Research Topics
Species | Darin D DoughertySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Brain correlates of antidepressant treatment outcome from neuroimaging studies in depressionDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
Psychiatr Clin North Am 30:91-103. 2007....- Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacksDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, Boston, USA
Depress Anxiety 23:175-7. 2006..These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression... - Single modality versus dual modality treatment for trichotillomania: sertraline, behavioral therapy, or both?Darin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
J Clin Psychiatry 67:1086-92. 2006..However, no randomized, controlled studies to date have compared the efficacy of individual SSRI or CBT treatment to the combination of both treatment modalities... - Somatic therapies for treatment-resistant depression: new neurotherapeutic interventionsDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
Psychiatr Clin North Am 30:31-7. 2007..Although the future of neurotherapeutic interventions in psychiatry is hard to predict, it is clear that these treatments will have a growing role in the field... - Pharmacotherapy for obsessive-compulsive disorderDarin D Dougherty
Massachusetts General Hospital, Charlestown, MA 02129, USA
J Clin Psychol 60:1195-202. 2004..There is substantially less evidence supporting other alternative strategies. Finally, neurosurgical and device-based approaches for treatment-refractory OCD are reviewed... - Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacksDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Arch Gen Psychiatry 61:795-804. 2004.... 
A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesiaDarin D Dougherty
Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, MA 02129, USA
Behav Brain Res 193:63-8. 2008..These findings include brain regions within both the lateral and medial pain networks...
Open-label study of high (30 mg) and moderate (20 mg) dose escitalopram for the treatment of obsessive-compulsive disorderDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
Int Clin Psychopharmacol 24:306-11. 2009..These results suggest that the 30 mg (vs. 20 mg) dose of escitalopram may provide a superior reduction in OCD symptoms for those sufferers with comorbid depression and/or anxiety...- Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorderThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 59:138-46. 2006..The most consistently reported cognitive difficulty in euthymic subjects with bipolar disorder is impairment in verbal episodic memory (i.e., the ability to learn new verbal information)... - Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptationSameer A Sheth
Nayef Al Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nature 488:218-21. 2012..In situations with stable cognitive demands, this signal promotes efficiency by hastening responses, but in situations with changing demands it engenders accuracy by delaying responses... - An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief reportThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, 2nd Floor, Charlestown, MA 02129, USA
Bipolar Disord 10:928-42. 2008..The purpose of the present study was to investigate with fMRI the interaction between acute sadness and working memory functioning in individuals with bipolar disorder... - Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depressionDarin D Dougherty
Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
J Neurosurg 99:1010-7. 2003..If confirmed, the availability of an index for noninvasively predicting a patient's response to cingulotomy for the treatment of major depression would be of great clinical value... - A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorderScott L Rauch
Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosurg 104:558-65. 2006..The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial... - Understanding the central pharmacokinetics of spheroidal oral drug absorption system (SODAS) dexmethylphenidate: a positron emission tomography study of dopamine transporter receptor occupancy measured with C-11 altropaneThomas J Spencer
The Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 73:346-52. 2012..However, there are no studies of central nervous system (CNS) dopamine transporter occupancies... - Autonomic and prefrontal cortex responses to autobiographical recall of emotionsCarl D Marci
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Cogn Affect Behav Neurosci 7:243-50. 2007..The findings suggest that a relative increase in sympathetic activity with a reciprocal decrease in parasympathetic activity may be necessary to generate frontal activity in autobiographical recall of emotions... - Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET studyHadine Joffe
