Research Topics
| Akshay DesaiSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Hyperkalemia in patients with heart failure: incidence, prevalence, and managementAkshay S Desai
Advanced Heart Disease Section, PBB A3 AB370, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Curr Heart Fail Rep 6:272-80. 2009....- Central aortic stiffness is increased in patients with heart failure and preserved ejection fractionAkshay S Desai
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
J Card Fail 15:658-64. 2009..Although heart failure in hypertensive patients is usually ascribed to intrinsic myocardial abnormalities, noncardiac factors may contribute... - Implantable defibrillators for the prevention of mortality in patients with nonischemic cardiomyopathy: a meta-analysis of randomized controlled trialsAkshay S Desai
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
JAMA 292:2874-9. 2004..However, conclusive evidence of survival benefit in patients with nonischemic cardiomyopathy (NICM) is still lacking... - Diabetes and heart failure: epidemiology, pathophysiology and managementAkshay S Desai
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, USA
Indian Heart J 57:295-303. 2005 - Impact of erythropoiesis-stimulating agents on morbidity and mortality in patients with heart failure: an updated, post-TREAT meta-analysisAkshay Desai
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
Eur J Heart Fail 12:936-42. 2010..We therefore examined the effect of treating anaemia with an ESA in patients with heart failure in a meta-analysis of randomized clinical trials, including the recently reported TREAT study... - Current understanding of heart failure with preserved ejection fractionAkshay Desai
Advanced Herat Disease Section, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02445, USA
Curr Opin Cardiol 22:578-85. 2007.... - Incidence and predictors of hyperkalemia in patients with heart failure: an analysis of the CHARM ProgramAkshay S Desai
Department of Cardiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 50:1959-66. 2007..We explored the incidence and predictors of hyperkalemia in a broad population of heart failure patients... - Heart failure with preserved ejection fraction: hypertension, diabetes, obesity/sleep apnea, and hypertrophic and infiltrative cardiomyopathyAkshay Desai
Brigham and Women s Hospital, Boston, MA 02115, USA
Heart Fail Clin 4:87-97. 2008..The article concludes with a brief discussion of "primary" diastolic HF due to infiltrative or restrictive cardiomyopathies... - Rationale and design of the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial: a randomized, controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fractionAkshay S Desai
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Am Heart J 162:966-972.e10. 2011..Aldosterone, a potent stimulator of myocardial and vascular fibrosis, may be a key mediator of HF progression in this population and is therefore an important therapeutic target... - Effect of intensive versus standard blood pressure lowering on diastolic function in patients with uncontrolled hypertension and diastolic dysfunctionScott D Solomon
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Hypertension 55:241-8. 2010.... - Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertensionAnne Catherine Pouleur
Brigham and Women s Hospital, Boston, MA 02115, USA
J Renin Angiotensin Aldosterone Syst 12:483-90. 2011..High circulating aldosterone levels stimulate myocardial fibrosis and left ventricular hypertrophy (LVH). However, it is not clear whether suppression of aldosterone directly contributes to LVH regression in hypertensive patients... - Highlights from the 57th annual scientific session of the American College of CardiologyFrederic S Resnic
Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02492, USA
J Thorac Cardiovasc Surg 136:244-7. 2008 - Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees PDavid A Morrow
TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am Heart J 158:335-341.e3. 2009..Because SCH 530348 does not interfere with other pathways for hemostasis, it is possible that SCH 530348 reduces thrombosis with less increase in bleeding than do other potent antiplatelet agents... - Images in clinical medicine. Spontaneous thrombolysis of an obstructed mechanical aortic valveNicole Wake
Brigham and Women's Hospital, Boston, MA 02115, USA
N Engl J Med 358:e31. 2008 - Patient expectations from implantable defibrillators to prevent death in heart failureGarrick C Stewart
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Card Fail 16:106-13. 2010..This study examined patient expectations from ICDs for primary prevention of sudden death in HF... - Images in cardiovascular medicine. Isolated right ventricular infarction resulting from occlusion of a nondominant right coronary arteryShawn A Gregory
Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Yawkey Center-Suite 5800, 55 Fruit St, Boston, MA 02114, USA
Circulation 110:e500-1. 2004 - Impaired skeletal muscle glucose uptake by [18F]fluorodeoxyglucose-positron emission tomography in patients with peripheral artery disease and intermittent claudicationReena L Pande
Brigham and Women s Hospital, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 31:190-6. 2011..We aimed to determine whether skeletal muscle glucose uptake, assessed by [(18)F]fluorodeoxyglucose positron emission tomography, is reduced in patients with claudication... - EXCEED: Exforge-intensive control of hypertension to evaluate efficacy in diastolic dysfunction: study rationale, design, and participant characteristicsAmira Hassanein
Brigham and Women s Hospital, Cardiovascular Division, Echo Core lab, Boston, MA 02115, USA
Ther Adv Cardiovasc Dis 3:429-39. 2009..Both diastolic dysfunction and increased vascular stiffness represent important measures of target-organ damage in hypertension. Whether intensive blood pressure (BP) control can further improve these measures remains unknown... - The effect of renin-angiotensin system inhibitors on mortality and heart failure hospitalization in patients with heart failure and preserved ejection fraction: a systematic review and meta-analysisRavi V Shah
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
J Card Fail 16:260-7. 2010.... - Economic consequences of routine coronary angiography in low- and intermediate-risk patients with unstable angina pectorisAkshay S Desai
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Am J Cardiol 92:363-7. 2003.... - Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunctionScott D Solomon
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
Eur Heart J 32:1227-34. 2011.... - Clinical predictors of hepatic fibrosis in chronic advanced heart failureJill M Gelow
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
Circ Heart Fail 3:59-64. 2010..We investigated the histopathologic spectrum of liver disease in a contemporary population with heart failure to identify the clinical correlates of hepatic fibrosis... - Therapeutic approaches to diastolic dysfunctionRajesh Janardhanan
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Curr Hypertens Rep 11:283-91. 2009.... - The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patientsLisa M Mielniczuk
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Card Fail 14:388-93. 2008..In chronic heart failure (HF), diuretic doses increase as the disease progresses, often after hospitalization for instability, and have been associated with worsening renal function and increased mortality... - Selecting patients for discussion of the ICD as primary prevention for sudden death in heart failureLynne Warner Stevenson
Advanced Heart Disease Section, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
J Card Fail 12:407-12. 2006..These estimates are presented in the context of adverse events, including unnecessary shocks, and the possibility that circumstances may arise for which the defibrillator may be inactivated to allow natural death...