Karin M Danzer
Affiliation: Massachusetts General Hospital
- Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathologyKarin M Danzer
CNS Research Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
J Neurochem 111:192-203. 2009..Our data indicate that extracellular alpha-syn oligomers can induce intracellular alpha-syn aggregation, therefore we hypothesize that a similar mechanism might lead to alpha-syn pathology propagation...
- Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomersKarin M Danzer
Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
J Neurochem 103:2401-7. 2007..Thus, PAKs may represent a target for various neurotoxic protein oligomers, and signaling deficits may contribute to the behavioral defects in chronic neurodegenerative diseases...