Genomes and Genes


Alejandro A Diaz


Affiliation: Massachusetts General Hospital
Country: USA


  1. Diaz A, Come C, Ross J, San Jose Estepar R, Han M, Loring S, et al. Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest. 2012;141:736-744 pubmed publisher
    ..Distensibility of large- to medium-sized airways is reduced in subjects with an EP CT scan subtype. Emphysema seems to alter airway-parenchyma interdependence.; No.: NCT00608764; URL: ..
  2. Diaz A, Han M, Come C, San Jose Estepar R, Ross J, Kim V, et al. Effect of emphysema on CT scan measures of airway dimensions in smokers. Chest. 2013;143:687-693 pubmed publisher
    ..The greater effect of subsegmental WA% on airflow obstruction is mitigated by emphysema. Part of the emphysema effect might be due to loss of airway tethering, leading to a reduction in TBA and an increase in WA%. ..
  3. Diaz A, Martinez C, Harmouche R, Young T, McDonald M, Ross J, et al. Pectoralis muscle area and mortality in smokers without airflow obstruction. Respir Res. 2018;19:62 pubmed publisher
    ..highest PMA quartile, HR 2.25 [1.25-4.03] P = 0.007) while former smokers did not. Low muscle mass as measured on chest CT scans is associated with increased mortality in current smokers without airflow obstruction. NCT00608764. ..
  4. KLIMENT C, Araki T, Doyle T, Gao W, Dupuis J, Latourelle J, et al. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med. 2015;15:134 pubmed publisher
    ..Moreover, HAAs were not associated with MUC5B promoter genotype. ..
  5. Diaz A, Petersen H, Meek P, Sood A, Celli B, Tesfaigzi Y. Differences in Health-Related Quality of Life Between New Mexican Hispanic and Non-Hispanic White Smokers. Chest. 2016;150:869-876 pubmed publisher
    ..A perception of diminished physical functioning and impairment in daily life activities contribute to the poorer HRQL among Hispanic subjects. ..
  6. Diaz A, Valim C, Yamashiro T, Estepar R, Ross J, Matsuoka S, et al. Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers. Chest. 2010;138:880-7 pubmed publisher
    ..84 and 0.92, respectively. TAC is lower in subjects with greater emphysematous destruction and is a predictor of a high BODE index. These results suggest that CT imaging-based TAC may be a unique COPD-related phenotype in smokers. ..
  7. Diaz A, Young T, Maselli D, Martinez C, Gill R, Nardelli P, et al. Quantitative CT Measures of Bronchiectasis in Smokers. Chest. 2017;151:1255-1262 pubmed publisher
    ..QCT measures of BA ratio, WT, and WA% may be useful to objectively identify and quantify bronchiectasis in smokers.; No.: NCT00608764; URL: ..
  8. Washko G, Kinney G, Ross J, San Jose Estepar R, Han M, Dransfield M, et al. Lung Mass in Smokers. Acad Radiol. 2017;24:386-392 pubmed publisher
    ..Baseline LM predicts the decline in lung function. ..
  9. Gonzalez G, Ash S, Vegas Sanchez Ferrero G, Onieva Onieva J, Rahaghi F, Ross J, et al. Disease Staging and Prognosis in Smokers Using Deep Learning in Chest Computed Tomography. Am J Respir Crit Care Med. 2017;: pubmed publisher
    ..At a population level CNN analysis may be a powerful tool for risk assessment. ..

More Information


  1. Diaz A, Strand M, Coxson H, Ross J, San Jose Estepar R, Lynch D, et al. Disease Severity Dependence of the Longitudinal Association Between CT Lung Density and Lung Function in Smokers. Chest. 2017;: pubmed publisher
    ..CT measures of lung density might reflect lung tissue changes; however, longitudinal data regarding the effects of CT lung tissue on FEV1 in smokers with and without COPD are scarce...