A Dunaif

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Current concepts in the polycystic ovary syndrome
    A Dunaif
    Division of Women s Health, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Annu Rev Med 52:401-19. 2001
  2. ncbi Insulin resistance in polycystic ovary syndrome: progress and paradoxes
    A M Venkatesan
    The Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Recent Prog Horm Res 56:295-308. 2001
  3. ncbi Insulin action in the polycystic ovary syndrome
    A Dunaif
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 28:341-59. 1999
  4. pmc Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways
    L Rui
    Harvard Medical School, Joslin Diabetes Center, 1 Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Invest 107:181-9. 2001
  5. ncbi Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus
    C G Solomon
    Division of Women s Health, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 286:2421-6. 2001
  6. ncbi Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome
    R B Fogel
    Sleep Disorders Section, Divisions of Endocrinology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 86:1175-80. 2001
  7. ncbi Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS)
    A Dunaif
    Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 281:E392-9. 2001

Collaborators

Detail Information

Publications7

  1. ncbi Current concepts in the polycystic ovary syndrome
    A Dunaif
    Division of Women s Health, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Annu Rev Med 52:401-19. 2001
    ..The strongest evidence to date points to a gene in the region of the insulin receptor. Insulin-sensitizing therapy mitigates the reproductive disturbances of PCOS...
  2. ncbi Insulin resistance in polycystic ovary syndrome: progress and paradoxes
    A M Venkatesan
    The Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Recent Prog Horm Res 56:295-308. 2001
    ..The explanations for tissue-specific and signaling pathway-specific differences in insulin action in PCOS are unknown but may involve differential roles of insulin receptor substrate (IRS)-1 and IRS-2 in insulin signal transduction...
  3. ncbi Insulin action in the polycystic ovary syndrome
    A Dunaif
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 28:341-59. 1999
    ..It is thought that one or several genetic defects may cause both the insulin resistance and reproductive abnormalities characteristic of PCOS...
  4. pmc Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways
    L Rui
    Harvard Medical School, Joslin Diabetes Center, 1 Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Invest 107:181-9. 2001
    ..Thus, distinct kinase pathways might converge at Ser307 to mediate feedback or heterologous inhibition of IRS-1 signaling to counterregulate the insulin response...
  5. ncbi Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus
    C G Solomon
    Division of Women s Health, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 286:2421-6. 2001
    ..Although oligomenorrhea has been associated cross-sectionally with insulin resistance and glucose intolerance, it is not known whether oligomenorrhea is a marker for increased future risk of type 2 diabetes mellitus (DM)...
  6. ncbi Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome
    R B Fogel
    Sleep Disorders Section, Divisions of Endocrinology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 86:1175-80. 2001
    ..05) in women with PCOS. We conclude that obese women with PCOS are at increased risk of OSA when compared with matched reproductively normal women. Women with PCOS should be carefully questioned regarding symptoms of sleep apnea...
  7. ncbi Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS)
    A Dunaif
    Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 281:E392-9. 2001
    ..05) in PCOS skeletal muscle, suggesting a compensatory change. We conclude that there is a physiologically relevant defect in insulin receptor signaling in PCOS that is independent of obesity and type 2 diabetes mellitus...