Igor Elman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder
    Igor Elman
    Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Boston, Massachusetts 02478 9106, USA
    Biol Psychiatry 66:1083-90. 2009
  2. ncbi Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents
    Igor Elman
    Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 31:2091-120. 2006
  3. ncbi Probing reward function in post-traumatic stress disorder with beautiful facial images
    Igor Elman
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 135:179-83. 2005
  4. ncbi Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteers
    Igor Elman
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States
    Addict Behav 30:859-64. 2005
  5. doi Impaired reproduction of three-dimensional objects by cocaine-dependent subjects
    Igor Elman
    Department of Psychiatry, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
    J Neuropsychiatry Clin Neurosci 20:478-84. 2008
  6. ncbi Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophrenia
    Igor Elman
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 176:369-75. 2004
  7. ncbi Acute cortisol administration triggers craving in individuals with cocaine dependence
    Igor Elman
    Behavioral Psychopharmacology Research Laboratory, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacol Bull 37:84-9. 2003
  8. ncbi Effects of acute metabolic stress on the peripheral vasopressinergic system in schizophrenia
    Igor Elman
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Psychopharmacol 17:317-23. 2003
  9. ncbi Psychosocial stress and its relationship to gambling urges in individuals with pathological gambling
    Igor Elman
    Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Belmont, Massachusetts 02478 9106, USA
    Am J Addict 19:332-9. 2010
  10. pmc Yohimbine-induced amygdala activation in pathological gamblers: a pilot study
    Igor Elman
    Bedford Veterans Administration Medical Center and Department of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Somerville, Massachusetts, United States of America
    PLoS ONE 7:e31118. 2012

