Darin D Dougherty

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Brain correlates of antidepressant treatment outcome from neuroimaging studies in depression
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 30:91-103. 2007
  2. pmc Somatic therapies for treatment-resistant depression: ECT, TMS, VNS, DBS
    Cristina Cusin
    Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Rm 2612, Charlestown, MA 02129, USA
    Biol Mood Anxiety Disord 2:14. 2012
  3. ncbi request reprint Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:175-7. 2006
  4. ncbi request reprint Somatic therapies for treatment-resistant depression: new neurotherapeutic interventions
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 30:31-7. 2007
  5. pmc A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia
    Darin D Dougherty
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, MA 02129, USA
    Behav Brain Res 193:63-8. 2008
  6. ncbi request reprint Pharmacotherapy for obsessive-compulsive disorder
    Darin D Dougherty
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Clin Psychol 60:1195-202. 2004
  7. ncbi request reprint Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacks
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Arch Gen Psychiatry 61:795-804. 2004
  8. ncbi request reprint Single modality versus dual modality treatment for trichotillomania: sertraline, behavioral therapy, or both?
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    J Clin Psychiatry 67:1086-92. 2006
  9. ncbi request reprint Open-label study of high (30 mg) and moderate (20 mg) dose escitalopram for the treatment of obsessive-compulsive disorder
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    Int Clin Psychopharmacol 24:306-11. 2009
  10. ncbi request reprint Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 59:138-46. 2006

Research Grants

  1. PHYSIOLOGIC STUDIES OF ANGER IN DEPRESSED PATIENTS
    Darin Dougherty; Fiscal Year: 2002

Detail Information

Publications61

  1. ncbi request reprint Brain correlates of antidepressant treatment outcome from neuroimaging studies in depression
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 30:91-103. 2007
    ....
  2. pmc Somatic therapies for treatment-resistant depression: ECT, TMS, VNS, DBS
    Cristina Cusin
    Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Rm 2612, Charlestown, MA 02129, USA
    Biol Mood Anxiety Disord 2:14. 2012
    ..VNS has been FDA-approved for TRD, however it is not indicated for management of acute illness. DBS for TRD is still an experimental area of investigation and double-blind clinical trials are underway...
  3. ncbi request reprint Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:175-7. 2006
    ..These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression...
  4. ncbi request reprint Somatic therapies for treatment-resistant depression: new neurotherapeutic interventions
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 30:31-7. 2007
    ..Although the future of neurotherapeutic interventions in psychiatry is hard to predict, it is clear that these treatments will have a growing role in the field...
  5. pmc A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia
    Darin D Dougherty
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, MA 02129, USA
    Behav Brain Res 193:63-8. 2008
    ..These findings include brain regions within both the lateral and medial pain networks...
  6. ncbi request reprint Pharmacotherapy for obsessive-compulsive disorder
    Darin D Dougherty
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Clin Psychol 60:1195-202. 2004
    ..There is substantially less evidence supporting other alternative strategies. Finally, neurosurgical and device-based approaches for treatment-refractory OCD are reviewed...
  7. ncbi request reprint Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacks
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Arch Gen Psychiatry 61:795-804. 2004
    ....
  8. ncbi request reprint Single modality versus dual modality treatment for trichotillomania: sertraline, behavioral therapy, or both?
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    J Clin Psychiatry 67:1086-92. 2006
    ..However, no randomized, controlled studies to date have compared the efficacy of individual SSRI or CBT treatment to the combination of both treatment modalities...
  9. ncbi request reprint Open-label study of high (30 mg) and moderate (20 mg) dose escitalopram for the treatment of obsessive-compulsive disorder
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    Int Clin Psychopharmacol 24:306-11. 2009
    ..These results suggest that the 30 mg (vs. 20 mg) dose of escitalopram may provide a superior reduction in OCD symptoms for those sufferers with comorbid depression and/or anxiety...
