J El-Khoury

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
    Dan Frenkel
    Department of Neurobiology, Sagol School of Neuroscience, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 699788, Israel
    Nat Commun 4:2030. 2013
  2. doi request reprint Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications
    Joseph El Khoury
    Division of Rheumatology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Trends Pharmacol Sci 29:626-32. 2008
  3. ncbi request reprint Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    Joseph El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Med 13:432-8. 2007
  4. ncbi request reprint Linezolid in the treatment of vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: report of a multicenter compassionate-use trial
    J El-Khoury
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Transpl Infect Dis 5:121-5. 2003
  5. ncbi request reprint A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 277:47373-9. 2002
  6. pmc CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    Cameron R Stewart
    Lipid Metabolism Unit, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:155-61. 2010
  7. ncbi request reprint Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals
    Eleftherios Mylonakis
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Microbiol 54:407-19. 2004
  8. pmc Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
    Terry K Means
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 206:637-53. 2009
  9. pmc Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    Suzanne E Hickman
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, and Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
    J Neurosci 28:8354-60. 2008
  10. pmc Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease
    Suzanne E Hickman
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
    CNS Neurol Disord Drug Targets 9:168-73. 2010

Research Grants

  1. Chemokines and microglia in Alzheimer's disease
    Joseph El Khoury; Fiscal Year: 2005
  2. CD36 in Alzheimer's Disease
    Joseph El Khoury; Fiscal Year: 2009
  3. Toll-Like Receptor Signaling in Alzheimer's Disease
    Kathryn Moore; Fiscal Year: 2009
  4. CD36 in Alzheimer's Disease
    Joseph El Khoury; Fiscal Year: 2010
  5. Toll-Like Receptor Signaling in Alzheimer's Disease
    Kathryn Moore; Fiscal Year: 2009
  6. Toll-Like Receptor Signaling in Alzheimer's Disease
    Kathryn J Moore; Fiscal Year: 2010

Collaborators

  • Andrew D Luster
  • Terry K Means
  • Changiz Geula
  • J A Fishman
  • Lynda M Stuart
  • Alexander Idnurm
  • Joseph El Khoury
  • Kathryn Moore
  • Kathryn J Moore
  • Suzanne E Hickman
  • Dan Frenkel
  • Kim Wilkinson
  • Cameron R Stewart
  • Kinya Terada
  • Eleftherios Mylonakis
  • Lindsay Puckett
  • Dorit Farfara
  • Lingzhi Zhao
  • Howard L Weiner
  • Nathan D Kingery
  • Janine M van Gils
  • Jiusheng Deng
  • Douglas T Golenbock
  • Annett Halle
  • William A Frazier
  • Katey J Rayner
  • Laurent Boyer
  • Adam Lacy-Hulbert
  • Ruiqin Zhong
  • Elizabeth K Allison
  • Michelle Toft
  • Roberto Moreno
  • James B Rottman
  • Joseph Heitman
  • Stephen B Calderwood
  • Frederick M Ausubel
  • Lea A Medeiros
  • Mason W Freeman

Detail Information

Publications10

  1. pmc Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
    Dan Frenkel
    Department of Neurobiology, Sagol School of Neuroscience, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 699788, Israel
    Nat Commun 4:2030. 2013
    ..In contrast, pharmacological upregulation of Scara1 expression on mononuclear phagocytes increases Aβ clearance. This approach is a potential treatment strategy for Alzheimer's disease. ..
  2. doi request reprint Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications
    Joseph El Khoury
    Division of Rheumatology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Trends Pharmacol Sci 29:626-32. 2008
    ..Here, we review the role of microglia in AD and the mechanisms of their accumulation and discuss implications for AD therapy...
  3. ncbi request reprint Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    Joseph El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Med 13:432-8. 2007
    ..Thus, Ccr2-dependent microglial accumulation plays a protective role in the early stages of Alzheimer disease by promoting Abeta clearance...
  4. ncbi request reprint Linezolid in the treatment of vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: report of a multicenter compassionate-use trial
    J El-Khoury
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Transpl Infect Dis 5:121-5. 2003
    ..Linezolid appears to be a safe and effective treatment option for VRE, even in the presence of bacteremia, and may lead to decreased mortality in solid organ transplant recipients with VRE infection...
  5. ncbi request reprint A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 277:47373-9. 2002
    ....
  6. pmc CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    Cameron R Stewart
    Lipid Metabolism Unit, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:155-61. 2010
    ....
  7. ncbi request reprint Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals
    Eleftherios Mylonakis
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Microbiol 54:407-19. 2004
    ..These findings show that the C. neoformans Kin1 kinase homologue is required for full virulence in disparate hosts and that C. elegans can be used as a substitute host to identify novel factors involved in fungal pathogenesis in mammals...
  8. pmc Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
    Terry K Means
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 206:637-53. 2009
    ..Binding of these pathogens to SCARF1 and CD36 was beta-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens...
  9. pmc Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    Suzanne E Hickman
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, and Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
    J Neurosci 28:8354-60. 2008
    ..Antiinflammatory therapy for AD should take this dichotomous microglial role into consideration...
  10. pmc Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease
    Suzanne E Hickman
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
    CNS Neurol Disord Drug Targets 9:168-73. 2010
    ....

Research Grants7

  1. Chemokines and microglia in Alzheimer's disease
    Joseph El Khoury; Fiscal Year: 2005
    ....
  2. CD36 in Alzheimer's Disease
    Joseph El Khoury; Fiscal Year: 2009
    ....
  3. Toll-Like Receptor Signaling in Alzheimer's Disease
    Kathryn Moore; Fiscal Year: 2009
    ....
  4. CD36 in Alzheimer's Disease
    Joseph El Khoury; Fiscal Year: 2010
    ....
  5. Toll-Like Receptor Signaling in Alzheimer's Disease
    Kathryn Moore; Fiscal Year: 2009
    ..abstract_text> ..
  6. Toll-Like Receptor Signaling in Alzheimer's Disease
    Kathryn J Moore; Fiscal Year: 2010
    ....