Research Topics
Genomes and GenesSpecies | Alysa E DoyleSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21Alysa E Doyle
Psychiatric and Neurodevelopmental Genetics Unit, Harvard Medical School, Center for Human Genetics Research at Massachusetts General Hospital, Boston MA 02114, USA
J Am Acad Child Adolesc Psychiatry 49:378-87. 2010....
Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13Alysa E Doyle
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1399-411. 2008..Overall, these data support the utility of neurocognitive traits as ADHD endophenotypes, but also highlight their limited genetic overlap with the disorder...- Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorderJoseph Biederman
Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
Psychiatry Res 170:199-203. 2009..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD... - Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary studyJoseph Biederman
Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies... - Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycleJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A 6900, Boston, MA 02114, USA
J Clin Psychiatry 72:11-6. 2011.... 
Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHDJoseph Biederman
Pediatric Psychopharmacology and Adult ADHD Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 195:240-6. 2007..Scores on the CBS above the 50th percentile identify adults with ADHD at significantly higher risk for functional morbidity beyond that conferred by the diagnosis of ADHD alone...- Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHDJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 59:460-7. 2006..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported... - Educational and occupational underattainment in adults with attention-deficit/hyperactivity disorder: a controlled studyJoseph Biederman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 69:1217-22. 2008..This study evaluated subjects to determine whether the educational and occupational deficits associated with ADHD are what would be expected given their intellectual abilities or lower than expected given their intellectual abilities... - Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorderJoseph Biederman
Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 69:1150-6. 2008..The main goal of this study was to evaluate the impact of stimulant medication on executive function deficits in a group of adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD; DSM-III-R criteria)... - A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHDMichael C Monuteaux
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology... - Are cognitive deficits in attention deficit/hyperactivity disorder related to the course of the disorder? A prospective controlled follow-up study of grown up boys with persistent and remitting courseJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology, Boston, MA, USA
Psychiatry Res 170:177-82. 2009..More work is needed to help define the implications of these deficits in individuals with a remitting course of ADHD... - Investigation of parent-of-origin effects in ADHD candidate genesJang Woo Kim
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:776-80. 2007..Thus, we conclude that a substantial parent-of-origin effect is unlikely for these leading ADHD candidate genes... - Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescenceJoseph Biederman
Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Dev Neuropsychol 33:44-61. 2008..These findings document the stability of EFDs in girls with ADHD from childhood into adolescence... - Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorderAriel B Brown
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples... - Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptomsMichael C Monuteaux
Massachusetts General Hospital, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 48:757-64. 2009..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD... - Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter geneJessica Lasky-Su
Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, and Pediatric psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
Addict Behav 31:1088-99. 2006..A sliding window of analysis of 3 SNPs also resulted in only nominal associations. CONCLUSIONS: SNPs in DAT do not appear to be associated with the phenotypes generated from drug frequency variables among individuals with ADHD... - Discordance between psychometric testing and questionnaire-based definitions of executive function deficits in individuals with ADHDJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Boston, MA 02114, USA
J Atten Disord 12:92-102. 2008.... - Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorderJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
Am J Psychiatry 163:1730-8. 2006..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)... - Neuropsychological functioning in girls with attention-deficit/hyperactivity disorder with and without learning disabilitiesLarry J Seidman
Massachusetts General Hospital, Boston, MA 02114, USA
Neuropsychology 20:166-77. 2006..These results extend to females the previously documented association of LDs with neuropsychological functioning in males with ADHD... - Can bipolar disorder-specific neuropsychological impairments in children be identified?Aude Henin
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Cambridge, MA 02138, USA
J Consult Clin Psychol 75:210-20. 2007..Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder... - Utility of an abbreviated questionnaire to identify individuals with ADHD at risk for functional impairmentsJoseph Biederman
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Psychiatr Res 42:304-10. 2008.... - Neuropsychological functioning in relatives of girls with and without ADHDAlysa E Doyle
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Psychol Med 35:1121-32. 2005..A limited number of studies have examined neuropsychological functioning in the family members of ADHD youth, and none have focused exclusively on relatives of females... - Neuropsychological functioning in youth with bipolar disorderAlysa E Doyle
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 58:540-8. 2005..We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD... - Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in childrenJoseph Biederman
Pediatric Psychopharmacology Unit, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Consult Clin Psychol 72:757-66. 2004..Children and adolescents with ADHD and EFDs were found to be at high risk for significant impairments in academic functioning. These results support screening children with ADHD for EFDs to prevent academic failure... - Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?Larry J Seidman
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
Dev Neuropsychol 27:79-105. 2005..These findings suggest that executive dysfunctions are correlates of ADHD regardless of gender and age, at least through the late teen years... - Attention-deficit/hyperactivity disorder endophenotypesAlysa E Doyle
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 57:1324-35. 2005..We conclude that these endophenotypes will not be a quick fix for the field but offer potential if careful consideration is given to issues of heterogeneity, measurement and statistical power... - Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?Alysa E Doyle
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Child Psychol Psychiatry 46:774-803. 2005..Thus far, potential endophenotypes for ADHD have not been systematically studied... - Diagnostic threshold for conduct disorder in girls and boysAlysa E Doyle
Clinical and Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, ACC-725, 15 Parkman Street, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 191:379-86. 2003..The current results support the possibility that differential rates of CD reflect actual differences in rates of antisocial behavior across gender... - Executive functions in attention-deficit/hyperactivity disorderAlysa E Doyle
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:21-6. 2006..To examine the association between weaknesses in executive functions and attention-deficit/hyperactivity disorder (ADHD)... - New developments in the treatment of ADHDJoseph Biederman
Dept. of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 67:148-59. 2006 - Familial links between attention deficit hyperactivity disorder, conduct disorder, and bipolar disorderAlysa E Doyle
Massachusetts General Hospital, 15 Parkman Street, ACC 725, Boston, MA 02114, USA
Curr Psychiatry Rep 4:146-52. 2002..The current article reviews evidence suggesting that parsing ADHD subjects based on comorbidity with conduct and bipolar disorders may yield familial subtypes that are suitable for genetic analyses... - Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes?Joel T Nigg
Department of Psychology, Michigan State University, East Lansing, Michigan 48824, USA
Biol Psychiatry 57:1224-30. 2005.... - Association between DRD4 gene and performance of children with ADHD in a test of sustained attentionChristian Kieling
Department of Psychiatry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre 90035 003, RS, Brazil
Biol Psychiatry 60:1163-5. 2006..The adoption of neuropsychological tests as endophenotypic measures can provide an increased sensitivity to specific dimensions of attention-deficit/hyperactivity disorder (ADHD)... - Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individualsJessica Lasky-Su
Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Am J Med Genet B Neuropsychiatr Genet 147:100-6. 2008..This analysis adds to previous findings by suggesting that variants at these loci may be specifically associated with inattentive symptoms... - Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic reviewErik G Willcutt
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
Biol Psychiatry 57:1336-46. 2005..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD... - Molecular genetics of attention-deficit/hyperactivity disorderStephen V Faraone
Medical Genetics Research Center and Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Biol Psychiatry 57:1313-23. 2005....
Research Grants
- Genetics of Executive Functions in ADHD & Non-ADHDAlysa Doyle; Fiscal Year: 2006..This training will prepare the candidate to be an independent researcher who can conduct interdisciplinary work on neuropsychology, genetics and developmental psychopathology. ..
- Genomewide linkage analyses of neurocognitive traits in sibling pairs with ADHDAlysa Doyle; Fiscal Year: 2007....