PATRICK THOMAS ELLINOR

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Personalized medicine and atrial fibrillation: will it ever happen?
    Steven A Lubitz
    Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, 149 13th Street, 4th Floor, Charlestown, MA 02129, USA
    BMC Med 10:155. 2012
  2. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
  3. pmc MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism
    Junjie Xiao
    Key Laboratory of Arrhythmias, Ministry of Education, China East Hospital, Tongji University School of Medicine, Shanghai, China
    J Transl Med 9:159. 2011
  4. pmc Aging syndrome genes and premature coronary artery disease
    Adrian F Low
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 6:38. 2005
  5. ncbi request reprint Cardiac sodium channel mutation in atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Heart Rhythm 5:99-105. 2008
  6. ncbi request reprint The genetics of atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Cardiovasc Electrophysiol 14:1007-9. 2003
  7. pmc Genetics of atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, 55 Fruit Street, and Harvard Medical School, Boston, MA 02114, USA
    Med Clin North Am 92:41-51, x. 2008
  8. pmc Potassium channel gene mutations rarely cause atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center and Cardiac Arrhythmia Service Massachusetts General Hospital, Boston, Massachusetts, USA
    BMC Med Genet 7:70. 2006
  9. ncbi request reprint C-Reactive protein in lone atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 97:1346-50. 2006
  10. ncbi request reprint Cardiac sodium channel gene variants and sudden cardiac death in women
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 117:16-23. 2008

