Victor J Dzau

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Predicting the future of human gene therapy for cardiovascular diseases: what will the management of coronary artery disease be like in 2005 and 2010?
    Victor J Dzau
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 92:32N-35N. 2003
  2. ncbi request reprint Current perceptions of cardiovascular gene therapy
    Victor J Dzau
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Cardiol 92:18N-23N. 2003
  3. ncbi request reprint Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies
    Victor J Dzau
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Med 8:1249-56. 2002
  4. ncbi request reprint Pathophysiologic and therapeutic importance of tissue ACE: a consensus report
    Victor J Dzau
    Department of Medicine, Brigham Women s Hospital, Boston, MA 02115, USA
    Cardiovasc Drugs Ther 16:149-60. 2002
  5. ncbi request reprint Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
    Nicolas Noiseux
    Department of Medicine, Brigham and Women s Hospital, Harvard University, Boston, MA 02115, USA
    Mol Ther 14:840-50. 2006
  6. ncbi request reprint Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells
    Deling Kong
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 109:1769-75. 2004
  7. ncbi request reprint Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries
    Deling Kong
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 110:2039-46. 2004
  8. ncbi request reprint Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation
    Shaodong Guo
    Cardiovascular Research Laboratories, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:12536-41. 2005
  9. pmc Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment
    James E Ip
    Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    Mol Biol Cell 18:2873-82. 2007
  10. pmc Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction
    Massimiliano Gnecchi
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Stem Cells 27:971-9. 2009

Detail Information

Publications62

  1. ncbi request reprint Predicting the future of human gene therapy for cardiovascular diseases: what will the management of coronary artery disease be like in 2005 and 2010?
    Victor J Dzau
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 92:32N-35N. 2003
    ..In the future, new technology using stable gene integration may lead to the development of more effective and lifelong therapy for diabetes, familial homozygous hypercholesterolemia, and other acquired diseases...
  2. ncbi request reprint Current perceptions of cardiovascular gene therapy
    Victor J Dzau
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Cardiol 92:18N-23N. 2003
    ..The success of a gene therapy will also rely on patients' perceptions and their willingness to receive the treatment. Any misconceptions based on unreliable information sources need to be addressed...
  3. ncbi request reprint Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies
    Victor J Dzau
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Med 8:1249-56. 2002
  4. ncbi request reprint Pathophysiologic and therapeutic importance of tissue ACE: a consensus report
    Victor J Dzau
    Department of Medicine, Brigham Women s Hospital, Boston, MA 02115, USA
    Cardiovasc Drugs Ther 16:149-60. 2002
    ..Pharmacologic studies show that while ACE inhibitors may differ according to their binding affinity for tissue ACE the clinical significance remains to be determined...
  5. ncbi request reprint Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
    Nicolas Noiseux
    Department of Medicine, Brigham and Women s Hospital, Harvard University, Boston, MA 02115, USA
    Mol Ther 14:840-50. 2006
    ....
  6. ncbi request reprint Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells
    Deling Kong
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 109:1769-75. 2004
    ..In this study, we examined the hypothesis that overexpression of vasculoprotective gene endothelial nitric oxide synthase (eNOS) and heme oxygenase-1 (HO-1) in EPCs enhances their ability to inhibit neointimal hyperplasia...
  7. ncbi request reprint Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries
    Deling Kong
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 110:2039-46. 2004
    ....
  8. ncbi request reprint Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation
    Shaodong Guo
    Cardiovascular Research Laboratories, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:12536-41. 2005
    ....
  9. pmc Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment
    James E Ip
    Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    Mol Biol Cell 18:2873-82. 2007
    ..The latter observation is distinctively different from that reported for hematopoietic stem cells (HSCs). Thus, our data show that BM-MSCs use a different pathway from HSCs for intramyocardial trafficking and engraftment...
  10. pmc Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction
    Massimiliano Gnecchi
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Stem Cells 27:971-9. 2009
    ..We conclude that administration of MSCs overexpressing Akt at the time of infarction results in preservation of normal metabolism and pH in the surviving myocardium...
  11. ncbi request reprint Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium
    Yaojiong Wu
    Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Res 99:315-22. 2006
    ..Thus, our results suggest an essential role of CD18 in mediating EPC recruitment and the subsequent functional effects on the infarcted heart...
