Vikram Deshpande

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    BMC Cancer 11:60. 2011
  2. ncbi request reprint Consensus statement on the pathology of IgG4-related disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 25:1181-92. 2012
  3. doi request reprint The pathology of IgG4-related disease: critical issues and challenges
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, 02114 USA
    Semin Diagn Pathol 29:191-6. 2012
  4. doi request reprint Fibrosing variant of Hashimoto thyroiditis is an IgG4 related disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Pathol 65:725-8. 2012
  5. doi request reprint Subclassification of autoimmune pancreatitis: a histologic classification with clinical significance
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Surg Pathol 35:26-35. 2011
  6. doi request reprint The clinical significance of incidental chronic colitis: a study of 17 cases
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Surg Pathol 34:463-9. 2010
  7. ncbi request reprint Endoscopic ultrasound guided fine needle aspiration biopsy of autoimmune pancreatitis: diagnostic criteria and pitfalls
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 29:1464-71. 2005
  8. doi request reprint IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material
    Vikram Deshpande
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Mod Pathol 22:1287-95. 2009
  9. doi request reprint Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Surg Pathol 34:1514-20. 2010
  10. doi request reprint Eosinophilic angiocentric fibrosis is a form of IgG4-related systemic disease
    Vikram Deshpande
    Department of Pathology, Division of Rheumatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:701-6. 2011

Detail Information

Publications88

  1. pmc Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    BMC Cancer 11:60. 2011
    ..The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined...
  2. ncbi request reprint Consensus statement on the pathology of IgG4-related disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 25:1181-92. 2012
    ..As the spectrum of this disease continues to expand, we advocate the use of strict criteria for accepting newly proposed entities or sites as components of the IgG4-related disease spectrum...
  3. doi request reprint The pathology of IgG4-related disease: critical issues and challenges
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, 02114 USA
    Semin Diagn Pathol 29:191-6. 2012
    ..This review aims to provide the histopathologist with a set of practical guidelines for the diagnosis of IgG4-RD, and also addresses the many controversies associated with the diagnostic aspects of this disease...
  4. doi request reprint Fibrosing variant of Hashimoto thyroiditis is an IgG4 related disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Pathol 65:725-8. 2012
    ..Although a proportion of cases of HT show elevated numbers of IgG4 positive plasma cells, these cases lack the histological features typically associated with IgG4-RD, and thus the relationship between HT and IgG4-RD remains unproven...
  5. doi request reprint Subclassification of autoimmune pancreatitis: a histologic classification with clinical significance
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Surg Pathol 35:26-35. 2011
    ..On the basis of these significant differences between the 2 types of AIP, we advocate the position that all subsequent studies attempt to substratify their patients into these 2 groups...
  6. doi request reprint The clinical significance of incidental chronic colitis: a study of 17 cases
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Surg Pathol 34:463-9. 2010
    ..In this study, we report the clinical, histologic, and follow-up data on 17 cases of histologically documented cases of chronic colitis in which a definitive etiologic factor could not be identified...
  7. ncbi request reprint Endoscopic ultrasound guided fine needle aspiration biopsy of autoimmune pancreatitis: diagnostic criteria and pitfalls
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 29:1464-71. 2005
    ....
  8. doi request reprint IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material
    Vikram Deshpande
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Mod Pathol 22:1287-95. 2009
    ..On a liver biopsy, the histological features of IgG4-associated cholangitis may be distinctive, and in conjunction with IgG4 immunohistochemical stain, may help distinguish this disease from primary sclerosing cholangitis...
  9. doi request reprint Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Surg Pathol 34:1514-20. 2010
    ..The morphologic and immunohistochemical similarity to pancreatic solid pseudopapillary neoplasm facilitates the accurate diagnosis of this rare ovarian neoplasm...
  10. doi request reprint Eosinophilic angiocentric fibrosis is a form of IgG4-related systemic disease
    Vikram Deshpande
    Department of Pathology, Division of Rheumatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:701-6. 2011
    ..After the serendipitous observation of an elevated serum concentration of IgG4 in 1 patient with EAF, we investigated the hypothesis that EAF is an IgG4-related systemic disease...
