Research Topics
| Igor ElmanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorderIgor Elman
Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Boston, Massachusetts 02478 9106, USA
Biol Psychiatry 66:1083-90. 2009..To pursue this issue, we administered a validated passive-viewing monetary reward task during functional magnetic resonance imaging (fMRI) to subjects with chronic PTSD and to mentally healthy individuals...
Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agentsIgor Elman
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 31:2091-120. 2006..These effects can further deteriorate eating patterns. Pathophysiological and therapeutic implications of these insights need further validation via prospective clinical trials and neuroimaging studies...- Impaired reproduction of three-dimensional objects by cocaine-dependent subjectsIgor Elman
Department of Psychiatry, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
J Neuropsychiatry Clin Neurosci 20:478-84. 2008..g., parietal lobe damage) and their role in the pathophysiology of cocaine dependence... - Psychosocial stress and its relationship to gambling urges in individuals with pathological gamblingIgor Elman
Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Belmont, Massachusetts 02478 9106, USA
Am J Addict 19:332-9. 2010..These findings support the role of psychosocial stress in the course of PG and suggest that the former association with the urge to gamble is relatively specific to stressful events assessed with the DSI... - Probing reward function in post-traumatic stress disorder with beautiful facial imagesIgor Elman
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychiatry Res 135:179-83. 2005..There were no significant group differences in the attractiveness ratings. However, PTSD patients expended less effort to extend the viewing time of the beautiful female faces. These findings suggest a reward deficit in PTSD... - Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteersIgor Elman
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States
Addict Behav 30:859-64. 2005..These different neuroendocrine response profiles point to important differences between dopaminergic effects of cortisol and cocaine... - Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophreniaIgor Elman
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 176:369-75. 2004..Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function... - Acute cortisol administration triggers craving in individuals with cocaine dependenceIgor Elman
Behavioral Psychopharmacology Research Laboratory, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
Psychopharmacol Bull 37:84-9. 2003..These pilot data suggest that cortisol can induce a state that is associated with drug abuse... - Effects of acute metabolic stress on the peripheral vasopressinergic system in schizophreniaIgor Elman
Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
J Psychopharmacol 17:317-23. 2003.... 
Probing reward function in posttraumatic stress disorder: expectancy and satisfaction with monetary gains and lossesJames W Hopper
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
J Psychiatr Res 42:802-7. 2008..Posttraumatic stress disorder (PTSD) may be associated with dysfunctional reward processing. The present study assessed for such dysfunction in both the expectancy and outcome phases of reward processing...- Psychosocial stress and the duration of cocaine use in non-treatment seeking individuals with cocaine dependenceKatherine H Karlsgodt
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Drug Alcohol Abuse 29:539-51. 2003.... - Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependenceDaniel D Langleben
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Psychopharmacology (Berl) 220:559-64. 2012..05 to 0.83 m... 
Effects of perceived cocaine availability on subjective and objective responses to the drugRINAH T YAMAMOTO
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA, USA
Subst Abuse Treat Prev Policy 2:30. 2007..Several lines of evidence suggest that cocaine expectancy and craving are two related phenomena. The present study assessed this potential link by contrasting reactions to varying degrees of the drug's perceived availability...- Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant imagesEric A Moulton
Pain Analgesia Imaging Neuroscience Group and Clinical Psychopathology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
J Neurosci 31:3795-804. 2011..The separate cortical networks suggest that noxious heat-evoked responses in the cerebellum can be divided into sensorimotor and emotional networks... - Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizotypal personality disorderVivian Mitropoulou
Department of Psychiatry, Mt Sinai School of Medicine Clinical Reseach Center, New York, NY 10029, USA
Schizophr Res 70:27-31. 2004..We hypothesized that SPD patients would demonstrate comparable or lower DA and HPA responses after 2-DG to HV... - The missing p in psychiatric training: why it is important to teach pain to psychiatristsIgor Elman
