA
J Renin Angiotensin Aldosterone Syst 8:85-92. 2007..72; p=0.008). Conversely, HbA1C correlated with none of the measures of renin system activation (r=0.05;p=0.7). In type 1 diabetic subjects, short-term hyperglycaemia, but not long-term glycaemic control, enhanced the RR to captopril... - Renin-angiotensin system polymorphisms and risk of hypertension: influence of environmental factorsJohn P Forman
Renal Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Clin Hypertens (Greenwich) 10:459-66. 2008..These data suggest that demographic and dietary factors may influence the associations between RAS polymorphisms and hypertension and could explain heterogeneity in prior studies... 
Higher levels of albuminuria within the normal range predict incident hypertensionJohn P Forman
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 19:1983-8. 2008..The definition of normal albumin excretion should be reevaluated...- Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertensionPaul N Hopkins
Cardiovascular Genetics, Cardiology Division, University of Utah, Salt Lake City, UT, USA
Circulation 105:1921-7. 2002..We examine herein angiotensinogen (AGT) as a candidate gene to help elucidate potential mechanisms for previously reported AGT linkage and association studies... - Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitusNorman K Hollenberg
Departments of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Kidney Int 63:172-8. 2003..This constellation is generally attributed to predominant efferent arteriolar dilation... - Plasma aldosterone concentration in the patient with diabetes mellitusNorman K Hollenberg
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Kidney Int 65:1435-9. 2004..Evidence for renin-system activation in many patients with type 1 diabetes mellitus has raised the possibility that aldosterone-widely recognized as a contributor to vascular injury-could play a role... - Uric acid and the state of the intrarenal renin-angiotensin system in humansTodd S Perlstein
Endocrinology, Diabetes and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Kidney Int 66:1465-70. 2004..The renal vascular response to exogenous angiotensin II (Ang II) provides an indirect measure of intrarenal RAS activity. We tested the hypothesis that the serum uric acid concentration predicts the renal vascular response to Ang II... - Renin inhibition: what are the therapeutic opportunities?Naomi D L Fisher
Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Am Soc Nephrol 16:592-9. 2005..This review evaluates the potential of renin inhibition as an adjunct to therapies that depend on renin system interruption... - Genetics of human hypertensionAnupam Agarwal
Harvard Medical School and Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Trends Endocrinol Metab 16:127-33. 2005.... - Oral contraceptives, angiotensin-dependent renal vasoconstriction, and risk of diabetic nephropathySofia B Ahmed
Department of Medicine, Brigham and Women s Hospital, PBB 3, 75 Francis St, Boston, MA 02115, USA
Diabetes Care 28:1988-94. 2005..RAS activation occurs in healthy women using oral contraceptives (OCs), but the effects of OC use on the diabetic kidney are unclear... - The renin-angiotensin system in blacks: active, passive, or what?Deborah A Price
Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
Curr Hypertens Rep 5:225-30. 2003..In this review, we present data to suggest that low systemic plasma renin activity in blacks may not be the primary abnormality, but rather the reflection of an overactive RAS at the tissue level in the kidney... - Is it the dark in dark chocolate?Norman K Hollenberg
Circulation 116:2360-2. 2007
Research Grants
- FLAVANOL-RICH COCOA TO REVERSE VASCULAR DISEASE OF AGINGNaomi Fisher; Fiscal Year: 2006..She will be well-positioned to submit an application for an RO1 with results from this study. Therapeutic interventions aimed at restoring vascular endothelial function hold tremendous clinical promise. ..
- Flavanol-Rich Cocoa, Vascular Responses and MechanismsNaomi D Fisher; Fiscal Year: 2010..This research examines the mechanisms by which flavanol-rich cocoa increases cerebral blood flow. Ultimately these data might lay the foundation for a trial in the prevention of cognitive decline. ..
- Flavanol-Rich Cocoa, Vascular Responses and MechanismsNaomi Fisher; Fiscal Year: 2009..This research examines the mechanisms by which flavanol-rich cocoa increases cerebral blood flow. Ultimately these data might lay the foundation for a trial in the prevention of cognitive decline. ..