  11. ncbi request reprint Intraosseous benign notochord cell tumors (BNCT): further evidence supporting a relationship to chordoma
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 31:1573-7. 2007
    ..To further investigate the relationship between BNCT and classic chordoma, we reviewed a large series of resected sacral/coccygeal chordomas in an attempt to identify the presence of coexisting BNCTs...
  12. ncbi request reprint Analysis of atypical urine cytology in a tertiary care center
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 105:468-75. 2005
    ..The objective of the current study was to evaluate retrospectively a large series of voided urine specimens that were reported as atypical. Standard cytomorphologic parameters were used with the aim of refining the atypical category...
  13. ncbi request reprint Cystic pancreatic endocrine tumor: a variant commonly confused with cystic adenocarcinoma
    Vikram Deshpande
    Department of Pathology, Cytology and Gastrointestinal Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer 111:47-53. 2007
    ..In the authors' experience, FNAB of cystic pancreatic endocrine tumors (PETs) frequently causes diagnostic difficulties, partly because of unexpected overlapping features with cystic ductal adenocarcinomas...
  14. ncbi request reprint Autoimmune pancreatitis: more than just a pancreatic disease? A contemporary review of its pathology
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 129:1148-54. 2005
    ..Autoimmune pancreatitis (AIP) is a chronic inflammatory condition of the pancreas constituting one quarter of Whipple resections performed for benign conditions in North America...
  15. doi request reprint CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Mod Pathol 23:54-61. 2010
    ....
  16. pmc Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term patient outcomes
    Alex B Haynes
    Department of Surgery, Massachusetts General Hospital, Wang Ambulatory Care Center 460, 15 Parkman St, Boston, MA 02114, USA
    Arch Surg 146:534-8. 2011
    ..To describe the characteristics and outcomes after resection of incidentally discovered, nonfunctioning pancreatic endocrine tumors (PETs)...
  17. doi request reprint Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations
    Darcy A Kerr
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Am J Surg Pathol 37:787-95. 2013
    ..The presence of IDH1/2 mutations can also help confirm the diagnosis of dedifferentiated chondrosarcoma when the tumor displays osteosarcomatous differentiation...
  18. pmc Does the mechanism of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma?
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    J Gastrointest Surg 14:261-7. 2010
    ..Lymph node metastases are prognostically significant in pancreatic ductal adenocarcinoma. Little is known about the significance of direct lymph node invasion...
  19. ncbi request reprint IgG4+ to IgG+ plasma cells ratio of ampulla can help differentiate autoimmune pancreatitis from other "mass forming" pancreatic lesions
    Alireza Sepehr
    Department of Pathology, Gastrointestinal Pathology Service, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 32:1770-9. 2008
    ..In conclusion, evaluation of ampullary histology and IgG4/IgG ratio might be proven beneficial in discriminating AIP from other mass forming pancreatic lesions...
  20. doi request reprint Endoscopic surveillance of patients with hereditary diffuse gastric cancer: biopsy recommendations after topographic distribution of cancer foci in a series of 10 CDH1-mutated gastrectomies
    Hiroshi Fujita
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2696, USA
    Am J Surg Pathol 36:1709-17. 2012
    ..Our results argue for the incorporation of cancer focus distribution into any biopsy protocol, although detection is likely to remain extremely low, and they call into question the validity of endoscopic surveillance...
  21. doi request reprint Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a "true" R0 resection?
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Surg 257:731-6. 2013
    ..Our aim was to compare the survival of patients undergoing an R1 resection with those having LA tumors and to explore the prognostic significance of a 1-mm surgical margin...
  22. pmc Pancreatic ductal adenocarcinoma: long-term survival does not equal cure
    Cristina R Ferrone
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Surgery 152:S43-9. 2012
    ..Our aim was to identify the prognostic factors for long-term survival after resection of pancreatic ductal adenocarcinoma related to patients, treatments, and tumor biology...
