Thomas F DeLaney

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc The use of radiation therapy in the management of selected patients with atypical lipomas
    Josephine Kang
    Harvard Radiation Oncology Program, Boston, MA 02215, USA Flushing Radiation Oncology Services, Queens, NY 11354, USA
    Sarcoma 2013:485483. 2013
  2. pmc Proton beam therapy
    W P Levin
    Massachusetts General Hospital Northeast Proton Therapy Center, Boston, MA 02114, USA
    Br J Cancer 93:849-54. 2005
  3. doi request reprint Radiation therapy: neoadjuvant, adjuvant, or not at all
    Thomas F DeLaney
    Harvard Medical School, Boston, MA, USA
    Surg Oncol Clin N Am 21:215-41. 2012
  4. ncbi request reprint Advanced-technology radiation therapy in the management of bone and soft tissue sarcomas
    Thomas F DeLaney
    Northeast Proton Therapy Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Control 12:27-35. 2005
  5. doi request reprint Proton therapy in the clinic
    Thomas F DeLaney
    Francis H Burr Proton Therapy Center, Massachusetts General Hospital, Boston, Mass, USA
    Front Radiat Ther Oncol 43:465-85. 2011
  6. ncbi request reprint Advanced-technology radiation therapy for bone sarcomas
    Samir Patel
    Department of Radiation Oncology, Francis H Burr Proton Therapy Center, Massachusetts General Hospital, Boston 02114, USA
    Cancer Control 15:21-37. 2008
  7. ncbi request reprint Clinical proton radiation therapy research at the Francis H. Burr Proton Therapy Center
    Thomas F DeLaney
    Division of Radiation Oncology, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA 02114, USA
    Technol Cancer Res Treat 6:61-6. 2007
  8. pmc Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 74:732-9. 2009
  9. ncbi request reprint Radiation therapy for control of soft-tissue sarcomas resected with positive margins
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 67:1460-9. 2007
  10. ncbi request reprint Radiotherapy for local control of osteosarcoma
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 61:492-8. 2005

Detail Information

Publications76

  1. pmc The use of radiation therapy in the management of selected patients with atypical lipomas
    Josephine Kang
    Harvard Radiation Oncology Program, Boston, MA 02215, USA Flushing Radiation Oncology Services, Queens, NY 11354, USA
    Sarcoma 2013:485483. 2013
    ..For recurrent tumors, pre-op RT of 50 Gy appears to be an effective and well-tolerated management approach...
  2. pmc Proton beam therapy
    W P Levin
    Massachusetts General Hospital Northeast Proton Therapy Center, Boston, MA 02114, USA
    Br J Cancer 93:849-54. 2005
    ..These characteristics make this form of radiotherapy an excellent choice for the treatment of tumours located next to critical structures such as the spinal cord, eyes, and brain, as well as for paediatric malignancies...
  3. doi request reprint Radiation therapy: neoadjuvant, adjuvant, or not at all
    Thomas F DeLaney
    Harvard Medical School, Boston, MA, USA
    Surg Oncol Clin N Am 21:215-41. 2012
    ..Radiation can be delivered by external beam or brachytherapy; it can be given pre-operatively, post-operatively, or intra-operatively. Indications for and advances in radiation therapy are discussed in this article...
  4. ncbi request reprint Advanced-technology radiation therapy in the management of bone and soft tissue sarcomas
    Thomas F DeLaney
    Northeast Proton Therapy Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Control 12:27-35. 2005
    ..For patients with sarcomas, radiotherapy can be used as neoadjuvant, adjuvant, or primary local therapy, depending on the site and type of sarcoma, the surgical approach, and the efficacy of chemotherapy...
  5. doi request reprint Proton therapy in the clinic
    Thomas F DeLaney
    Francis H Burr Proton Therapy Center, Massachusetts General Hospital, Boston, Mass, USA
    Front Radiat Ther Oncol 43:465-85. 2011
    ..Together, these offer practical strategies for expanding the clinical availability of proton therapy...