  10. ncbi request reprint Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 59:138-46. 2006
    ..The most consistently reported cognitive difficulty in euthymic subjects with bipolar disorder is impairment in verbal episodic memory (i.e., the ability to learn new verbal information)...
  11. pmc Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation
    Sameer A Sheth
    Nayef Al Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 488:218-21. 2012
    ..In situations with stable cognitive demands, this signal promotes efficiency by hastening responses, but in situations with changing demands it engenders accuracy by delaying responses...
  12. doi request reprint An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief report
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, 2nd Floor, Charlestown, MA 02129, USA
    Bipolar Disord 10:928-42. 2008
    ..The purpose of the present study was to investigate with fMRI the interaction between acute sadness and working memory functioning in individuals with bipolar disorder...
  13. ncbi request reprint Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression
    Darin D Dougherty
    Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurosurg 99:1010-7. 2003
    ..The purpose of this study was to identify possible neuroimaging predictors of treatment response to anterior cingulotomy in patients with major depression...
  14. ncbi request reprint A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder
    Scott L Rauch
    Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosurg 104:558-65. 2006
    ..The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial...
  15. pmc Functional genomics of attention-deficit/hyperactivity disorder (ADHD) risk alleles on dopamine transporter binding in ADHD and healthy control subjects
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Boston, Massachusetts 02114, USA
    Biol Psychiatry 74:84-9. 2013
    ....
  16. doi request reprint Understanding the central pharmacokinetics of spheroidal oral drug absorption system (SODAS) dexmethylphenidate: a positron emission tomography study of dopamine transporter receptor occupancy measured with C-11 altropane
    Thomas J Spencer
    The Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 73:346-52. 2012
    ..However, there are no studies of central nervous system (CNS) dopamine transporter occupancies...
  17. ncbi request reprint Autonomic and prefrontal cortex responses to autobiographical recall of emotions
    Carl D Marci
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cogn Affect Behav Neurosci 7:243-50. 2007
    ..The findings suggest that a relative increase in sympathetic activity with a reciprocal decrease in parasympathetic activity may be necessary to generate frontal activity in autobiographical recall of emotions...
  18. doi request reprint Studying task-related activity of individual neurons in the human brain
    Shaun R Patel
    Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Protoc 8:949-57. 2013
    ..We describe the protocol in detail and provide two examples of expected results. In addition, we discuss the potential difficulties and pitfalls related to intraoperative studies. This protocol takes ∼1.5 h to complete...
  19. doi request reprint Beneficial effect of subsequent lesion procedures after nonresponse to initial cingulotomy for severe, treatment-refractory obsessive-compulsive disorder
    Sarah K Bourne
    Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    Neurosurgery 72:196-202; discussion 202. 2013
    ..For patients who do not respond to AC, the benefit of additional lesion procedures vs continued medical management remains unknown...
  20. pmc Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET study
    Hadine Joffe
    Center for Women s Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:3207-15. 2012
    ..Previous studies have implicated the insula during the perception of hot flashes and the hypothalamus in thermoregulatory dysfunction...
  21. pmc Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder
    Anne J Blood
    Depression Clinic and Research Program, Mood and Motor Control Laboratory, Addiction Research Program, Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e13945. 2010
    ..There has been little investigation in MDD of midbrain and subcortical regions central to reward/aversion function, such as the ventral tegmental area/substantia nigra (VTA/SN), and medial forebrain bundle (MFB)...
  22. doi request reprint A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 68:964-70. 2010
    ..With positron emission tomography imaging, we determined DAT occupancy and changes in extracellular dopamine by armodafinil in vivo...
  23. ncbi request reprint Open-label escitalopram treatment for pathological skin picking
    Nancy J Keuthen
    Massachusetts General Hospital Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Int Clin Psychopharmacol 22:268-74. 2007
    ..These results suggest that escitalopram can be an effective agent in reducing pathological skin picking. The lack of medication response in a subset of our sample suggests the possibility of pathological skin picking subtypes...
  24. pmc Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 62:1059-61. 2007
    ..The findings of in vivo neuroimaging of DAT in ADHD have been somewhat discrepant, however...
