Omid C Farokhzad

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Nanoparticle-aptamer bioconjugates for cancer targeting
    Omid C Farokhzad
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Expert Opin Drug Deliv 3:311-24. 2006
  2. ncbi request reprint Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer
    Vaishali Bagalkot
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nano Lett 7:3065-70. 2007
  3. pmc ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation
    Andrew Z Wang
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nanomedicine (Lond) 5:361-8. 2010
  4. ncbi request reprint Microfluidic system for studying the interaction of nanoparticles and microparticles with cells
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anal Chem 77:5453-9. 2005
  5. doi request reprint Impact of nanotechnology on drug delivery
    Omid C Farokhzad
    Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    ACS Nano 3:16-20. 2009
  6. ncbi request reprint Nanomedicine: developing smarter therapeutic and diagnostic modalities
    Omid C Farokhzad
    Department of Anesthesiology, Peri operative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Adv Drug Deliv Rev 58:1456-9. 2006
  7. pmc Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
    Xiaoyang Xu
    Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:18638-43. 2013
  8. ncbi request reprint Spontaneous formation of heterogeneous patches on polymer-lipid core-shell particle surfaces during self-assembly
    Carolina Salvador-Morales
    Department of Anesthesiology, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Small 9:511-7. 2013
  9. pmc Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
    Nazila Kamaly
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chem Soc Rev 41:2971-3010. 2012
  10. pmc Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6315-20. 2006

Collaborators

  • ROBERT SAMUEL LANGER
  • Hirokazu Kaji
  • Ali Khademhosseini
  • Jeffrey M Karp
  • Rohit Karnik
  • Liangfang Zhang
  • Frank Alexis
  • P W Kantoff
  • Dan Peer
  • Dagang Guo
  • David M Dorfman
  • Erik K Bassett
  • Neil H Bander
  • M R Freeman
  • Nicolas Bertrand
  • Nazila Kamaly
  • Jinjun Shi
  • Zeyu Xiao
  • Carolina Salvador-Morales
  • Weiwei Gao
  • Benjamin A Teply
  • Jianjun Cheng
  • Andrew Z Wang
  • Etgar Levy-Nissenbaum
  • Xiaoyang Xu
  • Eric M Pridgen
  • Aleksandar F Radovic-Moreno
  • Sangyong Jon
  • Jun Wu
  • Xue Qing Zhang
  • Pedro M Valencia
  • Vaishali Bagalkot
  • Juliana M Chan
  • Nagesh Kolishetti
  • Frank Gu
  • Ines Sherifi
  • Jong Min Lim
  • Archana Swami
  • Eric Pridgen
  • Alexander R Votruba
  • Weian Zhao
  • Stephen J Lippard
  • Tewodros Mamo
  • Frank X Gu
  • Gaurav Luther
  • Christopher H Yim
  • Hyoungshin Park
  • Junji Fukuda
  • Xi Zhu
  • Minsoung Rhee
  • Bruce R Zetter
  • Yingjie Xu
  • Graham C Walker
  • Kun Xie
  • Danica S Cui
  • Ga Young Park
  • Grace Sock Leng Teo
  • Andrej Luptak
  • Joseph A Phillips
  • Judy Cheng
  • Changwei Ji
  • Elise Digga
  • Suman Bose
  • Ken Halvorsen
  • Chong Shen
  • Wesley P Wong
  • Cheryl H Cui
  • Jillian Frieder
  • Kai Yuet
  • Lucy Q Lin
  • Ulrich von Andrian
  • Shanta Dhar
  • E Ashley Moseman
  • Minh Huynh-Le
  • Alex Radovic-Moreno
  • Daniel R Kuritzkes
  • Farhan Murshed
  • Pooja Ghatalia
  • Wataru Aizu
  • Nina Mann
  • Andrew Wang
  • Mariam R Shaikh
  • Rong Tong
  • Aleksander Radovic-Moreno
  • Seok Y Jeong
  • Gordana Vunjak-Novakovic
  • Josephine Sung
  • Christopher Cannizzaro
  • Charles A Vacanti
  • Dennis Ho

Detail Information

Publications45

  1. ncbi request reprint Nanoparticle-aptamer bioconjugates for cancer targeting
    Omid C Farokhzad
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Expert Opin Drug Deliv 3:311-24. 2006
    ..The field of controlled release and the structure and properties of aptamers, as well as the criteria for constructing effective conjugates, will be discussed...