  6. ncbi request reprint Advanced-technology radiation therapy for bone sarcomas
    Samir Patel
    Department of Radiation Oncology, Francis H Burr Proton Therapy Center, Massachusetts General Hospital, Boston 02114, USA
    Cancer Control 15:21-37. 2008
    ....
  7. ncbi request reprint Clinical proton radiation therapy research at the Francis H. Burr Proton Therapy Center
    Thomas F DeLaney
    Division of Radiation Oncology, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA 02114, USA
    Technol Cancer Res Treat 6:61-6. 2007
    ..Patients' willingness to enter these clinical trials seems to be quite high; accrual to selected studies has been favorable...
  8. pmc Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 74:732-9. 2009
    ..Negative surgical margins are uncommon; hence, doses of >or=66 Gy are recommended. A Phase II clinical trial evaluated high-dose photon/proton XRT for spine sarcomas...
  9. ncbi request reprint Radiation therapy for control of soft-tissue sarcomas resected with positive margins
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 67:1460-9. 2007
    ..Positive margins (PM) remain after surgery in some soft-tissue sarcoma (STS) patients. We investigated the efficacy of radiation therapy (RT) in STS patients with PM...
  10. ncbi request reprint Radiotherapy for local control of osteosarcoma
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 61:492-8. 2005
    ..Local control of osteosarcoma in patients for whom a resection with satisfactory margins is not achieved can be difficult. This study evaluated the efficacy of radiotherapy (RT) in this setting...
  11. ncbi request reprint Optimizing radiation therapy and post-treatment function in the management of extremity soft tissue sarcoma
    Thomas F DeLaney
    Northeast Proton Therapy Center, Massachusetts General Hospital, 30 Fruit Street, Boston, MA 02114, USA
    Curr Treat Options Oncol 5:463-76. 2004
    ..The clinical considerations and the outcome data that must be considered in choosing the most appropriate treatment technique for the individual patient are discussed...
  12. ncbi request reprint Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 56:1117-27. 2003
    ..We report the mature outcome data on 48 treated patients and compare them with the data of an historical matched control patient population...
  13. ncbi request reprint Intraoperative dural irradiation by customized 192iridium and 90yttrium brachytherapy plaques
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 57:239-45. 2003
    ..Because a tumoricidal dose is difficult to achieve using external beam radiotherapy without exceeding the spinal cord tolerance, we developed intraoperative applicators to deliver additional dose to the dura...
  14. pmc Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: a 10-year single institution retrospective study
    Nicole J Look Hong
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Eur J Cancer 49:875-83. 2013
    ..The goal of this study is to assess outcomes in a recent cohort of patients treated on this regimen...
  15. ncbi request reprint Treatment and outcome of 82 patients with angiosarcoma
    John A Abraham
    Orthopedic Oncology, Department of Orthopedics, Massachusetts General Hospital, Yawkey 7B 7926, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Ann Surg Oncol 14:1953-67. 2007
    ..Angiosarcomas are an uncommon type of malignancy that are generally thought to behave usually in a locally aggressive fashion; they often metastasize to distant sites...
  16. doi request reprint Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas
    John T Mullen
    Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Cancer 118:3758-65. 2012
    ..We report the long-term follow-up data on 48 patients treated with this regimen compared to an historical matched-control patient population...
  17. pmc Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas
    Sam S Yoon
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 17:1515-29. 2010
    ..We sought to reduce local recurrence for retroperitoneal sarcomas by using a coordinated strategy of advanced radiation techniques and aggressive en-bloc surgical resection...
  18. ncbi request reprint Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor
    Lily Park
    Department of Radiation, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 65:1514-21. 2006
    ..To assess the efficacy of definitive treatment of sacral chordoma by high-dose proton/photon-beam radiation therapy alone or combined with surgery...
