Research Topics
Genomes and Genes
| David M DorfmanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
|
Detail Information
Publications
Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markersDavid M Dorfman
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Mod Pathol 25:1637-43. 2012..We conclude that CD200 is a practical and useful marker for the diagnosis of primary mediastinal large B cell lymphoma...
Loss of expression of the WNT/beta-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor-1 (TCF-1) in a subset of peripheral T cell lymphomasDavid M Dorfman
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 162:1539-44. 2003..LEF-1 and TCF-1 immunostaining can serve to identify specific subtypes of PTCL, and lends support to a bipartite model of PTCL development, based on expression of activation markers...
T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphomaDavid M Dorfman
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Pathol 36:10-5. 2005....- The CD117 immunohistochemistry tissue microarray survey for quality assurance and interlaboratory comparison: a College of American Pathologists Cell Markers Committee StudyDavid M Dorfman
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Arch Pathol Lab Med 130:779-82. 2006..Consequently, correct identification of c-Kit expression is important for the diagnosis and treatment of GISTs... - Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphomaDavid M Dorfman
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Am J Surg Pathol 30:802-10. 2006.... - Point-of-care (POC) versus central laboratory instrumentation for monitoring oral anticoagulationDavid M Dorfman
Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Vasc Med 10:23-7. 2005..Instead, a predefined cut-off range for high INR values generated by POC instruments should mandate confirmatory testing with central laboratory instrumentation... - CD200 (OX-2 membrane glycoprotein) expression in b cell-derived neoplasmsDavid M Dorfman
Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Am J Clin Pathol 134:726-33. 2010..Furthermore, since an anti-CD200 immunotherapeutic agent is in clinical trials, a number of B cell-derived neoplasms in addition to CLL/SLL may be suitable therapeutic targets... - CD200 (OX-2 membrane glycoprotein) is expressed by follicular T helper cells and in angioimmunoblastic T-cell lymphomaDavid M Dorfman
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Surg Pathol 35:76-83. 2011..We conclude that CD200 is a useful immunophenotypic marker of angioimmunoblastic T-cell lymphoma and may be a suitable therapeutic target for an anti-CD200 immunotherapy undergoing clinical trial... - The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasmsDavid M Dorfman
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Pathol 41:1486-94. 2010..We conclude that histiocytic and dendritic cell neoplasms consistently express TIM-3 and TIM-4 and that these molecules are new markers of neoplasms derived from histiocytic and dendritic cells... - T-bet, a T-cell-associated transcription factor, is expressed in a subset of B-cell lymphoproliferative disordersDavid M Dorfman
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Clin Pathol 122:292-7. 2004..In addition, T-bet should serve as a useful new marker for the diagnosis and subtyping of B-cell lymphoproliferative disorders... - Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cellsJingsong Wang
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Clin Invest 116:414-21. 2006..T-bet provides an attractive new target for the development of novel therapeutics for inflammatory arthritis... - Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H)Scott J Rodig
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Cancer Res 12:7174-9. 2006..The utility of CAMPATH in the treatment of other hematologic neoplasms has been explored; however, a comprehensive survey of CD52 expression among a broad spectrum of WHO-defined tumor types has not been completed... - Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomasDavid M Dorfman
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Am J Clin Pathol 120:866-73. 2003..T-bet expression in these neoplasms provides further support for a model of PTCL in which tumor subsets express markers of, and may be derived from, Th1- or Th2-committed T cells... - TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cellsNorimoto Kobayashi
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Harvard Medical School, Boston, MA 02115, USA
Immunity 27:927-40. 2007..These results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity... - The CD45 isoform B220 identifies select subsets of human B cells and B-cell lymphoproliferative disordersScott J Rodig
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Hum Pathol 36:51-7. 2005..Discordance between the B220 expression patterns of normal mantle and marginal zone B cells and their respective neoplastic counterparts may aid in the distinction between normal and neoplastic proliferations at these anatomical sites... - Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13Antonios O Aliprantis