  12. ncbi request reprint Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia
    Fulvio Morello
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 24:2149-54. 2004
    ..Two hypotheses were tested: the existence of a disease-specific modification of gene expression in FCHL and the detectability of such a transcriptional profile in blood derived cell lines...
  13. pmc SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a
    Arjun Deb
    Division of Cardiovascular Diseases and Mandel Center for Hypertension and Atherosclerosis Research, Department of Medicine, GSRB 2, Box 3178, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 26:35-44. 2008
    ..The inhibitory effects of Sfrp2 on Wnt3a expression identify Sfrp2 as a "checkpoint gene," which exerts its control on cardiomyogenesis through regulation of Wnt3a transcription...
  14. ncbi request reprint Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes
    Kenichi Matsushita
    Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
    Hypertension 48:1095-102. 2006
    ..Elucidation of the molecular mechanism should provide important insight into the pathophysiology of the metabolic syndrome and the development of future therapeutics...
  15. ncbi request reprint Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery
    Alok S Pachori
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 47:635-43. 2006
    ..We assessed the hypothesis that overexpression of the antioxidant enzyme heme oxygenase (HO)-1 may protect against chronic recurrent ischemia/reperfusion injury...
  16. pmc Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury
    Alok S Pachori
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:12282-7. 2004
    ..Application of this regulatable system using an endogenous physiological stimulus for expression of a therapeutic gene may be a feasible strategy for protecting tissues at risk of ischemia/reperfusion injury...
  17. ncbi request reprint Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement
    Massimiliano Gnecchi
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 20:661-9. 2006
    ..Taken together, our data support Akt-MSC-mediated paracrine mechanisms of myocardial protection and functional improvement...
  18. ncbi request reprint Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy
    Daniel P Griese
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:2710-5. 2003
    ..Current protocols for isolation of EPCs from peripheral blood rely on enrichment and selection of CD34+ mononuclear cells...
  19. ncbi request reprint Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus
    Alok S Pachori
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Biochem Biophys Res Commun 313:528-33. 2004
    ..These data demonstrate the efficacy of AAV-2 delivery for long-term myocardial gene therapy, but raise concerns about the possibility of ectopic transgene expression and germ cell line infection...
  20. pmc Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
    Wei He
    Mandel Center for Hypertension Research and Division of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:21110-5. 2010
    ..Our study demonstrates Sfrp2 at therapeutic doses can inhibit fibrosis and improve LV function at a later stage after MI...
  21. pmc Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
    Maria Mirotsou
    Department of Medicine, Duke University Medical Center and Mandel Center for Hypertension and Atherosclerosis Research, Durham, NC 27710, USA
    J Mol Cell Cardiol 50:280-9. 2011
    ..This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited"...
  22. ncbi request reprint Therapeutic potential of endothelial progenitor cells in cardiovascular diseases
    Victor J Dzau
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hypertension 46:7-18. 2005
    ..Large-scale multi-center randomized trials are required to evaluate the long-term safety and efficacy of EPC therapy. Despite these hurdles, the outlook for EPC-based therapy for cardiovascular disease is promising...
  23. ncbi request reprint Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution
    Virna L Sales
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 112:3328-36. 2005
    ..Normal adult animals have low AT2R expression; however, vascular injury and exposure to proinflammatory cytokines augment AT2R levels. We hypothesized that AT2R expression increases during initiation and progression of atherosclerosis...
  24. pmc Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway
    Alok S Pachori
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Cell Cardiol 43:580-92. 2007
    ..This effect is mediated, at least in part, via interaction with and activation of the PI3K/Akt pathway...
  25. pmc Abi3bp Is a Multifunctional Autocrine/Paracrine Factor that Regulates Mesenchymal Stem Cell Biology
    Conrad P Hodgkinson
    Mandel Center for Hypertension Research and Division of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Stem Cells 31:1669-82. 2013
    ..In summary, we have identified a novel extracellular matrix protein necessary for the switch from proliferation to differentiation in MSCs. STEM Cells 2013;31:1669-1682. ..
  26. pmc Genetic engineering of mesenchymal stem cells and its application in human disease therapy
    Conrad P Hodgkinson
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hum Gene Ther 21:1513-26. 2010
    ..Advancements in other disease areas are also discussed...
  27. pmc Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury
    Dan Frenkel
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int Immunol 21:817-29. 2009
    ..Modulation of cardiac inflammation by nasal troponin provides a novel treatment to decrease myocardial damage and enhance recovery after myocardial ischemia...
