Research Topics
| Raina N FichorovaSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
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Detail Information
Publications
Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signalingRaina N Fichorova
Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:2424-32. 2002..These data demonstrate that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling...- Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cellsKerstin Kleine-Lowinski
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Int J Cancer 107:407-15. 2003..These observations are consistent with a model in which MCP-1 expression by infected keratinocytes, which would stimulate an immune attack on HPV-transformed cells, is suppressed for invasive cervical cancer to appear... 
Guiding the vaginal microbicide trials with biomarkers of inflammationRaina N Fichorova
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 37:S184-93. 2004....- Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cellsRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Avenue, RF468, Boston, MA 02115, USA
Infect Immun 74:5773-9. 2006..These effects were dose dependent and sustained in the absence of cytotoxicity and IL-1beta release and utilized, at least in part, a signaling pathway independent from the Toll-like/IL-1 receptor adaptor protein MyD88... - Cluster analysis of placental inflammatory proteins can distinguish preeclampsia from preterm labor and premature membrane rupture in singleton deliveries less than 28 weeks of gestationJessica M Faupel-Badger
Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD 20892 7105, USA
Am J Reprod Immunol 66:488-94. 2011..The risks of complications are different between iatrogenic (e.g. PE) and spontaneous (e.g. PL and membrane rupture) causes of preterm delivery, suggesting different underlying biology contributes to these placental conditions... 
Persistence after birth of systemic inflammation associated with umbilical cord inflammationAlan Leviton
Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
J Reprod Immunol 90:235-43. 2011....- Blood protein concentrations in the first two postnatal weeks associated with early postnatal blood gas derangements among infants born before the 28th week of gestation. The ELGAN StudyAlan Leviton
Department of Neurology, Children s Hospital Boston, and Harvard Medical School, Boston, MA 02115, USA
Cytokine 56:392-8. 2011..To explore the relationships between blood gas derangements and blood concentrations of inflammation-related proteins shortly after preterm birth... - Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm deliverySunita Trivedi
Division of Endocrinology, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Am J Obstet Gynecol 206:236.e1-8. 2012..Our objective was to determine whether placental corticotropin-releasing hormone is activated in extreme preterm labor... - Novel vaginal microflora colonization model providing new insight into microbicide mechanism of actionRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts, USA
MBio 2:e00168-11. 2011..Our data also highlight the importance of differentiating the effects of biomedical interventions on epithelium-associated versus conventional planktonic bacterial growth when assessing vaginal mucosal health and immunity... - Systemic responses of preterm newborns with presumed or documented bacteraemiaAlan Leviton
Department of Neurology, Children s Hospital Boston, and Harvard Medical School, Boston, MA 02215 5349, USA
Acta Paediatr 101:355-9. 2012.... - Relationships among the concentrations of 25 inflammation-associated proteins during the first postnatal weeks in the blood of infants born before the 28th week of gestationAlan Leviton
Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 5724, USA
Cytokine 57:182-90. 2012..Inflammation appears to be involved in processes leading to organ damage in preterm newborns, yet little is known about the relationships among elevated concentrations of inflammation-associated proteins in the blood of preterm newborns... - Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivoRadiana T Trifonova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Antimicrob Agents Chemother 50:4005-10. 2006..This study identifies immunoinflammatory biomarkers that can discriminate between formulations better than toxicity assays and should be clinically validated in relevance to the risk of HIV-1 acquisition... - Biomarkers of leukocyte traffic and activation in the vaginal mucosaRadiana T Trifonova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Biomarkers 12:608-22. 2007..These biomarkers, which were also detected in human vaginal secretions, may be used to enhance the characterization of mucosal safety of vaginally applied compounds, both in animal as well as clinical studies... - Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapyRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
PLoS ONE 7:e48418. 2012..Metronidazole treatment amplified these proinflammatory responses. Thus, a new paradigm targeting the protozoan viruses along with the protozoan host may prevent trichomoniasis-attributable inflammatory sequelae... - Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cellsGeraldine O Canny
Center for Experimental Therapeutics and Reperfusion Injury, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA
J Infect Dis 194:498-502. 2006..The results of the present study suggest that BPI is tightly regulated and functionally expressed by epithelial cells in the female reproductive tract and may play a role in regulating bacterial colonization in the genital mucosa... - Baseline variation and associations between subject characteristics and five cytokine biomarkers of vaginal safety among healthy non-pregnant women in microbicide trialsRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Cytokine 55:134-40. 2011.... - Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA NewbornsJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Pediatr Res 69:68-73. 2011..These results confirm the predictive value of placental histology for the presence or absence of elevated inflammatory response in newborns... - Detection of implantation-related cytokines in cervicovaginal secretions and peripheral blood of fertile women during ovulatory menstrual cyclesAntonio R Gargiulo
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Fertil Steril 82:1226-34. 2004..To determine whether cytokines implicated in uterine receptivity are detectable in cervicovaginal secretions and/or serum of fertile women, and whether their concentrations undergo hormonal regulation during the menstrual cycle... - Trichomonasvirus: a new genus of protozoan viruses in the family TotiviridaeRussell P Goodman
Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA
Arch Virol 156:171-9. 2011.... - Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter studyRaina N Fichorova
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anal Chem 80:4741-51. 2008..This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface... - Maternal microbe-specific modulation of inflammatory response in extremely low-gestational-age newbornsRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics and Gynecology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
MBio 2:e00280-10. 2011..This study provides evidence that microorganisms colonizing the placenta provoke distinctive newborn inflammatory responses and that Lactobacillus may suppress these responses... - Impact of T. vaginalis infection on innate immune responses and reproductive outcomeRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02155, USA
J Reprod Immunol 83:185-9. 2009..The molecular mechanisms underlying reproductive complications and epidemiologic risks associated with T. vaginalis infection remain to be elucidated... - Mumps and ovarian cancer: modern interpretation of an historic associationDaniel W Cramer
Department of Obstetrics and Gynecology Epidemiology Center, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital BWH, Harvard Medical School, 221 Longwood Ave, RFB 366, Boston, MA 02115, USA
Cancer Causes Control 21:1193-201. 2010..To explain this association, we investigated whether mumps might engender immunity to ovarian cancer through antibodies against the cancer-associated antigen MUC1 abnormally expressed in the inflamed parotid gland... - Clinical isolates of Trichomonas vaginalis concurrently infected by strains of up to four Trichomonasvirus species (Family Totiviridae)Russell P Goodman
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 85:4258-70. 2011..vaginalis infections of the human genital mucosa... - Preclinical assessment of the proinflammatory potential of microbicide candidatesGustavo F Doncel
CONRAD, Intramural Preclinical Research, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
J Acquir Immune Defic Syndr 37:S174-80. 2004..This combined, sequential, preclinical evaluation system based on VK-2 cells in culture and a refined rabbit vaginal irritation model represents a valuable tool to assess the local safety profile of anti-HIV microbicide candidates... - Fourteen-day safety and acceptability study of 6% cellulose sulfate gel: a randomized double-blind Phase I safety studyJill L Schwartz
Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Contraception 74:133-40. 2006..Cellulose sulfate (CS) is a noncytotoxic antifertility agent that exhibits in vitro antimicrobial activity against sexually transmitted pathogens, including HIV...