Dianne Finkelstein

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Quantitatively determined survivin expression levels are of prognostic value in human gliomas
    Arnab Chakravarti
    Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA
    J Clin Oncol 20:1063-8. 2002
  2. ncbi request reprint Phase I trial and pharmacokinetics of escalating doses of paclitaxel and concurrent hyperfractionated radiotherapy with or without amifostine in patients with advanced head and neck carcinoma
    Philip C Amrein
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 104:1418-27. 2005
  3. pmc Web-browser encryption of personal health information
    Richard E Morse
    MGH Biostatistics Center, Massachusetts General Hospital, 50 Staniford St, Ste 560, Boston, MA 02114, USA
    BMC Med Inform Decis Mak 11:70. 2011
  4. pmc Design considerations in a sib-pair study of linkage for susceptibility loci in cancer
    Richard A Kerber
    Population Sciences Program, Hunstman Cancer Institute, Salt Lake City, UT, USA
    BMC Med Genet 9:64. 2008
  5. pmc Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status
    Steven J Skates
    Biostatistics Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 4:1401-8. 2011
  6. pmc A score test for association of a longitudinal marker and an event with missing data
    Dianne M Finkelstein
    Massachusetts General Hospital and Harvard University, Boston, Massachusetts 02114, USA
    Biometrics 66:726-32. 2010
  7. doi request reprint Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer
    Anthony C Nichols
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Cancer Res 16:2138-46. 2010
  8. doi request reprint Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis
    Kenneth K Tanabe
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    JAMA 299:53-60. 2008
  9. ncbi request reprint Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas
    Antonia E Stephen
    Department of Surgical Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 142:381-6. 2007
  10. ncbi request reprint Survival analysis of longitudinal microarrays
    Natasa Rajicic
    Massachusetts General Hospital, Biostatistics Unit 50 Staniford Street, Suite 560, Boston, MA, USA
    Bioinformatics 22:2643-9. 2006

