Federica Del Monte

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling
    Federica Del Monte
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:5622-7. 2004
  2. ncbi request reprint Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model
    Susumu Sakata
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, CNY 4, Charlestown, MA 02129, USA
    Am J Physiol Heart Circ Physiol 292:H1204-7. 2007
  3. doi request reprint Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban
    Tsuyoshi Tsuji
    Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Heart Circ Physiol 296:H310-7. 2009
  4. doi request reprint Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion
    Fabrice Prunier
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Circulation 118:614-24. 2008
  5. pmc Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins
    Susumu Sakata
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA
    J Mol Cell Cardiol 42:852-61. 2007
  6. pmc Cardiomyogenesis in the aging and failing human heart
    Jan Kajstura
    Department of Anesthesia, Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 126:1869-81. 2012
  7. ncbi request reprint Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer
    Susumu Sakata
    Cardiovascular Research Center, Cardiology Laboratory of Integrative Physiology and Imaging, Massachusetts General Hospital, 149 13th Street, CNY 4, Charlestown, MA 02129, USA
    Mol Ther 13:987-96. 2006
  8. ncbi request reprint In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis
    Djamel Lebeche
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 110:3435-43. 2004
  9. pmc Human cardiac stem cell differentiation is regulated by a mircrine mechanism
    Toru Hosoda
    Departments of Anesthesia and Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Circulation 123:1287-96. 2011
  10. doi request reprint Progressive nature of chronic mitral regurgitation and the role of tissue Doppler-derived indexes
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02115 2696, USA
    Am J Physiol Heart Circ Physiol 294:H2106-11. 2008