Detail Information

Publications34

  1. doi Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder
    Igor Elman
    Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Boston, Massachusetts 02478 9106, USA
    Biol Psychiatry 66:1083-90. 2009
    ..To pursue this issue, we administered a validated passive-viewing monetary reward task during functional magnetic resonance imaging (fMRI) to subjects with chronic PTSD and to mentally healthy individuals...
  2. ncbi Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents
    Igor Elman
    Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 31:2091-120. 2006
    ..These effects can further deteriorate eating patterns. Pathophysiological and therapeutic implications of these insights need further validation via prospective clinical trials and neuroimaging studies...
  3. ncbi Probing reward function in post-traumatic stress disorder with beautiful facial images
    Igor Elman
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 135:179-83. 2005
    ..There were no significant group differences in the attractiveness ratings. However, PTSD patients expended less effort to extend the viewing time of the beautiful female faces. These findings suggest a reward deficit in PTSD...
  4. ncbi Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteers
    Igor Elman
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States
    Addict Behav 30:859-64. 2005
    ..These different neuroendocrine response profiles point to important differences between dopaminergic effects of cortisol and cocaine...
  5. doi Impaired reproduction of three-dimensional objects by cocaine-dependent subjects
    Igor Elman
    Department of Psychiatry, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
    J Neuropsychiatry Clin Neurosci 20:478-84. 2008
    ..g., parietal lobe damage) and their role in the pathophysiology of cocaine dependence...
  6. ncbi Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophrenia
    Igor Elman
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 176:369-75. 2004
    ..Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function...
  7. ncbi Acute cortisol administration triggers craving in individuals with cocaine dependence
    Igor Elman
    Behavioral Psychopharmacology Research Laboratory, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacol Bull 37:84-9. 2003
    ..These pilot data suggest that cortisol can induce a state that is associated with drug abuse...
  8. ncbi Effects of acute metabolic stress on the peripheral vasopressinergic system in schizophrenia
    Igor Elman
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Psychopharmacol 17:317-23. 2003
    ....
  9. ncbi Psychosocial stress and its relationship to gambling urges in individuals with pathological gambling
    Igor Elman
    Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Belmont, Massachusetts 02478 9106, USA
    Am J Addict 19:332-9. 2010
    ..These findings support the role of psychosocial stress in the course of PG and suggest that the former association with the urge to gamble is relatively specific to stressful events assessed with the DSI...
  10. pmc Yohimbine-induced amygdala activation in pathological gamblers: a pilot study
    Igor Elman
    Bedford Veterans Administration Medical Center and Department of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Somerville, Massachusetts, United States of America
    PLoS ONE 7:e31118. 2012
    ..In this pilot functional magnetic resonance imaging (fMRI) study we assessed whether a prototype behavioral addiction, pathological gambling (PG), is likewise associated with an enhanced response to stress...
  11. ncbi Psychosocial stress and the duration of cocaine use in non-treatment seeking individuals with cocaine dependence
    Katherine H Karlsgodt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Drug Alcohol Abuse 29:539-51. 2003
    ....
  12. pmc Probing reward function in posttraumatic stress disorder: expectancy and satisfaction with monetary gains and losses
    James W Hopper
    Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
    J Psychiatr Res 42:802-7. 2008
    ..Posttraumatic stress disorder (PTSD) may be associated with dysfunctional reward processing. The present study assessed for such dysfunction in both the expectancy and outcome phases of reward processing...
  13. pmc Effects of perceived cocaine availability on subjective and objective responses to the drug
    RINAH T YAMAMOTO
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA, USA
    Subst Abuse Treat Prev Policy 2:30. 2007
    ..Several lines of evidence suggest that cocaine expectancy and craving are two related phenomena. The present study assessed this potential link by contrasting reactions to varying degrees of the drug's perceived availability...
  14. pmc Neurological soft signs in individuals with pathological gambling
    Igor Elman
    Providence VA Medical Center, Harvard Medical School, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e60885. 2013
    ..g., predate or follow the development of PG) as well as their response to therapeutic interventions and/or their ability to predict such a response...
  15. pmc Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Psychopharmacology (Berl) 220:559-64. 2012
    ..05 to 0.83 m...
  16. ncbi Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizotypal personality disorder
    Vivian Mitropoulou
    Department of Psychiatry, Mt Sinai School of Medicine Clinical Reseach Center, New York, NY 10029, USA
    Schizophr Res 70:27-31. 2004
    ..We hypothesized that SPD patients would demonstrate comparable or lower DA and HPA responses after 2-DG to HV...
  17. pmc Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images
    Eric A Moulton
    Pain Analgesia Imaging Neuroscience Group and Clinical Psychopathology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 31:3795-804. 2011
    ..The separate cortical networks suggest that noxious heat-evoked responses in the cerebellum can be divided into sensorimotor and emotional networks...
  18. pmc Gender differences in the motivational processing of babies are determined by their facial attractiveness
    Rinah Yamamoto
    Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e6042. 2009
    ..This study sought to determine how esthetic appearance of babies may affect their motivational processing by the adults...
