Iain Drummond

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Kidney development and disease in the zebrafish
    Iain A Drummond
    Department of Medicine, Harvard Medical School and Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Am Soc Nephrol 16:299-304. 2005
  2. pmc Polycystin-2 immunolocalization and function in zebrafish
    Tomoko Obara
    Nephrology Division, Massachusetts General Hospital 149 8000 and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Am Soc Nephrol 17:2706-18. 2006
  3. pmc The cilium in lights: new views of an ancient organelle
    Iain A Drummond
    Nephrology Division, Massachusetts General Hospital, 149 13th Street, Rm 149 8000, Charlestown, MA 02129, USA
    BMC Biol 11:74. 2013
  4. pmc Cilia functions in development
    Iain A Drummond
    Nephrology Division, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, 149, 13th Street, Charlestown, MA 02129, United States
    Curr Opin Cell Biol 24:24-30. 2012
  5. ncbi request reprint Zebrafish kidney development
    Iain A Drummond
    Department of Medicine, Harvard Medical School and Renal Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Methods Cell Biol 76:501-30. 2004
  6. pmc Fluid flow and guidance of collective cell migration
    Aleksandr Vasilyev
    Pathology Department, Massachusetts General Hospital, Charlestown, MA, USA
    Cell Adh Migr 4:353-7. 2010
  7. doi request reprint Zebrafish cilia
    Iain Drummond
    Nephrology Division, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Methods Enzymol 525:219-44. 2013
  8. pmc Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish
    Qi Zhang
    Ocular Genomics Institute and Berman Gund Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Biol Cell 23:3069-78. 2012
  9. doi request reprint Studying cilia in zebrafish
    Iain Drummond
    Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Methods Cell Biol 93:197-217. 2009
  10. ncbi request reprint Acute renal failure in zebrafish: a novel system to study a complex disease
    Dirk M Hentschel
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 288:F923-9. 2005

Research Grants

  1. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain A Drummond; Fiscal Year: 2010
  2. Polycystin2 Function in Kidney Development
    Iain Drummond; Fiscal Year: 2007
  3. Comparative analysis of osr1 function in nephrogenesis
    Iain Drummond; Fiscal Year: 2007
  4. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain Drummond; Fiscal Year: 2009
  5. Comparative analysis of osr1 function in nephrogenesis
    Iain Drummond; Fiscal Year: 2009
  6. Polycystin function in zebrafish (PA-06-158)
    Iain A Drummond; Fiscal Year: 2010
  7. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain Drummond; Fiscal Year: 2005
  8. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain Drummond; Fiscal Year: 2001
  9. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain Drummond; Fiscal Year: 2009

Collaborators

  • A F Schier
  • Bradley Yoder
  • Qin Liu
  • Kwon Moo Park
  • Dirk M Hentschel
  • Lilianna Solnica-Krezel
  • Sang Yeob Yeo
  • B H Paw
  • Fabrizio C Serluca
  • Friedhelm Hildebrandt
  • Yan Liu
  • Steve Mangos
  • Aleksandr Vasilyev
  • Tomoko Obara
  • Albrecht G Kramer-Zucker
  • Jinhua Zhao
  • Narendra Pathak
  • Qi Zhang
  • Nathan E Hellman
  • Pui Ying Lam
  • Sudha Mudumana
  • Sudha P Mudumana
  • Clemens C Möller
  • Jennifer R Panizzi
  • David R Beier
  • Felix Olale
  • Stephanie Wiessner
  • Victoria M Bedell
  • Boris E Shmukler
  • Edgar A Otto
  • Shanming Liu
  • Eric A Pierce
  • Chrissy Austin
  • Erin Merkel
  • Neeraj Sharma
  • Angela Zhao
  • Christina Austin
  • Aiping Liu
  • Zhaoxia Sun
  • Stephanie Le Corre
  • Igor Kondrychyn
  • Arindam Majumdar
  • Vladimir Korzh
  • Kar Lai Poon
  • Jochen Reiser
  • Albrecht Kramer-Zucker
  • Jason R Jessen
  • Steven Mangos
  • Alan K Stuart-Tilley
  • Christine E Kurschat
  • Abbie M Jensen
  • Dean Y Li
  • Pankaj Seth
  • Vikas P Sukhatme
  • Jeffrey Chung
  • Courtney J Haycraft
  • Lianwei Jiang
  • Seth L Alper
  • Gabriele E Ackermann
  • Leonard I Zon
  • Venkatesha Shivalingappa
  • Bruce Barut
  • Yi Zhou
  • Ramani Ramchandran
  • David H Vandorpe
  • Julia Hoefele
  • Frank Beekmann
  • Adelheid M Mueller
  • JOHN F O'TOOLE
  • Rainer G Ruf
  • Judith A Goodship
  • Bernhard Schermer
  • Daniel Landau
  • Hubert Nivet
  • Gerd Walz
  • Thomas Benzing
  • Corinne Antignac
  • Karl S Hiller
  • Matthias T Wolf
  • Tom Strachan
  • Andreas Kispert
  • Marie F Gagnadoux
  • John W Foreman
  • Shiei Kuida
  • Weining Lu
  • Ken Dewar
  • Jennifer Lehoczky