Center for Women s Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts 02114, USA
J Clin Endocrinol Metab 97:3207-15. 2012..Previous studies have implicated the insula during the perception of hot flashes and the hypothalamus in thermoregulatory dysfunction... - Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorderAnne J Blood
Depression Clinic and Research Program, Mood and Motor Control Laboratory, Addiction Research Program, Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
PLoS ONE 5:e13945. 2010..There has been little investigation in MDD of midbrain and subcortical regions central to reward/aversion function, such as the ventral tegmental area/substantia nigra (VTA/SN), and medial forebrain bundle (MFB)... - Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropaneThomas J Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 62:1059-61. 2007..The findings of in vivo neuroimaging of DAT in ADHD have been somewhat discrepant, however... - Open-label escitalopram treatment for pathological skin pickingNancy J Keuthen
Massachusetts General Hospital Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Int Clin Psychopharmacol 22:268-74. 2007..These results suggest that escitalopram can be an effective agent in reducing pathological skin picking. The lack of medication response in a subset of our sample suggests the possibility of pathological skin picking subtypes... - A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]racloprideThomas J Spencer
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 68:964-70. 2010..With positron emission tomography imaging, we determined DAT occupancy and changes in extracellular dopamine by armodafinil in vivo... - Limbic system surgery for treatment-refractory obsessive-compulsive disorder: a prospective long-term follow-up of 64 patientsSameer A Sheth
Departments of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
J Neurosurg 118:491-7. 2013..The authors present their results describing the efficacy and durability of limbic system surgery for OCD, characterizing a large cohort of patients treated at a single institution with a mean follow-up of more than 5 years... - Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatmentRenerio Fraguas
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Psychiatry Res 151:169-72. 2007..These preliminary findings indicate that automatic responses to induced emotions may predict antidepressant response in MDD patients. Confirmatory studies are warranted... - Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation studyScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuropsychopharmacology 27:782-91. 2002..Finally, this pattern is sufficiently robust as to be relatively independent of symptomatic state at the time of tracer uptake... - Emotional and cognitive stimuli differentially engage the default network during inductive reasoningMark C Eldaief
Department of Neurology, Division of Cognitive Neurology, Beth Israel Deaconess Medical Center 330 Brookline Avenue, KS 230, Boston, MA 02215, USA
Soc Cogn Affect Neurosci 7:380-92. 2012..In contrast, activation of the MTL subsystem during certainty argues that this form of reasoning involves the recruitment of mnemonic and semantic associations to derive conclusions... - A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorderKarleyton C Evans
Department of Psychiatry, Psychiatric Neuroscience Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Neuropsychopharmacology 34:390-8. 2009..Given the pharmacological profile of tiagabine, these findings suggest that its therapeutic effects in gSAD may be mediated by GABAergic modulation within the vmPFC... - Spontaneous and directed application of verbal learning strategies in bipolar disorder and obsessive-compulsive disorderThilo Deckersbach
Harvard Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bipolar Disord 7:166-75. 2005.... - A PET study examining pharmacokinetics and dopamine transporter occupancy of two long-acting formulations of methylphenidate in adultsThomas J Spencer
Pediatric Psychopharmacology Unit ACC 725, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Mol Med 25:261-5. 2010..Moreover, a relatively small difference in plasma levels (1.4 ng/ml at 10 h) was associated with a more impressive difference in DAT occupancy ( approximately 10% at 10 h)... - Regional cerebral brain metabolism correlates of neuroticism and extraversionThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital, Boston, USA
Depress Anxiety 23:133-8. 2006..No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively... - PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidateThomas J Spencer
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 163:387-95. 2006.... - Magnetic resonance imaging-guided stereotactic limbic leukotomy for treatment of intractable psychiatric diseaseAlonso Montoya
