Carlos Fernandez-del Castillo

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Evolution of the Whipple procedure at the Massachusetts General Hospital
    Carlos Fernandez-del Castillo
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Surgery 152:S56-63. 2012
  2. pmc Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term patient outcomes
    Alex B Haynes
    Department of Surgery, Massachusetts General Hospital, Wang Ambulatory Care Center 460, 15 Parkman St, Boston, MA 02114, USA
    Arch Surg 146:534-8. 2011
  3. ncbi request reprint Mucinous cystic neoplasms
    Carlos Fernandez-del Castillo
    Pancreas Surgery Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman St, ACC 460, Boston, MA 02114, USA
    J Gastrointest Surg 12:411-3. 2008
  4. ncbi request reprint Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients
    Carlos Fernandez-del Castillo
    Department of Surgery and Gastroenterology, Massachusetts General Hospital ACC 336, 15 Parkman Street, Boston, MA 02114, USA
    Arch Surg 138:427-3; discussion 433-4. 2003
  5. ncbi request reprint Surgery of cystic neoplasms
    Carlos Fernandez-del Castillo
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, ACC 336, Boston, MA 02114, USA
    Gastrointest Endosc Clin N Am 12:803-12, ix. 2002
  6. doi request reprint Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy
    Nils D Arvold
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 83:e337-43. 2012
  7. pmc Novel xenograft and cell line derived from an invasive intraductal papillary mucinous neoplasm of the pancreas give new insights into molecular mechanisms
    Stefan Fritz
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Pancreas 39:308-14. 2010
  8. pmc Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection
    J Ruben Rodriguez
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 133:72-9; quiz 309-10. 2007
  9. pmc Improved contemporary surgical management of insulinomas: a 25-year experience at the Massachusetts General Hospital
    Mehrdad Nikfarjam
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Ann Surg 247:165-72. 2008
  10. pmc Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005
    Parsia A Vagefi
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 142:347-54. 2007

Detail Information

Publications87

  1. pmc Evolution of the Whipple procedure at the Massachusetts General Hospital
    Carlos Fernandez-del Castillo
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Surgery 152:S56-63. 2012
    ..The goal of this study was to investigate the evolution of pancreatoduodenectomy at the Massachusetts General Hospital (MGH)...
  2. pmc Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term patient outcomes
    Alex B Haynes
    Department of Surgery, Massachusetts General Hospital, Wang Ambulatory Care Center 460, 15 Parkman St, Boston, MA 02114, USA
    Arch Surg 146:534-8. 2011
    ..To describe the characteristics and outcomes after resection of incidentally discovered, nonfunctioning pancreatic endocrine tumors (PETs)...
  3. ncbi request reprint Mucinous cystic neoplasms
    Carlos Fernandez-del Castillo
    Pancreas Surgery Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman St, ACC 460, Boston, MA 02114, USA
    J Gastrointest Surg 12:411-3. 2008
    ..Surgery is the treatment of choice, and prognosis is excellent in the absence of invasive carcinoma...
  4. ncbi request reprint Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients
    Carlos Fernandez-del Castillo
    Department of Surgery and Gastroenterology, Massachusetts General Hospital ACC 336, 15 Parkman Street, Boston, MA 02114, USA
    Arch Surg 138:427-3; discussion 433-4. 2003
    ..Widespread use of computed tomography and ultrasound has led to the identification of increasing numbers of patients with asymptomatic cystic lesions of the pancreas...
  5. ncbi request reprint Surgery of cystic neoplasms
    Carlos Fernandez-del Castillo
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, ACC 336, Boston, MA 02114, USA
    Gastrointest Endosc Clin N Am 12:803-12, ix. 2002
    ....
  6. doi request reprint Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy
    Nils D Arvold
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 83:e337-43. 2012
    ..The role of adjuvant radiotherapy (RT) in these patients has not been characterized...
  7. pmc Novel xenograft and cell line derived from an invasive intraductal papillary mucinous neoplasm of the pancreas give new insights into molecular mechanisms
    Stefan Fritz
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Pancreas 39:308-14. 2010
    ..Little is known about the genetic signature of IPMC. In this study, we describe a novel xenograft model and cell culture created to biologically and genetically characterize these tumors...