  19. pmc The missing p in psychiatric training: why it is important to teach pain to psychiatrists
    Igor Elman
    McLean Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 68:12-20. 2011
    ..Nonetheless, remarkably few pain-related themes are currently included in psychiatric residency training...
  20. doi Extended-release naltrexone modulates brain response to drug cues in abstinent heroin-dependent patients
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA Veterans Administration Health Care System, Philadelphia, PA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Addict Biol 19:262-71. 2014
    ..Our findings call for further evaluation of the brain fMRI response to drug-related cues and of the 6-beta-naltrexol levels as potential biomarkers of XRNTX therapeutic effects in patients with opioid dependence. ..
  21. ncbi Effects of risperidone on the peripheral noradrenegic system in patients with schizophrenia: a comparison with clozapine and placebo
    Igor Elman
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropsychopharmacology 27:293-300. 2002
    ..Our data suggest that both risperidone and clozapine elevate plasma NE levels via enhanced neurotransmitter spillover, with risperidone producing a smaller effect...
  22. ncbi Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence
    Igor Elman
    Department of Psychiatry, Motivation and Emotion Neuroscience Center, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Psychopharmacol 16:163-7. 2002
    ....
  23. ncbi Effect of methylphenidate on Stroop Color-Word task performance in children with attention deficit hyperactivity disorder
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Psychiatry Res 141:315-20. 2006
    ....
  24. ncbi Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cues
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
    Am J Psychiatry 165:390-4. 2008
    ..The authors sought to identify the functional neuroanatomy of the brain response to visual heroin-related stimuli in methadone maintenance patients...
  25. pmc Pain and analgesia: the value of salience circuits
    David Borsook
    Center for Pain and the Brain, Harvard Medical School, Boston, MA 02115, United States
    Prog Neurobiol 104:93-105. 2013
    ....
  26. doi Gender differences in psychosocial stress and in its relationship to gambling urges in individuals with pathological gambling
    Evelyne Tschibelu
    Clinical Psychopathology Laboratory, McLean Hospital and Harvard Medical School, Belmont, MA 02478 9106, USA
    J Addict Dis 30:81-7. 2011
    ..These data suggest distinctive determinants of gambling urges in women with pathological gambling vis-a-vis those of men...
  27. pmc Alterations in brain structure and functional connectivity in prescription opioid-dependent patients
    Jaymin Upadhyay
    P A I N Group, Harvard Medical School, c o Brain Imaging Centre, McLean Hospital, Department of Psychiatry, 115 Mill Street, Belmont, MA 02478 9106, USA
    Brain 133:2098-114. 2010
    ..These results may have important clinical implications for uncovering the effects of long-term prescription opioid use on brain structure and function...
  28. ncbi Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders
    David Borsook
    PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States
    Eur J Pain 11:7-20. 2007
    ..These underlying features have implications for understanding the neurobiology of functional illnesses such as depression and anxiety and for the development and evaluation of novel therapeutic interventions...
  29. doi Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine
    Jaymin Upadhyay
    Imaging Consortium for Drug Development, PAIN Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuroimage 59:3762-73. 2012
    ..Such methods may be useful during early clinical phase evaluation of potential analgesics in drug development...
  30. ncbi Decreased absolute amygdala volume in cocaine addicts
    Nikos Makris
    Motivation and Emotion Neuroscience Collaboration, Department of Radiology, Harvard Medical School, Boston, MA 02129, USA
    Neuron 44:729-40. 2004
    ..These findings argue for a condition that predisposes the individual to cocaine dependence by affecting the amygdala, or a primary event early in the course of cocaine use...
  31. pmc Neuroanatomic comparison of bipolar adolescents with and without cannabis use disorders
    Kelly Jarvis
    University of Cincinnati, Division of Bipolar Disorders Research, Department of Psychiatry, Cincinnati, OH 45267 0559, USA
    J Child Adolesc Psychopharmacol 18:557-63. 2008
    ..In this pilot study, we compared brain morphometry between bipolar adolescents with co-occurring cannabis use disorders (CUD) and bipolar adolescents without any substance use disorder...
  32. ncbi Effects of methylphenidate discontinuation on cerebral blood flow in prepubescent boys with attention deficit hyperactivity disorder
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Nucl Med 43:1624-9. 2002
    ..To address this issue, we assessed the effects of discontinuation of chronic MPH treatment on regional cerebral blood flow (rCBF) in ADHD patients...
  33. ncbi Amphetamine-induced dopamine release and post-synaptic specific binding in patients with mild tardive dyskinesia
    Caleb M Adler
    Experimental Therapeutics Branch, National Institute of Mental Health NIH, Bethesda, MD, USA
    Neuropsychopharmacology 26:295-300. 2002
    ..More research is needed to unravel the neurobiology of this debilitating disorder...

Research Grants6

  1. Neuroimaging of Drug Craving in Cocaine Dependence
    Igor Elman; Fiscal Year: 2002
    ..Furthermore, it may point the way for the development of novel therapeutic strategies for this disease ..
  2. PTSD and Drug Dependence: Neuroimaging of Reward Circui*
    Igor Elman; Fiscal Year: 2004
    ....
  3. PTSD and Drug Dependence: Neuroimaging of Reward Circui*
    Igor Elman; Fiscal Year: 2005
    ....
  4. PTSD and Drug Dependence: Neuroimaging of Reward Circui*
    Igor Elman; Fiscal Year: 2006
    ....
  5. PTSD and Drug Dependence: Neuroimaging of Reward Circuitry
    Igor Elman; Fiscal Year: 2007
    ....
  6. PTSD and Drug Dependence: Neuroimaging of Reward Circui*
    Igor Elman; Fiscal Year: 2007
    ..Number of publications and manuscdpts accepted for publication (not to exceed 10) Other items (list): Appendix I Color Plates of Figures in Preliminary Studies PHS 398 (Rev. 05/01) Page 3 Form Page 3 ..