Drew Endy

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Refactoring bacteriophage T7
    Leon Y Chan
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Syst Biol 1:2005.0018. 2005
  2. pmc Engineering BioBrick vectors from BioBrick parts
    Reshma P Shetty
    Department of Biological Engineering, MIT, 32 Vassar Street Rm 32 311, Cambridge, MA 02139, USA
    J Biol Eng 2:5. 2008
  3. ncbi request reprint Foundations for engineering biology
    Drew Endy
    Division of Biological Engineering, Massachusetts Institute of Technology, Room 68 580, Koch Biology Building, 31 Ames Street, Cambridge, Massachusetts 02139, USA
    Nature 438:449-53. 2005
  4. doi request reprint Genomics. Reconstruction of the genomes
    Drew Endy
    Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:1196-7. 2008
  5. pmc TABASCO: A single molecule, base-pair resolved gene expression simulator
    Sriram Kosuri
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 USA
    BMC Bioinformatics 8:480. 2007
  6. doi request reprint Refinement and standardization of synthetic biological parts and devices
    Barry Canton
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, 68 580, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 26:787-93. 2008
  7. pmc Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range
    Ty M Thomson
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:20265-70. 2011
  8. pmc Measuring the activity of BioBrick promoters using an in vivo reference standard
    Jason R Kelly
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 68 580, Cambridge Massachusetts 02139, USA
    J Biol Eng 3:4. 2009
  9. pmc Determination of cell fate selection during phage lambda infection
    François St-Pierre
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:20705-10. 2008
  10. pmc Stimulus design for model selection and validation in cell signaling
    Joshua F Apgar
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Comput Biol 4:e30. 2008

Research Grants

Collaborators

  • Sriram Kosuri
  • Roger Brent
  • Bruce Tidor
  • Kirsten R Benjamin
  • Thomas F Knight
  • Bruce Budowle
  • George Church
  • Ty M Thomson
  • Jason R Kelly
  • Barry Canton
  • Reshma P Shetty
  • Joshua F Apgar
  • François St-Pierre
  • Hans Bugl
  • Michele S Garfinkel
  • - Bio FAB Group
  • Leon Y Chan
  • Alice Y Ting
  • Richard C Yu
  • Andrew Gordon
  • Alejandro Colman-Lerner
  • Alan Bush
  • David Pincus
  • Tonya Love
  • Orna Resnekov
  • Kim de Mora
  • Joseph H Davis
  • Michael J Czar
  • Aaron L Glieberman
  • John Cumbers
  • Dileep D Monie
  • Caroline M Ajo Franklin
  • Adam J Rubin
  • Jared E Toettcher
  • Anna Labno
  • Forest M White
  • Ralf Wagner
  • John P Danner
  • Jenifer A L Smith
  • Scott J Steele
  • Gerald L Epstein
  • JOHN T MULLIGAN
  • Robert M Friedman
  • David A Roth
  • Han Oh Park
  • Bas Reichert
  • Robert J Molinari
  • Robert M Scripp
  • Joseph Jacobson
  • Jay Keasling
  • Christina Smolke
  • Jim Collins
  • David Baker
  • Ron Weiss
  • Paul Modrich

Detail Information

Publications14

  1. pmc Refactoring bacteriophage T7
    Leon Y Chan
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Syst Biol 1:2005.0018. 2005
    ..The viability of our initial design suggests that the genomes encoding natural biological systems can be systematically redesigned and built anew in service of scientific understanding or human intention...
  2. pmc Engineering BioBrick vectors from BioBrick parts
    Reshma P Shetty
    Department of Biological Engineering, MIT, 32 Vassar Street Rm 32 311, Cambridge, MA 02139, USA
    J Biol Eng 2:5. 2008
    ..Parts that conform to the BioBrick assembly standard are BioBrick standard biological parts. To date, over 2,000 BioBrick parts have been contributed to, and are available from, the Registry of Standard Biological Parts...
  3. ncbi request reprint Foundations for engineering biology
    Drew Endy
    Division of Biological Engineering, Massachusetts Institute of Technology, Room 68 580, Koch Biology Building, 31 Ames Street, Cambridge, Massachusetts 02139, USA
    Nature 438:449-53. 2005
    ..Vibrant, open research communities and strategic leadership are necessary to ensure that the development and application of biological technologies remains overwhelmingly constructive...
  4. doi request reprint Genomics. Reconstruction of the genomes
    Drew Endy
    Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:1196-7. 2008
  5. pmc TABASCO: A single molecule, base-pair resolved gene expression simulator
    Sriram Kosuri
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 USA
    BMC Bioinformatics 8:480. 2007
    ..However, for practical reasons including computational tractability, available simulators have not been able to represent genome-scale models of gene expression at this level of detail...
  6. doi request reprint Refinement and standardization of synthetic biological parts and devices
    Barry Canton
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, 68 580, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 26:787-93. 2008
    ..The process of refinement and characterization leading to the BBa_F2620 datasheet may serve as a starting template for producing many standardized genetically encoded objects...
  7. pmc Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range
    Ty M Thomson
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:20265-70. 2011
    ..Additional analysis and experiment suggest that scaffold abundance sets a tradeoff between maximum system output and system dynamic range, a prediction supported by recent experiments...
  8. pmc Measuring the activity of BioBrick promoters using an in vivo reference standard
    Jason R Kelly
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 68 580, Cambridge Massachusetts 02139, USA
    J Biol Eng 3:4. 2009
    ..Additional in vivo reference standards for other types of biological functions would seem likely to have similar utility, and could thus improve research on the design, production, and reuse of standard biological parts...
  9. pmc Determination of cell fate selection during phage lambda infection
    François St-Pierre
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:20705-10. 2008
    ..Other cell fate decisions now thought to be stochastic might also be determined by pre-existing variation...
  10. pmc Stimulus design for model selection and validation in cell signaling
    Joshua F Apgar
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Comput Biol 4:e30. 2008
    ..Taken together, these results provide a strong basis for using designed input stimuli as a tool for the development of cell signaling models...
  11. ncbi request reprint Signal transduction. Decoding NF-kappaB signaling
    Alice Y Ting
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 298:1189-90. 2002
  12. ncbi request reprint Synthetic genomics | options for governance
    Michele S Garfinkel
    J Craig Venter Institute, Rockville, Maryland, USA
    Biosecur Bioterror 5:359-62. 2007
  13. ncbi request reprint DNA synthesis and biological security
    Hans Bugl
    International Consortium for Polynucleotide Synthesis
    Nat Biotechnol 25:627-9. 2007
  14. ncbi request reprint Engineering life: building a fab for biology
    - Bio FAB Group
    University of Washington, USA
    Sci Am 294:44-51. 2006

Research Grants2