Raina N Fichorova

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
    Raina N Fichorova
    Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:2424-32. 2002
  2. ncbi request reprint Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells
    Kerstin Kleine-Lowinski
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Cancer 107:407-15. 2003
  3. pmc Guiding the vaginal microbicide trials with biomarkers of inflammation
    Raina N Fichorova
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 37:S184-93. 2004
  4. pmc Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Avenue, RF468, Boston, MA 02115, USA
    Infect Immun 74:5773-9. 2006
  5. pmc Cluster analysis of placental inflammatory proteins can distinguish preeclampsia from preterm labor and premature membrane rupture in singleton deliveries less than 28 weeks of gestation
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD 20892 7105, USA
    Am J Reprod Immunol 66:488-94. 2011
  6. doi request reprint Persistence after birth of systemic inflammation associated with umbilical cord inflammation
    Alan Leviton
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Reprod Immunol 90:235-43. 2011
  7. pmc Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    PLoS ONE 7:e48418. 2012
  8. doi request reprint Blood protein concentrations in the first two postnatal weeks associated with early postnatal blood gas derangements among infants born before the 28th week of gestation. The ELGAN Study
    Alan Leviton
    Department of Neurology, Children s Hospital Boston, and Harvard Medical School, Boston, MA 02115, USA
    Cytokine 56:392-8. 2011
  9. pmc Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery
    Sunita Trivedi
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 206:236.e1-8. 2012
  10. pmc The Villain Team-Up or how Trichomonas vaginalis and bacterial vaginosis alter innate immunity in concert
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Sex Transm Infect 89:460-6. 2013

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
    Raina N Fichorova
    Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:2424-32. 2002
    ..These data demonstrate that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling...
  2. ncbi request reprint Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells
    Kerstin Kleine-Lowinski
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Cancer 107:407-15. 2003
    ..These observations are consistent with a model in which MCP-1 expression by infected keratinocytes, which would stimulate an immune attack on HPV-transformed cells, is suppressed for invasive cervical cancer to appear...
  3. pmc Guiding the vaginal microbicide trials with biomarkers of inflammation
    Raina N Fichorova
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 37:S184-93. 2004
    ....
  4. pmc Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Avenue, RF468, Boston, MA 02115, USA
    Infect Immun 74:5773-9. 2006
    ..These effects were dose dependent and sustained in the absence of cytotoxicity and IL-1beta release and utilized, at least in part, a signaling pathway independent from the Toll-like/IL-1 receptor adaptor protein MyD88...
  5. pmc Cluster analysis of placental inflammatory proteins can distinguish preeclampsia from preterm labor and premature membrane rupture in singleton deliveries less than 28 weeks of gestation
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD 20892 7105, USA
    Am J Reprod Immunol 66:488-94. 2011
    ..The risks of complications are different between iatrogenic (e.g. PE) and spontaneous (e.g. PL and membrane rupture) causes of preterm delivery, suggesting different underlying biology contributes to these placental conditions...
  6. doi request reprint Persistence after birth of systemic inflammation associated with umbilical cord inflammation
    Alan Leviton
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Reprod Immunol 90:235-43. 2011
    ....
  7. pmc Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    PLoS ONE 7:e48418. 2012
    ..Metronidazole treatment amplified these proinflammatory responses. Thus, a new paradigm targeting the protozoan viruses along with the protozoan host may prevent trichomoniasis-attributable inflammatory sequelae...
  8. doi request reprint Blood protein concentrations in the first two postnatal weeks associated with early postnatal blood gas derangements among infants born before the 28th week of gestation. The ELGAN Study
    Alan Leviton
    Department of Neurology, Children s Hospital Boston, and Harvard Medical School, Boston, MA 02115, USA
    Cytokine 56:392-8. 2011
    ..To explore the relationships between blood gas derangements and blood concentrations of inflammation-related proteins shortly after preterm birth...
  9. pmc Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery
    Sunita Trivedi
    Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 206:236.e1-8. 2012
    ..Our objective was to determine whether placental corticotropin-releasing hormone is activated in extreme preterm labor...
  10. pmc The Villain Team-Up or how Trichomonas vaginalis and bacterial vaginosis alter innate immunity in concert
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Sex Transm Infect 89:460-6. 2013
    ....
  11. pmc Two-hit model of brain damage in the very preterm newborn: small for gestational age and postnatal systemic inflammation
    Alan Leviton
    Department of Neurology, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Res 73:362-70. 2013
    ..We sought to disentangle the contributions of perinatal systemic inflammation and being small for gestational age (SGA) to the occurrence of low Bayley Mental Development Indices (MDIs) at the age of 2 y...
  12. pmc Relationships among the concentrations of 25 inflammation-associated proteins during the first postnatal weeks in the blood of infants born before the 28th week of gestation
    Alan Leviton
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 5724, USA
    Cytokine 57:182-90. 2012
    ..Inflammation appears to be involved in processes leading to organ damage in preterm newborns, yet little is known about the relationships among elevated concentrations of inflammation-associated proteins in the blood of preterm newborns...
