Joel Finkelstein

..Teriparatide increases both bone formation and bone resorption...

..We have previously demonstrated that alendronate reduces the ability of teriparatide to increase bone mineral density (BMD) in osteoporotic men. The underlying basis for this observation is poorly understood...

..Rates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood...

..The stimulatory effect of teriparatide on bone mineral density (BMD) and bone turnover is initially exuberant, but then diminishes...

..Because parathyroid hormone increases both bone formation and bone resorption, it is possible that combining parathyroid hormone with an antiresorptive agent will enhance its effect on bone mineral density...

..These findings underscore the importance of both androgens and estrogens in male skeletal homeostasis and suggest that changes in skeletal sensitivity to PTH may play an important role in the pathogenesis of hypogonadal bone loss in men...

..We sought to estimate the percentage of patients who restart osteoporosis therapy after a prolonged lapse in medication use and to identify the factors associated with a return to compliance...

..The aim of this study was to determine whether lower BMD is associated with higher erosion scores among patients with RA...

..Dietary phosphate is a key regulator of circulating FGF-23; choice of assay is critical when studying FGF-23 physiology...

..04; 95% ci, 0.85-1.26)...

..Femoral neck BMD is highest in African-Americans and similar in Chinese, Japanese, and Caucasians. These findings may explain why Caucasian women have higher fracture rates than African-Americans and Asians...

..This study was undertaken to assess the level and determinants of compliance with drugs prescribed for osteoporosis...

..If these hormonal effects are sustained during long-term administration, regular use of this supplement by postmenopausal women could thus cause both beneficial and adverse effects...

..These results suggest that anastrozole therapy is unlikely to have an adverse effect on bone metabolism when taken over extended periods and may prove to be a valuable method of normalizing testosterone production in older men...

..To assess current osteoporosis treatment guidelines, studies of osteoporosis treatment, and interventions to improve osteoporosis treatment...

..06) and trochanter (P < 0.001). In men receiving a GnRH agonist, raloxifene significantly increases bone mineral density of the hip and tends to increase bone mineral density of the spine...

..In postmenopausal women, bone mineral density (BMD) declines after teriparatide therapy is stopped. The pattern of BMD loss after teriparatide therapy is stopped in men is less clear...

..To identify potential obstacles to bone mineral density (BMD) testing, we performed a structured review of current osteoporosis screening guidelines, studies of BMD testing patterns, and interventions to increase BMD testing...

..We found several correlates of readiness to undergo BMD screening that may be used to design effective interventions...

..These data also suggest that androgens may play an important role in the regulation of bone formation in men...

..We examined the relationship between statin use and bone density among postmenopausal women...

..We hypothesized that known CVD risk factors, including anthropometric characteristics, would explain much of the observed ethnic variation in CRP...

..Annual zoledronic acid increases BMD in postmenopausal women, but its efficacy in hypogonadal men is not known...

..Other factors, such as differences in bone accretion, are likely responsible for much of the ethnic variation in adult BMD...

..Less is known about the effects of bicalutamide monotherapy on bone mineral density and body composition...

..CONCLUSIONS: The results of the current study showed that fat mass increased and lean body mass decreased mostly during initial GnRH agonist therapy whereas BMD decreased steadily during initial and long-term treatment...

..To report the case of a man who presented with profoundly elevated parathyroid hormone levels in the setting of hypercalcemia, a palpable neck mass, renal disease, and metabolic bone disease...

..To study the relations between four domains of physical activity-sport, home, work, and active living-and bone mineral density (BMD)...

..All hormone concentrations were significantly correlated with body mass index. We conclude that serum sex steroid, FSH, and SHBG levels vary by ethnicity, but are highly confounded by ethnic disparities in body size...

..Comparisons to younger women indirectly support the inhibin hypothesis, which proposes that the initiating event in the menopausal transition is the loss of inhibin negative feedback on FSH secondary to a diminished follicular reserve...

..Because circulating androgens decline with age, the use of androgen supplementation for women to improve health and well-being has been increasing...

..OBJECTIVE AND CONTEXT: Our objective was to examine predictability of reproductive hormone concentrations for bone mineral density (BMD) loss during the menopausal transition...

..Elevated ratios of EM-1- and EM-2/E-precursor, and the presence of 6alpha-hydroxyandrostenedione are androstenedione administration markers...

..We propose to use XtremeCT in a wide range of studies of bone disease that span a multitude of disciplines and serve a wide range of investigators in Boston and throughout New England. ..

..Without continued K24 support, I will need to increase my clinical activities, reduce my research time, and forego training of new clinical investigators. ..

..We will build upon the rich foundation developed during SWAN I and II and link these data to important menopause-related and health outcomes in SWAN III. ..

..of male hypogonadism, assist clinicians in deciding when to treat young and old men with testosterone, and provide essential information for the rational selection of men for future clinical trials of androgen replacement in aging men ..

..of male hypogonadism, assist clinicians in deciding when to treat young and old men with testosterone, and provide essential information for the rational selection of men for future clinical trials of androgen replacement in aging men ..

..of male hypogonadism, assist clinicians in deciding when to treat young and old men with testosterone, and provide essential information for the rational selection of men for future clinical trials of androgen replacement in aging men ..