N D Fisher

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Body mass index and angiotensin-dependent control of the renal circulation in healthy humans
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 46:1316-20. 2005
  2. ncbi request reprint The state and responsiveness of the renin-angiotensin-aldosterone system in patients with type II diabetes mellitus
    D A Price
    Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
    Am J Hypertens 12:348-55. 1999
  3. ncbi request reprint Familial factors in the antihypertensive response to lisinopril
    N K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 14:218-23. 2001
  4. ncbi request reprint Familial aggregation of low-renin hypertension
    Naomi D L Fisher
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass 02115, USA
    Hypertension 39:914-8. 2002
  5. ncbi request reprint Renal perfusion in blacks: alterations caused by insuppressibility of intrarenal renin with salt
    Deborah A Price
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Hypertension 40:186-9. 2002
  6. ncbi request reprint Habitual flavonoid intake and endothelial function in healthy humans
    Naomi D L Fisher
    Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Coll Nutr 31:275-9. 2012
  7. ncbi request reprint Adrenal response to angiotensin II in black hypertension: lack of sexual dimorphism
    N D Fisher
    Departments of Medicine and Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertension 38:373-8. 2001
  8. ncbi request reprint Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans
    Naomi D L Fisher
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Hypertens 21:2281-6. 2003
  9. ncbi request reprint Is there a future for renin inhibitors?
    N D Fisher
    Departments of Radiology and Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, MA, USA
    Expert Opin Investig Drugs 10:417-26. 2001
  10. ncbi request reprint Flavanols for cardiovascular health: the science behind the sweetness
    Naomi D L Fisher
    Departments of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Hypertens 23:1453-9. 2005