  28. ncbi request reprint Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophy
    Maria Mirotsou
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiol Genomics 27:86-94. 2006
    ....
  29. pmc Searching for transcriptional regulators of Ang II-induced vascular pathology
    Victor J Dzau
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27708, USA
    J Clin Invest 115:2319-22. 2005
    ....
  30. ncbi request reprint Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease
    Afshin Ehsan
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 105:1686-92. 2002
    ....
  31. ncbi request reprint Molecular mechanism of juxtaglomerular cell hyperplasia: a unifying hypothesis
    Kenichi Matsushita
    Mandel Center for Hypertension Research, Duke University Medical Center, Durham, North Carolina, USA Cardiology Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Am Soc Hypertens 1:164-8. 2007
    ..This hypothesis may provide a potential explanation for the observation that the JG cells can maintain a highly specialized renin-producing phenotype while undergoing hyperplasia...
  32. pmc The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling
    Marco Lopez-Ilasaca
    Cardiovascular Research Laboratories, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Biol Cell 14:5038-50. 2003
    ....
  33. ncbi request reprint Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells
    Marco A Lopez-Ilasaca
    Cardiovascular Research Laboratories, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    FEBS Lett 579:648-54. 2005
    ..These results identify hCNK1 as a specific partner of Rho proteins both in vitro and in vivo and suggest a role of hCNK1 in the signal transduction of Rho proteins...
  34. ncbi request reprint Atherosclerosis 2005: recent discoveries and novel hypotheses
    Pascal J Goldschmidt-Clermont
    Cardiology Division, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 112:3348-53. 2005
  35. ncbi request reprint Risk factor criteria
    Meir J Stampfer
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Mass 02115, USA
    Circulation 109:IV3-5. 2004
  36. ncbi request reprint Molecular genetics and genomics of heart failure
    Choong Chin Liew
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Louis Pasteur Avenue, NRB room 0630K, Boston, Massachusetts 02115, USA
    Nat Rev Genet 5:811-25. 2004
    ..Here, we highlight the current understanding of the molecular and genetic basis of heart failure and show how recently developed genomic tools are providing a new perspective on this complex disease...
  37. ncbi request reprint Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach
    Maria Mirotsou
    Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Genomics 15:115-26. 2003
    ..Moreover, common pathways that are coregulated in both models exist, and these might be central to the hypertrophic phenotype regardless of the initial hypertrophic stimuli...
  38. ncbi request reprint Markers of malign across the cardiovascular continuum: interpretation and application
    Victor J Dzau
    Brigham and Women s Hospital, Boston, MA, USA
    Circulation 109:IV1-2. 2004
  39. ncbi request reprint Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
    Abeel A Mangi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115 USA
    Nat Med 9:1195-201. 2003
    ..Thus, mesenchymal stem cells genetically enhanced with Akt1 can repair infarcted myocardium, prevent remodeling and nearly normalize cardiac performance...
  40. ncbi request reprint Chromosomal distribution of the human cardiovascular transcriptome
    J David Barrans
    The Cardiovascular Genome Unit, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Thorn 1334, Boston, MA 02115, USA
    Genomics 81:519-24. 2003
    ..This report provides insight into a possible role for complex tissue-specific gene regulation in the human genome...
  41. ncbi request reprint An initiative in mentoring to promote residents' and faculty members' careers
    Bruce D Levy
    Internal Medicine, PBB Clinics 3, Brigham and Women s Faulkner Hospital, 75 Francis Street, Boston, MA 02115, USA
    Acad Med 79:845-50. 2004
    ..The authors conclude that the formal mentoring program has ensured that all trainees are provided with a mentor, which has facilitated faculty-housestaff interactions and increased recognition of faculty contributions to mentoring...
  42. ncbi request reprint Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism
    Leonard M Anderson
    Department of Medicine, Division of Cardiovascular Research, Laboratory of Genetic Physiology, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:15252-60. 2003
    ....
  43. ncbi request reprint Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene
    Luis G Melo
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 105:602-7. 2002
    ....
  44. ncbi request reprint The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease)
    Victor J Dzau
    Duke University Medical Center and Health System DUMC 3701, Durham, NC 27710, USA
    Circulation 114:2850-70. 2006
  45. ncbi request reprint Genetic therapies for cardiovascular diseases
    Luis G Melo
    Department of Physiology, Queen s University, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada
    Trends Mol Med 11:240-50. 2005
    ....
