M Eikermann

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Do Patients with Obstructive Sleep Apnea have an Increased Risk of Desaturation During Induction of Anesthesia for Weight Loss Surgery?
    Matthias Eikermann
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    Open Respir Med J 4:58-62. 2010
  2. pmc Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study
    Martina Grosse-Sundrup
    Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    BMJ 345:e6329. 2012
  3. doi Muscle weakness predicts pharyngeal dysfunction and symptomatic aspiration in long-term ventilated patients
    Hooman Mirzakhani
    Department of Anesthesia, Critical Care, and Pain Medicine and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 119:389-97. 2013
  4. doi Development and validation of a score for prediction of postoperative respiratory complications
    Britta Brueckmann
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 118:1276-85. 2013
  5. pmc Effects of pentobarbital on upper airway patency during sleep
    M Eikermann
    Dept of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 2696, USA
    Eur Respir J 36:569-76. 2010
  6. pmc Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats
    Matthias Eikermann
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114 2696, USA
    Anesthesiology 110:1327-34. 2009
  7. ncbi Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing
    M Eikermann
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Br J Anaesth 101:344-9. 2008
  8. doi Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing
    Matthias Eikermann
    Department of Anesthesia, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 108:897-906. 2008
  9. pmc Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
    Matthias Eikermann
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 107:621-9. 2007
  10. pmc Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction
    Matthias Eikermann
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 116:35-46. 2012