Research Grants

Detail Information

Publications39

  1. ncbi request reprint Body mass index and angiotensin-dependent control of the renal circulation in healthy humans
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 46:1316-20. 2005
    ..Weight loss should be considered in the overweight or obese patient for renal protection...
  2. ncbi request reprint The state and responsiveness of the renin-angiotensin-aldosterone system in patients with type II diabetes mellitus
    D A Price
    Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
    Am J Hypertens 12:348-55. 1999
    ..The infrequency of a low renin state, and the inappropriately high renin levels on a high salt intake, provide a rational basis for pharmacologic interruption of the renin system to treat patients with type II diabetes...
  3. ncbi request reprint Familial factors in the antihypertensive response to lisinopril
    N K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hypertens 14:218-23. 2001
    ..Although it is widely recognized that there are familial elements in the pathogenesis of hypertension, remarkably little is known about the influence of family history on response to specific antihypertensive agents...
  4. ncbi request reprint Familial aggregation of low-renin hypertension
    Naomi D L Fisher
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass 02115, USA
    Hypertension 39:914-8. 2002
    ..Familial determinants, which are probably but not definitely genetic, contribute to the low-renin hypertension state...
  5. ncbi request reprint Renal perfusion in blacks: alterations caused by insuppressibility of intrarenal renin with salt
    Deborah A Price
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Hypertension 40:186-9. 2002
    ..The mechanism involved may contribute to the increased susceptibility to renal injury in blacks...
  6. ncbi request reprint Habitual flavonoid intake and endothelial function in healthy humans
    Naomi D L Fisher
    Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Coll Nutr 31:275-9. 2012
    ..Our study was designed to test the hypothesis that this variation is determined in large part by a person's habitual dietary intake of flavonoids...
  7. ncbi request reprint Adrenal response to angiotensin II in black hypertension: lack of sexual dimorphism
    N D Fisher
    Departments of Medicine and Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertension 38:373-8. 2001
    ..Mechanisms protecting against a blunted adrenal response to Ang II in young white women are absent in blacks. These differences may contribute to the markedly increased prevalence of hypertension in young black women...
  8. ncbi request reprint Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans
    Naomi D L Fisher
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Hypertens 21:2281-6. 2003
    ..Cocoa can contain extraordinary concentrations of flavanols, a flavonoid subclass shown to activate nitric oxide synthase in vitro...
  9. ncbi request reprint Is there a future for renin inhibitors?
    N D Fisher
    Departments of Radiology and Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, MA, USA
    Expert Opin Investig Drugs 10:417-26. 2001
    ..We believe that the potential of renin inhibition in human therapy has been under estimated and still shows substantial promise...
  10. ncbi request reprint Flavanols for cardiovascular health: the science behind the sweetness
    Naomi D L Fisher
    Departments of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Hypertens 23:1453-9. 2005
    ..However, many new studies have brought more confusion than clarity to the enterprise. This review provides guidelines for legitimate research in this promising field...
  11. ncbi request reprint Cocoa flavanols and brain perfusion
    Naomi D L Fisher
    Department of Internal Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cardiovasc Pharmacol 47:S210-4. 2006
    ..With the modalities of transcranial Doppler and MRI, we have the capabilities of analyzing the potential benefits of flavanols on brain perfusion and, subsequently, on cognition...
  12. ncbi request reprint Aging and vascular responses to flavanol-rich cocoa
    Naomi D L Fisher
    Department of Medicine, Harvard Medical School and the Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Hypertens 24:1575-80. 2006
    ..We have previously shown that flavanol-rich cocoa induced peripheral vasodilation, improving endothelial function via a nitric oxide (NO)-dependent mechanism...
  13. doi request reprint Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans
    Naomi D L Fisher
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:3199-205. 2008
    ..We predicted that blockade with the direct oral renin inhibitor aliskiren would produce renal vascular responses exceeding those induced by angiotensin-converting enzyme inhibitors and angiotensin receptor blockers...
  14. doi request reprint Renin inhibitors
    Naomi D L Fisher
    Division of Endocrinology, Diabetes and Hypertension, Hypertension Services, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Hypertens (Greenwich) 13:662-6. 2011
    ..Increases in serum potassium >5.5 meq/L were infrequent in patients with essential hypertension treated with aliskiren alone (0.9% compared with 0.6% with placebo)...
  15. ncbi request reprint Hyperglycemia and angiotensin-mediated control of the renal circulation in healthy humans
    S Y Osei
    Department of Medicine and Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 33:559-64. 1999
    ..PRA did not change with hyperglycemia. Enhancement of renal vasodilation during hyperglycemia by captopril without alteration of PRA suggests activation of the intrarenal renin angiotensin system...
  16. ncbi request reprint Renal perfusion and function in healthy African Americans
    D A Price
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 59:1037-43. 2001
    ..Despite their increased risk of nephropathy, remarkably little is known about renal perfusion and function in healthy African Americans...
  17. ncbi request reprint Altered adrenal sensitivity to angiotensin II in low-renin essential hypertension
    N D Fisher
    Departments of Medicine and Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass 02115, USA
    Hypertension 34:388-94. 1999
    ..The factors that mediate enhanced adrenal response to Ang II with sodium restriction may be defective, suggesting the existence of alternative physiological mechanisms for sodium homeostasis in the low-renin state...
  18. ncbi request reprint Renal response to captopril reflects state of local renin system in healthy humans
    N D Fisher
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 56:635-41. 1999
    ..In this study we tested the hypothesis that variation in the renal vasodilator response to ACE inhibition in healthy humans reflected the variation in angiotensin-mediated renal vasoconstriction provoked by a low-salt diet...
  19. ncbi request reprint Salt intake and non-ACE pathways for intrarenal angiotensin II generation in man
    N K Hollenberg
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Renin Angiotensin Aldosterone Syst 2:14-8. 2001
    ....
  20. ncbi request reprint Age, gender, and non-modulation. A sexual dimorphism in essential hypertension
    N D Fisher
    Department of Medicine, Harvard Medical School, Boston, Mass, USA
    Hypertension 29:980-5. 1997
    ..This "override" of genotype, manifest by a very low frequency of non-modulation in young women, may participate in their known protection against cardiovascular disease...
  21. ncbi request reprint Renal hemodynamic response to an angiotensin II antagonist, eprosartan, in healthy men