  8. pmc Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection
    J Ruben Rodriguez
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 133:72-9; quiz 309-10. 2007
    ..This study describes the combined experience of 2 tertiary centers with branch-duct IPMNs aiming to validate these recommendations...
  9. pmc Improved contemporary surgical management of insulinomas: a 25-year experience at the Massachusetts General Hospital
    Mehrdad Nikfarjam
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Ann Surg 247:165-72. 2008
    ..To determine changes in the management strategy of patients with insulinomas and identify critical factors in patient outcome...
  10. pmc Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005
    Parsia A Vagefi
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 142:347-54. 2007
    ..To assess changing patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms (PNENs)...
  11. doi request reprint Phase I study of preoperative short-course chemoradiation with proton beam therapy and capecitabine for resectable pancreatic ductal adenocarcinoma of the head
    Theodore S Hong
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 79:151-7. 2011
    ..To evaluate the safety of 1 week of chemoradiation with proton beam therapy and capecitabine followed by early surgery...
  12. ncbi request reprint Cystic pancreatic neuroendocrine tumors: the value of cytology in preoperative diagnosis
    Vicente Morales-Oyarvide
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    Cancer Cytopathol 122:435-44. 2014
    ....
  13. doi request reprint Updated long-term outcomes and prognostic factors for patients with unresectable locally advanced pancreatic cancer treated with intraoperative radiotherapy at the Massachusetts General Hospital, 1978 to 2010
    Sophie Cai
    Harvard Medical School, Boston, Massachusetts
    Cancer 119:4196-204. 2013
    ....
  14. pmc Decreased inflammation and improved survival with recombinant human activated protein C treatment in experimental acute pancreatitis
    Guido Alsfasser
    Department of Surgery and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 141:670-6; discussion 676-7. 2006
    ..Drotrecogin alfa (activated), the pharmacologic form of activated protein C and the first Food and Drug Administration-approved drug for treatment of severe sepsis, is beneficial in experimental acute pancreatitis (AP)...
  15. doi request reprint Outcomes and tolerability of chemoradiation therapy for pancreatic cancer patients aged 75 years or older
    David T Miyamoto
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 77:1171-7. 2010
    ..To review the outcomes and tolerability of full-dose chemoradiation in elderly patients aged 75 years or older with localized pancreatic cancer...
  16. pmc 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital
    Nakul P Valsangkar
    General and GI Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Surgery 152:S4-12. 2012
    ..The objective of this study was to identify trends in the diagnosis and treatment of cystic neoplasms of the pancreas using a retrospective review of patients from a surgical database at an academic referral center during a 33-year period...
  17. ncbi request reprint Long-term outcomes of neoadjuvant chemotherapy before chemoradiation for locally advanced pancreatic cancer
    Nils D Arvold
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Cancer 118:3026-35. 2012
    ..Neoadjuvant chemotherapy before chemoradiation therapy (CRT) may improve outcomes for patients with locally advanced pancreatic cancer, but optimal management remains controversial, and prior reports have limited follow-up...
  18. pmc Current trends in pancreatic cystic neoplasms
    Cristina R Ferrone
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Surg 144:448-54. 2009
    ..To define how patients with pancreatic cysts are being diagnosed and treated...
  19. ncbi request reprint Endoscopic ultrasound guided fine needle aspiration biopsy of autoimmune pancreatitis: diagnostic criteria and pitfalls
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 29:1464-71. 2005
    ....
  20. pmc Does the mechanism of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma?
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    J Gastrointest Surg 14:261-7. 2010
    ..Lymph node metastases are prognostically significant in pancreatic ductal adenocarcinoma. Little is known about the significance of direct lymph node invasion...
  21. pmc Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia
    Oliver Strobel
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 138:1166-77. 2010
    ..A majority of PanIN are thought to arise from ducts. We identified a novel ductal compartment that is gathered in gland-like outpouches (pancreatic duct glands [PDG]) of major ducts and characterized its role in injury and metaplasia...
