Research Topics
Genomes and Genes
| Victor J DzauSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Predicting the future of human gene therapy for cardiovascular diseases: what will the management of coronary artery disease be like in 2005 and 2010?Victor J Dzau
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Cardiol 92:32N-35N. 2003..In the future, new technology using stable gene integration may lead to the development of more effective and lifelong therapy for diabetes, familial homozygous hypercholesterolemia, and other acquired diseases...- Current perceptions of cardiovascular gene therapyVictor J Dzau
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Cardiol 92:18N-23N. 2003..The success of a gene therapy will also rely on patients' perceptions and their willingness to receive the treatment. Any misconceptions based on unreliable information sources need to be addressed... - Pathophysiologic and therapeutic importance of tissue ACE: a consensus reportVictor J Dzau
Department of Medicine, Brigham Women s Hospital, Boston, MA 02115, USA
Cardiovasc Drugs Ther 16:149-60. 2002..Pharmacologic studies show that while ACE inhibitors may differ according to their binding affinity for tissue ACE the clinical significance remains to be determined... - Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategiesVictor J Dzau
Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
Nat Med 8:1249-56. 2002 - Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiationNicolas Noiseux
Department of Medicine, Brigham and Women's Hospital, Harvard University, Boston, MA 02115, USA
Mol Ther 14:840-50. 2006.... - Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cellsDeling Kong
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 109:1769-75. 2004..This cell-based gene therapy strategy may be useful in treatment of vascular disease... - Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteriesDeling Kong
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA
Circulation 110:2039-46. 2004..CONCLUSIONS: We postulate that cytokine-induced mobilization of CEPCs may be a suitable therapeutic strategy for prevention of restenosis after revascularization procedures... - Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activationShaodong Guo
Cardiovascular Research Laboratories, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:12536-41. 2005.... 
Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftmentJames E Ip
Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
Mol Biol Cell 18:2873-82. 2007..The latter observation is distinctively different from that reported for hematopoietic stem cells (HSCs). Thus, our data show that BM-MSCs use a different pathway from HSCs for intramyocardial trafficking and engraftment...- Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardiumYaojiong Wu
Department of Medicine, Duke University School of Medicine, Durham, NC, USA
Circ Res 99:315-22. 2006..Thus, our results suggest an essential role of CD18 in mediating EPC recruitment and the subsequent functional effects on the infarcted heart... - Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarctionMassimiliano Gnecchi
Department of Medicine, Duke University Medical Center, Durham, NC, USA
Stem Cells 27:971-9. 2009..We conclude that administration of MSCs overexpressing Akt at the time of infarction results in preservation of normal metabolism and pH in the surviving myocardium... - Differential gene expression of blood-derived cell lines in familial combined hyperlipidemiaFulvio Morello
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 24:2149-54. 2004.... - Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytesKenichi Matsushita
Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
Hypertension 48:1095-102. 2006..Elucidation of the molecular mechanism should provide important insight into the pathophysiology of the metabolic syndrome and the development of future therapeutics... - SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3aArjun Deb
Division of Cardiovascular Diseases and Mandel Center for Hypertension and Atherosclerosis Research, Department of Medicine, GSRB 2, Box 3178, Duke University Medical Center, Durham, North Carolina 27710, USA
Stem Cells 26:35-44. 2008..The inhibitory effects of Sfrp2 on Wnt3a expression identify Sfrp2 as a "checkpoint gene," which exerts its control on cardiomyogenesis through regulation of Wnt3a transcription... - Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injuryAlok S Pachori
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:12282-7. 2004..Application of this regulatable system using an endogenous physiological stimulus for expression of a therapeutic gene may be a feasible strategy for protecting tissues at risk of ischemia/reperfusion injury... - Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene deliveryAlok S Pachori
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Am Coll Cardiol 47:635-43. 2006.... - Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvementMassimiliano Gnecchi
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
FASEB J 20:661-9. 2006..Taken together, our data support Akt-MSC-mediated paracrine mechanisms of myocardial protection and functional improvement... - Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapyDaniel P Griese
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
Circulation 108:2710-5. 2003..These findings may have implications for novel and practical cell-based therapies for vascular disease... - Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virusAlok S Pachori