    D A Price
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 30:240-6. 1997
    ..Thus, eprosartan probably exerted its effect via the angiotensin receptor. More complete blockade of the renin system can be achieved by pharmacological interruption at this level, a finding that could have therapeutic implications...
  22. ncbi request reprint Effect of ACE inhibition on pressor, renal vascular, and adrenal responses to infusion of angiotensin I in normal subjects eating a low-salt diet
    N K Hollenberg
    Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 13:498-503. 2000
    ..Under the conditions of this study, ACE inhibition led to nonuniform changes in the response to exogenous Ang I, suggesting intrarenal conversion of Ang I to Ang II...
  23. ncbi request reprint The paradox of the low-renin state in diabetic nephropathy
    D A Price
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 10:2382-91. 1999
    ..This increase could account for suppressed circulating renin, the exaggerated renal vasodilator response to irbesartan, and the therapeutic effectiveness of interrupting the renin system in diabetic nephropathy...
  24. ncbi request reprint Effects of gender and genotype on the phenotypic expression of nonmodulating essential hypertension
    G H Williams
    Endocrine Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Kidney Int 57:1404-7. 2000
    ..This suggests that the expression of the nonmodulating phenotype, presumably secondary to changes in the expression of the angiotensinogen gene, is modulated by female sex hormones...
  25. ncbi request reprint Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitus
    M C Lansang
    Department of Medicine, Brigham and Women's Hospital, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 59:1432-8. 2001
    ..The high correlation between the renal hemodynamic response to captopril and to candesartan indicates that reduced angiotensin II formation is the main mechanism of action of the ACE inhibitor...
  26. ncbi request reprint Prorenin and angiotensin-dependent renal vasoconstriction in type 1 and type 2 diabetes
    Ana R Stankovic
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Am Soc Nephrol 17:3293-9. 2006
    ....
  27. ncbi request reprint Gender and the renal nitric oxide synthase system in healthy humans
    Sofia B Ahmed
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin J Am Soc Nephrol 2:926-31. 2007
    ..Animal models suggest that the renal vasculature of men may be significantly more dependent on nitric oxide than that of women...
  28. ncbi request reprint Short- and long-term glycaemic control and the state of the renin system in type 1 diabetes mellitus
    Radomir D Stevanovic
    Department of Medicine, Saint Mary s Hospital, Waterbury, CT 06706, USA
    J Renin Angiotensin Aldosterone Syst 8:85-92. 2007
    ..72; p=0.008). Conversely, HbA1C correlated with none of the measures of renin system activation (r=0.05;p=0.7). In type 1 diabetic subjects, short-term hyperglycaemia, but not long-term glycaemic control, enhanced the RR to captopril...
  29. ncbi request reprint Renin-angiotensin system polymorphisms and risk of hypertension: influence of environmental factors
    John P Forman
    Renal Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Clin Hypertens (Greenwich) 10:459-66. 2008
    ..These data suggest that demographic and dietary factors may influence the associations between RAS polymorphisms and hypertension and could explain heterogeneity in prior studies...
  30. pmc Higher levels of albuminuria within the normal range predict incident hypertension
    John P Forman
    Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 19:1983-8. 2008
    ..The definition of normal albumin excretion should be reevaluated...
  31. ncbi request reprint Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension
    Paul N Hopkins
    Cardiovascular Genetics, Cardiology Division, University of Utah, Salt Lake City, UT, USA
    Circulation 105:1921-7. 2002
    ..We examine herein angiotensinogen (AGT) as a candidate gene to help elucidate potential mechanisms for previously reported AGT linkage and association studies...
  32. ncbi request reprint Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus
    Norman K Hollenberg
    Departments of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 63:172-8. 2003
    ..This constellation is generally attributed to predominant efferent arteriolar dilation...
  33. ncbi request reprint Plasma aldosterone concentration in the patient with diabetes mellitus
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 65:1435-9. 2004
    ..Evidence for renin-system activation in many patients with type 1 diabetes mellitus has raised the possibility that aldosterone-widely recognized as a contributor to vascular injury-could play a role...
  34. ncbi request reprint Uric acid and the state of the intrarenal renin-angiotensin system in humans
    Todd S Perlstein
    Endocrinology, Diabetes and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 66:1465-70. 2004
    ..The renal vascular response to exogenous angiotensin II (Ang II) provides an indirect measure of intrarenal RAS activity. We tested the hypothesis that the serum uric acid concentration predicts the renal vascular response to Ang II...
  35. ncbi request reprint Renin inhibition: what are the therapeutic opportunities?
    Naomi D L Fisher
    Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Am Soc Nephrol 16:592-9. 2005
    ..This review evaluates the potential of renin inhibition as an adjunct to therapies that depend on renin system interruption...
  36. ncbi request reprint Genetics of human hypertension
    Anupam Agarwal
    Harvard Medical School and Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Trends Endocrinol Metab 16:127-33. 2005
    ....
  37. ncbi request reprint Oral contraceptives, angiotensin-dependent renal vasoconstriction, and risk of diabetic nephropathy
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, PBB 3, 75 Francis St, Boston, MA 02115, USA
    Diabetes Care 28:1988-94. 2005
    ..RAS activation occurs in healthy women using oral contraceptives (OCs), but the effects of OC use on the diabetic kidney are unclear...
  38. ncbi request reprint The renin-angiotensin system in blacks: active, passive, or what?
    Deborah A Price
    Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Curr Hypertens Rep 5:225-30. 2003
    ..In this review, we present data to suggest that low systemic plasma renin activity in blacks may not be the primary abnormality, but rather the reflection of an overactive RAS at the tissue level in the kidney...
  39. ncbi request reprint Is it the dark in dark chocolate?
    Norman K Hollenberg
    Circulation 116:2360-2. 2007

Research Grants3

  1. FLAVANOL-RICH COCOA TO REVERSE VASCULAR DISEASE OF AGING
    Naomi Fisher; Fiscal Year: 2006
    ..She will be well-positioned to submit an application for an RO1 with results from this study. Therapeutic interventions aimed at restoring vascular endothelial function hold tremendous clinical promise. ..
  2. Flavanol-Rich Cocoa, Vascular Responses and Mechanisms
    Naomi D Fisher; Fiscal Year: 2010
    ..This research examines the mechanisms by which flavanol-rich cocoa increases cerebral blood flow. Ultimately these data might lay the foundation for a trial in the prevention of cognitive decline. ..
  3. Flavanol-Rich Cocoa, Vascular Responses and Mechanisms
    Naomi Fisher; Fiscal Year: 2009
    ..This research examines the mechanisms by which flavanol-rich cocoa increases cerebral blood flow. Ultimately these data might lay the foundation for a trial in the prevention of cognitive decline. ..