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Neurosurgery 50:1043-9; discussion 1049-52. 2002..Adverse consequences associated with the procedure included affective, cognitive, and visceromotor sequelae, which were generally transient... - Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participantsRoy H Perlis
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Arch Gen Psychiatry 65:882-92. 2008.... - Prospective assessment of stereotactic ablative surgery for intractable major depressionDonald C Shields
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 64:449-54. 2008..Stereotactic ablative procedures such as anterior cingulotomy have been performed in severely affected, treatment-resistant patients, but the long-term results of such procedures are not fully understood... - An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor bindingDavid Mischoulon
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WAC 812, Boston, MA 02114, USA
Psychiatry Res 116:151-61. 2002..The effectiveness of nefazodone for depression with anger attacks may be related to widespread changes in 5HT2 receptor BP... - Major depressive disorder with anger attacks and subcortical MRI white matter hyperintensitiesDan V Iosifescu
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Nerv Ment Dis 195:175-8. 2007..Atypical and melancholic MDD subtypes were not significantly associated with brain WMH. In conclusion, subcortical brain vascular lesions may be more prevalent or severe in MDD with anger attacks... - Studying task-related activity of individual neurons in the human brainShaun R Patel
1 Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA
Nat Protoc 8:949-57. 2013..We describe the protocol in detail and provide two examples of expected results. In addition, we discuss the potential difficulties and pitfalls related to intraoperative studies. This protocol takes ∼1.5 h to complete... - Test-retest reliability during fear acquisition and fear extinction in humansMohamed A Zeidan
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
CNS Neurosci Ther 18:313-7. 2012..We, therefore, sought to test the within-subject reliability of a previously used 2-day, classical fear conditioning and extinction paradigm... - Neuroimaging and the functional neuroanatomy of psychotherapyJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Psychol Med 35:1385-98. 2005..This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders... - Mindfulness-based cognitive therapy for nonremitted patients with bipolar disorderThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
CNS Neurosci Ther 18:133-41. 2012..Despite periods of symptomatic recovery, many individuals with bipolar disorder continue to experience substantial residual mood symptoms that often lead to the recurrence of mood episodes... - Using neuroimaging to predict treatment response in mood and anxiety disordersKarleyton C Evans
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Ann Clin Psychiatry 18:33-42. 2006..However, the actual clinical utility of such tests remains to be shown... - Functional imaging of mood and anxiety disordersThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neuroimaging 16:1-10. 2006..We review functional neuroimaging findings pertaining to mood disorders (major depression, bipolar disorders) as well as selected anxiety disorders (posttraumatic stress disorder [PTSD] and obsessive-compulsive disorder [OCD])... - [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography demonstration of estrogen negative and positive feedback on luteinizing hormone secretion in womenWilliam E Ottowitz
Reproductive Endocrine Unit, BHX 5, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 93:3208-14. 2008..Precise regulation of the neuroendocrine components of the female reproductive axis involves both negative and positive feedback of estrogen on gonadotropin secretion... - Beneficial effect of subsequent lesion procedures after nonresponse to initial cingulotomy for severe, treatment-refractory obsessive-compulsive disorderSarah K Bourne
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
Neurosurgery 72:196-202; discussion 202. 2013..For patients who do not respond to AC, the benefit of additional lesion procedures vs continued medical management remains unknown... - In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporterThomas J Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 57:1293-300. 2005..Interpretation of the latter finding awaits clarification of the issue of timing of drug administration and imaging to disentangle receptor occupancy from downregulation... - Single-neuron responses in the human nucleus accumbens during a financial decision-making taskShaun R Patel
Nayef Al Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 32:7311-5. 2012..These results provide human single neuronal evidence that the nucleus accumbens is integral in making financial decisions... - Modulation of spontaneous breathing via limbic/paralimbic-bulbar circuitry: an event-related fMRI studyKarleyton C Evans