  22. pmc N0/N1, PNL, or LNR? The effect of lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma
    Nakul P Valsangkar
    Department of Surgery and Andrew L Warshaw, M D, Institute for Pancreatic Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Gastrointest Surg 17:257-66. 2013
    ..We evaluated the prognostic accuracy of LN variables (N0/N1), numbers of positive lymph nodes (PLN), and lymph node ratio (LNR) in the context of the total number of examined lymph nodes (ELN)...
  23. pmc Quality of life in pancreatic cancer: analysis by stage and treatment
    Stefano Crippa
    Wang Ambulatory Care Center 460, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    J Gastrointest Surg 12:783-93; discussion 793-4. 2008
    ..One-year survival was 74%, 30%, and 16% for groups 1, 2, and 3 respectively (p=0.001). Pancreatic cancer prognosis is still dismal. In addition to long-term survival benefits, surgery impacts favorably quality of life...
  24. pmc Implications and management of pancreatic fistulas following pancreaticoduodenectomy: the Massachusetts General Hospital experience
    Gregory Veillette
    Department of Surgery, Massachusetts General Hospital, 15 Parkman St, Wang Ambulatory Care Center 460, Boston, MA 02114, USA
    Arch Surg 143:476-81. 2008
    ..To describe the management and impact of pancreatic fistulas in a high-volume center...
  25. pmc Pancreatic ductal adenocarcinoma: long-term survival does not equal cure
    Cristina R Ferrone
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Surgery 152:S43-9. 2012
    ..Our aim was to identify the prognostic factors for long-term survival after resection of pancreatic ductal adenocarcinoma related to patients, treatments, and tumor biology...
  26. pmc Implications and cost of pancreatic leak following distal pancreatic resection
    J Ruben Rodriguez
    Center for Clinical Effectiveness in Surgery, Harvard Medical School, Boston, USA
    Arch Surg 141:361-5; discussion 366. 2006
    ..We sought to provide an economic framework for potential interventions aimed at reducing its occurrence...
  27. ncbi request reprint Transgastric pancreaticogastric anastomosis: an alternative operative approach for middle pancreatectomy
    Jennifer LaFemina
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 145:476-81. 2010
    ..To determine short-term outcomes following middle pancreatectomy with transgastric pancreaticogastric anastomosis...
  28. pmc Incidental pancreatic cysts: do we really know what we are watching?
    Camilo Correa-Gallego
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pancreatology 10:144-50. 2010
    ..Most cystic neoplasms of the pancreas (CNPs) are incidentally discovered. Their management continues to be debated and preoperative diagnosis is often inaccurate...
  29. pmc FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital Cancer Center experience
    Jason E Faris
    Department of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Oncologist 18:543-8. 2013
    ..However, the recurrences following R0 resection in three of five patients and the toxicities observed with the use of this regimen raise important questions about how to best treat patients with LAPC...
  30. ncbi request reprint Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat
    Tobias Keck
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 122:188-201. 2002
    ..We hypothesize that degeneration of the basement membrane by specific PMN-produced matrix metalloproteinases (MMPs) may facilitate this process...
  31. pmc Preoperative platelet count and survival prognosis in resected pancreatic ductal adenocarcinoma
    Ismael Dominguez
    Department of Surgery, Massachusetts General Hospital, Wang Ambulatory Care Center 460, 15 Parkman Street, Boston, Massachusetts 02114, USA
    World J Surg 32:1051-6. 2008
    ..High platelet counts are associated with an adverse effect on survival in various neoplastic entities. The prognostic relevance of preoperative platelet count in pancreatic cancer has not been clarified...
  32. ncbi request reprint Troponin I peptide (Glu94-Leu123), a cartilage-derived angiogenesis inhibitor: in vitro and in vivo effects on human endothelial cells and on pancreatic cancer
    Beatrice E Kern
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Gastrointest Surg 7:961-8; discussion 969. 2003
    ..5 vs. 11.1; P=0.03). The active region of troponin I is the one responsible for its antiangiogenic effect. The mechanism of action of this peptide is probably multifactorial...