  23. doi request reprint Comparative performance of MDCT and MRI with MR cholangiopancreatography in characterizing small pancreatic cysts
    Nisha I Sainani
    Division of Abdominal Imaging and Interventional Radiology, Department of Radiology, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114 2696, USA
    AJR Am J Roentgenol 193:722-31. 2009
    ..The objective of our study was to compare MDCT with MRI-MR cholangiopancreatography (MRCP) in characterizing small pancreatic cysts (< or = 3 cm) and predicting aggressiveness...
  24. doi request reprint Autoimmune pancreatitis-related cholecystitis: a morphologically and immunologically distinctive form of lymphoplasmacytic sclerosing cholecystitis
    Wei Lia Wang
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Histopathology 54:829-36. 2009
    ..The aim was to identify unique morphological and immunological features that could help distinguish gallbladders of AIP from those associated with PSC and PDACs...
  25. ncbi request reprint Autoimmune pancreatitis: a systemic immune complex mediated disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 30:1537-45. 2006
    ..Documentation of increased numbers of tissue IgG4 positive plasma cells, although not an entirely specific marker for AIP, may provide ancillary evidence for the diagnosis of a IgG4-related systemic disease...
  26. doi request reprint Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 144:441-7; discussion 447. 2009
    ....
  27. doi request reprint Leiomyoma of the gastrointestinal tract with interstitial cells of Cajal: a mimic of gastrointestinal stromal tumor
    Anita Deshpande
    Department of Pathology and Laboratory Medicine, Boston Medical Center Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA Department of Pathology, Oregon Health and Science University, Portland, OR
    Am J Surg Pathol 38:72-7. 2014
    ..ICCs are also identified in gastric and intestinal LMs, albeit in a smaller proportion of cases. Colonization and hyperplasia by non-neoplastic ICCs likely account for this phenomenon. ..
  28. doi request reprint Cystic pancreatic endocrine neoplasms: a distinct tumor type?
    Liliana Bordeianou
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Am Coll Surg 206:1154-8. 2008
    ..This study aims to describe the characteristics of CPENs in a large patient cohort...
  29. doi request reprint Does autoimmune pancreatitis increase the risk of pancreatic carcinoma?: a retrospective analysis of pancreatic resections
    Rajib Gupta
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Pancreas 42:506-10. 2013
    ..To estimate the risk of malignancy in autoimmune pancreatitis (AIP)...
  30. doi request reprint Chronic sclerosing sialadenitis (Küttner tumor) is an IgG4-associated disease
    Julia Turbiner Geyer
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 34:202-10. 2010
    ....
  31. ncbi request reprint Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease
    Lynn D Cornell
    Departments of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 31:1586-97. 2007
    ....
  32. ncbi request reprint Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma
    Stefan Fritz
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Surg 249:440-7. 2009
    ..To determine whether intraductal papillary mucinous neoplasms of the pancreas (IPMNs) have a different genetic background compared with ductal adenocarcinoma (PDAC)...
  33. doi request reprint Autoimmune pancreatitis: disease evolution, staging, response assessment, and CT features that predict response to corticosteroid therapy
    Dushyant V Sahani
    Department of Radiology, Massachusetts General Hospital Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114, USA
    Radiology 250:118-29. 2009
    ..To evaluate the evolution of morphologic features of autoimmune pancreatitis (AIP) at computed tomography (CT) and to identify imaging features that can predict AIP response to corticosteroid therapy (CST)...
  34. doi request reprint Autoimmune pancreatitis: a guide for the histopathologist
    Shweta Shinagare
    Department of Pathology, Tufts Medical Center, Boston, Massachusetts, USA
    Semin Diagn Pathol 29:197-204. 2012
    ..This review highlights the clinical and pathological differences between the 2 forms of AIP. We also review guidelines that assist in distinguishing AIP from its closest mimic, pancreatic adenocarcinoma...
  35. doi request reprint IgG4-related systemic disease as a cause of "idiopathic" orbital inflammation, including orbital myositis, and trigeminal nerve involvement
    Zachary S Wallace
    Department of Medicine, Harvard Medical School, Cambridge, Massachusetts, USA
    Surv Ophthalmol 57:26-33. 2012
    ..We review the differential of idiopathic orbital inflammatory disease, including IgG4-RD, and emphasize the need for biopsy for accurate diagnosis and to guide appropriate treatment...