  13. pmc Novel vaginal microflora colonization model providing new insight into microbicide mechanism of action
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts, USA
    MBio 2:e00168-11. 2011
    ....
  14. pmc Systemic responses of preterm newborns with presumed or documented bacteraemia
    Alan Leviton
    Department of Neurology, Children s Hospital Boston, and Harvard Medical School, Boston, MA 02215 5349, USA
    Acta Paediatr 101:355-9. 2012
    ....
  15. ncbi request reprint Biomarkers of leukocyte traffic and activation in the vaginal mucosa
    Radiana T Trifonova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biomarkers 12:608-22. 2007
    ..These biomarkers, which were also detected in human vaginal secretions, may be used to enhance the characterization of mucosal safety of vaginally applied compounds, both in animal as well as clinical studies...
  16. pmc Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo
    Radiana T Trifonova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Antimicrob Agents Chemother 50:4005-10. 2006
    ..This study identifies immunoinflammatory biomarkers that can discriminate between formulations better than toxicity assays and should be clinically validated in relevance to the risk of HIV-1 acquisition...
  17. ncbi request reprint Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cells
    Geraldine O Canny
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, 02115, USA
    J Infect Dis 194:498-502. 2006
    ..The results of the present study suggest that BPI is tightly regulated and functionally expressed by epithelial cells in the female reproductive tract and may play a role in regulating bacterial colonization in the genital mucosa...
  18. doi request reprint Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns
    Camilia R Martin
    Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Fetal Pediatr Pathol 32:222-34. 2013
    ..A better understanding of systemic inflammation might help prevent and treat these disorders...
  19. doi request reprint Baseline variation and associations between subject characteristics and five cytokine biomarkers of vaginal safety among healthy non-pregnant women in microbicide trials
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cytokine 55:134-40. 2011
    ....
  20. pmc Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA Newborns
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Pediatr Res 69:68-73. 2011
    ..These results confirm the predictive value of placental histology for the presence or absence of elevated inflammatory response in newborns...
  21. ncbi request reprint Detection of implantation-related cytokines in cervicovaginal secretions and peripheral blood of fertile women during ovulatory menstrual cycles
    Antonio R Gargiulo
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Fertil Steril 82:1226-34. 2004
    ..To determine whether cytokines implicated in uterine receptivity are detectable in cervicovaginal secretions and/or serum of fertile women, and whether their concentrations undergo hormonal regulation during the menstrual cycle...
  22. pmc Homeostatic properties of Lactobacillus jensenii engineered as a live vaginal anti-HIV microbicide
    Hidemi S Yamamoto
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Microbiol 13:4. 2013
    ....
  23. pmc Maternal microbe-specific modulation of inflammatory response in extremely low-gestational-age newborns
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics and Gynecology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    MBio 2:e00280-10. 2011
    ..This study provides evidence that microorganisms colonizing the placenta provoke distinctive newborn inflammatory responses and that Lactobacillus may suppress these responses...
  24. pmc Trichomonasvirus: a new genus of protozoan viruses in the family Totiviridae
    Russell P Goodman
    Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA
    Arch Virol 156:171-9. 2011
    ....
  25. pmc Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study
    Raina N Fichorova
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anal Chem 80:4741-51. 2008
    ..This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface...
  26. pmc Clinical isolates of Trichomonas vaginalis concurrently infected by strains of up to four Trichomonasvirus species (Family Totiviridae)
    Russell P Goodman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 85:4258-70. 2011
    ..vaginalis infections of the human genital mucosa...
  27. pmc Impact of T. vaginalis infection on innate immune responses and reproductive outcome
    Raina N Fichorova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02155, USA
    J Reprod Immunol 83:185-9. 2009
    ..The molecular mechanisms underlying reproductive complications and epidemiologic risks associated with T. vaginalis infection remain to be elucidated...
  28. pmc Mumps and ovarian cancer: modern interpretation of an historic association
    Daniel W Cramer
    Department of Obstetrics and Gynecology Epidemiology Center, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital BWH, Harvard Medical School, 221 Longwood Ave, RFB 366, Boston, MA 02115, USA
    Cancer Causes Control 21:1193-201. 2010
    ..To explain this association, we investigated whether mumps might engender immunity to ovarian cancer through antibodies against the cancer-associated antigen MUC1 abnormally expressed in the inflamed parotid gland...
  29. ncbi request reprint Preclinical assessment of the proinflammatory potential of microbicide candidates
    Gustavo F Doncel
    CONRAD, Intramural Preclinical Research, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Acquir Immune Defic Syndr 37:S174-80. 2004
    ..This combined, sequential, preclinical evaluation system based on VK-2 cells in culture and a refined rabbit vaginal irritation model represents a valuable tool to assess the local safety profile of anti-HIV microbicide candidates...
  30. ncbi request reprint Fourteen-day safety and acceptability study of 6% cellulose sulfate gel: a randomized double-blind Phase I safety study
    Jill L Schwartz
    Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 74:133-40. 2006
    ..Cellulose sulfate (CS) is a noncytotoxic antifertility agent that exhibits in vitro antimicrobial activity against sexually transmitted pathogens, including HIV...