Research Grants

  1. SERCA2a Abnormalities and Chaperones in Heart Failure
    Federica Del Monte; Fiscal Year: 2006

Detail Information

Publications52

  1. pmc Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling
    Federica Del Monte
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:5622-7. 2004
    ..SERCA2a group was consistent throughout the 48 h of monitoring. These results show that improving intracellular Ca(2+) handling by overexpression of SERCA2a restores contractile function and reduces ventricular arrhythmias during I/R...
  2. ncbi request reprint Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model
    Susumu Sakata
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, CNY 4, Charlestown, MA 02129, USA
    Am J Physiol Heart Circ Physiol 292:H1204-7. 2007
    ..In conclusion, in DM failing hearts, SERCA2a gene transfer can increase coronary blood flow and reduce cardiomyocyte size without reduction in collagen production...
  3. doi request reprint Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban
    Tsuyoshi Tsuji
    Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Heart Circ Physiol 296:H310-7. 2009
    ..We conclude that SERCA2a function enhanced by adenoviral gene transfer of asPLB prevents Ca2+ overload-induced LV contractile dysfunction in terms of mechanical work and especially energetics...
  4. doi request reprint Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion
    Fabrice Prunier
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Circulation 118:614-24. 2008
    ..We inquired whether sarcoplasmic reticulum Ca2+ ATPase pump (SERCA2a) overexpression could reduce ischemic ventricular arrhythmias by modulating Ca2+ overload...
  5. pmc Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins
    Susumu Sakata
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA
    J Mol Cell Cardiol 42:852-61. 2007
    ..Therefore enhancement of calcium handling either by resequestration into the SR or by intracellular buffering improves not only mechanical but energetic function in failing hearts...
  6. pmc Cardiomyogenesis in the aging and failing human heart
    Jan Kajstura
    Department of Anesthesia, Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 126:1869-81. 2012
    ....
  7. ncbi request reprint Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer
    Susumu Sakata
    Cardiovascular Research Center, Cardiology Laboratory of Integrative Physiology and Imaging, Massachusetts General Hospital, 149 13th Street, CNY 4, Charlestown, MA 02129, USA
    Mol Ther 13:987-96. 2006
    ..SERCA2a gene transfer transforms this inefficient energy utilization into a more efficient state and restores systolic and diastolic function to normal...
  8. ncbi request reprint In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis
    Djamel Lebeche
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 110:3435-43. 2004
    ..The relation between electrical remodeling and cardiac hypertrophy in vivo is unknown...
  9. pmc Human cardiac stem cell differentiation is regulated by a mircrine mechanism
    Toru Hosoda
    Departments of Anesthesia and Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Circulation 123:1287-96. 2011
    ..However, the interaction of CSCs with postmitotic myocytes results in the formation of cells with adult characteristics...
  10. doi request reprint Progressive nature of chronic mitral regurgitation and the role of tissue Doppler-derived indexes
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02115 2696, USA
    Am J Physiol Heart Circ Physiol 294:H2106-11. 2008
    ..001). Therefore, in a chronic model of MR, serial echocardiography demonstrated that MR begets MR and that those TD-derived indexes that initially increased post-MR decreased to baseline before any changes in LV ejection fraction...
  11. pmc Cardiomyogenesis in the adult human heart
    Jan Kajstura
    Department of Anesthesia and Medicine, and Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Circ Res 107:305-15. 2010
    ..The ability of the human heart to regenerate large quantities of myocytes remains controversial, and the extent of myocyte renewal claimed by different laboratories varies from none to nearly 20% per year...
  12. pmc Catheter-based antegrade intracoronary viral gene delivery with coronary venous blockade
    Motoya Hayase
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, CNY 4, Charlestown, MA 02129 2060, USA
    Am J Physiol Heart Circ Physiol 288:H2995-3000. 2005
    ..01) in the left ventricular wall and 0.91 +/- 0.1 vs. 0.66 +/- 0.07 ng (P </= 0.05) in the right ventricular wall. PAMGT with selective coronary venous blockade is feasible, reproducible, and safely achieved in a large-animal model...
  13. ncbi request reprint Targeted gene transfer in heart failure: implications for novel gene identification
    Federica Del Monte
    Harvard Medical School, Massachusetts General Hospital, Cardiology Division, Cardiology Laboratory of Integrative Physiology and Imaging, 55 Fruit Street, Boston, MA 02115, USA
    Curr Opin Mol Ther 6:381-94. 2004
    ..In addition, gene-based reconstitution of a normal phenotype allows us to closely examine the behavior of a large number of transcripts as the heart fails and is rescued by genetic manipulations...
  14. ncbi request reprint Efficient viral gene transfer to rodent hearts in vivo
    Federica Del Monte
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, USA
    Methods Mol Biol 219:179-93. 2003
  15. pmc Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes
    Sergio Signore
    Departments of Anesthesia and Medicine and Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA S S, A s, J F M, R K, M S, F D B, K I, C A, E W, A W, F S, B O, H Z, X L, T H, P G, A L, J K, P A, M R Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA F d M and Department of Cardiovascular and Thoracic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY D A D, O W, R E M
    Circulation 128:1286-97. 2013
    ..IP3Rs may be activated after Gαq-protein-coupled receptor stimulation, affecting Ca(2+) cycling, enhancing myocyte performance, and potentially favoring an increase in the incidence of arrhythmias...
  16. pmc Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity
    Jian Guan
    Divisions of Cardiovascular Medicine and Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 431, Boston, MA 02115, USA
    Basic Res Cardiol 108:378. 2013
    ..Collectively, this work identifies STC1 as a critical determinant of AL-LC cardiotoxicity. ..