  19. doi request reprint Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone
    Timothy D Wagner
    Department of Radiation Oncology, Brooke Army Medical Center, Fort Sam Houston, TX, USA
    Int J Radiat Oncol Biol Phys 73:259-66. 2009
    ....
  20. pmc Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists
    Dian Wang
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53045, USA
    Int J Radiat Oncol Biol Phys 81:e775-80. 2011
    ..To evaluate variability in the definition of preoperative radiotherapy gross tumor volume (GTV) and clinical target volume (CTV) delineated by sarcoma radiation oncologists...
  21. doi request reprint Chondrosarcoma of the mobile spine: a review of 21 cases treated at a single center
    Andrew J Schoenfeld
    Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 37:119-26. 2012
    ..Retrospective case series...
  22. doi request reprint An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control
    Bokyong Kim
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 77:843-50. 2010
    ..We retrospectively analyzed the pattern of local failure (LF) to help elucidate optimal field design...
  23. doi request reprint Low-dose neoadjuvant external beam radiation therapy for soft tissue sarcoma
    Kiran Devisetty
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 02114, USA
    Int J Radiat Oncol Biol Phys 80:779-86. 2011
    ..We examined whether low-dose neoadjuvant EBRT would decrease acute toxicity while maintaining LC...
  24. doi request reprint Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 86:484-90. 2013
    ..We report acute toxicities and feasibility of proton delivery for 12 women treated with postmastectomy proton radiation with or without reconstruction...
  25. pmc Prognostic factors and outcomes of patients with myxofibrosarcoma
    Nicole J Look Hong
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 20:80-6. 2013
    ..The objectives of this study were to analyze the prognostic factors and outcomes of patients with MFS treated at a single institution...
  26. pmc Proton radiotherapy: the biological effect of treating alternating subsets of fields for different treatment fractions
    Martijn Engelsman
    Francis H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02139, USA
    Int J Radiat Oncol Biol Phys 79:616-22. 2011
    ..We investigate using biological modeling if the resulting variation in daily dose to normal tissues has a relevant detrimental biological effect...
  27. doi request reprint Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas
    Ugwuji N Maduekwe
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    Ann Surg Oncol 16:1356-63. 2009
    ..The utility of sentinel lymph node biopsy (SLNB) for patients with these sarcoma subtypes is unknown...
  28. doi request reprint MRI surveillance following treatment of extremity soft tissue sarcoma
    Matthew D Cheney
    Harvard Radiation Oncology Program, Boston, Massachusetts
    J Surg Oncol 109:593-6. 2014
    ..The current study investigates the utility of surveillance nuclear magnetic resonance imaging (MRI) for detection of asymptomatic LRs...
  29. doi request reprint Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series
    John T Mullen
    Division of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA
    Ann Surg Oncol 19:4028-35. 2012
    ..Desmoid tumors are rare and exhibit a highly unpredictable natural history. We sought to analyze prognostic factors associated with recurrence in a large single-institution study of patients with desmoid tumors...
  30. pmc Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas
    Sam S Yoon
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 81:1081-90. 2011
    ..We sought to examine the safety and efficacy of bevacizumab (BV) and RT in soft tissue sarcomas and explore biomarkers to help determine the treatment response...
  31. pmc Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma
    I Frank Ciernik
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cancer 117:4522-30. 2011
    ..A study was undertaken to assess clinical outcome and the role of proton therapy for local control of osteosarcoma (OSA)...
  32. ncbi request reprint Dosimetric feasibility of hypofractionated proton radiotherapy for neoadjuvant pancreatic cancer treatment
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 68:1557-66. 2007
    ..To evaluate tumor and normal tissue dosimetry of a 5 cobalt gray equivalent (CGE) x 5 fraction proton radiotherapy schedule, before initiating a clinical trial of neoadjuvant, short-course proton radiotherapy for pancreatic adenocarcinoma...
