Research Topics
| Michael A FischerSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Academic detailing can play a key role in assessing and implementing comparative effectiveness research findingsMichael A Fischer
Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Health Aff (Millwood) 31:2206-12. 2012....
An algorithmic computerised order entry approach to assist in the prescribing of new therapeutic agents: case study of activated protein C at an academic medical centreMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Drug Saf 27:1253-61. 2004..The cost of the drug is approximately USD 6000-8000 per treated patient. Integration of this product into routine care has produced unique challenges concerning clinical decision making, safety and cost...- Prior authorization policies for selective cyclooxygenase-2 inhibitors in Medicaid: a policy reviewMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
Med Care 44:658-63. 2006..However, the evidence base for the prior authorization criteria has not been examined previously... - Restrictions on antidepressant medications for children: a review of Medicaid policyMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
Psychiatr Serv 58:135-8. 2007..This study evaluated Medicaid's prior-authorization policies restricting the prescribing of antidepressant medications for children... - Nononcologic use of human recombinant erythropoietin therapy in hospitalized patientsMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
Arch Intern Med 167:840-6. 2007..Little is known about the nature of rHuEPO use in hospitalized patients who receive rHuEPO therapy for nononcologic indications... 
Primary medication non-adherence: analysis of 195,930 electronic prescriptionsMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
J Gen Intern Med 25:284-90. 2010..Little is known about the frequency with which patients fail to fill prescriptions when new medications are started ("primary non-adherence") or predictors of failure to fill...- Impact of Medicaid prior authorization on angiotensin-receptor blockers: can policy promote rational prescribing?Michael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
Health Aff (Millwood) 26:800-7. 2007..3 percent per quarter; alternative approaches were unsuccessful. These findings have important implications for the development of rational drug reimbursement policy under Medicare Part D and other health insurance plans... - The National e-Prescribing Patient Safety Initiative: removing one hurdle, confronting othersMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02120, USA
Drug Saf 30:461-4. 2007 - Effect of electronic prescribing with formulary decision support on medication use and costMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
Arch Intern Med 168:2433-9. 2008..In April 2004, 2 large Massachusetts insurers began providing an e-prescribing system with FDS to community-based practices... - Trouble getting started: predictors of primary medication nonadherenceMichael A Fischer
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Med 124:1081.e9-22. 2011..The advent of electronic prescribing (e-prescribing) systems provides the opportunity to track initial prescriptions and identify nonadherence that may have previously been undetected... - Uptake of electronic prescribing in community-based practicesMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
J Gen Intern Med 23:358-63. 2008..In April 2004, 2 large insurers in Massachusetts began a program to fund e-prescribing systems for targeted clinicians and practices. We studied the adoption and uptake of e-prescribing by the targeted prescribers... - Conversion from intravenous to oral medications: assessment of a computerized intervention for hospitalized patientsMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Departments of Medicine and Emergency Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
Arch Intern Med 163:2585-9. 2003..We examined the effect of a computer-based intervention to prompt physicians to switch appropriate patients from intravenous to oral medications... - The hepatotoxicity of antifungal medications in bone marrow transplant recipientsMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Clin Infect Dis 41:301-7. 2005..Systemic antifungal medications can be lifesaving but can also have important toxicities. With a number of new antifungal drugs being introduced, there is a compelling need to define the toxicities associated with existing therapies... - Economic implications of evidence-based prescribing for hypertension: can better care cost less?Michael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
JAMA 291:1850-6. 2004..Suboptimal prescribing patterns contribute to the high cost of medications for elderly patients as well as the difficulty in providing affordable prescription drug benefits for older Americans... - Potential savings from increased use of generic drugs in the elderly: what the experience of Medicaid and other insurance programs means for a Medicare drug benefitMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Pharmacoepidemiol Drug Saf 13:207-14. 2004..Generic medications provide the same clinical effect at lower cost than brand name drugs but little is known about the extent to which such savings are achieved in drug benefit programs serving the elderly... - Medicaid prior-authorization programs and the use of cyclooxygenase-2 inhibitorsMichael A Fischer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
N Engl J Med 351:2187-94. 2004..To control these expenses, many state Medicaid programs have implemented prior-authorization requirements before coxibs can be prescribed. We evaluated the effect of such programs on the use of coxibs by Medicaid beneficiaries... - Prior authorization for biologic disease-modifying antirheumatic drugs: a description of US Medicaid programsMichael A Fischer
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Arthritis Rheum 59:1611-7. 2008..To evaluate state Medicaid prior authorization programs for biologic disease-modifying antirheumatic drugs (DMARDs)... - Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004Candace H Feldman
Brigham and Women s Hospital, Boston, Massachusetts