  17. ncbi request reprint Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
    Bernhard Kuhn
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 13:962-9. 2007
    ..Thus, periostin and the pathway that it regulates may provide a target for innovative strategies to treat heart failure...
  18. pmc Targeting calcium cycling proteins in heart failure through gene transfer
    Federica Del Monte
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Physiol 546:49-61. 2003
    ..In this review, we will examine our current understanding of these various factors. Gene transfer provides not only a potential therapeutic modality but also an approach to identifying and validating molecular targets...
  19. doi request reprint Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation
    Ronen Beeri
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 51:476-86. 2008
    ..We examined whether mitral regurgitation (MR) augments post-myocardial infarction (MI) remodeling...
  20. pmc The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction
    Polina Goichberg
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Circ Res 108:1071-83. 2011
    ..Understanding the mechanisms that regulate trafficking of human cardiac stem cells (hCSCs) may lead to development of new therapeutic approaches for the failing heart...
  21. ncbi request reprint Gene therapy for the treatment of heart failure--calcium signaling
    Oliver Y Bernecker
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Semin Thorac Cardiovasc Surg 15:268-76. 2003
    ..This article reviews recent advances in gene delivery techniques aimed at global myocardial transfection and discusses molecular therapeutic targets identified within intracellular calcium signaling pathways in heart failure...
  22. ncbi request reprint Modulating signaling pathways in hypertrophy and heart failure by gene transfer
    Fawzia Huq
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Card Fail 8:S389-400. 2002
    ....
  23. ncbi request reprint SERCA2a in heart failure: role and therapeutic prospects
    Davide Gianni
    Cardiovascular Research Centre, Heart Failure Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Bioenerg Biomembr 37:375-80. 2005
    ..This review focuses on the molecular characteristics of the pump, its role during the cardiac cycle and the prospects derived from the manipulation of SERCA2a for heart failure treatment...
  24. ncbi request reprint Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure
    Federica Del Monte
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Physiol Genomics 9:49-56. 2002
    ..Furthermore, our approach to delivery of transgenes results in homogenous gene expression in both hypertrophied and failing hearts...
  25. ncbi request reprint Targeting Ca2+ cycling proteins and the action potential in heart failure by gene transfer
    Roger Kaprielian
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, CNY 4, 4215, Charlestown, MA 02129, USA
    Basic Res Cardiol 97:I136-45. 2002
    ..Gene transfer, which serves initially as an experimental tool, may provide a novel therapeutic approach...
  26. doi request reprint Intracellular devastation in heart failure
    Federica Del Monte
    Cardiovascular Research, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Heart Fail Rev 13:151-62. 2008
    ..In this article, we will review the changes in calcium cycling that occur in myopathic hearts and how they can be effectively targeted. We will also focus on protein misfolding in the setting of cardiac dysfunction...
  27. ncbi request reprint Transgenic models of heart failure: elucidation of the molecular mechanisms of heart disease
    Djamel Lebeche
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Heart Fail Clin 1:219-36. 2005
  28. pmc Targeting phospholamban by gene transfer in human heart failure
    Federica Del Monte
    Cardiovascular Research Center, Massachusetts General Hospital, Heart Failure and Cardiac Transplantation Center, Boston, Mass 02129, USA
    Circulation 105:904-7. 2002
    ..In this study, we tested whether contractile function can be improved by decreasing the inhibitory effects of phospholamban on SERCA2a with adenoviral gene transfer of antisense phospholamban (asPL)...
  29. pmc Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy
    Davide Gianni
    Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA 02125, USA
    Circulation 121:1216-26. 2010
    ..In the brain of patients with dementia, proteinaceous aggregates and abnormal oligomeric assemblies of beta-amyloid impair cell function and lead to cell death...
  30. ncbi request reprint Transcriptional changes following restoration of SERCA2a levels in failing rat hearts
    Federica Del Monte
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    FASEB J 18:1474-6. 2004
    ..The microarray analysis identified new genes following SERCA2a restoration in heart failure, which will give us insights into their role in the normalization of multiple pathways within the failing cell...
  31. pmc PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury
    Tomohisa Nagoshi
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:2128-38. 2005
    ..These data demonstrate that PI3K-dependent but Akt-independent effectors are required for full cardioprotection and suggest a mechanism by which chronic Akt activation can become maladaptive...
  32. pmc Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway
    Jianru Shi
    Cardiac Muscle Research Laboratory, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:4188-93. 2010
    ....
  33. ncbi request reprint Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy
    Akira Nakayama
    Beth Israel Deaconess Medical Center, HIM 1023, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Imaging 1:365-77. 2002
    ..This imaging system may prove useful for the refinement of revascularization techniques, and for the administration of cardiac gene therapy...
  34. pmc Cardiac angiogenic imbalance leads to peripartum cardiomyopathy
    Ian S Patten
    Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02115, USA
    Nature 485:333-8. 2012
    ..The data also explain how late pregnancy poses a threat to cardiac homeostasis, and why pre-eclampsia and multiple gestation are important risk factors for the development of PPCM...
  35. pmc Atrial natriuretic peptide is negatively regulated by microRNA-425
    Pankaj Arora
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 123:3378-82. 2013