  25. doi request reprint Limbic system surgery for treatment-refractory obsessive-compulsive disorder: a prospective long-term follow-up of 64 patients
    Sameer A Sheth
    Departments of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurosurg 118:491-7. 2013
    ..The authors present their results describing the efficacy and durability of limbic system surgery for OCD, characterizing a large cohort of patients treated at a single institution with a mean follow-up of more than 5 years...
  26. ncbi request reprint Autonomic reactivity to induced emotion as potential predictor of response to antidepressant treatment
    Renerio Fraguas
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychiatry Res 151:169-72. 2007
    ..These preliminary findings indicate that automatic responses to induced emotions may predict antidepressant response in MDD patients. Confirmatory studies are warranted...
  27. ncbi request reprint Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 27:782-91. 2002
    ..Finally, this pattern is sufficiently robust as to be relatively independent of symptomatic state at the time of tracer uptake...
  28. pmc Emotional and cognitive stimuli differentially engage the default network during inductive reasoning
    Mark C Eldaief
    Department of Neurology, Division of Cognitive Neurology, Beth Israel Deaconess Medical Center 330 Brookline Avenue, KS 230, Boston, MA 02215, USA
    Soc Cogn Affect Neurosci 7:380-92. 2012
    ..In contrast, activation of the MTL subsystem during certainty argues that this form of reasoning involves the recruitment of mnemonic and semantic associations to derive conclusions...
  29. doi request reprint A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Psychiatric Neuroscience Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Neuropsychopharmacology 34:390-8. 2009
    ..Given the pharmacological profile of tiagabine, these findings suggest that its therapeutic effects in gSAD may be mediated by GABAergic modulation within the vmPFC...
  30. ncbi request reprint A PET study examining pharmacokinetics and dopamine transporter occupancy of two long-acting formulations of methylphenidate in adults
    Thomas J Spencer
    Pediatric Psychopharmacology Unit ACC 725, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Mol Med 25:261-5. 2010
    ..Moreover, a relatively small difference in plasma levels (1.4 ng/ml at 10 h) was associated with a more impressive difference in DAT occupancy ( approximately 10% at 10 h)...
  31. ncbi request reprint Regional cerebral brain metabolism correlates of neuroticism and extraversion
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:133-8. 2006
    ..No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively...
  32. ncbi request reprint PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidate
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 163:387-95. 2006
    ....
  33. ncbi request reprint Magnetic resonance imaging-guided stereotactic limbic leukotomy for treatment of intractable psychiatric disease
    Alonso Montoya
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurosurgery 50:1043-9; discussion 1049-52. 2002
    ..To assess the efficacy and complication rates of magnetic resonance imaging-guided stereotactic limbic leukotomy for the treatment of intractable major depressive disorder (MDD) and obsessive-compulsive disorder (OCD)...
  34. ncbi request reprint Spontaneous and directed application of verbal learning strategies in bipolar disorder and obsessive-compulsive disorder
    Thilo Deckersbach
    Harvard Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Bipolar Disord 7:166-75. 2005
    ....
  35. ncbi request reprint An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding
    David Mischoulon
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WAC 812, Boston, MA 02114, USA
    Psychiatry Res 116:151-61. 2002
    ..The effectiveness of nefazodone for depression with anger attacks may be related to widespread changes in 5HT2 receptor BP...
  36. ncbi request reprint Major depressive disorder with anger attacks and subcortical MRI white matter hyperintensities
    Dan V Iosifescu
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Nerv Ment Dis 195:175-8. 2007
    ..Atypical and melancholic MDD subtypes were not significantly associated with brain WMH. In conclusion, subcortical brain vascular lesions may be more prevalent or severe in MDD with anger attacks...
  37. pmc Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 65:882-92. 2008
    ....
