Alessio Fasano

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines
    Maria Fiorentino
    Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine Baltimore, MD, USA
    Front Immunol 4:17. 2013
  2. pmc Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders
    Carlo Catassi
    Department of Pediatrics, Universita Politecnica delle Marche, Ancona 60121, Italy
    Nutrients 5:3839-53. 2013
  3. doi request reprint Prevalence and natural history of potential celiac disease in at-family-risk infants prospectively investigated from birth
    Elena Lionetti
    Department of Pediatrics, University of Catania, Italy
    J Pediatr 161:908-14. 2012
  4. pmc Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3
    Karen M Lammers
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 135:194-204.e3. 2008
  5. pmc Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
    Amit Tripathi
    Mucosal Biology Research Center, Center for Vascular and Inflammatory Diseases and Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 20201, USA
    Proc Natl Acad Sci U S A 106:16799-804. 2009
  6. pmc Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity
    Anna Sapone
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Med 9:23. 2011
  7. pmc Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall
    Alessio Fasano
    University of Maryland School of Medicine, Mucosal Biology Research Center, Health Science Facility II, Baltimore, MD 21201, USA
    Am J Pathol 173:1243-52. 2008
  8. pmc The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation
    Simeon E Goldblum
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FASEB J 25:144-58. 2011
  9. pmc Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells
    Maria Fiorentino
    University of Maryland, Mucosal Biology Research Center, Baltimore, Maryland, USA
    Infect Immun 81:876-83. 2013
  10. doi request reprint The cannabinoid receptor type 2 Q63R variant increases the risk of celiac disease: implication for a novel molecular biomarker and future therapeutic intervention
    Francesca Rossi
    Department of Pediatrics, Second University of Naples, 80138 Naples, Italy
    Pharmacol Res 66:88-94. 2012