Detail Information

Publications27

  1. ncbi request reprint Kidney development and disease in the zebrafish
    Iain A Drummond
    Department of Medicine, Harvard Medical School and Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Am Soc Nephrol 16:299-304. 2005
    ..This short review outlines recent progress in applying the zebrafish pronephros to issues of human health and development...
  2. pmc Polycystin-2 immunolocalization and function in zebrafish
    Tomoko Obara
    Nephrology Division, Massachusetts General Hospital 149 8000 and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Am Soc Nephrol 17:2706-18. 2006
    ....
  3. pmc The cilium in lights: new views of an ancient organelle
    Iain A Drummond
    Nephrology Division, Massachusetts General Hospital, 149 13th Street, Rm 149 8000, Charlestown, MA 02129, USA
    BMC Biol 11:74. 2013
    ..See research article: http://www.ciliajournal.com/content/2/1/8. ..
  4. pmc Cilia functions in development
    Iain A Drummond
    Nephrology Division, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, 149, 13th Street, Charlestown, MA 02129, United States
    Curr Opin Cell Biol 24:24-30. 2012
    ..In this brief review I select examples of recent studies that have clarified and consolidated our understanding of the role of cilia in development...
  5. ncbi request reprint Zebrafish kidney development
    Iain A Drummond
    Department of Medicine, Harvard Medical School and Renal Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Methods Cell Biol 76:501-30. 2004
  6. pmc Fluid flow and guidance of collective cell migration
    Aleksandr Vasilyev
    Pathology Department, Massachusetts General Hospital, Charlestown, MA, USA
    Cell Adh Migr 4:353-7. 2010
    ..Intratubular migration leads to significant changes in kidney morphology. This novel process provides a powerful in vivo model for further exploration of the mechanisms underlying mechanotransduction and collective migration...
  7. doi request reprint Zebrafish cilia
    Iain Drummond
    Nephrology Division, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Methods Enzymol 525:219-44. 2013
    ..Techniques are described for analysis of mutants, gene knockdown using antisense morpholino oligos, visualizing cilia and cilia orientation in wholemount zebrafish embryos, live imaging cilia, and electron microscopy of zebrafish cilia...
  8. pmc Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish
    Qi Zhang
    Ocular Genomics Institute and Berman Gund Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Biol Cell 23:3069-78. 2012
    ..Our studies support the importance of Ttc26 function in ciliogenesis and suggest that screening for TTC26 mutations in human ciliopathies is justified...
  9. doi request reprint Studying cilia in zebrafish
    Iain Drummond
    Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Methods Cell Biol 93:197-217. 2009
    ....
  10. ncbi request reprint Acute renal failure in zebrafish: a novel system to study a complex disease
    Dirk M Hentschel
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 288:F923-9. 2005
    ..Therefore, zebrafish provides a unique model system, amenable to genetic manipulation and drug screening, to explore the pathophysiology of ARF and establish novel therapies with potential use in mammals...
  11. ncbi request reprint Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis
    Albrecht G Kramer-Zucker
    Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 132:1907-21. 2005
    ..In Kupffer's vesicle, loss of flow is associated with loss of left-right patterning, indicating that the 'nodal flow' mechanism of generating situs is conserved in non-mammalian vertebrates...
  12. pmc The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch
    Nathan E Hellman
    Nephrology Division, Massachusetts General Hospital, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 107:18499-504. 2010
    ....
  13. pmc Collective cell migration drives morphogenesis of the kidney nephron
    Aleksandr Vasilyev
    Nephrology Division, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    PLoS Biol 7:e9. 2009
    ..Our results establish intimate links between nephron function, fluid flow, and morphogenesis...
  14. pmc odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate
    Sudha P Mudumana
    Nephrology Division, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 135:3355-67. 2008
    ....
  15. ncbi request reprint Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros
    Yan Liu
    Nephrology Division, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 134:1111-22. 2007
    ....
  16. pmc The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation
    Narendra Pathak
    Nephrology Division, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Biol Cell 18:4353-64. 2007
    ..These results are the first in vivo evidence that tubulin polyglutamylation is required for vertebrate cilia motility and structure, and, when compromised, results in failed ciliogenesis...
  17. pmc Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes
    Albrecht G Kramer-Zucker
    Renal Unit, Massachusetts General Hospital 149 8000, 149 13th Street, Charlestown, MA 02129, USA
    Dev Biol 285:316-29. 2005
    ....
  18. pmc The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation
    Steve Mangos
    Massachusetts General Hospital, Department of Medicine, Nephrology Division, and Harvard Medical School Department of Genetics, Charlestown, MA 02129, USA
    Dis Model Mech 3:354-65. 2010
    ..Our results suggest that pkd1a/b and pkd2 interact to regulate ECM secretion or assembly, and that altered matrix integrity may be a primary defect underlying ADPKD tissue pathologies...
  19. pmc Dynamic expression of the osmosensory channel trpv4 in multiple developing organs in zebrafish
    Steve Mangos
    Nephrology Division, Massachusetts General Hospital 149 8000 Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Gene Expr Patterns 7:480-4. 2007
    ..At 72 hpf, expression of trpv4 in heart, kidney, brain, and lateral line organs persists while expression in the notochord is down-regulated...
  20. pmc Expression of trpC1 and trpC6 orthologs in zebrafish
    Clemens C Möller
    Nephrology Division and Program in Glomerular Disease, Massachusetts General Hospital and Harvard Medical School, Suite 8214, CNY 149 13th Street, Boston, MA 02129, USA
    Gene Expr Patterns 8:291-6. 2008
    ..Our results point to roles of TRPC channels in several tissues during zebrafish development, and suggest that the zebrafish may be a suitable model system to study the pathophysiology of TRPC1 and TRPC6 in specific cell types...
  21. ncbi request reprint New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia
    Jennifer R Panizzi
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Development 134:921-31. 2007
    ..Our studies in zebrafish embryos have identified new, essential roles for this RhoGEF in ciliated epithelia during vertebrate development...
  22. doi request reprint Some assembly required: renal hypodysplasia and the problem with faulty parts
    Iain A Drummond
    J Am Soc Nephrol 19:834-6. 2008
  23. ncbi request reprint Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization
    Boris E Shmukler
    Molecular Medicine and Renal Units, Beth Israel Deaconess Med Ctr E RW763, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Renal Physiol 289:F835-49. 2005
    ..These results will inform tests of the role of Ae2 in zebrafish kidney development and function...
  24. pmc roundabout4 is essential for angiogenesis in vivo
    Victoria M Bedell
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 9610 Medical Center Drive, Suite 320, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 102:6373-8. 2005
    ..Also, human robo4 gene functionally compensates for loss of robo4 gene function, suggesting evolutionary conservation. This article reports an endothelial-specific function for a robo gene in vertebrates in vivo...
  25. pmc Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination
    Edgar A Otto
    Department of Pediatrics, 8220C MSRB III, 1150 West Medical Center Drive, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 34:413-20. 2003
    ..The interaction and colocalization in cilia of inversin, nephrocystin and beta-tubulin connect pathogenetic aspects of NPHP to PKD, to primary cilia function and to left-right axis determination...
  26. ncbi request reprint A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish
    Shanming Liu
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Development 129:5839-46. 2002
    ..These results demonstrate that comparative analysis of gene function in different model systems represents a powerful means to annotate gene function...
  27. ncbi request reprint Endothelial signaling in kidney morphogenesis: a role for hemodynamic forces
    Fabrizio C Serluca
    Cardiovascular Research Center and Developmental Biology Laboratory, Boston, MA 02119, USA
    Curr Biol 12:492-7. 2002
    ..Thus, vascular flow is required for glomerular assembly, most probably acting via a stretch-responsive signaling system in the vessel wall...