Research Grants

Detail Information

Publications39

  1. pmc Personalized medicine and atrial fibrillation: will it ever happen?
    Steven A Lubitz
    Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, 149 13th Street, 4th Floor, Charlestown, MA 02129, USA
    BMC Med 10:155. 2012
    ..In this review we explore areas of potential clinical utility in AF management including those relating to pharmacogenetics and risk prediction...
  2. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
    ..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules...
  3. pmc MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism
    Junjie Xiao
    Key Laboratory of Arrhythmias, Ministry of Education, China East Hospital, Tongji University School of Medicine, Shanghai, China
    J Transl Med 9:159. 2011
    ..Circulating miRNAs are emerging biomarkers in heart failure, type 2 diabetes and other disease states; however, using plasma miRNAs as biomarkers for the diagnosis of APE is still unknown...
  4. pmc Aging syndrome genes and premature coronary artery disease
    Adrian F Low
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 6:38. 2005
    ..We evaluated whether common variants at the LMNA or KLOTHO genes are associated with rigorously defined premature CAD...
  5. ncbi request reprint Cardiac sodium channel mutation in atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Heart Rhythm 5:99-105. 2008
    ..Mutations in the sodium channel SCN5A have been implicated in many cardiac disorders, including the long QT syndrome, Brugada syndrome, conduction system disease, and dilated cardiomyopathy with atrial arrhythmias...
  6. ncbi request reprint The genetics of atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Cardiovasc Electrophysiol 14:1007-9. 2003
  7. pmc Genetics of atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, 55 Fruit Street, and Harvard Medical School, Boston, MA 02114, USA
    Med Clin North Am 92:41-51, x. 2008
    ..Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia...
  8. pmc Potassium channel gene mutations rarely cause atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center and Cardiac Arrhythmia Service Massachusetts General Hospital, Boston, Massachusetts, USA
    BMC Med Genet 7:70. 2006
    ..We sought to determine if mutations in KCNJ2 and KCNE1-5 are a common cause of atrial fibrillation...
  9. ncbi request reprint C-Reactive protein in lone atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 97:1346-50. 2006
    ....
  10. ncbi request reprint Cardiac sodium channel gene variants and sudden cardiac death in women
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 117:16-23. 2008
    ..Mutations or rare variants in these genes have been proposed as potential contributors to more common forms of SCD, but this hypothesis has not been assessed systematically...
  11. ncbi request reprint Increased incidence of subacute lead perforation noted with one implantable cardioverter-defibrillator
    Stephan B Danik
    Cardiac Arrhythmia Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Heart Rhythm 4:439-42. 2007
    ..While these advances have made the leads more versatile, new configurations may be associated with unforeseen complications...
  12. doi request reprint Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison
    Keith A Marill
    Department of Emergency Medicine, Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA
    Acad Emerg Med 17:297-306. 2010
    ..The objective was to compare the effectiveness of intravenous (IV) procainamide and amiodarone for the termination of spontaneous stable sustained ventricular tachycardia (VT)...
  13. doi request reprint Adenosine for wide-complex tachycardia: efficacy and safety
    Keith A Marill
    Department of Emergency Medicine KAM, Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 37:2512-8. 2009
    ..The etiology of sustained monomorphic wide QRS complex tachycardia is often uncertain acutely...
  14. pmc Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen
    David S Peal
    Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Circulation 123:23-30. 2011
    ..We describe a small-molecule screen using the zebrafish KCNH2 mutant breakdance to identify compounds that can rescue the LQT type 2 phenotype...
  15. ncbi request reprint Reduced apelin levels in lone atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Boston, MA, USA
    Eur Heart J 27:222-6. 2006
    ..This peptide has been reported to be down-regulated in subjects with acute heart failure, but has not been studied in other cardiovascular conditions. We studied apelin levels in 73 subjects with lone atrial fibrillation (AF)...
  16. ncbi request reprint Fungal infection of implantable cardioverter-defibrillators: case series of five patients managed over 22 years
    Ivan C K Ho
    Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, 02114, USA
    Heart Rhythm 3:919-23. 2006
    ..Fungal-related ICD infections have rarely been reported, and little is known about the presentation, prevalence, and treatment options for these morbid infections...
  17. pmc Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation
    Saumya Das
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Heart Rhythm 6:1146-53. 2009
    ..Mutations in several ion channel genes have been reported to cause rare cases of familial atrial fibrillation (AF)...
  18. ncbi request reprint Discordant atrial natriuretic peptide and brain natriuretic peptide levels in lone atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Am Coll Cardiol 45:82-6. 2005
    ..We sought to characterize natriuretic peptide levels in a cohort of rigorously characterized subjects with lone atrial fibrillation (AF)...
  19. ncbi request reprint A novel locus for dilated cardiomyopathy, diffuse myocardial fibrosis, and sudden death on chromosome 10q25-26
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Am Coll Cardiol 48:106-11. 2006
    ..We sought to identify the genetic locus for an inherited form of dilated cardiomyopathy (DCM) that is characterized by diffuse myocardial fibrosis and sudden death...
  20. pmc Association between familial atrial fibrillation and risk of new-onset atrial fibrillation
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    JAMA 304:2263-9. 2010
    ..Although the heritability of atrial fibrillation (AF) is established, the contribution of familial AF to predicting new-onset AF remains unknown...
  21. pmc Common variants in KCNN3 are associated with lone atrial fibrillation
    Patrick T Ellinor
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 4 These authors contributed equally to this work
    Nat Genet 42:240-4. 2010
    ..52, 95% CI 1.40-1.64; P = 1.83 x 10(-21)). rs13376333 is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization...
  22. pmc P-wave indices, distribution and quality control assessment (from the Framingham Heart Study)
    Jared W Magnani