Collaborators

Detail Information

Publications24

  1. pmc In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines
    Maria Fiorentino
    Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine Baltimore, MD, USA
    Front Immunol 4:17. 2013
    ..We conclude that wild-type S. Typhi causes marked transient alterations of the intestinal mucosa that are more pronounced than those observed with Ty21a or new generation attenuated typhoid vaccine candidates...
  2. pmc Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders
    Carlo Catassi
    Department of Pediatrics, Universita Politecnica delle Marche, Ancona 60121, Italy
    Nutrients 5:3839-53. 2013
    ..In this paper we report the major advances and current trends on NCGS. ..
  3. doi request reprint Prevalence and natural history of potential celiac disease in at-family-risk infants prospectively investigated from birth
    Elena Lionetti
    Department of Pediatrics, University of Catania, Italy
    J Pediatr 161:908-14. 2012
    ....
  4. pmc Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3
    Karen M Lammers
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 135:194-204.e3. 2008
    ..We aimed to establish the molecular basis of gliadin interaction with intestinal mucosa leading to intestinal barrier impairment...
  5. pmc Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
    Amit Tripathi
    Mucosal Biology Research Center, Center for Vascular and Inflammatory Diseases and Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 20201, USA
    Proc Natl Acad Sci U S A 106:16799-804. 2009
    ..Our results therefore characterize zonulin as a previously undescribed ligand that engages a key signalosome involved in the pathogenesis of human immune-mediated diseases that can be targeted for therapeutic interventions...
  6. pmc Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity
    Anna Sapone
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Med 9:23. 2011
    ....
  7. pmc Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall
    Alessio Fasano
    University of Maryland School of Medicine, Mucosal Biology Research Center, Health Science Facility II, Baltimore, MD 21201, USA
    Am J Pathol 173:1243-52. 2008
    ..Understanding the role of zonulin-dependent intestinal barrier dysfunction in the pathogenesis of autoimmune diseases is an area of translational research that encompasses many fields...
  8. pmc The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation
    Simeon E Goldblum
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    FASEB J 25:144-58. 2011
    ..These modifications provoke selective disengagement of ZO-1 from its binding partners, occludin, claudin 1, and myosin 1C, coincident with opening of tjs...
  9. pmc Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells
    Maria Fiorentino
    University of Maryland, Mucosal Biology Research Center, Baltimore, Maryland, USA
    Infect Immun 81:876-83. 2013
    ..The NCI-N87 cell line provides an excellent model for the in vitro study of H. pylori pathogenesis and the epithelial cell host response to infection...
  10. doi request reprint The cannabinoid receptor type 2 Q63R variant increases the risk of celiac disease: implication for a novel molecular biomarker and future therapeutic intervention
    Francesca Rossi
    Department of Pediatrics, Second University of Naples, 80138 Naples, Italy
    Pharmacol Res 66:88-94. 2012
    ..Indeed, we provide here further evidence that CB2 receptor plays a critical role in autoimmunity susceptibility and indicates that it represents a molecular target to pharmacologically modulate the immune components in CD...
  11. pmc Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients
    Justin R Hollon
    Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Brady 320, Baltimore, MD, USA
    BMC Gastroenterol 13:40. 2013
    ..We aim to demonstrate that this diet reclassifies the majority of patients thought to have RCD type 1 (RCD1)...
  12. pmc Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease
    Karen M Lammers
    University of Maryland School of Medicine, Mucosal Biology Research Center, Baltimore, MD, USA
    Immunology 132:432-40. 2011
    ....
  13. ncbi request reprint Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives
    Anna Sapone
    Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street, Room 345, Baltimore, MD 21201, USA
    Diabetes 55:1443-9. 2006
    ....
  14. ncbi request reprint Natural history of celiac disease autoimmunity in a USA cohort followed since 1974
    Carlo Catassi
    Center for Celiac Research and Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Ann Med 42:530-8. 2010
    ..The natural history and the possible changes of celiac disease (CD) prevalence over time are still unclear...
  15. doi request reprint Presentation of celiac disease
    Norelle Rizkalla Reilly
    Department of Pediatrics, Celiac Disease Center, Columbia University, New York, NY 10032, USA
    Gastrointest Endosc Clin N Am 22:613-21. 2012
    ..The groups most commonly screened include family members of patients with celiac disease, Down syndrome, and autoimmune diseases...
  16. doi request reprint Early feeding practices and their impact on development of celiac disease
    Alessio Fasano
    Mucosal Biology Research and Center for Celiac Research, School of Medicine, University of Maryland, Baltimore, MD, USA
    Nestle Nutr Workshop Ser Pediatr Program 68:201-9; discussion 210-3. 2011
    ....
  17. doi request reprint Leaky gut and autoimmune diseases
    Alessio Fasano
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Rev Allergy Immunol 42:71-8. 2012
    ..Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases...
  18. pmc Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host
    Samuel M Alaish
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Gut Microbes 4:292-305. 2013
    ....
  19. doi request reprint Major signaling pathways in intestinal stem cells
    Tim Vanuytsel
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Biochim Biophys Acta 1830:2410-26. 2013
    ..The discovery of markers to identify the intestinal stem cell population and the generation of powerful transgenic mouse models to study stem cell physiology have led to seminal discoveries in stem cell biology...
  20. pmc Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease
    Kristina M Harris
    Pathology Department, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Immunol 135:430-9. 2010
    ..Therefore, genetic and/or environmental factors that control IL-15 expression and responsiveness in the intestine likely participate in the pathogenesis of CD...
  21. ncbi request reprint The new epidemiology of celiac disease
    Carlo Catassi
    Department of Pediatrics, Universita Politecnica delle Marche, 60121, Ancona, Italy Center for Celiac Research, Massachustetts General Hospital for Children and Celiac Program at Harvard Medical School, Boston, MA
    J Pediatr Gastroenterol Nutr 59:S7-9. 2014
    ..A significant change in diet habits, particularly in gluten consumption as well as in infant feeding patterns are probably the main factors that can account for these new trends in CD epidemiology. ..
  22. doi request reprint Pediatric celiac disease
    Shamila Zawahir
    Mucosal Biology Research Center, Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Pediatr 21:655-60. 2009
    ..Knowledge about the varied clinical manifestations and the proper approach to screening and diagnosing celiac disease will lead to appropriate early intervention in affected children..
  23. ncbi request reprint Celiac disease: is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advances
    Swati Gadewar
    Department of Pediatrics, Mucosal Biology Research Center, University of Maryland School of Medicine, Health Science Facility II Room 8345, 20 Penn Street, Baltimore, MD 21201, USA
    Curr Gastroenterol Rep 7:455-61. 2005
    ..There are several targets for new treatments. This article briefly summarizes the National Institutes of Health Consensus Statement and gives an overview of new findings in recent years and of future therapeutic options for CD...
  24. ncbi request reprint Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
    Sandro Drago
    Mucosal Biology Research Center, Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Scand J Gastroenterol 41:408-19. 2006
    ..We investigated whether gliadin has any immediate effect on zonulin release and signaling...