Research Grants24

  1. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain A Drummond; Fiscal Year: 2010
    ..The overall goal of these studies is to 1) identify novel ciliogenic genes 2) generate new tools to study cilia formation and 3) categorize the large number of cilia associated proteins in terms of their function(s). ..
  2. Polycystin2 Function in Kidney Development
    Iain Drummond; Fiscal Year: 2007
    ..abstract_text> ..
  3. Comparative analysis of osr1 function in nephrogenesis
    Iain Drummond; Fiscal Year: 2007
    ..The studies may also lead to increased understanding of congenital kidney anomalies and may yield important information that can be used to generate kidney tissue for therapeutic purposes. ..
  4. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain Drummond; Fiscal Year: 2009
    ..The overall goal of these studies is to 1) identify novel ciliogenic genes 2) generate new tools to study cilia formation and 3) categorize the large number of cilia associated proteins in terms of their function(s). ..
  5. Comparative analysis of osr1 function in nephrogenesis
    Iain Drummond; Fiscal Year: 2009
    ..The studies may also lead to increased understanding of congenital kidney anomalies and may yield important information that can be used to generate kidney tissue for therapeutic purposes. ..
  6. Polycystin function in zebrafish (PA-06-158)
    Iain A Drummond; Fiscal Year: 2010
    ..Understanding the cellular basis of this disease will create new opportunities to improve the lives of those that suffer from it. ..
  7. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain Drummond; Fiscal Year: 2005
    ..abstract_text> ..
  8. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain Drummond; Fiscal Year: 2001
    ..It is likely that the 15 genes whe have defined in zebrafish form the basis of a genetic pathway underlying the terminal differentiation of epithelial cells. ..
  9. GENETIC ANALYSIS OF ZEBRAFISH KIDNEY DEVELOPMENT
    Iain Drummond; Fiscal Year: 2009
    ..The overall goal of these studies is to 1) identify novel ciliogenic genes 2) generate new tools to study cilia formation and 3) categorize the large number of cilia associated proteins in terms of their function(s). ..