  36. doi request reprint Rituximab for the treatment of IgG4-related disease: lessons from 10 consecutive patients
    Arezou Khosroshahi
    Rheumatology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Medicine (Baltimore) 91:57-66. 2012
    ..Serum IgG4 concentrations may remain low, and clinical disease activity may remain quiescent even after B cell reconstitution in a significant proportion of patients...
  37. pmc Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Gut 60:1712-20. 2011
    ..The authors investigate the clinicopathological characteristics and the impact on survival of both the invasive component and its background IPMN...
  38. doi request reprint Novel endoscopic therapeutic modalities for superficial neoplasms arising in Barrett's esophagus: a primer for surgical pathologists
    Gregory Y Lauwers
    Gastrointestinal Pathology Unit, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 USA
    Mod Pathol 22:489-98. 2009
    ....
  39. doi request reprint Pseudocyst of the pancreas: the role of cytology and special stains for mucin
    Elvira Gonzalez Obeso
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cancer 117:101-7. 2009
    ..In this study, the authors explored the cytomorphologic features of pseudocyst of the pancreas and evaluated the role of Alcian blue and mucicarmine stains in the cytologic evaluation of pancreatic cysts...
  40. doi request reprint Serous cystadenoma of the pancreas: limitations and pitfalls of endoscopic ultrasound-guided fine-needle aspiration biopsy
    Nicole A Belsley
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 114:102-10. 2008
    ..In the current study, the authors evaluated the diagnostic sensitivity of endoscopic ultrasound (EUS)-guided fine-needle aspiration biopsy (FNAB) and cross-sectional imaging for SCA...
  41. doi request reprint IgG4-related disease and hypertrophic pachymeningitis
    Zachary S Wallace
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Medicine (Baltimore) 92:206-16. 2013
    ..This case series demonstrates that IgG4-RD may be the most common etiology of noninfectious HP and highlights the necessity of biopsy for accurate diagnosis. ..
  42. pmc Improved contemporary surgical management of insulinomas: a 25-year experience at the Massachusetts General Hospital
    Mehrdad Nikfarjam
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Ann Surg 247:165-72. 2008
    ..To determine changes in the management strategy of patients with insulinomas and identify critical factors in patient outcome...
  43. doi request reprint Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions with mural nodules
    Tze S Khor
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02478, USA
    Am J Surg Pathol 36:1579-91. 2012
    ..These findings provide preliminary evidence that ACAs represent a cystic neoplastic lesion...
  44. pmc Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers
    David T Ting
    Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    Science 331:593-6. 2011
    ..The overexpression of satellite transcripts in cancer may reflect global alterations in heterochromatin silencing and could potentially be useful as a biomarker for cancer detection...
  45. doi request reprint The Clinical and Pathological Features of IgG(4)-Related Disease
    Arezou Khosroshahi
    Rheumatology Unit Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Curr Rheumatol Rep 13:473-81. 2011
    ..This paper focuses on the clinical and pathological features of IgG(4)-RD...
  46. doi request reprint Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum
    Mollie Dahlgren
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arthritis Care Res (Hoboken) 62:1312-8. 2010
    ..IgG4-related systemic disease is characterized by IgG4+ plasma cell infiltration and fibrosis throughout many organs. We hypothesized that Riedel's thyroiditis is part of the IgG4-related systemic disease spectrum...
  47. doi request reprint Cholesterol crystal embolization presenting as either solid or cystic pancreatic lesion
    Ioannis T Konstantinidis
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Surg Oncol 102:706-8. 2010
    ..CCE should be considered in patients with significant vascular disease, arrhythmias or vascular manipulation who present with a pancreatic mass...
  48. doi request reprint A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma
    Theodore S Hong
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Electronic address
    Int J Radiat Oncol Biol Phys . 2014
    ..To evaluate the safety, efficacy and biomarkers of short-course proton beam radiation and capecitabine, followed by pancreaticoduodenectomy in a phase 1/2 study in pancreatic ductal adenocarcinoma (PDAC) patients...
