Francesca Demichelis

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi An automated procedure to properly handle digital images in large scale tissue microarray experiments
    Francesca Demichelis
    ITC-irst, SRA Division, Bioinformatics Group, Via Sommarive 18, 38050 Povo, Trento, Italy
    Comput Methods Programs Biomed 79:197-208. 2005
  2. ncbi The role of SPINK1 in ETS rearrangement-negative prostate cancers
    Scott A Tomlins
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:519-28. 2008
  3. ncbi Internet-based Profiler system as integrative framework to support translational research
    Robert Kim
    Department of Pathology, Brigham and Women s Hospital, Boston, USA
    BMC Bioinformatics 6:304. 2005
  4. ncbi A hierarchical Naïve Bayes Model for handling sample heterogeneity in classification problems: an application to tissue microarrays
    Francesca Demichelis
    Bionformatics, SRA, ITC irst and Dept of Information and Communication Technology, University of Trento, Trento, Italy
    BMC Bioinformatics 7:514. 2006
  5. ncbi Digital storage of glass slides for quality assurance in histopathology and cytopathology
    Francesca Demichelis
    ITC irst, Telemedicine and Medical Informatics Laboratory, Trento, Italy
    J Telemed Telecare 8:138-42. 2002
  6. ncbi M-CAM expression as marker of poor prognosis in epithelial ovarian cancer
    Daniela Aldovini
    Department of Pathology, S Chiara Hospital, Trento, Italy
    Int J Cancer 119:1920-6. 2006
  7. ncbi TMABoost: an integrated system for comprehensive management of tissue microarray data
    Francesca Demichelis
    Bioinformatics Group, Automated Reasoning Systems Division, Centre for Scientific and Technological Research, Italy
    IEEE Trans Inf Technol Biomed 10:19-27. 2006
  8. ncbi Defining aggressive prostate cancer using a 12-gene model
    Tarek A Bismar
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Neoplasia 8:59-68. 2006
  9. ncbi Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer
    Sunita R Setlur
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    J Natl Cancer Inst 100:815-25. 2008
  10. ncbi Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer
    Kirsten D Mertz
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Int J Cancer 123:569-76. 2008

Collaborators

Detail Information

Publications17

  1. ncbi An automated procedure to properly handle digital images in large scale tissue microarray experiments
    Francesca Demichelis
    ITC-irst, SRA Division, Bioinformatics Group, Via Sommarive 18, 38050 Povo, Trento, Italy
    Comput Methods Programs Biomed 79:197-208. 2005
    ..Algorithm accuracy tests and assessment of working constraints are discussed. Our approach speeds up TMA data collection and enables large scale investigation...
  2. ncbi The role of SPINK1 in ETS rearrangement-negative prostate cancers
    Scott A Tomlins
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:519-28. 2008
    ..We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers...
  3. ncbi Internet-based Profiler system as integrative framework to support translational research
    Robert Kim
    Department of Pathology, Brigham and Women s Hospital, Boston, USA
    BMC Bioinformatics 6:304. 2005
    ..The Profiler system allows investigator to reliably track, store, and evaluate TMA experiments. Here within we describe the process that has evolved through an empirical basis over the past 5 years at two academic institutions...
  4. ncbi A hierarchical Naïve Bayes Model for handling sample heterogeneity in classification problems: an application to tissue microarrays
    Francesca Demichelis
    Bionformatics, SRA, ITC irst and Dept of Information and Communication Technology, University of Trento, Trento, Italy
    BMC Bioinformatics 7:514. 2006
    ..The aim of this paper is to provide and validate a classification model taking into consideration the uncertainty associated with measuring replicate samples...
  5. ncbi Digital storage of glass slides for quality assurance in histopathology and cytopathology
    Francesca Demichelis
    ITC irst, Telemedicine and Medical Informatics Laboratory, Trento, Italy
    J Telemed Telecare 8:138-42. 2002
    ..Use of virtual slides should encourage the diffusion of national quality assurance programmes, which at present suffer from certain organizational and logistical limitations...
  6. ncbi M-CAM expression as marker of poor prognosis in epithelial ovarian cancer
    Daniela Aldovini
    Department of Pathology, S Chiara Hospital, Trento, Italy
    Int J Cancer 119:1920-6. 2006
    ..In particular, M-CAM expression identifies a subgroup of front-line therapy-responding patients who undergo dramatic relapses, thus helping to better select patients who might benefit from new/alternative therapeutic modalities...
  7. ncbi TMABoost: an integrated system for comprehensive management of tissue microarray data
    Francesca Demichelis
    Bioinformatics Group, Automated Reasoning Systems Division, Centre for Scientific and Technological Research, Italy
    IEEE Trans Inf Technol Biomed 10:19-27. 2006
    ..In this paper, we present the architecture and the components of this system...
  8. ncbi Defining aggressive prostate cancer using a 12-gene model
    Tarek A Bismar
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Neoplasia 8:59-68. 2006
    ..0015). This study demonstrates that cross-platform models can lead to predictive models with the possible advantage of being more robust through this selection process...
  9. ncbi Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer
    Sunita R Setlur
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    J Natl Cancer Inst 100:815-25. 2008
    ....
  10. ncbi Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer
    Kirsten D Mertz
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Int J Cancer 123:569-76. 2008
    ..Distinct molecular subtypes of ccRCC with prognostic relevance were identified, and the CK7/CK19 expressing subtype is associated with better outcome...
  11. ncbi Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours
    Dolores Di Vizio
    Department of Functional and Biomorphological Science, University Federico II, Naples, Italy
    BMC Cancer 8:134. 2008
    ..The aim of our study was to investigate the role of morphologic parameters and expression of cells cycle regulators as prognosticators in GIST...
  12. ncbi SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines
    Francesca Demichelis
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Nucleic Acids Res 36:2446-56. 2008
    ....
  13. ncbi Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort
    Lorelei A Mucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:249-51. 2008
    ..We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer...
  14. ncbi Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma
    Rameen Beroukhim
    Broad Institute, Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:20007-12. 2007
    ..Our results support the feasibility and utility of systematic characterization of the cancer genome...
  15. ncbi Integrative microarray analysis of pathways dysregulated in metastatic prostate cancer
    Sunita R Setlur
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 67:10296-303. 2007
    ..Our results indicate that this pathway is especially dysregulated in hormone-refractory prostate cancer...
  16. ncbi Automated immunofluorescence analysis defines microvessel area as a prognostic parameter in clear cell renal cell cancer
    Kirsten D Mertz
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 38:1454-62. 2007
    ..MVA determination by AQUA is an objective and reliable method to quantify tumor vascularization in ccRCC. A large MVA correlates with a high MVD and is associated with better patient prognosis...
  17. ncbi TMPRSS2-ETS fusion prostate cancer: biological and clinical implications
    Francesca Demichelis
    Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Pathol 60:1185-6. 2007