  2. ncbi request reprint Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer
    Vaishali Bagalkot
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nano Lett 7:3065-70. 2007
    ..We demonstrate the specificity and sensitivity of this nanoparticle conjugate as a cancer imaging, therapy and sensing system in vitro...
  3. pmc ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation
    Andrew Z Wang
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nanomedicine (Lond) 5:361-8. 2010
    ..However, it is limited by its high toxicity. In this study, we report the development of a novel NP (nanoparticle) therapeutic, ChemoRad NP, which can deliver biologically targeted chemoradiation...
  4. ncbi request reprint Microfluidic system for studying the interaction of nanoparticles and microparticles with cells
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anal Chem 77:5453-9. 2005
    ..The scalability, low cost, reproducibility, and high-throughput capability of this technology is potentially beneficial to examining and optimizing a wide array of cell-particle systems prior to in vivo experiments...
  5. doi request reprint Impact of nanotechnology on drug delivery
    Omid C Farokhzad
    Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    ACS Nano 3:16-20. 2009
    ..Herein, we focus on the application of nanotechnology to drug delivery and highlight several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics...
  6. ncbi request reprint Nanomedicine: developing smarter therapeutic and diagnostic modalities
    Omid C Farokhzad
    Department of Anesthesiology, Peri operative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Adv Drug Deliv Rev 58:1456-9. 2006
    ..In this commentary the field of "nanomedicine" is briefly reviewed form the perspective of where we were; where we are today; and where we are likely to go tomorrow...
  7. pmc Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
    Xiaoyang Xu
    Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:18638-43. 2013
    ..Administering these NPs revealed a synergistic effect on tumor inhibition in a human Lymph Node Carcinoma of the Prostate xenograft mouse model that was strikingly more effective than platinum monotherapy. ..
  8. ncbi request reprint Spontaneous formation of heterogeneous patches on polymer-lipid core-shell particle surfaces during self-assembly
    Carolina Salvador-Morales
    Department of Anesthesiology, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    Small 9:511-7. 2013
    ..This discovery could have important implications for the future design of self-assembled NPs and MPs for different biomedical applications...
  9. pmc Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
    Nazila Kamaly
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chem Soc Rev 41:2971-3010. 2012
    ..Additionally, we highlight some recent examples from the literature, which demonstrate current trends and novel concepts in both the design and utility of targeted polymeric NPs (444 references)...
  10. pmc Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6315-20. 2006
    ..Dtxl alone had a survivability of only 14%. Saline and nanoparticles without drug were similarly nonefficacious. This report demonstrates the potential utility of nanoparticle-aptamer bioconjugates for a therapeutic application...
  11. pmc Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection
    Zeyu Xiao
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    ACS Nano 6:696-704. 2012
    ..A similar cell-uptake selection strategy may be used to develop specific internalizing ligands for a myriad of other diseases and can potentially facilitate delivering various molecules, including drugs and siRNAs, into target cells...
  12. doi request reprint Nanotechnology and aptamers: applications in drug delivery
    Etgar Levy-Nissenbaum
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Trends Biotechnol 26:442-9. 2008
    ..In this review, we will highlight recent developments in using aptamers in nanotechnology solutions for treating and diagnosing disease...