  33. doi request reprint Superior prognostic importance of perineural invasion vs. lymph node involvement after curative resection of duodenal adenocarcinoma
    Stefano Cecchini
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    J Gastrointest Surg 16:113-20; discussion 120. 2012
    ..Our aim is to examine prognostic factors in patients who underwent a curative resection of their duodenal adenocarcinoma...
  34. pmc Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates
    Cristina R Ferrone
    Department of General Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Gastrointest Surg 12:1691-7; discussion 1697-8. 2008
    ..Pancreatic fistula is a major source of morbidity after distal pancreatectomy (DP). We reviewed 462 consecutive patients undergoing DP to determine if the method of stump closure impacted fistula rates...
  35. ncbi request reprint Pancreatic cysts 3 cm or smaller: how aggressive should treatment be?
    Dushyant V Sahani
    Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Boston, 02114, USA
    Radiology 238:912-9. 2006
    ....
  36. ncbi request reprint Delaying chemoradiation until after completion of adjuvant chemotherapy for pancreatic cancer may not impact local control
    Jennifer Y Wo
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Electronic address
    Pract Radiat Oncol 4:e117-23. 2014
    ..To date, the impact of timing of adjuvant CRT on long-term outcomes has not been evaluated. This study evaluates the effect of timing of adjuvant CRT on locoregional control (LRC) and overall survival (OS)...
  37. pmc Debridement and closed packing for sterile or infected necrotizing pancreatitis: insights into indications and outcomes in 167 patients
    J Ruben Rodriguez
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann Surg 247:294-9. 2008
    ..To examine the surgical indications and clinical outcomes of a large cohort of patients with necrotizing pancreatitis...
  38. doi request reprint Twenty-three years of the Warshaw operation for distal pancreatectomy with preservation of the spleen
    Cristina R Ferrone
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    Ann Surg 253:1136-9. 2011
    ..To describe our series of distal pancreatectomies with preservation of the spleen utilizing the Warshaw operation with a focus on possible long-term complications due to the development of gastric varices...
  39. doi request reprint Cystic pancreatic endocrine neoplasms: a distinct tumor type?
    Liliana Bordeianou
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Am Coll Surg 206:1154-8. 2008
    ..This study aims to describe the characteristics of CPENs in a large patient cohort...
  40. ncbi request reprint [Malignancy prediction in endocrine pancreas neoplasias]
    Carlos Fernandez-del Castillo
    Escuela de Medicina de Harvard, Massachusetts General Hospital, Boston 02114, USA
    Rev Invest Clin 57:481-7. 2005
  41. ncbi request reprint Management of intraductal papillary mucinous neoplasms
    Stefano Crippa
    Department of Surgery, Massachusetts General Hospital, Wang Ambulatory Care Center WACC 460, 15 Parkmann Street, Boston, MA 02114, USA
    Curr Gastroenterol Rep 10:136-43. 2008
    ..In this systematic review, we analyze the most recent publications related to IPMNs, with particular emphasis on problems related to managing this challenging disease...
  42. doi request reprint Gallbladder lesions identified on ultrasound. Lessons from the last 10 years
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Gastrointest Surg 16:549-53. 2012
    ..Possible mass lesions identified on ultrasound (US) of the gallbladder may prompt an aggressive surgical intervention due to the possibility of a malignant neoplasm...
  43. ncbi request reprint Case records of the Massachusetts General Hospital. Case 20-2005. A 58-year-old man with locally advanced pancreatic cancer
    David P Ryan
    Department of Hematology and Oncology, Massachusetts General Hospital, Boston, USA
    N Engl J Med 352:2734-41. 2005
  44. pmc Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Gut 60:1712-20. 2011
    ..The authors investigate the clinicopathological characteristics and the impact on survival of both the invasive component and its background IPMN...
  45. pmc Metastatic tumors in the pancreas in the modern era
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    J Am Coll Surg 211:749-53. 2010
    ..Our aim was to describe the clinicopathologic characteristics and patient outcomes in a modern series of patients who underwent metastasectomy, with an emphasis on RCC...
  46. ncbi request reprint Prevention of pancreatic fistula with a new synthetic, absorbable sealant: evaluation in a dog model
    James H Balcom
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Am Coll Surg 195:490-6. 2002
    ..Our objective was to test the efficacy of the sealant in preventing pancreatic leaks in a dog model of distal pancreatectomy...