  33. pmc Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy
    John T Mullen
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts
    Cancer 120:3676-82. 2014
    ..In the current study, the authors sought to determine the prognostic significance of treatment-induced pathologic necrosis in patients receiving neoadjuvant chemoradiotherapy for STS...
  34. doi request reprint Phase I study of preoperative short-course chemoradiation with proton beam therapy and capecitabine for resectable pancreatic ductal adenocarcinoma of the head
    Theodore S Hong
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 79:151-7. 2011
    ..To evaluate the safety of 1 week of chemoradiation with proton beam therapy and capecitabine followed by early surgery...
  35. ncbi request reprint Dosimetric comparison of proton and photon three-dimensional, conformal, external beam accelerated partial breast irradiation techniques
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 65:1572-8. 2006
    ..To compare the dosimetry of proton and photon-electron three-dimensional, conformal, external beam accelerated partial breast irradiation (3D-CPBI)...
  36. pmc A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors
    Theodore S Hong
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Electronic address
    Pract Radiat Oncol 4:316-22. 2014
    ..To evaluate the feasibility of a respiratory-gated proton beam therapy for liver tumors...
  37. doi request reprint Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas
    Thomas F DeLaney
    Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    J Surg Oncol 110:115-22. 2014
    ..Negative surgical margins are uncommon for spine sarcomas; hence, adjuvant radiotherapy (RT) may be recommended but tumor dose may be constrained by spinal cord, nerve, and viscera tolerance...
  38. pmc Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparison
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 69:444-53. 2007
    ..To compare intensity-modulated photon radiotherapy (IMRT) with three-dimensional conformal proton therapy (3D-CPT) for early-stage prostate cancer, and explore the potential utility of intensity-modulated proton therapy (IMPT)...
  39. ncbi request reprint A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer
    Neil E Martin
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:5447-54. 2004
    ....
  40. pmc RTOG sarcoma radiation oncologists reach consensus on gross tumor volume and clinical target volume on computed tomographic images for preoperative radiotherapy of primary soft tissue sarcoma of extremity in Radiation Therapy Oncology Group studies
    Dian Wang
    Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53045, USA
    Int J Radiat Oncol Biol Phys 81:e525-8. 2011
    ..To develop a Radiation Therapy Oncology Group (RTOG) atlas delineating gross tumor volume (GTV) and clinical target volume (CTV) to be used for preoperative radiotherapy of primary extremity soft tissue sarcoma (STS)...
  41. ncbi request reprint Anterior spinal arthrodesis with structural cortical allografts and instrumentation for spine tumor surgery
    Kai Uwe Lewandrowski
    Department of Orthopaedics, Massachusetts General Hospital, Boston, Massachusets, USA
    Spine (Phila Pa 1976) 29:1150-8; discussion 1159. 2004
    ..A retrospective analysis of clinical outcomes is presented...
  42. doi request reprint Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel
    Elizabeth H Baldini
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    Int J Radiat Oncol Biol Phys 92:602-12. 2015
    ..An international expert panel was convened to develop consensus treatment guidelines for preoperative RT for RPS...
  43. ncbi request reprint Accelerated partial-breast irradiation using proton beams: initial clinical experience
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:691-8. 2006
    ..We present our initial clinical experience with proton, three-dimensional, conformal, external beam, partial-breast irradiation (3D-CPBI)...
  44. ncbi request reprint Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons/protons
    Damien C Weber
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Radiother Oncol 81:243-9. 2006
    ..To investigate the visual outcomes of patients with advanced sinonasal malignancies treated with proton/photon accelerated fractionated radiation (AFR)...
  45. doi request reprint Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital
    Andrew J Schoenfeld
    Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Spine J 10:708-14. 2010
    ..Because of the low incidence, treatment recommendations for spinal osteosarcoma are guided by the results of small series and case reports. Many include patients who presented for treatment over the course of three to four decades...
  46. doi request reprint Management of acral myxoinflammatory fibroblastic sarcoma
    Ajay Tejwani
    Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cancer 116:5733-9. 2010
    ..In this report, the outcome of 17 patients with AMFS treated at the study institution was reported...
