Alysa E Doyle

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21
    Alysa E Doyle
    Psychiatric and Neurodevelopmental Genetics Unit, Harvard Medical School, Center for Human Genetics Research at Massachusetts General Hospital, Boston MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 49:378-87. 2010
  2. doi request reprint Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13
    Alysa E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1399-411. 2008
  3. pmc Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
  4. pmc Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
  5. doi request reprint Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycle
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A 6900, Boston, MA 02114, USA
    J Clin Psychiatry 72:11-6. 2011
  6. ncbi request reprint Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHD
    Joseph Biederman
    Pediatric Psychopharmacology and Adult ADHD Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:240-6. 2007
  7. ncbi request reprint Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 59:460-7. 2006
  8. ncbi request reprint Educational and occupational underattainment in adults with attention-deficit/hyperactivity disorder: a controlled study
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1217-22. 2008
  9. ncbi request reprint Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1150-6. 2008
  10. doi request reprint A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008

Detail Information

Publications36

  1. pmc Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21
    Alysa E Doyle
    Psychiatric and Neurodevelopmental Genetics Unit, Harvard Medical School, Center for Human Genetics Research at Massachusetts General Hospital, Boston MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 49:378-87. 2010
    ....
  2. doi request reprint Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13
    Alysa E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1399-411. 2008
    ..Overall, these data support the utility of neurocognitive traits as ADHD endophenotypes, but also highlight their limited genetic overlap with the disorder...
  3. pmc Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
    ..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD...
  4. pmc Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
    ..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies...
  5. doi request reprint Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycle
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A 6900, Boston, MA 02114, USA
    J Clin Psychiatry 72:11-6. 2011
    ....
  6. ncbi request reprint Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHD
    Joseph Biederman
    Pediatric Psychopharmacology and Adult ADHD Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:240-6. 2007
    ..Scores on the CBS above the 50th percentile identify adults with ADHD at significantly higher risk for functional morbidity beyond that conferred by the diagnosis of ADHD alone...
  7. ncbi request reprint Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 59:460-7. 2006
    ..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported...
  8. ncbi request reprint Educational and occupational underattainment in adults with attention-deficit/hyperactivity disorder: a controlled study
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1217-22. 2008
    ..This study evaluated subjects to determine whether the educational and occupational deficits associated with ADHD are what would be expected given their intellectual abilities or lower than expected given their intellectual abilities...
  9. ncbi request reprint Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1150-6. 2008
    ..The main goal of this study was to evaluate the impact of stimulant medication on executive function deficits in a group of adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD; DSM-III-R criteria)...
  10. doi request reprint A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008
    ..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology...
  11. pmc Are cognitive deficits in attention deficit/hyperactivity disorder related to the course of the disorder? A prospective controlled follow-up study of grown up boys with persistent and remitting course
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology, Boston, MA, USA
    Psychiatry Res 170:177-82. 2009
    ..More work is needed to help define the implications of these deficits in individuals with a remitting course of ADHD...
  12. ncbi request reprint Investigation of parent-of-origin effects in ADHD candidate genes
    Jang Woo Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:776-80. 2007
    ..Thus, we conclude that a substantial parent-of-origin effect is unlikely for these leading ADHD candidate genes...
  13. doi request reprint Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescence
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Dev Neuropsychol 33:44-61. 2008
    ..These findings document the stability of EFDs in girls with ADHD from childhood into adolescence...
  14. pmc Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder
    Ariel B Brown
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010
    ..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
  15. doi request reprint Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms
    Michael C Monuteaux
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 48:757-64. 2009
    ..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD...
  16. ncbi request reprint Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter gene
    Jessica Lasky-Su
    Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, and Pediatric psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    Addict Behav 31:1088-99. 2006
    ..To determine whether SNPs within the dopamine transporter gene (DAT) are associated with quantitative phenotypes generated from drug frequency variables in an ADHD sample...
  17. ncbi request reprint Discordance between psychometric testing and questionnaire-based definitions of executive function deficits in individuals with ADHD
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Boston, MA 02114, USA
    J Atten Disord 12:92-102. 2008