Department of Psychiatry, Division of Neurotherapeutics, Massachusetts General Hospital East, 13th Street, Building 149, Suite 2625, Charlestown, MA 02129, USA
Neuroimage 47:961-71. 2009..We propose that the identified limbic/paralimbic-bulbar circuitry plays a significant role in cognitive and emotional modulation of spontaneous breathing... - The neural network basis for abnormalities of attention and executive function in major depressive disorder: implications for application of the medical disease model to psychiatric disordersWilliam E Ottowitz
Psychiatric Neuroscience Program, Massachusetts General Hospital, Charlestown, Mass 02129, USA
Harv Rev Psychiatry 10:86-99. 2002.... - Prospective long-term follow-up of 44 patients who received cingulotomy for treatment-refractory obsessive-compulsive disorderDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Am J Psychiatry 159:269-75. 2002..Cingulotomy remains a viable treatment option for patients with severe treatment-refractory OCD... - Mindfulness-based cognitive therapy for bipolar disorder: effects on cognitive functioningJonathan P Stange
Department of Psychology, Temple University, USA
J Psychiatr Pract 17:410-9. 2011..These results provide preliminary evidence that MBCT may be a treatment option that can be used as an adjunct to medication to improve cognitive functioning in bipolar disorder... - Temporary interruption of deep brain stimulation for Parkinson's disease during outpatient electroconvulsive therapy for major depression: a novel treatment strategySimon Ducharme
McGill University, Montreal, QC, Canada, and Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Neuropsychiatry Clin Neurosci 23:194-7. 2011..Cases reported had no adverse events, but DBS was withheld throughout the weeks of the ECT course. The authors report the first case of temporary interruption of DBS only during the minutes of each outpatient ECT... - Body dysmorphic disorder and obsessive-compulsive disorder: similarities, differences and the classification debateAnne Chosak
OCD and Related Disorders Program, Simches Research Building, Massachusetts General Hospital, 185 Cambridge Street, Boston MA 02114, USA
Expert Rev Neurother 8:1209-18. 2008..This article describes the association between obsessive-compulsive disorder and body dysmorphic disorder as evidenced by the emerging literature, and presents theoretical and clinical implications of this association... - Presence of irritability during depressive episodes in bipolar disorderThilo Deckersbach
Department of Psychiatry, Psychiatric Neuroscience Program and Bipolar Research Program, Harvard Medical School 149 2611, Massachusetts General Hospital Bldg 149, 13th Street, Charlestown, MA 02129, USA
CNS Spectr 9:227-31. 2004.... - Neuroimaging contributions to novel surgical treatments for intractable obsessive-compulsive disorderAlexandra M Rodman
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA
Expert Rev Neurother 12:219-27. 2012..Here we review studies that elucidate the pathophysiology of OCD, illustrate modern neurosurgical treatments and investigate predictive correlates of treatment outcome... - Neural and endocrine correlates of sadness in women: implications for neural network regulation of HPA activityWilliam E Ottowitz
Department of Nuclear Medicine, St Elizabeth s Hospital, Boston Massachusetts, USA
J Neuropsychiatry Clin Neurosci 16:446-55. 2004..Dysfunction of these sites may contribute to the cortisol dysregulation observed in some subjects with major depression... - Current posttraumatic stress disorder and history of trauma in trichotillomaniaBeth S Gershuny
Department of Psychology, Skidmore College, 815 N Broadway, Saratoga Springs, NY 12866, USA
J Clin Psychol 62:1521-9. 2006..The authors also speculate that in traumatized individuals, TTM may represent a form of coping vis-à-vis self-soothing or self-harm... - FDG-PET analysis of amygdalar-cortical network covariance during pre- versus post-menopausal estrogen levels: potential relevance to resting state networks, mood, and cognitionWilliam E Ottowitz
Graduate School of Arts and Sciences, Department of Statistics, Columbia University, New York, NY 10027, USA
Neuro Endocrinol Lett 29:467-74. 2008.... - Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSDLisa M Shin
Department of Psychology, Tufts University, Medford, MA 02155, USA
Arch Gen Psychiatry 61:168-76. 2004..However, the functional relationship between these brain regions in PTSD has not been directly examined... - [What is the role of psychiatric neurosurgery in the 21st Century?]Scott L Rauch
Rev Bras Psiquiatr 26:4-5. 2004
Research Grants
- PHYSIOLOGIC STUDIES OF ANGER IN DEPRESSED PATIENTSDarin Dougherty; Fiscal Year: 2002..abstract_text> ..