  49. ncbi request reprint Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005
    Parsia A Vagefi
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 142:347-54. 2007
    ..To assess changing patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms (PNENs)...
  50. doi request reprint Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway
    He Wang
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Mod Pathol 26:139-47. 2013
    ..Further analysis of signaling pathways is critical for designing clinical trials in gastroenteropancreatic neuroendocrine tumors...
  51. doi request reprint Rethinking Ormond's disease: "idiopathic" retroperitoneal fibrosis in the era of IgG4-related disease
    Arezou Khosroshahi
    Rheumatology Unit, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Medicine (Baltimore) 92:82-91. 2013
    ..Elevated IgG4/total IgG ratios in tissue biopsies are more useful than the number of IgG4+ plasma cells per high-power field in cases of RPF that are highly fibrotic...
  52. pmc TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression
    Aram F Hezel
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 72:4840-5. 2012
    ..Therefore, our findings indicate that αvβ6 and TGF-β act in a common tumor suppressor pathway whose pharmacologic inactivation promotes pancreatic cancer progression...
  53. doi request reprint Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy
    Nils D Arvold
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 83:e337-43. 2012
    ..The role of adjuvant radiotherapy (RT) in these patients has not been characterized...
  54. pmc STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis
    Ryan B Corcoran
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Cancer Res 71:5020-9. 2011
    ..Moreover, our work suggests that gp130 and phospho-STAT3 expression may be effective biomarkers for predicting response to JAK2 inhibitors...
  55. doi request reprint Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease
    Arezou Khosroshahi
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:1755-62. 2010
    ..This study was performed to assess the clinical and serologic responses to B lymphocyte depletion therapy with rituximab in patients with IgG4-RSD...
  56. pmc Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma: radiologic-pathologic correlation
    Anjuli A Shah
    Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Boston, MA 02114, United States
    World J Gastroenterol 15:2739-47. 2009
    ..To identify multi-detector computed tomography (MDCT) features most predictive of serous cystadenomas (SCAs), correlating with histopathology, and to study the impact of cyst size and MDCT technique on reader performance...
  57. doi request reprint Peutz-Jeghers syndrome: a critical look at colonic Peutz-Jeghers polyps
    Julie Y Tse
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 26:1235-40. 2013
    ....
  58. doi request reprint Epithelioid hemangioma of bone revisited: a study of 50 cases
    G Petur Nielsen
    Department of Pathology and James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 33:270-7. 2009
    ..Epithelioid hemangioma of bone is a benign lesion that may be multifocal and affect separate tissue and is successfully treated with curettage or marginal en bloc excision...
  59. doi request reprint IgG4-related disease in the head and neck
    Judith A Ferry
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Boston, Massachusetts, USA
    Semin Diagn Pathol 29:235-44. 2012
    ..In this review, we discuss the histologic and immunohistochemical features of IgG4-related disease of the head and neck and provide guidance for distinguishing this disease from its many mimics...
  60. doi request reprint Cystic papillary pattern in pancreatic ductal adenocarcinoma: a heretofore undescribed morphologic pattern that mimics intraductal papillary mucinous carcinoma
    Paul J Kelly
    Department of Pathology, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Am J Surg Pathol 36:696-701. 2012
    ..In this report we describe our experience with a heretofore undescribed histologic pattern of pancreatic adenocarcinoma that mimics intraductal papillary mucinous carcinoma, both morphologically and radiologically...
  61. ncbi request reprint Cytological and cyst fluid analysis of small (< or =3 cm) branch duct intraductal papillary mucinous neoplasms adds value to patient management decisions
    Martha Bishop Pitman
    James Homer Wright Pathology Laboratories and Cytopathology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pancreatology 8:277-84. 2008
    ..The aim of our study was to compare this proposed algorithm to one that incorporates cytology with less than malignant epithelial cells and cyst fluid carcinoembryonic antigen (CEA)...