  13. pmc Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing
    Jinjun Shi
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Electronic address
    Nanomedicine 10:897-900. 2014
    ..We expect that this sustained-release siRNA NP platform could be of interest in both fundamental biological studies and clinical applications...
  14. ncbi request reprint Nanocarriers as an emerging platform for cancer therapy
    Dan Peer
    Department of Anesthesia, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Nanotechnol 2:751-60. 2007
    ..We detail the arsenal of nanocarriers and molecules available for selective tumour targeting, and emphasize the challenges in cancer treatment...
  15. doi request reprint Progress in siRNA delivery using multifunctional nanoparticles
    Weiwei Gao
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 629:53-67. 2010
    ..This chapter reviews recent progress using a multifunctional approach to design and engineer polymeric nanoparticles for siRNA delivery...
  16. doi request reprint New frontiers in nanotechnology for cancer treatment
    Frank Alexis
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Urol Oncol 26:74-85. 2008
    ..In this review we discuss the recent advances of cancer nanotechnology with particular attention to nanoparticle systems that are in clinical practice or in various stages of development for cancer imaging and therapy...
  17. pmc Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy
    Nagesh Kolishetti
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:17939-44. 2010
    ..This work reveals the potential of a single, programmable nanoparticle to blend and deliver a combination of drugs for cancer treatment...
  18. pmc Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study
    Jong Min Lim
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Nanomedicine 10:401-9. 2014
    ..Microfluidic parallelization thus enables synthesis of NPs with tunable properties with production rates suitable for both in vitro and in vivo studies...
  19. pmc pH-Responsive nanoparticles for drug delivery
    Weiwei Gao
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, United States
    Mol Pharm 7:1913-20. 2010
    ..The novel developments described here may revise the classical outlook that NPs are passive delivery vehicles, in favor of responsive, sensing vehicles that use environmental cues to achieve maximal drug potency...
  20. pmc Biofunctionalized targeted nanoparticles for therapeutic applications
    Andrew Z Wang
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Expert Opin Biol Ther 8:1063-70. 2008
    ....
  21. ncbi request reprint Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer Res 64:7668-72. 2004
    ..To our knowledge, this represents the first report of targeted drug delivery with nanoparticle-aptamer bioconjugates...
  22. doi request reprint Multifunctional nanoparticles for prostate cancer therapy
    Carolina Salvador-Morales
    Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Expert Rev Anticancer Ther 9:211-21. 2009
    ....
  23. pmc Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups
    Carolina Salvador-Morales
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women s Hospital Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Biomaterials 30:2231-40. 2009
    ....
  24. pmc Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine
    Xue Qing Zhang
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Adv Drug Deliv Rev 64:1363-84. 2012
    ....
  25. ncbi request reprint Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation
    Jinjun Shi
    Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Acc Chem Res 44:1123-34. 2011
    ..We also recount our efforts in the design and optimization of NPs for medical applications, which formed the foundation for the clinical translation of the first-in-man targeted and controlled-release NPs (BIND-014) for cancer therapy...
  26. pmc Drug delivery systems in urology--getting "smarter"
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Urology 68:463-9. 2006
  27. pmc Nanotechnology in drug delivery and tissue engineering: from discovery to applications
    Jinjun Shi
    MIT Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nano Lett 10:3223-30. 2010
    ....
  28. pmc Emerging nanotechnology approaches for HIV/AIDS treatment and prevention
    Tewodros Mamo
    Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Nanomedicine (Lond) 5:269-85. 2010
    ....
  29. pmc Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities
    Zeyu Xiao
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    ACS Nano 6:3670-6. 2012
    ..With continuous efforts, we expect aptamer-functionalized nanoparticles to advance from preclinical into clinical development for further evaluation...
  30. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
    ....
  31. pmc DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy
    Zeyu Xiao
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, 02115 USA MIT Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
    Angew Chem Int Ed Engl 51:11853-7. 2012
    ..This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo...