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Biochem Biophys Res Commun 313:528-33. 2004..These data demonstrate the efficacy of AAV-2 delivery for long-term myocardial gene therapy, but raise concerns about the possibility of ectopic transgene expression and germ cell line infection... - Paracrine mechanisms of stem cell reparative and regenerative actions in the heartMaria Mirotsou
Department of Medicine, Duke University Medical Center and Mandel Center for Hypertension and Atherosclerosis Research, Durham, NC 27710, USA
J Mol Cell Cardiol 50:280-9. 2011..This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited"... - Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarctionWei He
Mandel Center for Hypertension Research and Division of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 107:21110-5. 2010..Our study demonstrates Sfrp2 at therapeutic doses can inhibit fibrosis and improve LV function at a later stage after MI... - Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolutionVirna L Sales
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Circulation 112:3328-36. 2005..Normal adult animals have low AT2R expression; however, vascular injury and exposure to proinflammatory cytokines augment AT2R levels. We hypothesized that AT2R expression increases during initiation and progression of atherosclerosis... - Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathwayAlok S Pachori
Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
J Mol Cell Cardiol 43:580-92. 2007..This effect is mediated, at least in part, via interaction with and activation of the PI3K/Akt pathway... - Therapeutic potential of endothelial progenitor cells in cardiovascular diseasesVictor J Dzau
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Hypertension 46:7-18. 2005..Large-scale multi-center randomized trials are required to evaluate the long-term safety and efficacy of EPC therapy. Despite these hurdles, the outlook for EPC-based therapy for cardiovascular disease is promising... - Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injuryDan Frenkel
Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Int Immunol 21:817-29. 2009..Modulation of cardiac inflammation by nasal troponin provides a novel treatment to decrease myocardial damage and enhance recovery after myocardial ischemia... - Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophyMaria Mirotsou
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Physiol Genomics 27:86-94. 2006.... - Genetic engineering of mesenchymal stem cells and its application in human disease therapyConrad P Hodgkinson
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Hum Gene Ther 21:1513-26. 2010..Advancements in other disease areas are also discussed... - Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal diseaseAfshin Ehsan
Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Mass 02115, USA
Circulation 105:1686-92. 2002..Additionally, there is a selective effect of E2F decoy gene therapy on target smooth muscle cells with sparing of this endothelial healing... - Searching for transcriptional regulators of Ang II-induced vascular pathologyVictor J Dzau
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27708, USA
J Clin Invest 115:2319-22. 2005.... - Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cellsMarco A Lopez-Ilasaca
Cardiovascular Research Laboratories, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
FEBS Lett 579:648-54. 2005..These results identify hCNK1 as a specific partner of Rho proteins both in vitro and in vivo and suggest a role of hCNK1 in the signal transduction of Rho proteins... - Molecular mechanism of juxtaglomerular cell hyperplasia: a unifying hypothesisKenichi Matsushita
Mandel Center for Hypertension Research, Duke University Medical Center, Durham, North Carolina, USA Cardiology Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
J Am Soc Hypertens 1:164-8. 2007..This hypothesis may provide a potential explanation for the observation that the JG cells can maintain a highly specialized renin-producing phenotype while undergoing hyperplasia... - The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signalingMarco Lopez-Ilasaca
Cardiovascular Research Laboratories, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Biol Cell 14:5038-50. 2003.... - Atherosclerosis 2005: recent discoveries and novel hypothesesPascal J Goldschmidt-Clermont
Cardiology Division, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Circulation 112:3348-53. 2005 - Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approachMaria Mirotsou
Cardiovascular Research, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Physiol Genomics 15:115-26. 2003..Moreover, common pathways that are coregulated in both models exist, and these might be central to the hypertrophic phenotype regardless of the initial hypertrophic stimuli... - Molecular genetics and genomics of heart failureChoong Chin Liew
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Louis Pasteur Avenue, NRB room 0630K, Boston, Massachusetts 02115, USA
Nat Rev Genet 5:811-25. 2004..Here, we highlight the current understanding of the molecular and genetic basis of heart failure and show how recently developed genomic tools are providing a new perspective on this complex disease... - Markers of malign across the cardiovascular continuum: interpretation and applicationVictor J Dzau
Brigham and Women's Hospital, Boston, MA, USA
Circulation 109:IV1-2. 2004 - Risk factor criteriaMeir J Stampfer
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Mass 02115, USA
Circulation 109:IV3-5. 2004 - Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted heartsAbeel A Mangi
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115 USA