  62. ncbi request reprint Cytokeratin 19 is a powerful predictor of survival in pancreatic endocrine tumors
    Vikram Deshpande
    Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 28:1145-53. 2004
    ..We hypothesize that a subgroup of PETs may share a common histogenesis with pancreatic adenocarcinomas...
  63. doi request reprint Well-differentiated osteosarcoma of the jaw bones: a clinicopathologic study of 15 cases
    Elizabeth G Demicco
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 34:1647-55. 2010
    ..Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent...
  64. doi request reprint Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Am J Surg Pathol 34:300-13. 2010
    ..Examination of the areas of disagreement reveals significant opportunities for collaborative study to resolve unanswered questions...
  65. doi request reprint Autoimmune pancreatitis-related diabetes: quantitative analysis of endocrine islet cells and inflammatory infiltrate
    Alton B Farris
    Department of Pathology, Emory University Hospital, Atlanta, GA 30322, USA
    Virchows Arch 457:329-36. 2010
    ..Endocrine cell neogenesis and relative islet preservation despite islet inflammatory infiltration may explain the paradoxical GCI in AIP...
  66. doi request reprint Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 32:524-33. 2008
    ..4%) of GED (P = 0.005 for both comparisons). In conclusion, our study indicates that foveolar and adenomatous types of GED have distinct clinicopathologic features, mucin profiles, and association with different types of IM...
  67. pmc KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs
    Alexandros Tzatsos
    Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA
    J Clin Invest 123:727-39. 2013
    ..These results defined epigenetic programs through which KDM2B subverts cellular differentiation and drives the pathogenesis of an aggressive subset of PDAC...
  68. ncbi request reprint Autoimmune pancreatitis
    Dmitry L Finkelberg
    Department of Medicine Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 355:2670-6. 2006
  69. pmc Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
    Darrell R Borger
    Division of Hematology Oncology, Massachusetts General Hospital, Boston 02114 2698, USA
    Oncologist 17:72-9. 2012
    ..These findings define a specific metabolic abnormality in this largely incurable type of gastrointestinal cancer and present a potentially new target for therapy...
  70. ncbi request reprint Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps
    Alton B Farris
    Department of Pathology, Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 32:30-5. 2008
    ..However, this level of variability is acceptable because the presence of SSA indicates increased risk of developing additional serrated polyps and carcinoma, and surveillance is appropriate...
  71. doi request reprint IgG4-related systemic disease accounts for a significant proportion of thoracic lymphoplasmacytic aortitis cases
    John H Stone
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Arthritis Care Res (Hoboken) 62:316-22. 2010
    ..We aimed to determine the percentage of noninfectious thoracic aortitis cases that are associated with IgG4-related systemic disease and to establish pathologic criteria for identifying involvement of the thoracic aorta by this disorder...
  72. doi request reprint Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis
    Eva Maria Duerr
    Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Endocr Relat Cancer 15:243-56. 2008
    ..This suggests that molecular profiling may enhance tumor classification schemes. Potential gene targets have also been identified, and PDGFR and RET are candidates that may represent novel therapeutic targets...
  73. doi request reprint Gastric hyperplastic polyps: a heterogeneous clinicopathologic group including a distinct subset best categorized as mucosal prolapse polyp
    Elvira Gonzalez-Obeso
    Department, Hospital General de Ciudad Real, Ciudad Real, Spain
    Am J Surg Pathol 35:670-7. 2011
    ..Gastric hyperplastic polyps are the second most common subtype of gastric polyps. There has been an ongoing debate about their precise diagnostic criteria and etiological associations...
  74. ncbi request reprint Epithelioid angiosarcoma of the bone: a series of 10 cases
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Surg Pathol 27:709-16. 2003
    ....
  75. pmc Development of an IgG4-RD Responder Index
    Mollie N Carruthers
    Rheumatology Unit, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Rheumatol 2012:259408. 2012
    ..This paper describes the philosophy and goals of the IgG4-RD RI, the steps in the development of this instrument to date, and future plans for validation of this instrument as an outcome measure...