    ....
  18. ncbi request reprint Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
    Am J Psychiatry 163:1730-8. 2006
    ..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)...
  19. ncbi request reprint Neuropsychological functioning in girls with attention-deficit/hyperactivity disorder with and without learning disabilities
    Larry J Seidman
    Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropsychology 20:166-77. 2006
    ..These results extend to females the previously documented association of LDs with neuropsychological functioning in males with ADHD...
  20. ncbi request reprint Can bipolar disorder-specific neuropsychological impairments in children be identified?
    Aude Henin
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Consult Clin Psychol 75:210-20. 2007
    ..Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder...
  21. pmc Utility of an abbreviated questionnaire to identify individuals with ADHD at risk for functional impairments
    Joseph Biederman
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Res 42:304-10. 2008
    ....
  22. ncbi request reprint Neuropsychological functioning in relatives of girls with and without ADHD
    Alysa E Doyle
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1121-32. 2005
    ..A limited number of studies have examined neuropsychological functioning in the family members of ADHD youth, and none have focused exclusively on relatives of females...
  23. ncbi request reprint Neuropsychological functioning in youth with bipolar disorder
    Alysa E Doyle
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 58:540-8. 2005
    ..We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD...
  24. ncbi request reprint Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in children
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Consult Clin Psychol 72:757-66. 2004
    ..Children and adolescents with ADHD and EFDs were found to be at high risk for significant impairments in academic functioning. These results support screening children with ADHD for EFDs to prevent academic failure...
  25. ncbi request reprint Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neuropsychol 27:79-105. 2005
    ..These findings suggest that executive dysfunctions are correlates of ADHD regardless of gender and age, at least through the late teen years...
  26. ncbi request reprint Attention-deficit/hyperactivity disorder endophenotypes
    Alysa E Doyle
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 57:1324-35. 2005
    ..We conclude that these endophenotypes will not be a quick fix for the field but offer potential if careful consideration is given to issues of heterogeneity, measurement and statistical power...
  27. ncbi request reprint Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?
    Alysa E Doyle
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Child Psychol Psychiatry 46:774-803. 2005
    ..Thus far, potential endophenotypes for ADHD have not been systematically studied...
  28. ncbi request reprint Diagnostic threshold for conduct disorder in girls and boys
    Alysa E Doyle
    Clinical and Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, ACC 725, 15 Parkman Street, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 191:379-86. 2003
    ..The current results support the possibility that differential rates of CD reflect actual differences in rates of antisocial behavior across gender...
  29. ncbi request reprint Executive functions in attention-deficit/hyperactivity disorder
    Alysa E Doyle
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:21-6. 2006
    ..To examine the association between weaknesses in executive functions and attention-deficit/hyperactivity disorder (ADHD)...
  30. ncbi request reprint New developments in the treatment of ADHD
    Joseph Biederman
    Dept of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 67:148-59. 2006
  31. ncbi request reprint Familial links between attention deficit hyperactivity disorder, conduct disorder, and bipolar disorder
    Alysa E Doyle
    Massachusetts General Hospital, 15 Parkman Street, ACC 725, Boston, MA 02114, USA
    Curr Psychiatry Rep 4:146-52. 2002
    ..The current article reviews evidence suggesting that parsing ADHD subjects based on comorbidity with conduct and bipolar disorders may yield familial subtypes that are suitable for genetic analyses...
  32. ncbi request reprint Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes?
    Joel T Nigg
    Department of Psychology, Michigan State University, East Lansing, Michigan 48824, USA
    Biol Psychiatry 57:1224-30. 2005
    ....
  33. ncbi request reprint Association between DRD4 gene and performance of children with ADHD in a test of sustained attention
    Christian Kieling
    Department of Psychiatry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre 90035 003, RS, Brazil
    Biol Psychiatry 60:1163-5. 2006
    ..The adoption of neuropsychological tests as endophenotypic measures can provide an increased sensitivity to specific dimensions of attention-deficit/hyperactivity disorder (ADHD)...
  34. ncbi request reprint Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals
    Jessica Lasky-Su
    Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 147:100-6. 2008
    ..This analysis adds to previous findings by suggesting that variants at these loci may be specifically associated with inattentive symptoms...
  35. ncbi request reprint Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Psychiatry 57:1336-46. 2005
    ..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...
  36. ncbi request reprint Molecular genetics of attention-deficit/hyperactivity disorder
    Stephen V Faraone
    Medical Genetics Research Center and Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Biol Psychiatry 57:1313-23. 2005
    ....

Research Grants3

  1. Genetics of Executive Functions in ADHD & Non-ADHD
    Alysa Doyle; Fiscal Year: 2006
    ..This training will prepare the candidate to be an independent researcher who can conduct interdisciplinary work on neuropsychology, genetics and developmental psychopathology. ..
  2. Genomewide linkage analyses of neurocognitive traits in sibling pairs with ADHD
    Alysa Doyle; Fiscal Year: 2007
    ....