Nat Med 9:1195-201. 2003..Thus, mesenchymal stem cells genetically enhanced with Akt1 can repair infarcted myocardium, prevent remodeling and nearly normalize cardiac performance... - Chromosomal distribution of the human cardiovascular transcriptomeJ David Barrans
The Cardiovascular Genome Unit, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Thorn 1334, Boston, MA 02115, USA
Genomics 81:519-24. 2003..This report provides insight into a possible role for complex tissue-specific gene regulation in the human genome... - Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanismLeonard M Anderson
Department of Medicine, Division of Cardiovascular Research, Laboratory of Genetic Physiology, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:15252-60. 2003.... - An initiative in mentoring to promote residents' and faculty members' careersBruce D Levy
Internal Medicine, PBB Clinics-3, Brigham and Women's/Faulkner Hospital, 75 Francis Street, Boston, MA 02115, USA
Acad Med 79:845-50. 2004..The authors conclude that the formal mentoring program has ensured that all trainees are provided with a mentor, which has facilitated faculty-housestaff interactions and increased recognition of faculty contributions to mentoring... - Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase geneLuis G Melo
Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Circulation 105:602-7. 2002.... - Molecular approaches for the treatment of atherosclerosisMichael J Mann
Division of Cardiothoracic Surgery, University of California San Francisco, 505 Parnassus, San Francisco, CA, USA
Cardiol Clin 20:633-43. 2002..As the understanding of the genetic basis of vascular disease continues to grow and the tools for in vivo genetic manipulation continue to improve, vascular gene therapies might someday become a part of routine patient care... - The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease)Victor J Dzau
Duke University Medical Center and Health System DUMC 3701, Durham, NC 27710, USA
Circulation 114:2850-70. 2006 - Genetic therapies for cardiovascular diseasesLuis G Melo
Department of Physiology, Queen s University, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada
Trends Mol Med 11:240-50. 2005.... - Endothelium-targeted gene and cell-based therapies for cardiovascular diseaseLuis G Melo
Department of Physiology, Queen s University, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada
Arterioscler Thromb Vasc Biol 24:1761-74. 2004.... - Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffnessSéverine Durier
Department of Pharmacology and INSERM EMI 107, Paris, France
Circulation 108:1845-51. 2003.... - The future of Physiological GenomicsVictor J Dzau
Physiol Genomics 14:167-8. 2003 - Which inhibitor of the renin-angiotensin system should be used in chronic heart failure and acute myocardial infarction?John J V McMurray
Department of Cardiology, Western Infirmary, Glasgow, Scotland, G12 8QQ, UK
Circulation 110:3281-8. 2004 - Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomesNaruya Tomita
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 15 Yamada Oka, Suita 565 0871, Japan
J Gene Med 4:527-35. 2002..At experimental level several in vivo gene transfer methods have been reported... - Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarctionXiaoli Liu
Department of Physiology, Botterell Hall, Queen s University, 18 Stuart Street, Kingston, Ontario, Canada
Am J Physiol Heart Circ Physiol 293:H48-59. 2007..These results suggest that preemptive HO-1 gene delivery may be useful as a therapeutic strategy to reduce post-MI LV remodeling and heart failure... - The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part II: Clinical trial evidence (acute coronary syndromes through renal disease) and future directionsVictor J Dzau
Duke University Medical Center and Health System DUMC 3701, Durham, NC 27710, USA
Circulation 114:2871-91. 2006 - Liver X receptors alpha and beta regulate renin expression in vivoFulvio Morello
Duke University Medical Center, Durham, NC 27710, USA
J Clin Invest 115:1913-22. 2005.... - Enhancing stem cell therapy through genetic modificationVictor J Dzau
J Am Coll Cardiol 46:1351-3. 2005 - Genetic markers: progress and potential for cardiovascular diseaseGary H Gibbons
Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA
Circulation 109:IV47-58. 2004 - Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular functionXiaoli Liu
Department of Physiology, Queen's University, Kingston, Ontario, Canada
FASEB J 20:207-16. 2006..Our data indicate that rAAV-HO-1 gene transfer markedly reduces fibrosis and ventricular remodeling and restores LV function and chamber dimensions after myocardial infarction... - Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimismLuis G Melo
Department of Physiology, Queen's University, 20 Stuart St, Kingston, Ontario K7L 3N6, Canada
Circulation 109:2386-93. 2004 - Gene and cell-based therapies for heart diseaseLuis G Melo
Department of Physiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
FASEB J 18:648-63. 2004.... - Cell cycle-dependent regulation of smooth muscle cell activationRuediger C Braun-Dullaeus
Cardiothoracic Surgery, University of California, San Francisco Medical School, San Francisco, Calif, USA
Arterioscler Thromb Vasc Biol 24:845-50. 2004.... - Evolving revascularization approaches for myocardial ischemiaNeal S Kleiman
Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Texas, USA
Am J Cardiol 92:9N-17N. 2003..Ongoing angiogenic gene therapy clinical trials are evaluating which factors, vectors, and delivery techniques hold the greatest promise for management of patients with chronic stable angina... - Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set"William C Aird
Physiol Genomics 10:1-3. 2002