Elise E Drouin

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease
    Elise E Drouin
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Arthritis Rheum 65:186-96. 2013
  2. pmc Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Immunol 45:2323-32. 2008
  3. pmc Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Immunol 45:180-9. 2008
  4. ncbi request reprint Molecular characterization of the OspA(161-175) T cell epitope associated with treatment-resistant Lyme arthritis: differences among the three pathogenic species of Borrelia burgdorferi sensu lato
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Autoimmun 23:281-92. 2004
  5. pmc Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 203:961-71. 2006
  6. ncbi request reprint Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis
    Priya Kannian
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 179:6336-42. 2007
  7. pmc Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis
    Shiqian Shen
    Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthritis Rheum 62:2127-37. 2010
  8. ncbi request reprint Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis
    Allen C Steere
    Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 48:534-40. 2003
  9. pmc Borrelia burgdorferi RST1 (OspC type A) genotype is associated with greater inflammation and more severe Lyme disease
    Klemen Strle
    Division of Rheumatology, Allergy and Immunology, the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 178:2726-39. 2011
  10. pmc Relationship between immunity to Borrelia burgdorferi outer-surface protein A (OspA) and Lyme arthritis
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Clin Infect Dis 52:s259-65. 2011

Collaborators

Detail Information

Publications16

  1. pmc A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease
    Elise E Drouin
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Arthritis Rheum 65:186-96. 2013
    ..In this study we aimed to identify autoantigens in patients with antibiotic-refractory Lyme arthritis, in which infection-induced autoimmunity is thought to play an important role...
  2. pmc Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Immunol 45:2323-32. 2008
    ..Therefore, while additional Bb epitopes may be involved in the development of antibiotic-refractory Lyme arthritis, recognition of OspA(163-175) remains the only known Bb epitope associated with this disease course...
  3. pmc Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Immunol 45:180-9. 2008
    ..However, molecular mimicry due to sequence homology between OspA(165-173) and a human peptide seems unlikely to be the critical mechanism...
  4. ncbi request reprint Molecular characterization of the OspA(161-175) T cell epitope associated with treatment-resistant Lyme arthritis: differences among the three pathogenic species of Borrelia burgdorferi sensu lato
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Autoimmun 23:281-92. 2004
    ..These observations are consistent with the hypothesis that T cell recognition of this epitope is important in the induction of autoimmunity in treatment-resistant Lyme arthritis...
  5. pmc Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 203:961-71. 2006
    ..4; P < 0.001). We conclude that binding of a single spirochetal peptide to certain DRB molecules is a marker for antibiotic-refractory Lyme arthritis and might play a role in the pathogenesis of the disease...
  6. ncbi request reprint Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis
    Priya Kannian
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 179:6336-42. 2007
    ..However, the marked decline in the frequency of such cells with antibiotic therapy suggests that persistent synovitis in the refractory group is not perpetuated by these cells...
  7. pmc Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis
    Shiqian Shen
    Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthritis Rheum 62:2127-37. 2010
    ..In a murine model of antibiotic-refractory Lyme arthritis, the numbers of Treg cells are dramatically reduced. The aim of this study was to examine Treg cell numbers and function in patients with antibiotic-refractory Lyme arthritis...
  8. ncbi request reprint Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis
    Allen C Steere
    Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 48:534-40. 2003
    ..To assess the binding of outer surface protein A (OspA) and human lymphocyte function-associated antigen 1 (hLFA-1) peptides to 5 major histocompatibility complex (MHC) molecules...
  9. pmc Borrelia burgdorferi RST1 (OspC type A) genotype is associated with greater inflammation and more severe Lyme disease
    Klemen Strle
    Division of Rheumatology, Allergy and Immunology, the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 178:2726-39. 2011
    ..Thus, the B. burgdorferi RST1 (OspC type A) genotype, followed by the RST3 (OspC type I) genotype, causes greater inflammation and more severe disease, establishing a link between spirochetal virulence and host inflammation...
  10. pmc Relationship between immunity to Borrelia burgdorferi outer-surface protein A (OspA) and Lyme arthritis
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Clin Infect Dis 52:s259-65. 2011
    ..Thus, a vaccine-induced immune response to OspA does not replicate the sequence of events needed in the natural infection to induce antibiotic-refractory Lyme arthritis...
  11. pmc Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis
    Robert J Seward
    Center for Biomedical Mass Spectrometry, Department of Biochemistry, Boston University School of Medicine, and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts 02118, USA
    Mol Cell Proteomics 10:M110.002477. 2011
    ..New insights into the naturally presented HLA-DR epitope repertoire in target tissues may allow the identification of pathogenic T cell epitopes, and this could lead to innovative therapeutic interventions...
  12. pmc Dysregulation of CD4+CD25(high) T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis
    Nalini K Vudattu
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arthritis Rheum 65:1643-53. 2013
    ....
  13. pmc Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii
    Klemen Strle
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Infect Dis 200:1936-43. 2009
    ..These results demonstrate in vitro and in vivo that B. burgdorferi has greater inflammatory potential than B. afzelii and B. garinii, which may account in part for variations in the clinical manifestations of Lyme borreliosis...
  14. pmc Human Lyme arthritis and the immunoglobulin G antibody response to the 37-kilodalton arthritis-related protein of Borrelia burgdorferi
    Carlos A Salazar
    Massachusetts General Hospital, 55 Fruit St, CNY 149 8301, Boston, MA 02114, USA
    Infect Immun 73:2951-7. 2005
    ..Thus, after the first several weeks of infection, 60 to 80% of patients had IgG antibody responses to GST-Arp, but this response did not correlate with the severity or duration of Lyme arthritis...
  15. doi request reprint Elevated Levels of IL-23 in a Subset of Patients With Post-Lyme Disease Symptoms Following Erythema Migrans
    Klemen Strle
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston
    Clin Infect Dis 58:372-80. 2014
    ....
  16. ncbi request reprint The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA
    Elise E Drouin
    Division of Molecular Genetics, Dana Farber Cancer Institute and Harvard Medical School, and Department of Biology, Boston University, Boston, MA 02215, USA
    J Immunol 168:2847-56. 2002
    ..LSF interacts with both histone deacetylases and the corepressor Sin3A. We propose that LSF represses CSR by histone deacetylation of chromatin within S regions, thereby limiting accessibility to the switch recombination machinery...