Joel Finkelstein

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Gonadal steroids and body composition, strength, and sexual function in men
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 369:1011-22. 2013
  2. pmc Changes in bone resorption across the menopause transition: effects of reproductive hormones, body size, and ethnicity
    MaryFran R Sowers
    MD, Endocrine Unit, Thier 1051, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 98:2854-63. 2013
  3. ncbi request reprint Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men
    Joel S Finkelstein
    Endocrine Unit, Bulfinch 327, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2882-7. 2006
  4. pmc Bone mineral density changes during the menopause transition in a multiethnic cohort of women
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:861-8. 2008
  5. ncbi request reprint The effects of parathyroid hormone, alendronate, or both in men with osteoporosis
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    N Engl J Med 349:1216-26. 2003
  6. pmc Effects of teriparatide retreatment in osteoporotic men and women
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2495-501. 2009
  7. pmc Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis
    Joel S Finkelstein
    Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:1838-45. 2010
  8. ncbi request reprint Effects of selective testosterone and estradiol withdrawal on skeletal sensitivity to parathyroid hormone in men
    Hang Lee
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1069-75. 2006
  9. ncbi request reprint Gaps in treatment among users of osteoporosis medications: the dynamics of noncompliance
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass 02120, USA
    Am J Med 120:251-6. 2007
  10. pmc Effects of teriparatide treatment and discontinuation in postmenopausal women and eugonadal men with osteoporosis
    Benjamin Z Leder
    Endocrine Unit, THR 1047, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 94:2915-21. 2009

