Affiliation: Massachusetts General Hospital
- Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rateAaron Deykin
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 165:1597-601. 2002..07 with the fastest offline method, p = 0.46). These data indicate that the choice of expiratory flow rate and collection method can be based on practicality and patient comfort without compromising the utility of this test for asthma...
- Biomarker-driven care in asthma: are we there?Aaron Deykin
Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Bosto, MA 02115, USA
J Allergy Clin Immunol 118:565-8. 2006....
- Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroidsAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Allergy Clin Immunol 115:720-7. 2005..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
- Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthmaAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 175:228-34. 2007..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
- beta-Adrenergic receptor polymorphisms and response to salmeterolMichael E Wechsler
Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
Am J Respir Crit Care Med 173:519-26. 2006..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
- Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trialElliot Israel
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lancet 364:1505-12. 2004..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
- The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretionFiona K Gibbons
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
J Clin Immunol 25:437-44. 2005..018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response...
- Do "placebo responders" exist?Ted J Kaptchuk
Osher Research Center, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA
Contemp Clin Trials 29:587-95. 2008..Finally, this paper proposes one model to rigorously investigate the stability of placebo responses...
- Advances in lung transplantation for patients who have cystic fibrosisHilary J Goldberg
Department of Medicine, Harvard Medical School, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA
Clin Chest Med 28:445-57. 2007..This article outlines some of these challenges and describes recent advances in approaching this endeavor in patients who have CF...
- Capnogram shape in obstructive lung diseaseBaruch Krauss
Division of Emergency Medicine, Children s Hospital Boston, MA 02115, USA
Anesth Analg 100:884-8, table of contents. 2005..Differences between OD capnograms and normal and RD capnograms, correlating to changes in FEV(1), were sufficiently large enough to suggest that the capnogram could be used to discriminate between OD and normal...
- Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantationPhilip A Linden
Division of Thoracic Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
J Thorac Cardiovasc Surg 131:438-46. 2006..We evaluated the risk and physiologic effect of laparoscopic fundoplication in patients on the lung transplant waiting list...
- Prostanoid DP receptor variants and asthmaAaron Deykin
N Engl J Med 352:837-8; author reply 837-8. 2005
- Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthmaStephen C Lazarus
University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
Am J Respir Crit Care Med 175:783-90. 2007..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
- The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trialRichard J Martin
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:73-80. 2007..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
- Targeting biologic markers in asthma--is exhaled nitric oxide the bull's-eye?Aaron Deykin
N Engl J Med 352:2233-5. 2005
- Daily versus as-needed corticosteroids for mild persistent asthmaHomer A Boushey
University of California at San Francisco, San Francisco, USA
N Engl J Med 352:1519-28. 2005..Further studies are required to determine whether this novel approach to treatment should be recommended...
- Association between oxygen consumption and nitric oxide production during the relaxation responseJeffery A Dusek
Mind Body Medical Institute, 824 Boylston Street, Chestnut Hill, MA 02467, USA
Med Sci Monit 12:CR1-10. 2006..We evaluated whether depth of RR elicitation was correlated with changes in NO, as measured by percentage changes in fractional exhaled nitric oxide (F(E)NO)...