  32. pmc Bioinspired multivalent DNA network for capture and release of cells
    Weian Zhao
    Center for Regenerative Therapeutics and Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:19626-31. 2012
    ..This work suggests that 3D DNA networks may have broad implications for detection and isolation of cells and other bioparticles...
  33. pmc Design of a mechanical clutch-based needle-insertion device
    Erik K Bassett
    Department of Mechanical Engineering, Harvard MIT Division of Health Science and Technology, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:5540-5. 2009
    ..A predictive analytical model was generated and validated with empirical data and used to develop prototypes of a complete device then tested in vitro on muscle tissue and in vivo on a porcine laparoscopic model with promising results...
  34. ncbi request reprint Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays
    Ali Khademhosseini
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 5:1380-6. 2005
    ..The ability to position many cell types on particular regions within a two dimensional substrate could potentially lead to improved high-throughput methods applicable to drug screening and tissue engineering...
  35. ncbi request reprint Magnetically responsive polymeric microparticles for oral delivery of protein drugs
    Jianjun Cheng
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA
    Pharm Res 23:557-64. 2006
    ..To address this challenge, we evaluated the effect of prolonged gastrointestinal transit on the bioavailability of insulin carried by magnetically responsive microparticles in the presence of an external magnetic field...
  36. ncbi request reprint Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components
    Junji Fukuda
    Department of Chemical Engineering, Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 27:1479-86. 2006
    ..This biocompatible co-culture system could potentially provide a new tool to study cell behavior such as cell-cell communication and cell-matrix interactions, as well as tissue-engineering applications...
  37. pmc Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    Jianjun Cheng
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biomaterials 28:869-76. 2007
    ..22%+/-0.07% of injected dose per gram of tissue; mean+/-SD, n=4, p=0.002). The ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies...
  38. ncbi request reprint An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform
    Vaishali Bagalkot
    Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryoung dong, Buk Gu, Gwangju 500712, South Korea
    Angew Chem Int Ed Engl 45:8149-52. 2006
  39. ncbi request reprint Nanofabrication and microfabrication of functional materials for tissue engineering
    Hyoungshin Park
    Division of Health Sciences and Technology, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng 13:1867-77. 2007
    ..It is our opinion that these novel materials and technologies will bring engineered tissues one step closer to practical application in the clinic. This review discusses their application to cardiac, liver, and nerve tissue engineering...
  40. ncbi request reprint Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates
    Liangfang Zhang
    Department of Chemical Engineering and Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    ChemMedChem 2:1268-71. 2007
  41. ncbi request reprint Biodegradable, polymeric nanoparticle delivery systems for cancer therapy
    Eric M Pridgen
    MIT Harvard Center for Cancer Nanotechnology Excellence, Department of Chemical Engineering, Cambridge, MA 02139, USA
    Nanomedicine (Lond) 2:669-80. 2007
    ..More sophisticated nanoparticle designs are now in development, including particles able to release multiple drugs for enhanced treatment efficacy and targeted, multifunctional particles capable of combining imaging and drug release...
  42. pmc The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules
    Benjamin A Teply
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 29:1216-23. 2008
    ..The corresponding bioavailability of insulin was 5.11% compared with 0.87% for the control group (p=0.007)...
  43. pmc Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
    Frank Gu
    Department of Chemical Engineering, Harvard MIT Center of Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:2586-91. 2008
    ..This approach may contribute to further development of targeted NPs as highly selective and effective therapeutic modalities...
  44. doi request reprint Microfluidic platform for controlled synthesis of polymeric nanoparticles
    Rohit Karnik
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nano Lett 8:2906-12. 2008
    ..This work suggests that microfluidics may find applications for the development and optimization of polymeric nanoparticles in the newly emerging field of nanomedicine...
  45. ncbi request reprint Nanotechnology for drug delivery: the perfect partnership
    Omid C Farokhzad
    Expert Opin Drug Deliv 5:927-9. 2008
    ....