Arthritis Rheum 65:753-63. 2013..This study was undertaken to investigate the epidemiology and sociodemographics of SLE and LN in the low-income US Medicaid population... - State generic substitution laws can lower drug outlays under MedicaidWilliam H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Health Aff (Millwood) 29:1383-90. 2010..Although these consent requirements are probably intended to increase patient autonomy, policy makers should consider the sizable opportunity costs... - At Pitney Bowes, value-based insurance design cut copayments and increased drug adherenceNiteesh K Choudhry
Harvard Medical School, USA
Health Aff (Millwood) 29:1995-2001. 2010..Our study thus provides an empirical basis for the use of this approach to improve the quality of health care... - Underuse of ACE inhibitors and angiotensin II receptor blockers in elderly patients with diabetesWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Kidney Dis 46:1080-7. 2005..However, little is known about the adequacy of adherence to these guidelines in elderly patients with diabetes and predictors of such appropriate ACE-inhibitor or ARB use... - The impact of reducing cardiovascular medication copayments on health spending and resource utilizationNiteesh K Choudhry
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
J Am Coll Cardiol 60:1817-24. 2012..The aim of this study was to evaluate the impact of reductions in statin and clopidogrel copayments on cardiovascular resource utilization, major coronary events, and insurer spending... - Warnings without guidance: patient responses to an FDA warning about ezetimibeWilliam H Shrank
Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston 02120, USA
Med Care 50:479-84. 2012..We investigated the proportion of patients who discontinued therapy and switched to a clinically appropriate alternative after the FDA communication... - Healthcare information technology interventions to improve cardiovascular and diabetes medication adherenceAlexander S Misono
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
Am J Manag Care 16:SP82-92. 2010..To determine the efficacy of healthcare information technology (HIT) interventions in improving adherence... - Modes of delivery for interventions to improve cardiovascular medication adherenceSarah L Cutrona
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA, USA
Am J Manag Care 16:929-42. 2010..To determine the optimal modes of delivery for interventions to improve adherence to cardiovascular medications... - Targeting cardiovascular medication adherence interventionsSarah L Cutrona
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
J Am Pharm Assoc (2003) 52:381-97. 2012..To determine whether adherence interventions should be administered to all medication takers or targeted to nonadherers... - The epidemiology of prescriptions abandoned at the pharmacyWilliam H Shrank
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
Ann Intern Med 153:633-40. 2010..Understanding the epidemiology and correlates of prescription abandonment may have an important effect on health care quality... - Comparative effectiveness of preventative therapy for venous thromboembolism after coronary artery bypass graft surgeryAlexander Kulik
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Circ Cardiovasc Interv 5:590-6. 2012..Controversy exists regarding the optimal preventative therapy for venous thromboembolism (VTE) after coronary artery bypass graft (CABG) surgery. We sought to compare the effectiveness and safety of the most commonly used regimens... - The implications of therapeutic complexity on adherence to cardiovascular medicationsNiteesh K Choudhry
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
Arch Intern Med 171:814-22. 2011..Our objective was to estimate the extent of prescribing and filling complexity in patients prescribed a cardiovascular medication and to evaluate its association with adherence... - Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implicationsNihar R Desai
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Med 125:302.e1-7. 2012..We aimed to evaluate temporal trends in the use of specific drugs for the initial management of type 2 diabetes and to estimate the economic consequences of non-recommended care... - Is there a relationship between patient beliefs or communication about generic drugs and medication utilization?William H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Med Care 47:319-25. 2009..Insurers and policymakers strive to stimulate more cost-effective prescribing and, increasingly, are educating beneficiaries about generics... - Patient, physician, and payment predictors of statin adherenceDavid C Chan
Department of Medicine, Division of General Internal Medicine, Brigham and Women s Hospital, Boston, MA, USA
Med Care 48:196-202. 2010..Although many patient, physician, and payment predictors of adherence have been described, knowledge of their relative strength and overall ability to explain adherence is limited... - Angiotensin inhibition after myocardial infarction: does drug class matter?Wolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
J Gen Intern Med 21:1242-7. 2006..Little is known about their relative use after MI in typical care settings, and about their relative effectiveness outside the clinical trial setting... - Physician perceptions about generic drugsWilliam H Shrank
Brigham and Women s Hospital and Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Boston, MA, USA
Ann Pharmacother 45:31-8. 2011..With constrained health-care resources, there is a need to understand barriers to cost-effective medication use... - Are caregivers adherent to their own medications?William H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
J Am Pharm Assoc (2003) 51:492-8. 2011..To explore caregiver adherence to chronic medications and predictors of appropriate medication use... - The consequences of requesting "dispense as written"William H Shrank
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Med 124:309-17. 2011..Patients also can make these requests. Little is known about the frequency and correlates of dispense as written requests or their association with medication filling... - Risk of death in elderly users of conventional vs. atypical antipsychotic medicationsPhilip S Wang
Department of Psychiatry, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
N Engl J Med 353:2335-41. 2005..However, the advisory did not apply to conventional antipsychotic medications; the risk of death with these older agents is not known... - Economic consequences of underuse of generic drugs: evidence from Medicaid and implications for prescription drug benefit plansMichael A Fischer