  47. pmc Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy
    Katia Parodi
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 68:920-34. 2007
    ..To investigate the feasibility and value of positron emission tomography and computed tomography (PET/CT) for treatment verification after proton radiotherapy...
  48. pmc [18F]-Fluoromisonidazole positron emission tomography/computed tomography visualization of tumor hypoxia in patients with chordoma of the mobile and sacrococcygeal spine
    Matthew D Cheney
    Harvard Radiation Oncology Program, Boston, Massachusetts Electronic address
    Int J Radiat Oncol Biol Phys 90:1030-6. 2014
    ..To investigate [18F]-fluoromisonidazole positron emission tomography/computed tomography (FMISO-PET/CT) detection of targetable hypoxic subvolumes (HSVs) in chordoma of the mobile or sacrococcygeal spine...
  49. pmc CT perfusion as an imaging biomarker in monitoring response to neoadjuvant bevacizumab and radiation in soft-tissue sarcomas: comparison with tumor morphology, circulating and tumor biomarkers, and gene expression
    Avinash Kambadakone
    1 Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, White 270, 55 Fruit St, Boston, MA 02114
    AJR Am J Roentgenol 204:W11-8. 2015
    ....
  50. doi request reprint A case study in proton pencil-beam scanning delivery
    Hanne M Kooy
    F H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 76:624-30. 2010
    ..The aim of radiotherapy is to improve the target to healthy tissue dose differential. We illustrate how PBS achieves this aim in a patient with a bulky tumor...
  51. doi request reprint Role of post-operative radiation boost for soft tissue sarcomas with positive margins following pre-operative radiation and surgery
    Elizabeth Pan
    Department of Radiation Oncology, Boston, Massachusetts Massachusetts General Hospital, Boston, Massachusetts University of Southern California Keck School of Medicine, Los Angeles, California
    J Surg Oncol 110:817-22. 2014
    ..We assessed the contribution of a boost to local control (LC), disease-free survival (DFS), and overall survival (OS)...
  52. pmc Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA
    Radiat Oncol 8:71. 2013
    ..This study investigates the use of protons for PMRT in selected patients with unfavorable cardiac anatomy. We also report the first clinical application of protons for these patients...
  53. ncbi request reprint Accelerated partial breast irradiation using proton beams: Initial dosimetric experience
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 65:1404-10. 2006
    ..We present our initial experience with protons for three-dimensional, conformal, external-beam accelerated partial breast irradiation (3D-CPBI)...
  54. ncbi request reprint Sarcoma and skin radiation oncology
    Elena Antoaneta Nedea
    Northeast Proton Therapy Center, Massachusetts General Hospital, 30 Fruit Street, Boston, MA 02114, USA
    Hematol Oncol Clin North Am 20:401-29. 2006
    ..Radiotherapy can be an important component of treatment in these patients. It can help optimize local control of the tumor and often allows preservation of organ function with excellent cosmesis...
  55. pmc Quality of life outcomes in proton and photon treated pediatric brain tumor survivors
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Proton Center, Boston, United States Electronic address
    Radiother Oncol 113:89-94. 2014
    ..This study compares HRQoL in PRT and photon (XRT) pediatric brain tumor survivors...
  56. ncbi request reprint Real-time rationing of scarce resources: the Northeast Proton Therapy Center experience
    Reshma Jagsi
    DPhil, Massachusetts General Hospital, Department of Radiation Oncology, Cox 3, 100 Blossom St, Boston, MA 02114, USA
    J Clin Oncol 22:2246-50. 2004
  57. ncbi request reprint Malignant transformation of synovial chondromatosis of the shoulder to chondrosarcoma. A case report
    Alexander P Sah
    Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Bone Joint Surg Am 89:1321-8. 2007
  58. doi request reprint Post-operative renal function following nephrectomy as part of en bloc resection of retroperitoneal sarcoma (RPS)
    Melissa A Hull
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts
    J Surg Oncol 112:98-102. 2015
    ..Although resection of RPS with en bloc nephrectomy confers the potential benefit of improved locoregional tumor control, little has been published about the long-term post-operative renal function of these patients...