Detail Information

Publications37

  1. doi request reprint Gonadal steroids and body composition, strength, and sexual function in men
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 369:1011-22. 2013
    ..Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various testosterone levels or whether deficiencies of testosterone, estradiol, or both account for clinical manifestations...
  2. pmc Changes in bone resorption across the menopause transition: effects of reproductive hormones, body size, and ethnicity
    MaryFran R Sowers
    MD, Endocrine Unit, Thier 1051, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 98:2854-63. 2013
    ..Ethnic differences in BMI, and corresponding ethnic differences in bone resorption, appear to account for much of the ethnic variation in perimenopausal bone loss. ..
  3. ncbi request reprint Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men
    Joel S Finkelstein
    Endocrine Unit, Bulfinch 327, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2882-7. 2006
    ..We have previously demonstrated that alendronate reduces the ability of teriparatide to increase bone mineral density (BMD) in osteoporotic men. The underlying basis for this observation is poorly understood...
  4. pmc Bone mineral density changes during the menopause transition in a multiethnic cohort of women
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:861-8. 2008
    ..Rates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood...
  5. ncbi request reprint The effects of parathyroid hormone, alendronate, or both in men with osteoporosis
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    N Engl J Med 349:1216-26. 2003
    ..Because parathyroid hormone increases both bone formation and bone resorption, it is possible that combining parathyroid hormone with an antiresorptive agent will enhance its effect on bone mineral density...
  6. pmc Effects of teriparatide retreatment in osteoporotic men and women
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2495-501. 2009
    ..The stimulatory effect of teriparatide on bone mineral density (BMD) and bone turnover is initially exuberant, but then diminishes...
  7. pmc Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis
    Joel S Finkelstein
    Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:1838-45. 2010
    ..Teriparatide increases both bone formation and bone resorption...
  8. ncbi request reprint Effects of selective testosterone and estradiol withdrawal on skeletal sensitivity to parathyroid hormone in men
    Hang Lee
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1069-75. 2006
    ....
  9. ncbi request reprint Gaps in treatment among users of osteoporosis medications: the dynamics of noncompliance
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass 02120, USA
    Am J Med 120:251-6. 2007
    ..We sought to estimate the percentage of patients who restart osteoporosis therapy after a prolonged lapse in medication use and to identify the factors associated with a return to compliance...
  10. pmc Effects of teriparatide treatment and discontinuation in postmenopausal women and eugonadal men with osteoporosis
    Benjamin Z Leder
    Endocrine Unit, THR 1047, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 94:2915-21. 2009
    ..In postmenopausal women, bone mineral density (BMD) declines after teriparatide therapy is stopped. The pattern of BMD loss after teriparatide therapy is stopped in men is less clear...
  11. ncbi request reprint Compliance with osteoporosis medications
    Daniel H Solomon
    Divisions of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA 02120, USA
    Arch Intern Med 165:2414-9. 2005
    ..This study was undertaken to assess the level and determinants of compliance with drugs prescribed for osteoporosis...
  12. ncbi request reprint Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women
    Sherri Ann M Burnett
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Bone Miner Res 21:1187-96. 2006
    ..Dietary phosphate is a key regulator of circulating FGF-23; choice of assay is critical when studying FGF-23 physiology...
  13. ncbi request reprint Osteoporosis improvement: a large-scale randomized controlled trial of patient and primary care physician education
    Daniel H Solomon
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Bone Miner Res 22:1808-15. 2007
    ..04; 95% ci, 0.85-1.26)...
  14. pmc High-risk patients' readiness to undergo BMD testing for osteoporosis diagnosis in Pennsylvania
    Jennifer M Polinski
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Int Q Community Health Educ 29:223-40. 2008
    ..We found several correlates of readiness to undergo BMD screening that may be used to design effective interventions...
  15. pmc The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis
    Daniel H Solomon
    Brigham and Women s Hospital, Division of Rheumatology, Boston, Massachusetts 02115, USA
    Arthritis Rheum 60:1624-31. 2009
    ..The aim of this study was to determine whether lower BMD is associated with higher erosion scores among patients with RA...
  16. ncbi request reprint Effect of aromatase inhibition on bone metabolism in elderly hypogonadal men
    Benjamin Z Leder
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Bulfinch 327, Fruit Street, Boston, MA 02114, USA
    Osteoporos Int 16:1487-94. 2005
    ..These results suggest that anastrozole therapy is unlikely to have an adverse effect on bone metabolism when taken over extended periods and may prove to be a valuable method of normalizing testosterone production in older men...
  17. ncbi request reprint Differential effects of androgens and estrogens on bone turnover in normal men
    Benjamin Z Leder
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:204-10. 2003
    ..These data also suggest that androgens may play an important role in the regulation of bone formation in men...
  18. pmc Patterns of bone mineral density testing: current guidelines, testing rates, and interventions
    Charles A Morris
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Gen Intern Med 19:783-90. 2004
    ..To identify potential obstacles to bone mineral density (BMD) testing, we performed a structured review of current osteoporosis screening guidelines, studies of BMD testing patterns, and interventions to increase BMD testing...
  19. ncbi request reprint Underuse of osteoporosis medications in elderly patients with fractures
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Am J Med 115:398-400. 2003
  20. ncbi request reprint Raloxifene to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer: a randomized controlled trial
    Matthew R Smith
    Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3841-6. 2004
    ..06) and trochanter (P < 0.001). In men receiving a GnRH agonist, raloxifene significantly increases bone mineral density of the hip and tends to increase bone mineral density of the spine...
  21. ncbi request reprint Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA org
    J Clin Endocrinol Metab 87:3057-67. 2002
    ..Femoral neck BMD is highest in African-Americans and similar in Chinese, Japanese, and Caucasians. These findings may explain why Caucasian women have higher fracture rates than African-Americans and Asians...
  22. ncbi request reprint Statin lipid-lowering drugs and bone mineral density
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 14:219-26. 2005
    ..We examined the relationship between statin use and bone density among postmenopausal women...
  23. ncbi request reprint Medication use patterns for osteoporosis: an assessment of guidelines, treatment rates, and quality improvement interventions
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
    Mayo Clin Proc 80:194-202. 2005
    ..To assess current osteoporosis treatment guidelines, studies of osteoporosis treatment, and interventions to improve osteoporosis treatment...
  24. ncbi request reprint Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women
    Benjamin Z Leder
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:5449-54. 2002
    ..If these hormonal effects are sustained during long-term administration, regular use of this supplement by postmenopausal women could thus cause both beneficial and adverse effects...
  25. doi request reprint Ethnic differences in C-reactive protein concentrations
    Alyson Kelley-Hedgepeth
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA
    Clin Chem 54:1027-37. 2008
    ..We hypothesized that known CVD risk factors, including anthropometric characteristics, would explain much of the observed ethnic variation in CRP...
  26. ncbi request reprint Ethnic variation in bone turnover in pre- and early perimenopausal women: effects of anthropometric and lifestyle factors
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA org
    J Clin Endocrinol Metab 87:3051-6. 2002
    ..Other factors, such as differences in bone accretion, are likely responsible for much of the ethnic variation in adult BMD...
  27. pmc Randomized controlled trial of annual zoledronic acid to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer
    M Dror Michaelson
    Division of Hematology and Oncology and Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 25:1038-42. 2007
    ..Annual zoledronic acid increases BMD in postmenopausal women, but its efficacy in hypogonadal men is not known...
  28. ncbi request reprint Bicalutamide monotherapy versus leuprolide monotherapy for prostate cancer: effects on bone mineral density and body composition
    Matthew R Smith
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 22:2546-53. 2004
    ..Less is known about the effects of bicalutamide monotherapy on bone mineral density and body composition...
  29. ncbi request reprint Changes in bone mineral density and body composition during initial and long-term gonadotropin-releasing hormone agonist treatment for prostate carcinoma
    Hang Lee
    Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 104:1633-7. 2005
    ..To the authors' knowledge, little is known regarding either the long-term effects of treatment or predictors of treatment-related changes in BMD and body composition...
  30. ncbi request reprint An unusual case of primary hyperparathyroidism with profoundly elevated parathyroid hormone levels
    Allan F Moore
    Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Endocr Pract 14:892-7. 2008
    ..To report the case of a man who presented with profoundly elevated parathyroid hormone levels in the setting of hypercalcemia, a palpable neck mass, renal disease, and metabolic bone disease...
  31. ncbi request reprint Correlates of circulating androgens in mid-life women: the study of women's health across the nation
    Nanette Santoro
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Mazer 316, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 90:4836-45. 2005
    ..Because circulating androgens decline with age, the use of androgen supplementation for women to improve health and well-being has been increasing...
  32. ncbi request reprint Sport and home physical activity are independently associated with bone density
    Gail A Greendale
    David Geffen School of Medicine at UCLA, Division of Geriatrics, Los Angeles, CA 90095 1687, USA
    Med Sci Sports Exerc 35:506-12. 2003
    ..To study the relations between four domains of physical activity-sport, home, work, and active living-and bone mineral density (BMD)...
  33. ncbi request reprint Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status
    John F Randolph
    Clinical Centers University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 88:1516-22. 2003
    ..All hormone concentrations were significantly correlated with body mass index. We conclude that serum sex steroid, FSH, and SHBG levels vary by ethnicity, but are highly confounded by ethnic disparities in body size...
  34. ncbi request reprint Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: The Study of Women's Health across the Nation (SWAN) Daily Hormone Study
    Nanette Santoro
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Endocrinol Metab 89:2622-31. 2004
    ..Comparisons to younger women indirectly support the inhibin hypothesis, which proposes that the initiating event in the menopausal transition is the loss of inhibin negative feedback on FSH secondary to a diminished follicular reserve...
  35. ncbi request reprint Calcium plus vitamin D for postmenopausal women--bone app├ętit?
    Joel S Finkelstein
    N Engl J Med 354:750-2. 2006
  36. ncbi request reprint Hormone predictors of bone mineral density changes during the menopausal transition
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 339 East Liberty Street, Suite 310, Ann Arbor, MI 48104, USA
    J Clin Endocrinol Metab 91:1261-7. 2006
    ..OBJECTIVE AND CONTEXT: Our objective was to examine predictability of reproductive hormone concentrations for bone mineral density (BMD) loss during the menopausal transition...
  37. ncbi request reprint Effects of androstenedione administration on epitestosterone metabolism in men
    Don H Catlin
    UCLA Olympic Analytical Laboratory, Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90025, USA
    Steroids 67:559-64. 2002
    ..Elevated ratios of EM-1- and EM-2/E-precursor, and the presence of 6alpha-hydroxyandrostenedione are androstenedione administration markers...