    ..This study identifies miR-425 as a regulator of ANP production, raising the possibility that miR-425 antagonists could be used to treat disorders of salt overload, including hypertension and heart failure. ..
  36. pmc Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling
    Saumya Das
    Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 126:2208-19. 2012
    ..Here, we investigated the downstream phosphatidylinositol 3-kinase effector, serum- and glucocorticoid-regulated kinase-1 (SGK1), in heart failure and its complications...
  37. doi request reprint Myocyte turnover in the aging human heart
    Jan Kajstura
    Department of Anesthesia and Medicine and Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 107:1374-86. 2010
    ..The turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology...
  38. ncbi request reprint Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells
    Fabrice Prunier
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, CNY 4, Rm 4215, Charlestown, MA 02129, USA
    Am J Physiol Heart Circ Physiol 292:H522-9. 2007
    ..We found that chronic EPO treatment reduces MI size and improves cardiac function only at a dose that induces EPC mobilization in blood and that increases capillary density in the infarct border zone...
  39. ncbi request reprint Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function
    Kimberly N Gregory
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267 0575, USA
    J Mol Cell Cardiol 40:653-65. 2006
    ..Collectively, these data suggest that HRC may be an integral regulatory protein involved in cardiac muscle SR Ca uptake and Ca homeostasis...
  40. ncbi request reprint Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes
    Babar Chaudhri
    National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London SW3 6LY, United Kingdom
    Am J Physiol Heart Circ Physiol 283:H2450-7. 2002
    ..We find no evidence for Ca(2+) overload induced by SERCA2a overexpression alone or in combination with catecholamines...
  41. ncbi request reprint Titin isoform switch in ischemic human heart disease
    Ciprian Neagoe
    Institute of Physiology and Pathophysiology, University of Heidelberg, Germany
    Circulation 106:1333-41. 2002
    ..Human heart sarcomeres coexpress 2 principal titin isoforms, a more compliant N2BA isoform and a stiffer N2B isoform. In comparison, normal rat hearts express almost no N2BA titin...
  42. pmc Type 1 phosphatase, a negative regulator of cardiac function
    Andrew N Carr
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Cell Biol 22:4124-35. 2002
    ..Thus, PP1 is an important regulator of cardiac function, and inhibition of its activity may represent a novel therapeutic target in heart failure...
  43. ncbi request reprint Dissociation of hypertrophic growth from changes in myocyte contractile function
    Sian E Harding
    National Heart and Lung Institute, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, London, UK
    J Card Fail 8:S415-20. 2002
    ..Additionally, in an animal model, physiologic growth concurrent with pathophysiologic hypertrophy induces similar changes in myocyte macroarchitecture but without the deleterious consequences for contractile function...
  44. ncbi request reprint Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1
    Anand Pathak
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0575, USA
    Circ Res 96:756-66. 2005
    ..Thus, the inhibitor 1 of the type 1 phosphatase may represent an attractive new therapeutic target...
  45. ncbi request reprint Cardiac-specific gene expression facilitated by an enhanced myosin light chain promoter
    Wolfgang Boecker
    Klinikum Grosshadern
    Mol Imaging 3:69-75. 2004
    ..Adenoviral gene transfer has been shown to be effective in cardiac myocytes in vitro and in vivo. A major limitation of myocardial gene therapy is the extracardiac transgene expression...
  46. ncbi request reprint Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat
    Larissa Lipskaia
    INSERM U621 IFR 14, UPMC CHU Pitié Salpêtrière, Paris, France
    Circ Res 97:488-95. 2005
    ..In conclusion, we provide the first evidence that increasing SERCA2a activity inhibits VSMC proliferation and balloon injury-induced neointima formation...
  47. ncbi request reprint Gene transfer in cardiac myocytes
    Babar B Chaudhri
    Imperial College, London, UK
    Surg Clin North Am 84:141-59, ix-x. 2004
    ..Lessons gleaned from gene transfer experiments on local modulation of cardiac genetic programs will guide attempts to transform early investigations into established therapy...
  48. ncbi request reprint Contractile effects of adenovirally-mediated increases in SERCA2a activity: a comparison between adult rat and rabbit ventricular myocytes
    Babar Chaudhri
    National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Mol Cell Biochem 251:103-9. 2003
    ..Both SERCA2a overexpression and phospholamban down-regulation are effective strategies, and neither appears to produce supraphysiological stimulatory effects on contraction or relaxation...
  49. ncbi request reprint Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase
    Demetrios A Arvanitis
    Molecular Biology Division, Center for Basic Research, Foundation for Biomedical Research of the Academy of Athens, Athens, Greece
    Am J Physiol Heart Circ Physiol 293:H1581-9. 2007
    ..Collectively, our data suggest that HRC may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart...
  50. ncbi request reprint Defects in calcium control
    Federica Del Monte
    Gwathmey, Inc, Cambridge, Massachusetts, USA
    J Card Fail 8:S421-31. 2002
    ..Action potentials were also recorded from isolated muscle strips. Findings from isolated myocytes loaded with an intracellular calcium indicator are also reported...
  51. doi request reprint Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: sex-related differences
    Georges E Haddad
    Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, District of Columbia, USA
    Physiol Genomics 33:267-77. 2008
    ..Our observations further suggest for the first time ever novel targets for treatment of IDCM in women and men...
  52. ncbi request reprint Antisense strategies for treatment of heart failure
    Sian E Harding
    National Heart and Lung Institute, Imperial College, London, UK
    Methods Mol Med 106:69-82. 2005

Research Grants1

  1. SERCA2a Abnormalities and Chaperones in Heart Failure
    Federica Del Monte; Fiscal Year: 2006
    ..abstract_text> ..