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02120, USA
Health Serv Res 38:1051-63. 2003..Further savings could be realized if lowest available prices were used nationwide. Concentrating on specific agents may be a productive way to address the unrealized savings... - Effects of noncardiovascular comorbidities on antihypertensive use in elderly hypertensivesPhilip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Hypertension 46:273-9. 2005..Highly prevalent, noncardiovascular conditions appear to deter use of antihypertensives in elderly with hypertension... - Extensions of intellectual property rights and delayed adoption of generic drugs: effects on medicaid spendingAaron S Kesselheim
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, in Boston, Massachusetts, USA
Health Aff (Millwood) 25:1637-47. 2006..The delay in availability, elevated prices, and slow uptake of generic alternatives for these three drugs alone cost Medicaid 1.5 billion dollars in 2000-2004... - Risk of fractures in older adults using antihypertensive medicationsDaniel H Solomon
Division of Rheumatology and Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Bone Miner Res 26:1561-7. 2011..It is concluded that the risk of fracture differs across users of different antihypertensive medications... - Patient, physician, pharmacy, and pharmacy benefit design factors related to generic medication useWilliam H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
J Gen Intern Med 22:1298-304. 2007..Increased use of generic medications conserves insurer and patient financial resources and may increase patient adherence... - Medicaid's prior authorization program and access to atypical antipsychotic medicationsJennifer M Polinski
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, Massachusetts, USA
Health Aff (Millwood) 26:750-60. 2007..More than a year later, no state had changed its PA policy in response. We discuss the roles of Medicaid and other insurers in responding to emerging drug safety issues and their challenges in weighing drug risks and benefits... - Physician effectiveness in interventions to improve cardiovascular medication adherence: a systematic reviewSarah L Cutrona
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
J Gen Intern Med 25:1090-6. 2010..Medications for the prevention and treatment of cardiovascular disease save lives but adherence is often inadequate. The optimal role for physicians in improving adherence remains unclear... - Patterns of outpatient antihypertensive medication use during pregnancy in a Medicaid populationBrian T Bateman
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hypertension 60:913-20. 2012..1%) in the third trimester. Antihypertensive use during pregnancy is relatively common and increasing. The wide range of agents used during pregnancy includes medications considered contraindicated during pregnancy... - Prevalence, incidence, and demographics of systemic lupus erythematosus and lupus nephritis from 2000 to 2004 among children in the US Medicaid beneficiary populationLinda T Hiraki
Harvard School of Public Health and Brigham and Women s Hospital, Boston, Massachusetts, USA
Arthritis Rheum 64:2669-76. 2012..To investigate the nationwide prevalence, incidence, and sociodemographics of systemic lupus erythematosus (SLE) and lupus nephritis among children in the US Medicaid beneficiary population... - Effect of the Women's Health Initiative on osteoporosis therapy and expenditure in MedicaidJacob A Udell
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA
J Bone Miner Res 21:765-71. 2006..Determining whether these trends are clinically appropriate and cost effective for osteoporosis therapy will have important implications for the development of future drug reimbursement programs, especially for elderly patients... - Patients' perceptions of generic medicationsWilliam H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, at Brigham and Women s Hospital Harvard Medical School in Boston, Massachusetts, USA
Health Aff (Millwood) 28:546-56. 2009..These findings underscore the challenge that providers, insurers, and policymakers face in stimulating the cost-effective use of medications... - Strategies for the management of suspected heparin-induced thrombocytopenia: a cost-effectiveness analysisAmanda R Patrick
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham, Massachusetts 02120, USA
Pharmacoeconomics 25:949-61. 2007..Drugs used to treat HIT are costly and may carry an increased risk of bleeding... - Differences between integrated and stand-alone E-prescribing systems have implications for future useCatherine M DesRoches
Mongan Institute for Health Policy, Partners HealthCare, Boston, Massachusetts, USA
Health Aff (Millwood) 29:2268-77. 2010..Because many stand-alone systems cannot meet meaningful-use requirements, there is likely to be a shift toward integrated systems... - The rise and fall of Natrecor for congestive heart failure: implications for drug policyAaron S Kesselheim
Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
Health Aff (Millwood) 25:1095-102. 2006..Based on the nesiritide experience, we suggest several ways to improve policies for drug approval, postmarketing surveillance, and drug utilization... - Potential savings from an evidence-based consumer-oriented public education campaign on prescription drugsJulie M Donohue
Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A613, Pittsburgh, PA 15261, USA
Health Serv Res 43:1557-75. 2008..To estimate potential savings associated with the Consumer Reports Best Buy Drugs program, a national educational program that provides consumers with price and effectiveness information on prescription drugs... - Acute pancreatitis associated with rofecoxibRavi K Amaravadi
Am J Gastroenterol 97:1077-8. 2002 - Topical calcineurin inhibitors for atopic dermatitis: balancing clinical benefit and possible risksAbrar A Qureshi
Arch Dermatol 142:633-7. 2006 - Topical calcineurin inhibitors revisitedAbrar Qureshi
Arch Dermatol 143:545-6. 2007
Research Grants
- Impact of office-based e-prescribing on prescribing processes and outcomesMichael Fischer; Fiscal Year: 2007..The findings of this research will provide important lessons for clinicians, researchers, insurers, policy-makers, patients, and all those with an interest in improving the use of prescription drugs. ..
- Impact of Medicaid Policy on cardiovascular drug use and clinical outcomesMichael A Fischer; Fiscal Year: 2010....