Department of Infectious Diseases and Immunology, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:2827-30. 2007..T-bet, and its transcriptional network, represent an attractive target for the treatment of systemic sclerosis and other fibrosing disorders... - Characteristic expression patterns of TCL1, CD38, and CD44 identify aggressive lymphomas harboring a MYC translocationScott J Rodig
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Am J Surg Pathol 32:113-22. 2008..Thus staining for TCL1, CD38, and CD44 are useful ancillary tests to identify B-cell tumors for which confirmatory cytogenetic and/or fluorescent in situ hybridization studies assessing the status of the MYC locus should be pursued... - BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disordersScott J Rodig
Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Hum Pathol 36:1113-9. 2005.... - Interlaboratory comparison of immunohistochemical testing for HER2: results of the 2004 and 2005 College of American Pathologists HER2 Immunohistochemistry Tissue Microarray SurveyPatrick L Fitzgibbons
Department of Pathology, St Jude Medical Center, Fullerton, Calif, USA
Arch Pathol Lab Med 130:1440-5. 2006..Cores found to be IHC-positive or IHC-negative by participant consensus can be used as validated benchmarks for interlaboratory comparison, allowing laboratories to assess their performance and determine if improvements are needed... - CXCR4/CD184 immunoreactivity in T-cell non-Hodgkin lymphomas with an overall Th1- Th2+ immunophenotypeAndrew P Weng
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Am J Clin Pathol 119:424-30. 2003..Our findings also suggest that CXCR4/CD184, which is expressed by a number of malignant neoplasms and may have a role in tumor metastasis, may have a similar function in CXCR4+ T-cell non-Hodgkin lymphomas... - Patterns of expression of CD56 and CD117 on neoplastic plasma cells and association with genetically distinct subtypes of plasma cell myelomaOlga Pozdnyakova
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Leuk Lymphoma 53:1905-10. 2012.... - CCR6 is a functional chemokine receptor that serves to identify select B-cell non-Hodgkin's lymphomasScott J Rodig
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Hum Pathol 33:1227-33. 2002..Thus, CCR6 is a useful new marker identifying a subset of B-cell non-Hodgkin's lymphomas and likely contributes to the localization of select extranodal lymphomas at mucosal sites... - Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine productionJulia A Brown
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:1257-66. 2003..PD-L1 is also highly expressed on most carcinomas but minimally expressed on adjacent normal tissue suggesting a role in attenuating antitumor immune responses... - Germinal-center T-helper-cell markers PD-1 and CXCL13 are both expressed by neoplastic cells in angioimmunoblastic T-cell lymphomaHongbo Yu
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Clin Pathol 131:33-41. 2009..The similar pattern of expression of CXCL13 and PD-1 in AITL provides further evidence that AITL is a neoplasm derived from germinal-center T-helper cells... - Carcinoma showing thymus-like differentiation of the thyroid (CASTLE): a comparative study: evidence of thymic differentiation and solid cell nest originJulie D R Reimann
Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 30:994-1001. 2006..Moreover CD5, HMWK, CEA and p63 can be used to help distinguish CASTLE from other thyroid neoplasms... - Single tube, six-color flow cytometric analysis is a sensitive and cost-effective technique for assaying clonal plasma cellsDerek K Marsee
Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Am J Clin Pathol 133:694-9. 2010..Taken together, this study demonstrates that 6-color flow cytometry is an excellent, cost-effective means to assay for clonal plasma cells in a noncontrolled patient population... - CD69 expression correlates with expression of other markers of Th1 T cell differentiation in peripheral T cell lymphomasDavid M Dorfman
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Hum Pathol 33:330-4. 2002..In addition, CD69 is a useful immunohistochemical marker for specific T cell lymphomas in frozen and paraffin-embedded tissue... - CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cellsHenry Y Dong
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
Leuk Lymphoma 43:1855-8. 2002..Our findings demonstrate that CD148 and CD27 are expressed in a wide range of B cell non-Hodgkin's lymphomas, and, therefore, do not serve to distinguish between neoplastic cells of naïve and memory B cell derivation... - Do nontriploid partial hydatidiform moles exist? A histologic and flow cytometric reevaluation of nontriploid specimensDavid R Genest
Department of Obstetrics and Gynecology, New England Trophoblastic Disease Center, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