Research Grants9

  1. Physiologic effects of androgen and estrogen deficiency in young and old men
    Joel S Finkelstein; Fiscal Year: 2010
    ..of male hypogonadism, assist clinicians in deciding when to treat young and old men with testosterone, and provide essential information for the rational selection of men for future clinical trials of androgen replacement in aging men ..
  2. X-Treme CT Equipment Grant
    Joel Finkelstein; Fiscal Year: 2007
    ..We propose to use XtremeCT in a wide range of studies of bone disease that span a multitude of disciplines and serve a wide range of investigators in Boston and throughout New England. ..
  3. EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONE
    Joel Finkelstein; Fiscal Year: 2007
    ..Without continued K24 support, I will need to increase my clinical activities, reduce my research time, and forego training of new clinical investigators. ..
  4. Study of Women's Health Across the Nation - III
    Joel Finkelstein; Fiscal Year: 2007
    ..We will build upon the rich foundation developed during SWAN I and II and link these data to important menopause-related and health outcomes in SWAN III. ..
  5. Physiologic effects of androgen and estrogen deficiency in young and old men
    Joel Finkelstein; Fiscal Year: 2007
    ..of male hypogonadism, assist clinicians in deciding when to treat young and old men with testosterone, and provide essential information for the rational selection of men for future clinical trials of androgen replacement in aging men ..
  6. Physiologic effects of androgen and estrogen deficiency in young and old men
    Joel Finkelstein; Fiscal Year: 2009
    ..of male hypogonadism, assist clinicians in deciding when to treat young and old men with testosterone, and provide essential information for the rational selection of men for future clinical trials of androgen replacement in aging men ..