David M Dorfman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 25:1637-43. 2012
  2. pmc Loss of expression of the WNT/beta-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor-1 (TCF-1) in a subset of peripheral T cell lymphomas
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 162:1539-44. 2003
  3. ncbi request reprint T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 36:10-5. 2005
  4. ncbi request reprint Point-of-care (POC) versus central laboratory instrumentation for monitoring oral anticoagulation
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Vasc Med 10:23-7. 2005
  5. pmc Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 30:802-10. 2006
  6. ncbi request reprint The CD117 immunohistochemistry tissue microarray survey for quality assurance and interlaboratory comparison: a College of American Pathologists Cell Markers Committee Study
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arch Pathol Lab Med 130:779-82. 2006
  7. pmc The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 41:1486-94. 2010
  8. doi request reprint CD200 (OX-2 membrane glycoprotein) expression in b cell-derived neoplasms
    David M Dorfman
    Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Clin Pathol 134:726-33. 2010
  9. doi request reprint CD200 (OX-2 membrane glycoprotein) is expressed by follicular T helper cells and in angioimmunoblastic T-cell lymphoma
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 35:76-83. 2011
  10. doi request reprint CD200 flow cytometric assessment and semiquantitative immunohistochemical staining distinguishes hairy cell leukemia from hairy cell leukemia-variant and other B-cell lymphoproliferative disorders
    Vinodh Pillai
    Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115
    Am J Clin Pathol 140:536-43. 2013

Collaborators

Detail Information

Publications48

  1. doi request reprint Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 25:1637-43. 2012
    ..We conclude that CD200 is a practical and useful marker for the diagnosis of primary mediastinal large B cell lymphoma...
  2. pmc Loss of expression of the WNT/beta-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor-1 (TCF-1) in a subset of peripheral T cell lymphomas
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 162:1539-44. 2003
    ..LEF-1 and TCF-1 immunostaining can serve to identify specific subtypes of PTCL, and lends support to a bipartite model of PTCL development, based on expression of activation markers...
  3. ncbi request reprint T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 36:10-5. 2005
    ....
  4. ncbi request reprint Point-of-care (POC) versus central laboratory instrumentation for monitoring oral anticoagulation
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Vasc Med 10:23-7. 2005
    ..Instead, a predefined cut-off range for high INR values generated by POC instruments should mandate confirmatory testing with central laboratory instrumentation...
  5. pmc Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 30:802-10. 2006
    ....
  6. ncbi request reprint The CD117 immunohistochemistry tissue microarray survey for quality assurance and interlaboratory comparison: a College of American Pathologists Cell Markers Committee Study
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arch Pathol Lab Med 130:779-82. 2006
    ..Consequently, correct identification of c-Kit expression is important for the diagnosis and treatment of GISTs...
  7. pmc The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 41:1486-94. 2010
    ..We conclude that histiocytic and dendritic cell neoplasms consistently express TIM-3 and TIM-4 and that these molecules are new markers of neoplasms derived from histiocytic and dendritic cells...
  8. doi request reprint CD200 (OX-2 membrane glycoprotein) expression in b cell-derived neoplasms
    David M Dorfman
    Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Clin Pathol 134:726-33. 2010
    ..Furthermore, since an anti-CD200 immunotherapeutic agent is in clinical trials, a number of B cell-derived neoplasms in addition to CLL/SLL may be suitable therapeutic targets...
  9. doi request reprint CD200 (OX-2 membrane glycoprotein) is expressed by follicular T helper cells and in angioimmunoblastic T-cell lymphoma
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 35:76-83. 2011
    ..We conclude that CD200 is a useful immunophenotypic marker of angioimmunoblastic T-cell lymphoma and may be a suitable therapeutic target for an anti-CD200 immunotherapy undergoing clinical trial...
  10. doi request reprint CD200 flow cytometric assessment and semiquantitative immunohistochemical staining distinguishes hairy cell leukemia from hairy cell leukemia-variant and other B-cell lymphoproliferative disorders
    Vinodh Pillai
    Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115
    Am J Clin Pathol 140:536-43. 2013
    ..To evaluate CD200 expression in B-cell proliferative disorders...