J Reprod Med 47:363-8. 2002..To study whether nontriploid partial hydatidiform moles truly exist... - Ploidy and imprinting in hydatidiform moles. Complementary use of flow cytometry and immunohistochemistry of the imprinted gene product p57KIP2 to assist molar classificationDavid R Genest
Division of Women s and Perinatal Pathology, Hematology Laboratory, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Reprod Med 47:342-6. 2002..To determine whether the combination of flow cytometry and immunohistochemistry for p57 expression is useful for the pathologic classification of diagnostically challenging hydatidiform moles... - High-sensitivity flow cytometric analysis for the evaluation of systemic mastocytosis including the identification of a new flow cytometric criterion for bone marrow involvementOlga Pozdnyakova
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Amory 3, Boston, MA 02115, USA
Am J Clin Pathol 138:416-24. 2012..We conclude that flow cytometry is a sensitive and specific test for the presence of systemic mastocytosis, particularly when the presence of a discrete CD117-positive mast cell population is regarded as a diagnostic criterion... - The terminal ileum is affected in patients with lymphocytic or collagenous colitisHeidi Sapp
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Am J Surg Pathol 26:1484-92. 2002..The results suggest that the terminal ileum may be involved by a similar pathogenic process as the colon in LC and CC... - CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemiaZachary R Hunter
Bing Program for Waldenstrom's Macroglobulinemia, Dana-Farber Cancer Institute, LG102, 44 Binney Street, Boston, MA 02215, USA
Clin Lymphoma 5:246-9. 2005..These studies demonstrate that CD5, CD10, and CD23 are commonly found in WM and that their expression should not exclude the diagnosis of WM. Moreover, expression of CD23 may define a clinically distinct subset of patients with WM... - Enterocolic fistula associated with an intestinal lymphomaVictor Wang
Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts, USA
MedGenMed 9:28. 2007 - Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform moleFabiola Medeiros
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 27:247-51. 2008.... - Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytesEwa Sicinska
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Mol Cell Biol 26:8052-60. 2006..Collectively, these results demonstrate that cyclin D3 is an essential cell cycle recipient of G-CSF signaling, and they provide a molecular link of how G-CSF-dependent signaling triggers cell proliferation... - A pilot surrogate endpoint biomarker study of celecoxib in oral premalignant lesionsLori J Wirth
Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Cancer Prev Res (Phila) 1:339-48. 2008..Treatment with celecoxib in subjects with OPLs favorably modulates the primary mediator of cyclooxygenase-2 activity, PGE(2), after 12 weeks... - Normal D-dimer levels in emergency department patients suspected of acute pulmonary embolismKelly L Dunn
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 40:1475-8. 2002..By paying more attention to normal D-dimer results, fewer chest CT scans and lung scans will be required, and improvements may be realized in diagnostic efficiency and cost reduction... - Concurrent herpes simplex viral lymphadenitis and mantle cell lymphoma: a case report and review of the literatureMonika E Pilichowska
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Arch Pathol Lab Med 130:536-9. 2006..The recognition of herpes simplex virus infection with MCL is important for treatment as well as to rule out transformation of MCL to a higher-grade lesion... - The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient miceVictor Boyartchuk
Program in Gene Function and Expression, University of Massachusetts Medical School, Boston 02115, USA
J Immunol 173:5112-20. 2004..The polymorphic gene(s) encoded within the sst1 locus that controls macrophage interactions with the two intracellular pathogens remains to be elucidated... - Automated flow cytometric analysis of blood cells in cerebrospinal fluid: analytic performanceMarthe W Aune
St Olaf's University Hospital, Trondheim, Norway
Am J Clin Pathol 121:690-700. 2004..Study results demonstrate that the automated ADVIA 120 CSF Assay is an acceptable alternative to the labor-intensive manual method... - Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteinsFrederick L Moore
Department of Obstetrics, Gynecology and Reproductive Sciences, Programs in Human Genetics and Cancer Genetics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 100:538-43. 2003..These data implicate PUM2 as a component of conserved cellular machinery that may be required for germ cell development... - Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsiaErrol R Norwitz
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Am J Obstet Gynecol 193:957-64. 2005..Patients with sPE have nanomolar amounts of free hemoglobin in their CSF. Further studies are needed to confirm these observations and determine their physiologic implications...