  59. pmc Retroperitoneal Sarcoma Target Volume and Organ at Risk Contour Delineation Agreement Among NRG Sarcoma Radiation Oncologists
    Elizabeth H Baldini
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    Int J Radiat Oncol Biol Phys 92:1053-9. 2015
    ..The purpose of this study was to evaluate the variability in target volume and organ at risk (OAR) contour delineation for retroperitoneal sarcoma (RPS) among 12 sarcoma radiation oncologists...
  60. doi request reprint A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma
    Theodore S Hong
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Electronic address
    Int J Radiat Oncol Biol Phys 89:830-8. 2014
    ..To evaluate the safety, efficacy and biomarkers of short-course proton beam radiation and capecitabine, followed by pancreaticoduodenectomy in a phase 1/2 study in pancreatic ductal adenocarcinoma (PDAC) patients...
  61. pmc Comparison of Perioperative Radiation Therapy and Surgery Versus Surgery Alone in 204 Patients With Primary Retroperitoneal Sarcoma: A Retrospective 2-Institution Study
    Kaitlyn J Kelly
    Department of Surgery, Sarcoma Disease Management Program, Memorial Sloan Kettering Cancer Center, New York, NY Department of Surgery, Massachusetts General Hospital, Boston, MA Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
    Ann Surg 262:156-62. 2015
    ..To compare outcomes of patients with retroperitoneal or pelvic sarcoma treated with perioperative radiation therapy (RT) versus those treated without perioperative RT...
  62. pmc Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial
    Dian Wang
    Dian Wang, Rush University Medical Center, Chicago, IL Qiang Zhang, NRG Oncology Statistics and Data Management Center, Philadelphia, PA Burton L Eisenberg, Hoag University of Southern California Norris Cancer Center, Los Angeles, CA John M Kane and Anurag K Singh, Roswell Park Cancer Institute, Buffalo, NY X Allen Li and Manpreet Bedi, Medical College of Wisconsin, Milwaukee, WI David Lucas, University of Michigan, Ann Arbor, MI Ivy A Petersen, Mayo Clinic, Rochester, MN Thomas F DeLaney, Massachusetts General Hospital, Boston, MA Carolyn R Freeman, McGill University Health Centre, Montreal, Quebec George Dundas, Cross Cancer Institute, Edmonton, Alberta, Canada Steven E Finkelstein, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL Ying J Hitchcock, University of Utah, Salt Lake City, UT and David G Kirsch, Duke University Medical Center, Durham, NC
    J Clin Oncol 33:2231-8. 2015
    ..We performed a multi-institutional prospective phase II trial to assess late toxicities in patients with extremity soft tissue sarcoma (STS) treated with preoperative image-guided radiation therapy (IGRT) to a reduced target volume...
  63. doi request reprint Surgical placement of biologic mesh spacers prior to external beam radiation for retroperitoneal and pelvic tumors
    Sam S Yoon
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts Electronic address
    Pract Radiat Oncol 3:199-208. 2013
    ..To determine the feasibility of surgical placement of biologic mesh spacers to displace bowel and other radiation-sensitive organs prior to external beam radiation for difficult retroperitoneal and pelvic tumors...
  64. doi request reprint Role of resection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis type 1
    Gavin P Dunn
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosurg 118:142-8. 2013
    ..Here, the authors aim to examine what role the extent of resection and other covariates play in the long-term survival of patients with NF1 in the setting of MPNST...