  47. doi request reprint Pancreatic surgery for adenocarcinoma
    Andrew L Warshaw
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Gastroenterol 28:488-93. 2012
    ..Nonetheless, recent observations have continued to provide incremental improvement in both our evidence for treatment regimens and the technology, resulting in better outcomes...
  48. doi request reprint Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions with mural nodules
    Tze S Khor
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02478, USA
    Am J Surg Pathol 36:1579-91. 2012
    ..These findings provide preliminary evidence that ACAs represent a cystic neoplastic lesion...
  49. ncbi request reprint Cystic pancreatic lesions: a simple imaging-based classification system for guiding management
    Dushyant V Sahani
    Division of Abdominal Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Radiographics 25:1471-84. 2005
    ..Endoscopic ultrasonography-guided aspiration and biopsy is useful in cases that are indeterminate at cross-sectional imaging or that require observation...
  50. doi request reprint Cholesterol crystal embolization presenting as either solid or cystic pancreatic lesion
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Surg Oncol 102:706-8. 2010
    ..CCE should be considered in patients with significant vascular disease, arrhythmias or vascular manipulation who present with a pancreatic mass...
  51. ncbi request reprint Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations--correlation with MRCP
    Dushyant V Sahani
    Department of Abdominal Imaging and Interventions, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114, USA
    Radiology 238:560-9. 2006
    ....
  52. pmc Identification of a novel kindred with familial pancreatitis and pancreatic cancer
    Jennifer LaFemina
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Pancreatology 9:273-9. 2009
    ..Multiple causative mutations have been identified. Here we describe a pancreatitis/pancreatic cancer (P/PC) family, which demonstrates pancreatitis and pancreatic cancer resulting from an uncharacterized mutation...
  53. doi request reprint Comparative performance of MDCT and MRI with MR cholangiopancreatography in characterizing small pancreatic cysts
    Nisha I Sainani
    Division of Abdominal Imaging and Interventional Radiology, Department of Radiology, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114 2696, USA
    AJR Am J Roentgenol 193:722-31. 2009
    ..The objective of our study was to compare MDCT with MRI-MR cholangiopancreatography (MRCP) in characterizing small pancreatic cysts (< or = 3 cm) and predicting aggressiveness...
  54. pmc Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma
    Stefan Fritz
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Surg 249:440-7. 2009
    ..To determine whether intraductal papillary mucinous neoplasms of the pancreas (IPMNs) have a different genetic background compared with ductal adenocarcinoma (PDAC)...
  55. pmc Serous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment
    Jennifer F Tseng
    Departments of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Surg 242:413-9; discussion 419-21. 2005
    ..To define the natural history and optimal management of serous cystadenoma of the pancreas...
  56. doi request reprint Phase I study of neoadjuvant accelerated short course radiation therapy with photons and capecitabine for resectable pancreatic cancer
    Jennifer Y Wo
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, United States Electronic address
    Radiother Oncol 110:160-4. 2014
    ..In this phase I study, we sought to determine the feasibility and tolerability of neoadjuvant short course radiotherapy (SC-CRT) delivered with photon RT with concurrent capecitabine for resectable pancreatic adenocarcinoma...
  57. pmc Imaging of acute mesenteric ischemia using multidetector CT and CT angiography in a porcine model
    David E Rosow
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Gastrointest Surg 9:1262-74; discussion 1274-5. 2005
    ..These results indicate that M.D.CT-CTA holds great promise for the early detection necessary for successful treatment of acute mesenteric ischemia...
  58. ncbi request reprint Complete dorsal pancreatectomy with preservation of the ventral pancreas: a new surgical technique
    Sarah P Thayer
    Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Surgery 131:577-80. 2002
  59. doi request reprint Autoimmune pancreatitis: disease evolution, staging, response assessment, and CT features that predict response to corticosteroid therapy
    Dushyant V Sahani
    Department of Radiology, Massachusetts General Hospital Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114, USA
    Radiology 250:118-29. 2009
    ..To evaluate the evolution of morphologic features of autoimmune pancreatitis (AIP) at computed tomography (CT) and to identify imaging features that can predict AIP response to corticosteroid therapy (CST)...