  38. ncbi request reprint Prospective assessment of stereotactic ablative surgery for intractable major depression
    Donald C Shields
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 64:449-54. 2008
    ..Stereotactic ablative procedures such as anterior cingulotomy have been performed in severely affected, treatment-resistant patients, but the long-term results of such procedures are not fully understood...
  39. doi request reprint Test-retest reliability during fear acquisition and fear extinction in humans
    Mohamed A Zeidan
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    CNS Neurosci Ther 18:313-7. 2012
    ..We, therefore, sought to test the within-subject reliability of a previously used 2-day, classical fear conditioning and extinction paradigm...
  40. ncbi request reprint Neuroimaging and the functional neuroanatomy of psychotherapy
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1385-98. 2005
    ..This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders...
  41. pmc Mindfulness-based cognitive therapy for nonremitted patients with bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Neurosci Ther 18:133-41. 2012
    ..Despite periods of symptomatic recovery, many individuals with bipolar disorder continue to experience substantial residual mood symptoms that often lead to the recurrence of mood episodes...
  42. pmc [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography demonstration of estrogen negative and positive feedback on luteinizing hormone secretion in women
    William E Ottowitz
    Reproductive Endocrine Unit, BHX 5, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3208-14. 2008
    ..Precise regulation of the neuroendocrine components of the female reproductive axis involves both negative and positive feedback of estrogen on gonadotropin secretion...
  43. ncbi request reprint Functional imaging of mood and anxiety disorders
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neuroimaging 16:1-10. 2006
    ..We review functional neuroimaging findings pertaining to mood disorders (major depression, bipolar disorders) as well as selected anxiety disorders (posttraumatic stress disorder [PTSD] and obsessive-compulsive disorder [OCD])...
  44. ncbi request reprint Using neuroimaging to predict treatment response in mood and anxiety disorders
    Karleyton C Evans
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Ann Clin Psychiatry 18:33-42. 2006
    ..Given the variance in patient responses to psychiatric treatments, the use of such predictive tools could be tremendously valuable, especially in situations where treatments carry substantial risks or costs...
  45. ncbi request reprint In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1293-300. 2005
    ..Interpretation of the latter finding awaits clarification of the issue of timing of drug administration and imaging to disentangle receptor occupancy from downregulation...
  46. pmc Single-neuron responses in the human nucleus accumbens during a financial decision-making task
    Shaun R Patel
    Nayef Al Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 32:7311-5. 2012
    ..These results provide human single neuronal evidence that the nucleus accumbens is integral in making financial decisions...
  47. pmc Mindfulness-based cognitive therapy for bipolar disorder: effects on cognitive functioning
    Jonathan P Stange
    Department of Psychology, Temple University, USA
    J Psychiatr Pract 17:410-9. 2011
    ..These results provide preliminary evidence that MBCT may be a treatment option that can be used as an adjunct to medication to improve cognitive functioning in bipolar disorder...
  48. pmc Modulation of spontaneous breathing via limbic/paralimbic-bulbar circuitry: an event-related fMRI study
    Karleyton C Evans
    Department of Psychiatry, Division of Neurotherapeutics, Massachusetts General Hospital East, 13th Street, Building 149, Suite 2625, Charlestown, MA 02129, USA
    Neuroimage 47:961-71. 2009
    ..We propose that the identified limbic/paralimbic-bulbar circuitry plays a significant role in cognitive and emotional modulation of spontaneous breathing...
  49. ncbi request reprint The neural network basis for abnormalities of attention and executive function in major depressive disorder: implications for application of the medical disease model to psychiatric disorders
    William E Ottowitz
    Psychiatric Neuroscience Program, Massachusetts General Hospital, Charlestown, Mass 02129, USA
    Harv Rev Psychiatry 10:86-99. 2002
    ....
  50. doi request reprint Body dysmorphic disorder and obsessive-compulsive disorder: similarities, differences and the classification debate
    Anne Chosak
    OCD and Related Disorders Program, Simches Research Building, Massachusetts General Hospital, 185 Cambridge Street, Boston MA 02114, USA
    Expert Rev Neurother 8:1209-18. 2008
    ..This article describes the association between obsessive-compulsive disorder and body dysmorphic disorder as evidenced by the emerging literature, and presents theoretical and clinical implications of this association...