    Boston University School of Medicine, Section of Cardiology, School of Public Health, Boston, MA 01702 5827, USA
    Ann Noninvasive Electrocardiol 15:77-84. 2010
    ..We therefore sought to determine the reproducibility of P-wave indices in a community-based cohort...
  23. pmc Independent susceptibility markers for atrial fibrillation on chromosome 4q25
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02114, USA
    Circulation 122:976-84. 2010
    ..Genetic variants on chromosome 4q25 are associated with atrial fibrillation (AF). We sought to determine whether there is more than 1 susceptibility signal at this locus...
  24. pmc Challenges in the classification of atrial fibrillation
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, 4th Floor, Charlestown, MA 02129, USA
    Nat Rev Cardiol 7:451-60. 2010
    ..A future classification scheme should ideally combine elements such as the risk of stroke, an assessment of symptoms, and the degree of impairment of the atrial substrate...
  25. pmc Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery
    Simon C Body
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circ Cardiovasc Genet 2:499-506. 2009
    ..However, their role in postoperative AF is unknown. We hypothesized that genetic variants in the 4q25 chromosomal region are independently associated with postoperative AF after coronary artery bypass graft surgery...
  26. pmc Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
    Emelia J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:879-81. 2009
    ..19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15))...
  27. ncbi request reprint Variability in implantable cardioverter defibrillator pulse generator longevity between manufacturers
    Patrick T Ellinor
    Cardiac Arrhythmia Service, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Pacing Clin Electrophysiol 26:71-5. 2003
    ..003 and P < 0.0001, respectively. This difference was attributable to reduced longevity in the Angstrom series of defibrillators...
  28. ncbi request reprint Locus for atrial fibrillation maps to chromosome 6q14-16
    Patrick T Ellinor
    Cardiovascular Research Center, Cardiac Arrhythmia Service, and Cardiology Division, Massachusetts General Hospital, Boston, Mass 02129, USA
    Circulation 107:2880-3. 2003
    ..Inherited forms of AF exist, but the causative gene has been defined only in a single family. We have identified a large family (family FAF-1) in which AF segregates as a Mendelian trait...
  29. ncbi request reprint Clinical subtypes of lone atrial fibrillation
    Kristen K Patton
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Pacing Clin Electrophysiol 28:630-8. 2005
    ..In the face of increasing evidence of underlying genetic heterogeneity for lone atrial fibrillation (LAF), we undertook a clinical analysis of subjects to identify the phenotypic subsets of this arrhythmia...
  30. ncbi request reprint Familial aggregation in lone atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service, Massachusetts General Hospital, 149 13th Street, 4th Floor, Charlestown, Boston, MA, 02129, USA
    Hum Genet 118:179-84. 2005
    ..0; 2.5-6.5) and fathers (2.0; 1.2-3.6). Relatives of probands with lone AF are at a substantially increased risk of developing this arrhythmia suggesting a Mendelian genetic contribution to the etiology of this common trait...
  31. ncbi request reprint Case records of the Massachusetts General Hospital. Case 37-2005. A 35-year-old man with cardiac arrest while sleeping
    Keith A Marill
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, USA
    N Engl J Med 353:2492-501. 2005
  32. ncbi request reprint Impact of the multicenter automatic defibrillator implantation trial on clinical practice
    Ivan C K Ho
    Department of Medicine and the Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston 02114, USA
    Ann Noninvasive Electrocardiol 11:20-7. 2006
    ....
  33. ncbi request reprint In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation
    David J Milan
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Heart Circ Physiol 291:H269-73. 2006
    ..The development of rigorous tools for the phenotyping of adult zebrafish will complement the high-throughput assays currently under development for embryonic and larval fish...
  34. pmc Genome-wide association studies in cardiac electrophysiology: recent discoveries and implications for clinical practice
    David J Milan
    Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Heart Rhythm 7:1141-8. 2010
    ..This review will summarize recent genome-wide association study results within cardiac electrophysiology and discuss their broader implications in basic science and clinical medicine...
  35. ncbi request reprint Myocardial blood flow and oxygen consumption in patients with Friedreich's ataxia prior to the onset of cardiomyopathy
    Shawn A Gregory
    Departments of Medicine Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Coron Artery Dis 18:15-22. 2007
    ....
  36. pmc Atrial fibrillation in congestive heart failure
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Heart Fail Clin 6:187-200. 2010
    ....
  37. ncbi request reprint Factors affecting error in integration of electroanatomic mapping with CT and MR imaging during catheter ablation of atrial fibrillation
    E Kevin Heist
    Cardiac Arrhythmia Service and Cardiac Unit, Massachusetts General Hospital, Gray 109, 55 Fruit St, Boston, MA, 02114, USA
    J Interv Card Electrophysiol 17:21-7. 2006
    ..We sought to examine the effect of patient- and technique-related factors on integration accuracy of electroanatomic mapping with CT and MR imaging of the left atrium...
  38. ncbi request reprint Increasing US emergency department visit rates and subsequent hospital admissions for atrial fibrillation from 1993 to 2004
    Alden J McDonald
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Emerg Med 51:58-65. 2008
    ..The clinical epidemiology of US emergency department (ED) visits for atrial fibrillation is uncertain. This study seeks to describe recent trends in ED visits for atrial fibrillation...
  39. ncbi request reprint Catheter ablation of peri-AV nodal atrial tachycardia from the noncoronary cusp of the aortic valve
    Saumya Das
    Cardiac Arrhythmia Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Cardiovasc Electrophysiol 19:231-7. 2008
    ....

Research Grants2

  1. Determining the Role of the Potassium Channel, KCNN3, in Atrial Fibrillation
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    ..We propose to examine the role of KCNN3 in atrial fibrillation using a combination of human studies from the United States and Europe, cell lines, and mouse models with alterations in KCNN3 function. ..
  2. The Genetic Basis of Atrial Fibrillation
    Patrick Ellinor; Fiscal Year: 2007
    ..Fishman. [] PHS 39812590 (Rev. 05101) Page % Continuation Format Page o Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..