  60. pmc Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms
    Dirk Bausch
    Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2622, USA
    J Gastrointest Surg 13:1948-54; discussion 1954. 2009
    ..Improved detection of malignancy using novel biomarkers may therefore improve diagnostic accuracy. One such promising novel biomarker is Plectin-1 (Plec-1)...
  61. ncbi request reprint Understanding hospital readmissions after pancreaticoduodenectomy: can we prevent them?: a 10-year contemporary experience with 1,173 patients at the Massachusetts General Hospital
    Zhi Ven Fong
    Department of Surgery, Massachusetts General Hospital, 15 Parkman Street, Boston, 02114 3117, MA, USA
    J Gastrointest Surg 18:137-44; discussion 144-5. 2014
    ..We sought to delineate the natural history and predictive factors of readmissions after PD...
  62. pmc Distal pancreatectomy with splenic preservation revisited
    J Ruben Rodriguez
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Surgery 141:619-25. 2007
    ..The purpose of this study was to examine the short-term implications of this operation, comparing it to the outcomes following distal pancreatectomy with splenectomy...
  63. ncbi request reprint Surgical treatment of intraductal papillary mucinous neoplasms of the pancreas: the conservative approach
    Carlos Fernandez-del Castillo
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Gastrointest Surg 6:660-1. 2002
  64. ncbi request reprint Perioperative matrix metalloproteinase inhibition therapy does not impair wound or anastomotic healing
    James H Balcom
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Gastrointest Surg 6:488-95. 2002
    ..Perioperative treatment with MMP inhibition does not impair wound or enteric healing in a rat model of laparotomy and small bowel resection. MMP inhibitors are safe for use as adjuvant therapy after resection for cancer...
  65. pmc Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    Sarah P Thayer
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 425:851-6. 2003
    ..These data suggest that this pathway may have an early and critical role in the genesis of this cancer, and that maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis...
  66. doi request reprint Pancreatic cancer tumor size on CT scan versus pathologic specimen: implications for radiation treatment planning
    Nils D Arvold
    Harvard Radiation Oncology Program, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 80:1383-90. 2011
    ..Dimensions of the primary tumor are increasingly relevant in an era of highly conformal radiotherapy...
  67. ncbi request reprint Dosimetric feasibility of hypofractionated proton radiotherapy for neoadjuvant pancreatic cancer treatment
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 68:1557-66. 2007
    ..To evaluate tumor and normal tissue dosimetry of a 5 cobalt gray equivalent (CGE) x 5 fraction proton radiotherapy schedule, before initiating a clinical trial of neoadjuvant, short-course proton radiotherapy for pancreatic adenocarcinoma...
  68. ncbi request reprint Cystic neoplasms of the pancreas
    William R Brugge
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 351:1218-26. 2004
  69. doi request reprint Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway
    He Wang
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Mod Pathol 26:139-47. 2013
    ..Further analysis of signaling pathways is critical for designing clinical trials in gastroenteropancreatic neuroendocrine tumors...
  70. doi request reprint Diagnosis and management of cystic pancreatic lesions
    Dushyant V Sahani
    Department of Radiology, Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114, USA
    AJR Am J Roentgenol 200:343-54. 2013
    ..The purpose of this review is to outline the management guidelines for the care of patients with cystic pancreatic lesions...
  71. doi request reprint Gastroenteropancreatic neuroendocrine tumors: role of imaging in diagnosis and management
    Dushyant V Sahani
    Department of Radiology, Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114, USA
    Radiology 266:38-61. 2013
    ....
  72. doi request reprint Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 144:441-7; discussion 447. 2009
    ....
  73. doi request reprint Assessment of pancreatic tumor resectability with multidetector computed tomography: semiautomated console-generated images versus dedicated workstation-generated images
    Anand K Singh
    Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Acad Radiol 15:1058-68. 2008
    ....
  74. ncbi request reprint Patients undergoing treatment for pancreatic adenocarcinoma can mount an effective immune response to vaccinations
    Jennifer F Tseng
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Pancreatology 5:67-74. 2005
    ..We sought to determine whether patients undergoing postresection or primary medical treatment for pancreatic adenocarcinoma were immunocompetent...