Collaborators

Detail Information

Publications27

  1. pmc Do Patients with Obstructive Sleep Apnea have an Increased Risk of Desaturation During Induction of Anesthesia for Weight Loss Surgery?
    Matthias Eikermann
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    Open Respir Med J 4:58-62. 2010
    ..It is possible, that patients with OSA have a higher incidence of desaturation during induction of anesthesia...
  2. pmc Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study
    Martina Grosse-Sundrup
    Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    BMJ 345:e6329. 2012
    ..To determine whether use of intermediate acting neuromuscular blocking agents during general anesthesia increases the incidence of postoperative respiratory complications...
  3. doi Muscle weakness predicts pharyngeal dysfunction and symptomatic aspiration in long-term ventilated patients
    Hooman Mirzakhani
    Department of Anesthesia, Critical Care, and Pain Medicine and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 119:389-97. 2013
    ..The authors hypothesized that muscle strength measurements can be used to predict pharyngeal dysfunction (endoscopic evaluation-primary hypothesis), as well as symptomatic aspiration occurring during a 3-month follow-up period...
  4. doi Development and validation of a score for prediction of postoperative respiratory complications
    Britta Brueckmann
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 118:1276-85. 2013
    ..Postoperative respiratory failure is associated with increased morbidity and mortality, as well as high costs of hospital care...
  5. pmc Effects of pentobarbital on upper airway patency during sleep
    M Eikermann
    Dept of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 2696, USA
    Eur Respir J 36:569-76. 2010
    ..Pentobarbital did not affect the genioglossus negative-pressure reflex. Pentobarbital increases the time to arousal and stimulates genioglossus muscle activity, but it also increases upper airway resistance during sleep...
  6. pmc Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats
    Matthias Eikermann
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114 2696, USA
    Anesthesiology 110:1327-34. 2009
    ..The authors assessed the effects of pentobarbital on upper airway dilator and respiratory pump muscle function in rats and compared these results with the effects of normal sleep...
  7. ncbi Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing
    M Eikermann
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Br J Anaesth 101:344-9. 2008
    ..Sugammadex reverses neuromuscular block by encapsulating rocuronium. However, its effects on upper airway integrity and breathing are unknown...
  8. doi Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing
    Matthias Eikermann
    Department of Anesthesia, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 108:897-906. 2008
    ..The authors sought to understand which anesthetics increase or decrease upper airway dilator muscle activity and to study the mechanisms mediating the effect...
  9. pmc Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
    Matthias Eikermann
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 107:621-9. 2007
    ..The authors hypothesized that cholinesterase inhibition when given the in absence of neuromuscular blockade (NB) would decrease upper airway dilatory muscle activity and consequently upper airway volume...
  10. pmc Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction
    Matthias Eikermann
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 116:35-46. 2012
    ..Procedural sedation is frequently performed in spontaneously breathing patients, but hypnotics and opioids decrease respiratory drive and place the upper airway at risk for collapse...
  11. doi Neuromuscular blocking agents for electroconvulsive therapy: a systematic review
    H Mirzakhani
    Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Acta Anaesthesiol Scand 56:3-16. 2012
    ..Suxamethonium is commonly used, but nondepolarising NMBAs are indicated in patients with certain comorbidities. In this review, we summarise current concepts of NMBA management for ECT...
  12. pmc Influence of wakefulness on pharyngeal airway muscle activity
    Yu Lun Lo
    Brigham and Women s Hospital, Sleep Disorders Research Program, 75 Francis Street, Boston, Massachusetts 02115, USA
    Thorax 62:799-805. 2007
    ..A study was therefore undertaken to assess the isolated impact of sleep on upper airway muscle activity after minimising respiratory/mechanical inputs...
  13. doi Postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge
    A Butterly
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Br J Anaesth 105:304-9. 2010
    ..9] is associated with increased morbidity and may delay postoperative recovery room (PACU) discharge. We tested the hypothesis that postoperative T4/T1 <0.9 increases PACU length of stay...
  14. pmc The influence of aging on pharyngeal collapsibility during sleep
    Matthias Eikermann
    Department of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Chest 131:1702-9. 2007
    ..We tested the hypotheses that upper airway closing pressure (PCLOSE) and the increase in pharyngeal resistance during sleep (primary outcomes) as well as measures of arousal threshold (secondary outcomes) increase with age...
  15. pmc Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea
    Amy S Jordan
    Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Sleep 32:361-8. 2009
    ....
  16. pmc Genioglossus premotoneurons and the negative pressure reflex in rats
    Nancy L Chamberlin
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 579:515-26. 2007
    ..These results suggest that perihypoglossal GG premotoneurons near the obex mediate the NPR and those caudal to the obex are important mediators of respiratory-related GG activity but are not involved in the NPR...
  17. doi Increased sensitivity to a nondepolarizing muscle relaxant in a patient with acquired neuromyotonia
    Greg Ginsburg
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Shriners Hospital for Children Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Muscle Nerve 40:139-42. 2009
    ....
  18. doi Measurement of muscle strength in the intensive care unit
    Edward A Bittner
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care Med 37:S321-30. 2009
    ..Stimulated (evoked) force of skeletal muscles, such as the adductor pollicis, can be assessed repetitively, independent of brain function, even in heavily sedated patients during high acuity of their disease...
  19. doi Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial
    Friedrich K Pühringer
    Department for Anesthesiology and Intensive Care Medicine, Klinikum am Steinenberg, Reutlingen, Germany
    Anesthesiology 109:188-97. 2008
    ..The efficacy and safety of sugammadex for the reversal of profound, high-dose rocuronium-induced neuromuscular blockade was evaluated...
  20. pmc Muscle weakness after administration of neuromuscular blocking agents: do not immobilize the diaphragm unnecessarily
    Matthias Eikermann
    Crit Care Med 35:1634-5; author reply 1635. 2007
  21. ncbi The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade
    Matthias Eikermann
    Oberarzt der Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Am J Respir Crit Care Med 175:9-15. 2007
    ....
  22. ncbi Postoperative upper airway obstruction after recovery of the train of four ratio of the adductor pollicis muscle from neuromuscular blockade
    Matthias Eikermann
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Germany
    Anesth Analg 102:937-42. 2006
    ..9 predicts with high probability an absence of neuromuscular blocking drug-induced UAO, but outliers, i.e., persistent effects of neuromuscular blockade on upper airway integrity despite recovery of the TOF ratio, may still occur...
  23. ncbi Fade of pulmonary function during residual neuromuscular blockade
    Matthias Eikermann
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstr 55, D 45122 Essen, Germany
    Chest 127:1703-9. 2005
    ..We tested the hypothesis that fade of pulmonary function, ie, a decrease in values of FVC with the second spirometric maneuver compared to the first maneuver, occurs during impaired neuromuscular transmission...
  24. ncbi Accelerometry of adductor pollicis muscle predicts recovery of respiratory function from neuromuscular blockade
    Matthias Eikermann
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Germany
    Anesthesiology 98:1333-7. 2003
    ....
  25. pmc Is brachial artery peak velocity variation ready for prime time?
    Matthias Eikermann
    Chest 131:1279-81. 2007
  26. ncbi Does fade with 100-Hz tetanic stimulation reliably detect residual neuromuscular blockade?
    Matthias Eikermann
    Anesth Analg 104:215; author reply 215-6. 2007