SUSAN ERDMAN

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 66:57-61. 2006
  2. ncbi request reprint Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 66:7395-400. 2006
  3. pmc Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice
    Theofilos Poutahidis
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS ONE 8:e73933. 2013
  4. doi request reprint Cancer inflammation and regulatory T cells
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 127:768-79. 2010
  5. doi request reprint Roles for inflammation and regulatory T cells in colon cancer
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 38:76-87. 2010
  6. doi request reprint Unifying roles for regulatory T cells and inflammation in cancer
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 126:1651-65. 2010
  7. pmc Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice
    S E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1027-32. 2009
  8. ncbi request reprint Typhlocolitis in NF-kappa B-deficient mice
    S Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 166:1443-7. 2001
  9. ncbi request reprint CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
    Susan E Erdman
    Division of Comparative Medicine and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:3998-4004. 2005
  10. pmc CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 162:691-702. 2003

Research Grants

  1. Role of IL10 and TGFb1 in colon cancer
    SUSAN ERDMAN; Fiscal Year: 2007
  2. Role of IL10 and TGFb1 in colon cancer
    Susan E Erdman; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 66:57-61. 2006
    ..These findings define a novel mouse model of inflammation-driven mammary carcinoma and suggest that epithelial carcinogenesis can be mitigated by anti-inflammatory cells and cytokines known to regulate IBD in humans and mice...
  2. ncbi request reprint Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 66:7395-400. 2006
    ..The possibility that dysregulated gut microbial infections in humans may lead to cancer in anatomically distant organs, such as breast, highlights the need for novel immune-based strategies in cancer prevention and treatment...
  3. pmc Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice
    Theofilos Poutahidis
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS ONE 8:e73933. 2013
    ..Taken together, these data confirm that systemic inflammation triggered by GI tract bacteria plays a pivotal role in tumorigenesis of the prostate gland. ..
  4. doi request reprint Cancer inflammation and regulatory T cells
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 127:768-79. 2010
    ..Taken together, these data help explain increased inflammation-associated cancer rates in hygienic societies and identify targets to abrogate cancer and restore overall health...
  5. doi request reprint Roles for inflammation and regulatory T cells in colon cancer
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 38:76-87. 2010
    ..Taken together, these data help explain the paradox of inflammation and T(REG) in cancer and indicate that targeted stimulation of T(REG) may promote health and significantly reduce risk of cancer...
  6. doi request reprint Unifying roles for regulatory T cells and inflammation in cancer
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 126:1651-65. 2010
    ..Enhancing protective T(REG) functions may promote healthful longevity and significantly reduce risk of cancer...
  7. pmc Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice
    S E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1027-32. 2009
    ..Collectively, these results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated NO production in colon carcinogenesis...
  8. ncbi request reprint Typhlocolitis in NF-kappa B-deficient mice
    S Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 166:1443-7. 2001
    ..T cell development in NF-kappaB-deficient mice was normal. These data indicate that p50 and p65 subunits of NF-kappaB have an unexpected role in inhibiting the development of colitis...
  9. ncbi request reprint CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
    Susan E Erdman
    Division of Comparative Medicine and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:3998-4004. 2005
    ..Similarities with cancer of the breast, prostate, lung, and other sites raise the possibility of broader roles for regulatory lymphocytes in prevention and treatment of epithelial cancers in humans...
  10. pmc CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 162:691-702. 2003
    ..These roles for T cells in protection against colon carcinoma may have implications for new modes of prevention and treatment of cancer in humans...
  11. ncbi request reprint CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 63:6042-50. 2003
    ..Regulatory lymphocytes and cytokines may have implications for novel therapies for colon cancer in humans...
  12. doi request reprint CD4+ lymphocytes modulate prostate cancer progression in mice
    Theofilos Poutahidis
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Int J Cancer 125:868-78. 2009
    ..Taken together, chronically elevated proinflammatory cytokines promoted carcinoma in Apc(Min/+) mice. T(REG) lymphocytes downregulated inflammation-associated carcinogenic processes and contributed to immune and epithelial homeostasis...
  13. pmc Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis
    Chung Wei Lee
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Infect Immun 75:2699-707. 2007
    ..pylori-mediated inflammation and in regulatory effects between wt T(R) and IL-10(-/-) T(R) cells suggest that IL-10 expression by wt T(R) cells is important to regulatory suppression of gastric inflammation...
  14. pmc Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 72:1116-25. 2004
    ..jejuni to escape immune surveillance. NF-kappaB-deficient mice should be a useful model to further study the role of CDT and other aspects of C. jejuni pathogenesis...
  15. pmc Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis
    Koichiro Watanabe
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Infect Immun 76:5834-42. 2008
    ....
  16. pmc Mast cells are an essential hematopoietic component for polyp development
    Elias Gounaris
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:19977-82. 2007
    ..Our data suggest that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention...
  17. pmc Prevalence of murine Helicobacter spp. Infection is reduced by restocking research colonies with Helicobacter-free mice
    Jennifer Ls Lofgren
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Am Assoc Lab Anim Sci 51:436-42. 2012
    ....
  18. pmc c-Rel is essential for the development of innate and T cell-induced colitis
    Yanyan Wang
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 180:8118-25. 2008
    ..Thus, c-Rel plays a critical role in regulating the innate inflammatory response to microflora within the lower bowel, likely through its ability to modulate expression of IL-12/23 family members...
  19. ncbi request reprint Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma
    Theofilos Poutahidis
    Division of Comparative Medicine
    Carcinogenesis 28:2614-23. 2007
    ..These data provide insights into etiopathogenesis of inflammation-associated epithelial invasion and maintenance of epithelial homeostasis...
  20. ncbi request reprint A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock
    Mihaela Gadjeva
    Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 173:5786-93. 2004
    ....
  21. ncbi request reprint NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40
    Michal F Tomczak
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 171:1484-92. 2003
    ..These results suggest that inhibition of H. hepaticus-induced IL-12 p40 expression by NF-kappaB subunits is critical to preventing colonic inflammation in response to inflammatory microflora...
  22. ncbi request reprint Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B
    Michal F Tomczak
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:7332-9. 2006
    ..These results suggest that the absence of the p50/p105 subunit of NF-kappaB within hemopoietic cells of the innate immune system interferes with the ability of IL-10 to suppress inflammatory gene expression and Hh-induced colitis...
  23. ncbi request reprint Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus
    Michal F Tomczak
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 176:1244-51. 2006
    ..Thus, a defect in ERK activation could play a pivotal role in the superinduction of IL-12 p40 observed after challenge of macrophages lacking the p50/p105 subunit of NF-kappaB with H. hepaticus...

Research Grants5

  1. Role of IL10 and TGFb1 in colon cancer
    SUSAN ERDMAN; Fiscal Year: 2007
    ..Information gained from these studies may elucidate pivotal mechanisms and uncover novel strategies for prevention and treatment of human colon cancer. ..
  2. Role of IL10 and TGFb1 in colon cancer
    Susan E Erdman; Fiscal Year: 2010
    ..We propose to build upon our recent scientific breakthroughs and test strategies in mice that will stimulate potent and highly beneficial Treg to prevent cancer and impart healthful longevity in humans. ..