  65. pmc Consolidation whole abdomen irradiation following adjuvant carboplatin-paclitaxel based chemotherapy for advanced uterine epithelial cancer: feasibility, toxicity and outcomes
    Nathalie Rochet
    Department of Radiation Oncology, Massachusetts General Hospital Harvard Medical School, 100 Blossom Street, COX3, Boston, MA 02114, USA
    Radiat Oncol 8:236. 2013
    ..To evaluate feasibility and preliminary outcomes associated with sequential whole abdomen irradiation (WAI) as consolidative treatment following comprehensive surgery and systemic chemotherapy for advanced endometrial cancer...
  66. doi request reprint Analysis of setup uncertainties for extremity sarcoma patients using surface imaging
    David P Gierga
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts Electronic address
    Pract Radiat Oncol 4:261-6. 2014
    ..A surface imaging technique was utilized to quantify the setup uncertainties for sarcoma patients and to assess whether surface imaging could improve the accuracy of patient positioning...
  67. ncbi request reprint A Phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer
    Stephen M Hahn
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Clin Cancer Res 8:1065-72. 2002
    ..The objective of this Phase I trial was to determine the maximally tolerated dose of the FTI L-778,123 in combination with radiotherapy in non-small cell lung cancer (NSCLC) and head and neck cancer (HNC)...
  68. ncbi request reprint Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514
    William G Kraybill
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Clin Oncol 24:619-25. 2006
    ..On the basis of a positive reported single-institution pilot study, the Radiation Therapy Oncology Group initiated phase II trial 9514 to evaluate its neoadjuvant regimen in a multi-institutional Intergroup setting...
  69. ncbi request reprint A treatment planning comparison of intensity modulated photon and proton therapy for paraspinal sarcomas
    Damien C Weber
    Department of Radiation Medicine, Paul Scherrer Institute, Villigen PSI, Switzerland
    Int J Radiat Oncol Biol Phys 58:1596-606. 2004
    ..Finally, a 10% and 20% dose escalation with IM protons was planned, and the consequential organ at risk (OAR) irradiation was evaluated...
  70. ncbi request reprint Proton beam radiation therapy
    Shannon M Macdonald
    New York University Cancer Center, New York University Medical Center, New York, USA
    Cancer Invest 24:199-208. 2006
  71. ncbi request reprint Results of radiation therapy for unresected soft-tissue sarcomas
    Lucyna Kepka
    Department of Radiation Oncology, M Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    Int J Radiat Oncol Biol Phys 63:852-9. 2005
    ..Definitive radiotherapy is uncommonly used in the management of soft-tissue sarcoma (STS). The purpose of the study was to evaluate the results of radiotherapy for unresected STSs treated in a single institution...
  72. ncbi request reprint Results of radiation therapy performed after unplanned surgery (without re-excision) for soft tissue sarcomas
    Lucyna Kepka
    Department of Radiation Oncology, M Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    J Surg Oncol 92:39-45. 2005
    ..The treatment of choice, in such cases, is re-excision combined (if indicated) with radiation. However, there are clinical situations when treatment by radiation alone is recommended. Here results of such an approach are assessed...
  73. ncbi request reprint Neutron dose in proton radiation therapy: in regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7)
    Harald Paganetti
    Int J Radiat Oncol Biol Phys 66:1594-5; author reply 1595. 2006
  74. ncbi request reprint Diagnosis of sarcoma by core biopsy
    Thomas F DeLaney
    J Surg Oncol 94:1-2. 2006
  75. ncbi request reprint Musculoskeletal desmoid tumors
    Harish S Hosalkar
    Department of Orthopaedic Surgery, University of Pennsyvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Am Acad Orthop Surg 16:188-98. 2008
    ..Chemotherapy in low doses is an excellent first-round treatment in any patient in whom contemplated local treatment may produce local morbidity and adjacent tissue injury...
  76. ncbi request reprint Soft tissue sarcoma
    George D Demetri
    Dana Faber Brigham and Women s Cancer Center, USA
    J Natl Compr Canc Netw 5:364-99. 2007