McLean Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arch Gen Psychiatry 68:12-20. 2011..Nonetheless, remarkably few pain-related themes are currently included in psychiatric residency training... - Gender differences in the motivational processing of babies are determined by their facial attractivenessRinah Yamamoto
Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 4:e6042. 2009..This study sought to determine how esthetic appearance of babies may affect their motivational processing by the adults... - Effects of risperidone on the peripheral noradrenegic system in patients with schizophrenia: a comparison with clozapine and placeboIgor Elman
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Neuropsychopharmacology 27:293-300. 2002..Our data suggest that both risperidone and clozapine elevate plasma NE levels via enhanced neurotransmitter spillover, with risperidone producing a smaller effect... - Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependenceIgor Elman
Department of Psychiatry, Motivation and Emotion Neuroscience Center, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Psychopharmacol 16:163-7. 2002.... - Effect of methylphenidate on Stroop Color-Word task performance in children with attention deficit hyperactivity disorderDaniel D Langleben
Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Psychiatry Res 141:315-20. 2006.... - Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cuesDaniel D Langleben
Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
Am J Psychiatry 165:390-4. 2008..The authors sought to identify the functional neuroanatomy of the brain response to visual heroin-related stimuli in methadone maintenance patients... - Gender differences in psychosocial stress and in its relationship to gambling urges in individuals with pathological gamblingEvelyne Tschibelu
Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Belmont, MA 02478 9106, USA
J Addict Dis 30:81-7. 2011..These data suggest distinctive determinants of gambling urges in women with pathological gambling vis-a-vis those of men... - Alterations in brain structure and functional connectivity in prescription opioid-dependent patientsJaymin Upadhyay
P A I N Group, Harvard Medical School, c o Brain Imaging Centre, McLean Hospital, Department of Psychiatry, 115 Mill Street, Belmont, MA 02478 9106, USA
Brain 133:2098-114. 2010..These results may have important clinical implications for uncovering the effects of long-term prescription opioid use on brain structure and function... - Reward-aversion circuitry in analgesia and pain: implications for psychiatric disordersDavid Borsook
PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States
Eur J Pain 11:7-20. 2007..These underlying features have implications for understanding the neurobiology of functional illnesses such as depression and anxiety and for the development and evaluation of novel therapeutic interventions... - Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphineJaymin Upadhyay
Imaging Consortium for Drug Development, PAIN Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuroimage 59:3762-73. 2012..Such methods may be useful during early clinical phase evaluation of potential analgesics in drug development... - Neuroanatomic comparison of bipolar adolescents with and without cannabis use disordersKelly Jarvis
University of Cincinnati, Division of Bipolar Disorders Research, Department of Psychiatry, Cincinnati, OH 45267 0559, USA
J Child Adolesc Psychopharmacol 18:557-63. 2008..In this pilot study, we compared brain morphometry between bipolar adolescents with co-occurring cannabis use disorders (CUD) and bipolar adolescents without any substance use disorder... - Decreased absolute amygdala volume in cocaine addictsNikos Makris
Motivation and Emotion Neuroscience Collaboration, Department of Radiology, Harvard Medical School, Boston, MA 02129, USA
Neuron 44:729-40. 2004..These findings argue for a condition that predisposes the individual to cocaine dependence by affecting the amygdala, or a primary event early in the course of cocaine use... - Effects of methylphenidate discontinuation on cerebral blood flow in prepubescent boys with attention deficit hyperactivity disorderDaniel D Langleben
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Nucl Med 43:1624-9. 2002..To address this issue, we assessed the effects of discontinuation of chronic MPH treatment on regional cerebral blood flow (rCBF) in ADHD patients... - Amphetamine-induced dopamine release and post-synaptic specific binding in patients with mild tardive dyskinesiaCaleb M Adler
Experimental Therapeutics Branch, National Institute of Mental Health/NIH, Bethesda, MD, USA
Neuropsychopharmacology 26:295-300. 2002..More research is needed to unravel the neurobiology of this debilitating disorder...
Research Grants
- Neuroimaging of Drug Craving in Cocaine DependenceIgor Elman; Fiscal Year: 2002..Furthermore, it may point the way for the development of novel therapeutic strategies for this disease ..
- PTSD and Drug Dependence: Neuroimaging of Reward CircuitryIgor Elman; Fiscal Year: 2007....
- PTSD and Drug Dependence: Neuroimaging of Reward Circui*Igor Elman; Fiscal Year: 2007..Number of publications and manuscdpts accepted for publication (not to exceed 10) Other items (list): Appendix I Color Plates of Figures in Preliminary Studies PHS 398 (Rev. 05/01) Page 3 Form Page 3 ..