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Quantitatively determined survivin expression levels are of prognostic value in human gliomas
    Arnab Chakravarti
    Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA
    J Clin Oncol 20:1063-8. 2002
    ..Its expression has been found to be of prognostic significance in several tumor types. This is the first study on the prognostic significance of survivin expression in human gliomas...
  2. ncbi request reprint Phase I trial and pharmacokinetics of escalating doses of paclitaxel and concurrent hyperfractionated radiotherapy with or without amifostine in patients with advanced head and neck carcinoma
    Philip C Amrein
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 104:1418-27. 2005
    ....
  3. pmc Web-browser encryption of personal health information
    Richard E Morse
    MGH Biostatistics Center, Massachusetts General Hospital, 50 Staniford St, Ste 560, Boston, MA 02114, USA
    BMC Med Inform Decis Mak 11:70. 2011
    ..However it is important to protect patient confidentiality, as many medical conditions are stigmatized and disclosure could result in personal and/or financial loss...
  4. pmc Design considerations in a sib-pair study of linkage for susceptibility loci in cancer
    Richard A Kerber
    Population Sciences Program, Hunstman Cancer Institute, Salt Lake City, UT, USA
    BMC Med Genet 9:64. 2008
    ..However, the sibpair design is still valuable because it requires few assumptions other than acceptably high penetrance to identify genetic loci...
  5. pmc Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status
    Steven J Skates
    Biostatistics Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 4:1401-8. 2011
    ....
  6. pmc A score test for association of a longitudinal marker and an event with missing data
    Dianne M Finkelstein
    Massachusetts General Hospital and Harvard University, Boston, Massachusetts 02114, USA
    Biometrics 66:726-32. 2010
    ..The problem was motivated by data from an observational study of patients with diabetes...
  7. doi request reprint Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer
    Anthony C Nichols
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Cancer Res 16:2138-46. 2010
    ..To determine whether Bcl2 and HPV together might further characterize treatment response, we examined whether the prognostic value of Bcl2 was independent of HPV status...
  8. doi request reprint Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis
    Kenneth K Tanabe
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    JAMA 299:53-60. 2008
    ..Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels...
  9. ncbi request reprint Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas
    Antonia E Stephen
    Department of Surgical Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 142:381-6. 2007
    ..To investigate why some patients with single parathyroid adenomas have negative preoperative sestamibi scans...
  10. ncbi request reprint Survival analysis of longitudinal microarrays
    Natasa Rajicic
    Massachusetts General Hospital, Biostatistics Unit 50 Staniford Street, Suite 560, Boston, MA, USA
    Bioinformatics 22:2643-9. 2006
    ..When gene expressions are measured over time, there are methods for differentiating temporal patterns. However, methods have not yet been proposed for the survival analysis of longitudinally collected microarrays...
  11. ncbi request reprint Results of whole-brain radiation as salvage of methotrexate failure for immunocompetent patients with primary CNS lymphoma
    Paul L Nguyen
    Massachusetts General Hospital, Department of Radiation Oncology, 100 Blossom St, Boston, MA 02114, USA
    J Clin Oncol 23:1507-13. 2005
    ..This study evaluates the efficacy and toxicity of whole-brain radiation therapy (WBRT) as salvage therapy for immunocompetent patients who failed initial high-dose methotrexate for primary CNS lymphoma (PCNSL)...
  12. ncbi request reprint Comparing survival of a sample to that of a standard population
    Dianne M Finkelstein
    Biostatistics Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Natl Cancer Inst 95:1434-9. 2003
  13. ncbi request reprint Phase II study of paclitaxel and carboplatin for malignant melanoma
    F Stephen Hodi
    Adult Oncology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Clin Oncol 25:283-6. 2002
    ..Comparisons with other treatment regimens and the search for additional active compounds against melanoma are needed...
  14. doi request reprint Breast cancer after treatment of Hodgkin's lymphoma: risk factors that really matter
    Mohamed A Alm El-Din
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 73:69-74. 2009
    ..To evaluate the risk of breast cancer (BC) and the contributing risk factors in women after supradiaphragmatic irradiation (SDI) for Hodgkin's lymphoma (HL)...
  15. ncbi request reprint Regression of microalbuminuria in type 1 diabetes
    Bruce A Perkins
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 348:2285-93. 2003
    ..In the present study, we aimed to determine the frequency of a significant reduction in urinary albumin excretion and factors affecting such reduction in patients with type 1 diabetes and microalbuminuria...
  16. ncbi request reprint Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan
    Edyta Tyminski
    Molecular Neuro oncology Laboratories, Neurosurgery Service and Biostatistics Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Cancer Res 65:6850-7. 2005
    ..Therefore, MGH2 provides effective multimodal therapy for gliomas in preclinical models when combined with these chemotherapy agents...
  17. ncbi request reprint Model-based predictions of BRCA1/2 mutation status in breast carcinoma patients treated at an academic medical center
    Kristen M Shannon
    Division of Hematology Oncology, Massachusetts General Hospital, Boston 02114, USA
    Cancer 94:305-13. 2002
    ....
  18. ncbi request reprint Study of either ifosfamide or teniposide compared to a standard chemotherapy for extensive disease small cell lung cancer: an Eastern Cooperative Oncology Group randomized study (E1588)
    David S Ettinger
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, Room G 88, 1650 Orleans Street, Baltimore, MD, USA
    Lung Cancer 37:311-8. 2002
    ....
  19. ncbi request reprint Predicting time to prostate cancer recurrence based on joint models for non-linear longitudinal biomarkers and event time outcomes
    Donna K Pauler
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 702, Seattle, WA 98109, USA
    Stat Med 21:3897-911. 2002
    ..Based on these data, predictive schemes for detecting cancer recurrence in new patients based on their longitudinal trajectory are derived...
  20. pmc Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms
    Daphne W Bell
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Clin Cancer Res 14:4079-84. 2008
    ....
  21. ncbi request reprint Prognosis and management of extramammary Paget's disease and the association with secondary malignancies
    Jean Pierre E N Pierie
    Department of Surgery, Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands
    J Am Coll Surg 196:45-50. 2003
    ..Extramammary Paget's disease (EMPD) is a rare clinical entity and can be associated with other malignancies. We analyzed our experience for prognosis and impact of therapy on outcomes...
  22. pmc Validity of models for predicting BRCA1 and BRCA2 mutations
    Giovanni Parmigiani
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21205 2011, USA
    Ann Intern Med 147:441-50. 2007
    ..At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood...
  23. ncbi request reprint Modelling the relationship between continuous covariates and clinical events using isotonic regression
    Marek Ancukiewicz
    Massachusetts General Hospital, Boston, MA, U S A
    Stat Med 22:3151-9. 2003
    ..These methods will be applied to graphically display the risk for an AIDS patient of an opportunistic infection as a function of CD4 count...
  24. ncbi request reprint Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma
    Cristina R Ferrone
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 24:2897-902. 2006
    ..The purpose of this study was to determine whether preoperative CA19-9 levels can predict stage of disease or survival and whether a change in preoperative to postoperative CA19-9 or the postoperative CA19-9 predicts overall survival...

Research Grants12

  1. Methods for Statistical Analysis of Cancer Genetic Network Studies
    Dianne Finkelstein; Fiscal Year: 2007
    ....
  2. COORDINATING CENTER FOR THE CANCER GENETICS NETWORK
    Dianne Finkelstein; Fiscal Year: 2006
    ..We will coordinate our activities with the other members of the Informatics Technology group. ..
  3. Analysis of Longitudinal High Dimensional Data for Burn and Trauma Studies
    Dianne Finkelstein; Fiscal Year: 2007
    ..This knowledge can be used to improve the treatment of severely burned patients resulting in more rapid and complete recovery. ..
  4. STATISTICAL METHODS FOR RESEARCH IN CANCER AND AIDS
    Dianne Finkelstein; Fiscal Year: 2004
    ....
  5. STATISTICAL METHODS FOR RESEARCH IN CANCER AND AIDS
    Dianne Finkelstein; Fiscal Year: 1999
    ....