  76. ncbi request reprint Ductulo-insular pancreatic endocrine neoplasms: clinicopathologic analysis of a unique subtype of pancreatic endocrine neoplasms
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 27:461-8. 2003
    ..We conclude that DI-PETs are not uncommon and that they are biologically similar to other PETs. We also hypothesize that the ductal cells develop by transdifferentiation of the endocrine cells...
  77. pmc Recurrent chromosomal copy number alterations in sporadic chordomas
    Long Phi Le
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18846. 2011
    ..Sporadic chordomas may rely on mechanisms other than copy number gain if they indeed exploit T/brachyury for proliferation...
  78. doi request reprint Case records of the Massachusetts General Hospital. Case 16-2008. A 46-year-old woman with bone pain
    Marie B Demay
    Endocrine Unit, Massachusetts General Hospital, USA
    N Engl J Med 358:2266-74. 2008
  79. ncbi request reprint Buried dysplasia and early adenocarcinoma arising in barrett esophagus after porfimer-photodynamic therapy
    Mari Mino-Kenudson
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 31:403-9. 2007
    ..Thorough endoscopic surveillance with extensive biopsies, especially of the sites previously positive for neoplasia is important to avoid overlooking buried neoplasms that may progress...
  80. ncbi request reprint False-negative core needle biopsies of the breast: an analysis of clinical, radiologic, and pathologic findings in 27 concecutive cases of missed breast cancer
    Varsha I Shah
    Department of Pathology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Cancer 97:1824-31. 2003
    ..However, the discordance may not be recognized, resulting in a logistic delay in the diagnosis...
  81. pmc Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma
    Michael R O'Dell
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Cancer Res 72:1557-67. 2012
    ..These findings establish a new genetically and histopathologically faithful model of IHCC and lend experimental support to the hypothesis that IPBN and VMC are precursors to invasive cancers...
  82. ncbi request reprint Cytomorphological correlates of epidermal growth factor receptor mutations in lung carcinoma
    Elena F Brachtel
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Diagn Cytopathol 35:257-62. 2007
    ..Cytomorphological features could serve as an adjunctive predictive marker of response to TKIs and possibly to other new therapies in development...
  83. pmc Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma
    Ruben Plentz
    Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 136:1741-9.e6. 2009
    ..We investigated the role of this pathway in PDAC progression...
  84. doi request reprint Usefulness of EMA, GLUT-1, and XIAP for the cytologic diagnosis of malignant mesothelioma in body cavity fluids
    Jian Shen
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Clin Pathol 131:516-23. 2009
    ..EMA demonstrated the best accuracy, with an area under the curve of 0.91 as compared with XIAP (0.67), GLUT-1m (0.74), and GLUT-1p (0.80). Based on these findings, EMA is a better marker than XIAP or GLUT-1 for the diagnosis of MM...
  85. doi request reprint Anal canal duplication associated with presacral cyst
    Johannes R Kratz
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Pediatr Surg 43:1749-52. 2008
    ..This is an unusual presentation of an already rare entity. An overview of the clinical presentation, radiologic workup, surgical treatment, and histologic features of anal canal duplications is provided...
  86. ncbi request reprint Intramuscular juvenile xanthogranuloma: sonographic and MR findings
    James K David
    Division of Pediatric Radiology, Department of Radiology, Massachusetts General Hospital, 34 Fruit Street, White 246, Boston 02114, USA
    Pediatr Radiol 33:203-6. 2003
    ..Juvenile xanthogranuloma is a rare benign lesion, most often cutaneous or subcutaneous, and found in infants...
  87. ncbi request reprint Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis
    Ian Brown
    Sullivan Nicolaides Pathology, Taringa, Queensland, Australia
    Arch Pathol Lab Med 130:1020-5. 2006
    ..A wide variety of immunologic stimuli can raise intraepithelial lymphocyte numbers. Among the other common associations are enteric infection, autoimmune disease, drugs, and gastric Helicobacter infection...
  88. ncbi request reprint Case record of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 2-2003. A 60-year-old man with mild congestive heart failure of uncertain cause
    Peter M Yurchak
    N Engl J Med 348:243-9. 2003