  51. ncbi request reprint Prospective long-term follow-up of 44 patients who received cingulotomy for treatment-refractory obsessive-compulsive disorder
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Psychiatry 159:269-75. 2002
    ..Long-term outcome associated with cingulotomy for obsessive-compulsive disorder (OCD) was prospectively assessed. Findings are reported for 18 patients previously described in 1995 and for 26 new patients...
  52. doi request reprint Temporary interruption of deep brain stimulation for Parkinson's disease during outpatient electroconvulsive therapy for major depression: a novel treatment strategy
    Simon Ducharme
    McGill University, Montreal, QC, Canada, and Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Neuropsychiatry Clin Neurosci 23:194-7. 2011
    ..Cases reported had no adverse events, but DBS was withheld throughout the weeks of the ECT course. The authors report the first case of temporary interruption of DBS only during the minutes of each outpatient ECT...
  53. ncbi request reprint Presence of irritability during depressive episodes in bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Psychiatric Neuroscience Program and Bipolar Research Program, Harvard Medical School 149 2611, Massachusetts General Hospital Bldg 149, 13th Street, Charlestown, MA 02129, USA
    CNS Spectr 9:227-31. 2004
    ....
  54. ncbi request reprint Device-based brain stimulation to augment fear extinction: implications for PTSD treatment and beyond
    Marie France Marin
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Depress Anxiety 31:269-78. 2014
    ....
  55. doi request reprint Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive-compulsive disorder
    Marcelo Q Hoexter
    Department and Institute of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Eur Neuropsychopharmacol 23:569-80. 2013
    ..Clinical registration information: http://clinicaltrials.gov-NCT00680602...
  56. doi request reprint Neuroimaging contributions to novel surgical treatments for intractable obsessive-compulsive disorder
    Alexandra M Rodman
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA
    Expert Rev Neurother 12:219-27. 2012
    ..Here we review studies that elucidate the pathophysiology of OCD, illustrate modern neurosurgical treatments and investigate predictive correlates of treatment outcome...
  57. ncbi request reprint Current posttraumatic stress disorder and history of trauma in trichotillomania
    Beth S Gershuny
    Department of Psychology, Skidmore College, 815 N Broadway, Saratoga Springs, NY 12866, USA
    J Clin Psychol 62:1521-9. 2006
    ..The authors also speculate that in traumatized individuals, TTM may represent a form of coping vis-à-vis self-soothing or self-harm...
  58. ncbi request reprint Neural and endocrine correlates of sadness in women: implications for neural network regulation of HPA activity
    William E Ottowitz
    Department of Nuclear Medicine, St Elizabeth s Hospital, Boston Massachusetts, USA
    J Neuropsychiatry Clin Neurosci 16:446-55. 2004
    ..Dysfunction of these sites may contribute to the cortisol dysregulation observed in some subjects with major depression...
  59. ncbi request reprint Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Arch Gen Psychiatry 61:168-76. 2004
    ..However, the functional relationship between these brain regions in PTSD has not been directly examined...
  60. ncbi request reprint FDG-PET analysis of amygdalar-cortical network covariance during pre- versus post-menopausal estrogen levels: potential relevance to resting state networks, mood, and cognition
    William E Ottowitz
    Graduate School of Arts and Sciences, Department of Statistics, Columbia University, New York, NY 10027, USA
    Neuro Endocrinol Lett 29:467-74. 2008
    ....
  61. ncbi request reprint [What is the role of psychiatric neurosurgery in the 21st Century?]
    Scott L Rauch
    Rev Bras Psiquiatr 26:4-5. 2004

Research Grants1

  1. PHYSIOLOGIC STUDIES OF ANGER IN DEPRESSED PATIENTS
    Darin Dougherty; Fiscal Year: 2002
    ..abstract_text> ..