  11. ncbi request reprint T-bet, a T-cell-associated transcription factor, is expressed in a subset of B-cell lymphoproliferative disorders
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 122:292-7. 2004
    ..In addition, T-bet should serve as a useful new marker for the diagnosis and subtyping of B-cell lymphoproliferative disorders...
  12. ncbi request reprint Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H)
    Scott J Rodig
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Cancer Res 12:7174-9. 2006
    ..The utility of CAMPATH in the treatment of other hematologic neoplasms has been explored; however, a comprehensive survey of CD52 expression among a broad spectrum of WHO-defined tumor types has not been completed...
  13. ncbi request reprint Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomas
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Clin Pathol 120:866-73. 2003
    ..T-bet expression in these neoplasms provides further support for a model of PTCL in which tumor subsets express markers of, and may be derived from, Th1- or Th2-committed T cells...
  14. pmc Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
    Jingsong Wang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 116:414-21. 2006
    ..T-bet provides an attractive new target for the development of novel therapeutics for inflammatory arthritis...
  15. ncbi request reprint The CD45 isoform B220 identifies select subsets of human B cells and B-cell lymphoproliferative disorders
    Scott J Rodig
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 36:51-7. 2005
    ..Discordance between the B220 expression patterns of normal mantle and marginal zone B cells and their respective neoplastic counterparts may aid in the distinction between normal and neoplastic proliferations at these anatomical sites...
  16. pmc Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13
    Antonios O Aliprantis
    Department of Infectious Diseases and Immunology, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:2827-30. 2007
    ..T-bet, and its transcriptional network, represent an attractive target for the treatment of systemic sclerosis and other fibrosing disorders...
  17. pmc TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells
    Norimoto Kobayashi
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Harvard Medical School, Boston, MA 02115, USA
    Immunity 27:927-40. 2007
    ..These results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity...
  18. ncbi request reprint Interlaboratory comparison of immunohistochemical testing for HER2: results of the 2004 and 2005 College of American Pathologists HER2 Immunohistochemistry Tissue Microarray Survey
    Patrick L Fitzgibbons
    Department of Pathology, St Jude Medical Center, Fullerton, Calif, USA
    Arch Pathol Lab Med 130:1440-5. 2006
    ....
  19. ncbi request reprint CXCR4/CD184 immunoreactivity in T-cell non-Hodgkin lymphomas with an overall Th1- Th2+ immunophenotype
    Andrew P Weng
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Pathol 119:424-30. 2003
    ..Our findings also suggest that CXCR4/CD184, which is expressed by a number of malignant neoplasms and may have a role in tumor metastasis, may have a similar function in CXCR4+ T-cell non-Hodgkin lymphomas...
  20. ncbi request reprint Characteristic expression patterns of TCL1, CD38, and CD44 identify aggressive lymphomas harboring a MYC translocation
    Scott J Rodig
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Surg Pathol 32:113-22. 2008
    ..Thus staining for TCL1, CD38, and CD44 are useful ancillary tests to identify B-cell tumors for which confirmatory cytogenetic and/or fluorescent in situ hybridization studies assessing the status of the MYC locus should be pursued...
  21. ncbi request reprint BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders
    Scott J Rodig
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 36:1113-9. 2005
    ....
  22. doi request reprint Patterns of expression of CD56 and CD117 on neoplastic plasma cells and association with genetically distinct subtypes of plasma cell myeloma
    Olga Pozdnyakova
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Leuk Lymphoma 53:1905-10. 2012
    ....
  23. doi request reprint Germinal-center T-helper-cell markers PD-1 and CXCL13 are both expressed by neoplastic cells in angioimmunoblastic T-cell lymphoma
    Hongbo Yu
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Pathol 131:33-41. 2009
    ..The similar pattern of expression of CXCL13 and PD-1 in AITL provides further evidence that AITL is a neoplasm derived from germinal-center T-helper cells...