  46. ncbi request reprint Endothelium-targeted gene and cell-based therapies for cardiovascular disease
    Luis G Melo
    Department of Physiology, Queen s University, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada
    Arterioscler Thromb Vasc Biol 24:1761-74. 2004
    ....
  47. ncbi request reprint Molecular approaches for the treatment of atherosclerosis
    Michael J Mann
    Division of Cardiothoracic Surgery, University of California San Francisco, 505 Parnassus, San Francisco, CA, USA
    Cardiol Clin 20:633-43. 2002
    ..As the understanding of the genetic basis of vascular disease continues to grow and the tools for in vivo genetic manipulation continue to improve, vascular gene therapies might someday become a part of routine patient care...
  48. ncbi request reprint The future of Physiological Genomics
    Victor J Dzau
    Physiol Genomics 14:167-8. 2003
  49. ncbi request reprint Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness
    Séverine Durier
    Department of Pharmacology and INSERM EMI 107, Paris, France
    Circulation 108:1845-51. 2003
    ....
  50. ncbi request reprint Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes
    Naruya Tomita
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 15 Yamada Oka, Suita 565 0871, Japan
    J Gene Med 4:527-35. 2002
    ..At experimental level several in vivo gene transfer methods have been reported...
  51. ncbi request reprint Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction
    Xiaoli Liu
    Department of Physiology, Botterell Hall, Queen s University, 18 Stuart Street, Kingston, Ontario, Canada
    Am J Physiol Heart Circ Physiol 293:H48-59. 2007
    ..These results suggest that preemptive HO-1 gene delivery may be useful as a therapeutic strategy to reduce post-MI LV remodeling and heart failure...
  52. ncbi request reprint The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part II: Clinical trial evidence (acute coronary syndromes through renal disease) and future directions
    Victor J Dzau
    Duke University Medical Center and Health System DUMC 3701, Durham, NC 27710, USA
    Circulation 114:2871-91. 2006
  53. ncbi request reprint Which inhibitor of the renin-angiotensin system should be used in chronic heart failure and acute myocardial infarction?
    John J V McMurray
    Department of Cardiology, Western Infirmary, Glasgow, Scotland, G12 8QQ, UK
    Circulation 110:3281-8. 2004
  54. pmc Liver X receptors alpha and beta regulate renin expression in vivo
    Fulvio Morello
    Duke University Medical Center, Durham, NC 27710, USA
    J Clin Invest 115:1913-22. 2005
    ....
  55. ncbi request reprint Enhancing stem cell therapy through genetic modification
    Victor J Dzau
    J Am Coll Cardiol 46:1351-3. 2005
  56. ncbi request reprint Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function
    Xiaoli Liu
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    FASEB J 20:207-16. 2006
    ..Our data indicate that rAAV-HO-1 gene transfer markedly reduces fibrosis and ventricular remodeling and restores LV function and chamber dimensions after myocardial infarction...
  57. ncbi request reprint Genetic markers: progress and potential for cardiovascular disease
    Gary H Gibbons
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA
    Circulation 109:IV47-58. 2004
  58. ncbi request reprint Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism
    Luis G Melo
    Department of Physiology, Queen s University, 20 Stuart St, Kingston, Ontario K7L 3N6, Canada
    Circulation 109:2386-93. 2004
  59. ncbi request reprint Gene and cell-based therapies for heart disease
    Luis G Melo
    Department of Physiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    FASEB J 18:648-63. 2004
    ....
  60. ncbi request reprint Cell cycle-dependent regulation of smooth muscle cell activation
    Ruediger C Braun-Dullaeus
    Cardiothoracic Surgery, University of California, San Francisco Medical School, San Francisco, Calif, USA
    Arterioscler Thromb Vasc Biol 24:845-50. 2004
    ..In this study, we demonstrate that an association exists between cell cycle progression and the expression of genes involved in cellular activation...
  61. ncbi request reprint Evolving revascularization approaches for myocardial ischemia
    Neal S Kleiman
    Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Texas, USA
    Am J Cardiol 92:9N-17N. 2003
    ..Ongoing angiogenic gene therapy clinical trials are evaluating which factors, vectors, and delivery techniques hold the greatest promise for management of patients with chronic stable angina...
  62. ncbi request reprint Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set"
    William C Aird
    Physiol Genomics 10:1-3. 2002