Affiliation: Massachusetts General Hospital
- Current concepts in the polycystic ovary syndromeA Dunaif
Division of Women s Health, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
Annu Rev Med 52:401-19. 2001..The strongest evidence to date points to a gene in the region of the insulin receptor. Insulin-sensitizing therapy mitigates the reproductive disturbances of PCOS...
- Insulin resistance in polycystic ovary syndrome: progress and paradoxesA M Venkatesan
The Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Recent Prog Horm Res 56:295-308. 2001..The explanations for tissue-specific and signaling pathway-specific differences in insulin action in PCOS are unknown but may involve differential roles of insulin receptor substrate (IRS)-1 and IRS-2 in insulin signal transduction...
- Insulin action in the polycystic ovary syndromeA Dunaif
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Endocrinol Metab Clin North Am 28:341-59. 1999..It is thought that one or several genetic defects may cause both the insulin resistance and reproductive abnormalities characteristic of PCOS...
- Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathwaysL Rui
Harvard Medical School, Joslin Diabetes Center, 1 Joslin Place, Boston, Massachusetts 02215, USA
J Clin Invest 107:181-9. 2001..Thus, distinct kinase pathways might converge at Ser307 to mediate feedback or heterologous inhibition of IRS-1 signaling to counterregulate the insulin response...
- Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitusC G Solomon
Division of Women s Health, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
JAMA 286:2421-6. 2001..Although oligomenorrhea has been associated cross-sectionally with insulin resistance and glucose intolerance, it is not known whether oligomenorrhea is a marker for increased future risk of type 2 diabetes mellitus (DM)...
- Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndromeR B Fogel
Sleep Disorders Section, Divisions of Endocrinology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 86:1175-80. 2001..05) in women with PCOS. We conclude that obese women with PCOS are at increased risk of OSA when compared with matched reproductively normal women. Women with PCOS should be carefully questioned regarding symptoms of sleep apnea...
- Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS)A Dunaif
Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Am J Physiol Endocrinol Metab 281:E392-9. 2001..05) in PCOS skeletal muscle, suggesting a compensatory change. We conclude that there is a physiologically relevant defect in insulin receptor signaling in PCOS that is independent of obesity and type 2 diabetes mellitus...