  24. doi request reprint Single tube, six-color flow cytometric analysis is a sensitive and cost-effective technique for assaying clonal plasma cells
    Derek K Marsee
    Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Clin Pathol 133:694-9. 2010
    ..Taken together, this study demonstrates that 6-color flow cytometry is an excellent, cost-effective means to assay for clonal plasma cells in a noncontrolled patient population...
  25. ncbi request reprint Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production
    Julia A Brown
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:1257-66. 2003
    ..PD-L1 is also highly expressed on most carcinomas but minimally expressed on adjacent normal tissue suggesting a role in attenuating antitumor immune responses...
  26. ncbi request reprint Carcinoma showing thymus-like differentiation of the thyroid (CASTLE): a comparative study: evidence of thymic differentiation and solid cell nest origin
    Julie D R Reimann
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 30:994-1001. 2006
    ..Moreover CD5, HMWK, CEA and p63 can be used to help distinguish CASTLE from other thyroid neoplasms...
  27. ncbi request reprint CCR6 is a functional chemokine receptor that serves to identify select B-cell non-Hodgkin's lymphomas
    Scott J Rodig
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hum Pathol 33:1227-33. 2002
    ..Thus, CCR6 is a useful new marker identifying a subset of B-cell non-Hodgkin's lymphomas and likely contributes to the localization of select extranodal lymphomas at mucosal sites...
  28. ncbi request reprint CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells
    Henry Y Dong
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Leuk Lymphoma 43:1855-8. 2002
    ..Our findings demonstrate that CD148 and CD27 are expressed in a wide range of B cell non-Hodgkin's lymphomas, and, therefore, do not serve to distinguish between neoplastic cells of naïve and memory B cell derivation...
  29. ncbi request reprint CD69 expression correlates with expression of other markers of Th1 T cell differentiation in peripheral T cell lymphomas
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 33:330-4. 2002
    ..In addition, CD69 is a useful immunohistochemical marker for specific T cell lymphomas in frozen and paraffin-embedded tissue...
  30. ncbi request reprint Ploidy and imprinting in hydatidiform moles. Complementary use of flow cytometry and immunohistochemistry of the imprinted gene product p57KIP2 to assist molar classification
    David R Genest
    Division of Women s and Perinatal Pathology, Hematology Laboratory, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Reprod Med 47:342-6. 2002
    ..To determine whether the combination of flow cytometry and immunohistochemistry for p57 expression is useful for the pathologic classification of diagnostically challenging hydatidiform moles...
  31. ncbi request reprint Do nontriploid partial hydatidiform moles exist? A histologic and flow cytometric reevaluation of nontriploid specimens
    David R Genest
    Department of Obstetrics and Gynecology, New England Trophoblastic Disease Center, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    J Reprod Med 47:363-8. 2002
    ..To study whether nontriploid partial hydatidiform moles truly exist...
  32. doi request reprint A simplified flow cytometric immunophenotyping procedure for the diagnosis of effusions caused by epithelial malignancies
    Vinodh Pillai
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 139:672-81. 2013
    ..Flow cytometry is a useful adjunct to cytology for the diagnosis of a malignant effusion and is particularly useful if the cytologic diagnosis is atypical/suspicious or if the cytologic preparations are hypocellular or hemorrhagic...
  33. doi request reprint High-sensitivity flow cytometric analysis for the evaluation of systemic mastocytosis including the identification of a new flow cytometric criterion for bone marrow involvement
    Olga Pozdnyakova
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Amory 3, Boston, MA 02115, USA
    Am J Clin Pathol 138:416-24. 2012
    ..We conclude that flow cytometry is a sensitive and specific test for the presence of systemic mastocytosis, particularly when the presence of a discrete CD117-positive mast cell population is regarded as a diagnostic criterion...
  34. pmc Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes
    Ewa Sicinska
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 26:8052-60. 2006
    ..Collectively, these results demonstrate that cyclin D3 is an essential cell cycle recipient of G-CSF signaling, and they provide a molecular link of how G-CSF-dependent signaling triggers cell proliferation...
  35. doi request reprint Comparison of Russell viper venom-based and activated partial thromboplastin time-based screening assays for resistance to activated protein C
    Adrianna Z Herskovits
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 130:796-804. 2008
    ....