  75. ncbi request reprint Cytokeratin 19 is a powerful predictor of survival in pancreatic endocrine tumors
    Vikram Deshpande
    Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 28:1145-53. 2004
    ..We hypothesize that a subgroup of PETs may share a common histogenesis with pancreatic adenocarcinomas...
  76. ncbi request reprint Management of pancreatic serous cystadenomas
    Jennifer A Wargo
    Harvard Medical School, Massachusetts General Hospital, White 506, 55 Fruit St, Boston, MA 02114, USA
    Adv Surg 43:23-34. 2009
    ..In addition, large (> 4 cm) serous cystadenomas should be resected in appropriate surgical candidates given their propensity for growth and developing symptoms...
  77. ncbi request reprint Multidisciplinary approach to diagnosis and management of intraductal papillary mucinous neoplasms of the pancreas
    Dushyant V Sahani
    Department of Radiology, Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 7:259-69. 2009
    ..Furthermore, issues of multifocality and increased predisposition of the pancreas to ductal adenocarcinoma must be addressed at follow-up evaluation. A follow-up management algorithm also is proposed in this review...
  78. ncbi request reprint Pylorus-preserving pancreaticoduodenectomy in the treatment of chronic pancreatitis
    Ramon E Jimenez
    Department of Surgery, Hartford Hospital, University of Connecticut School of Medicine, 80 Seymour Street, P O Box 5037, Hartford, Connecticut 06102, USA
    World J Surg 27:1211-6. 2003
    ..Our experience fails to show a distinct superiority of the PPPD over the Whipple operation...
  79. doi request reprint Pancreatic cysts: preoperative diagnosis and clinical management
    Martha Bishop Pitman
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Cytopathol 118:1-13. 2010
    ..High CEA level supports a mucinous cyst, as do KRAS mutation and good quality DNA levels. KRAS mutation and multiple LOH support malignancy...
  80. doi request reprint Molecular characteristics and biological behaviours of the oncocytic and pancreatobiliary subtypes of intraductal papillary mucinous neoplasms
    Hong D Xiao
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Pathol 224:508-16. 2011
    ..However, the less frequent TP53 overexpression associated with the significantly lower rates of invasion and nodal disease in the oncocytic type correlates with better outcomes compared to the pancreatobiliary type...
  81. doi request reprint Clinical challenges and images in GI: image 3. Pancreatic acinar cell carcinoma with subcutaneous fat necrosis
    Marisa Cevasco
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Gastroenterology 135:1054, 1433. 2008
  82. ncbi request reprint Consensus statement on the pathology of IgG4-related disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 25:1181-92. 2012
    ..As the spectrum of this disease continues to expand, we advocate the use of strict criteria for accepting newly proposed entities or sites as components of the IgG4-related disease spectrum...
  83. ncbi request reprint Ductulo-insular pancreatic endocrine neoplasms: clinicopathologic analysis of a unique subtype of pancreatic endocrine neoplasms
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 27:461-8. 2003
    ..We conclude that DI-PETs are not uncommon and that they are biologically similar to other PETs. We also hypothesize that the ductal cells develop by transdifferentiation of the endocrine cells...
  84. pmc New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma
    Ugwuji N Maduekwe
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 17:1267-77. 2010
    ..The ratio of metastatic to examined nodes (N ratio) is an effective prognostic tool, but has not been examined in Western patients undergoing primarily D1 lymphadenectomy...
  85. ncbi request reprint Neutrophil metabolic activity but not neutrophil sequestration reflects the development of pancreatitis-associated lung injury
    Werner Hartwig
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Crit Care Med 30:2075-82. 2002
    ....
  86. ncbi request reprint Direct medical costs of acute pancreatitis hospitalizations in the United States
    Peter J Fagenholz
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Pancreas 35:302-7. 2007
    ..To determine the direct medical costs of hospitalizations for acute pancreatitis in the United States and analyze the demographic characteristics of hospitalized patients...
  87. pmc Beta cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo
    Oliver Strobel
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:4419-24. 2007
    ....