  36. ncbi request reprint The terminal ileum is affected in patients with lymphocytic or collagenous colitis
    Heidi Sapp
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Am J Surg Pathol 26:1484-92. 2002
    ..The results suggest that the terminal ileum may be involved by a similar pathogenic process as the colon in LC and CC...
  37. ncbi request reprint CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemia
    Zachary R Hunter
    Bing Program for Waldenstrom s Macroglobulinemia, Dana Farber Cancer Institute, LG102, 44 Binney Street, Boston, MA 02215, USA
    Clin Lymphoma 5:246-9. 2005
    ..These studies demonstrate that CD5, CD10, and CD23 are commonly found in WM and that their expression should not exclude the diagnosis of WM. Moreover, expression of CD23 may define a clinically distinct subset of patients with WM...
  38. doi request reprint An improved algorithm for activated protein C resistance and factor V Leiden screening
    Adrianna Z Herskovits
    Department of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Clin Pathol 140:379-86. 2013
    ..To evaluate the performance of a Russell viper venom-based activated protein C resistance (APCR) screening test relative to DNA analysis for the factor V Leiden mutation...
  39. doi request reprint Radiotherapy in the management of localized primary cutaneous B-cell lymphoma
    Itai Pashtan
    Harvard Radiation Oncology Program, Boston, MA, USA
    Leuk Lymphoma 54:726-30. 2013
    ..8 years, the 5-year overall survival rate was 100%, the relapse-free survival rate was 71% (95% confidence interval, 46-86%) and there were no local recurrences, suggesting that radiotherapy to a dose of 30 Gy may be sufficient for cure...
  40. doi request reprint A pilot surrogate endpoint biomarker study of celecoxib in oral premalignant lesions
    Lori J Wirth
    Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 1:339-48. 2008
    ..Treatment with celecoxib in subjects with OPLs favorably modulates the primary mediator of cyclooxygenase-2 activity, PGE(2), after 12 weeks...
  41. ncbi request reprint Concurrent herpes simplex viral lymphadenitis and mantle cell lymphoma: a case report and review of the literature
    Monika E Pilichowska
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Pathol Lab Med 130:536-9. 2006
    ..The recognition of herpes simplex virus infection with MCL is important for treatment as well as to rule out transformation of MCL to a higher-grade lesion...
  42. pmc Enterocolic fistula associated with an intestinal lymphoma
    Victor Wang
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    MedGenMed 9:28. 2007
  43. ncbi request reprint Normal D-dimer levels in emergency department patients suspected of acute pulmonary embolism
    Kelly L Dunn
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 40:1475-8. 2002
    ....
  44. doi request reprint Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform mole
    Fabiola Medeiros
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 27:247-51. 2008
    ....
  45. ncbi request reprint Automated flow cytometric analysis of blood cells in cerebrospinal fluid: analytic performance
    Marthe W Aune
    St Olaf s University Hospital, Trondheim, Norway
    Am J Clin Pathol 121:690-700. 2004
    ..Study results demonstrate that the automated ADVIA 120 CSF Assay is an acceptable alternative to the labor-intensive manual method...
  46. pmc Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins
    Frederick L Moore
    Department of Obstetrics, Gynecology and Reproductive Sciences, Programs in Human Genetics and Cancer Genetics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 100:538-43. 2003
    ..These data implicate PUM2 as a component of conserved cellular machinery that may be required for germ cell development...
  47. ncbi request reprint Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia
    Errol R Norwitz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Am J Obstet Gynecol 193:957-64. 2005
    ..Preeclampsia is an idiopathic multisystem disorder specific to human pregnancy. This study used proteomic analysis of cerebrospinal fluid (CSF) to identify protein biomarkers characteristic of preeclampsia and related to its severity...
  48. ncbi request reprint The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice
    Victor Boyartchuk
    Program in Gene Function and Expression, University of Massachusetts Medical School, Boston 02115, USA
    J Immunol 173:5112-20. 2004
    ..The polymorphic gene(s) encoded within the sst1 locus that controls macrophage interactions with the two intracellular pathogens remains to be elucidated...